GGRNA | NM_003633.3

LOCUS       NM_003633               5520 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens ectodermal-neural cortex 1 (with BTB domain) (ENC1),
            transcript variant 1, mRNA.
ACCESSION   NM_003633
VERSION     NM_003633.3  GI:375156566
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5520)
  AUTHORS   Seng,S., Avraham,H.K., Birrane,G., Jiang,S., Li,H., Katz,G.,
            Bass,C.E., Zagozdzon,R. and Avraham,S.
  TITLE     NRP/B mutations impair Nrf2-dependent NQO1 induction in human
            primary brain tumors
  JOURNAL   Oncogene 28 (3), 378-389 (2009)
   PUBMED   18981988
  REMARK    GeneRIF: NRP/B mutations impair Nrf2-dependent NQO1 induction in
            primary brain tumors.
REFERENCE   2  (bases 1 to 5520)
  AUTHORS   Wang,X.J. and Zhang,D.D.
  TITLE     Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational
            level
  JOURNAL   PLoS ONE 4 (5), E5492 (2009)
   PUBMED   19424503
  REMARK    GeneRIF: ENC1 functions as a negative regulator of Nrf2 through
            suppressing Nrf2 protein translation.
REFERENCE   3  (bases 1 to 5520)
  AUTHORS   Seng,S., Avraham,H.K., Jiang,S., Yang,S., Sekine,M., Kimelman,N.,
            Li,H. and Avraham,S.
  TITLE     The nuclear matrix protein, NRP/B, enhances Nrf2-mediated oxidative
            stress responses in breast cancer cells
  JOURNAL   Cancer Res. 67 (18), 8596-8604 (2007)
   PUBMED   17875699
  REMARK    GeneRIF: NRP/B enhances oxidative stress responses in breast cancer
            cells via the Nrf2 pathway, identifying a novel role of nuclear
            matrix protein(s) in oxidative stress responses.
REFERENCE   4  (bases 1 to 5520)
  AUTHORS   Fujita,M., Furukawa,Y., Tsunoda,T., Tanaka,T., Ogawa,M. and
            Nakamura,Y.
  TITLE     Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a
            downstream target of the beta-catenin/T-cell factor complex, in
            colorectal carcinomas
  JOURNAL   Cancer Res. 61 (21), 7722-7726 (2001)
   PUBMED   11691783
REFERENCE   5  (bases 1 to 5520)
  AUTHORS   Kim,T.A., Ota,S., Jiang,S., Pasztor,L.M., White,R.A. and Avraham,S.
  TITLE     Genomic organization, chromosomal localization and regulation of
            expression of the neuronal nuclear matrix protein NRP/B in human
            brain tumors
  JOURNAL   Gene 255 (1), 105-116 (2000)
   PUBMED   10974570
REFERENCE   6  (bases 1 to 5520)
  AUTHORS   Zhao,L., Gregoire,F. and Sul,H.S.
  TITLE     Transient induction of ENC-1, a Kelch-related actin-binding
            protein, is required for adipocyte differentiation
  JOURNAL   J. Biol. Chem. 275 (22), 16845-16850 (2000)
   PUBMED   10828068
REFERENCE   7  (bases 1 to 5520)
  AUTHORS   Hernandez,M.C., Andres-Barquin,P.J., Kuo,W.L. and Israel,M.A.
  TITLE     Assignment of the ectodermal-neural cortex 1 gene (ENC1) to human
            chromosome band 5q13 by in situ hybridization
  JOURNAL   Cytogenet. Cell Genet. 87 (1-2), 89-90 (1999)
   PUBMED   10640818
REFERENCE   8  (bases 1 to 5520)
  AUTHORS   Hernandez,M.C., Andres-Barquin,P.J., Holt,I. and Israel,M.A.
  TITLE     Cloning of human ENC-1 and evaluation of its expression and
            regulation in nervous system tumors
  JOURNAL   Exp. Cell Res. 242 (2), 470-477 (1998)
   PUBMED   9683534
REFERENCE   9  (bases 1 to 5520)
  AUTHORS   Kim,T.A., Lim,J., Ota,S., Raja,S., Rogers,R., Rivnay,B., Avraham,H.
            and Avraham,S.
  TITLE     NRP/B, a novel nuclear matrix protein, associates with p110(RB) and
            is involved in neuronal differentiation
  JOURNAL   J. Cell Biol. 141 (3), 553-566 (1998)
   PUBMED   9566959
REFERENCE   10 (bases 1 to 5520)
  AUTHORS   Polyak,K., Xia,Y., Zweier,J.L., Kinzler,K.W. and Vogelstein,B.
  TITLE     A model for p53-induced apoptosis
  JOURNAL   Nature 389 (6648), 300-305 (1997)
   PUBMED   9305847
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026405.5 and BC000418.2.
            On Feb 10, 2012 this sequence version replaced gi:189491643.
            
            Summary: This gene encodes a member of the kelch-related family of
            actin-binding proteins. The encoded protein plays a role in the
            oxidative stress response as a regulator of the transcription
            factor Nrf2, and expression of this gene may play a role in
            malignant transformation. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) represents the most abundant
            transcript. Variants 1, 2, and 3 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096578.1, AF059611.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025083 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-730               AC026405.5         99393-100122        c
            731-3006            BC000418.2         1-2276
            3007-5520           AC026405.5         86104-88617         c
FEATURES             Location/Qualifiers
     source          1..5520
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13"
     gene            1..5520
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /note="ectodermal-neural cortex 1 (with BTB domain)"
                     /db_xref="GeneID:8507"
                     /db_xref="HGNC:3345"
                     /db_xref="HPRD:05529"
                     /db_xref="MIM:605173"
     exon            1..1118
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    1081..1083
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /note="upstream in-frame stop codon"
     exon            1119..2933
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /inference="alignment:Splign:1.39.8"
     variation       1127
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:9176"
     CDS             1132..2901
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear restricted protein, BTB domain-like (brain); tumor
                     protein p53 inducible protein 10; kelch-like 35;
                     ectoderm-neural cortex protein 1; kelch-like protein 37;
                     p53-induced gene 10 protein; nuclear matrix protein NRP/B;
                     ectodermal-neural cortex 1 (with BTB-like domain);
                     kelch-like family member 37"
                     /codon_start=1
                     /product="ectoderm-neural cortex protein 1 isoform 1"
                     /protein_id="NP_003624.1"
                     /db_xref="GI:4505461"
                     /db_xref="CCDS:CCDS4021.1"
                     /db_xref="GeneID:8507"
                     /db_xref="HGNC:3345"
                     /db_xref="HPRD:05529"
                     /db_xref="MIM:605173"
                     /translation="

MSVSVHENRKSRASSGSINIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLLGGQTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITTVPYSLIPTAFVSTWKHLPS

"
     misc_feature    1237..1551
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /note="BTB/POZ domain; Region: BTB; pfam00651"
                     /db_xref="CDD:201372"
     misc_feature    1252..2829
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /note="kelch-like protein; Provisional; Region: PHA03098"
                     /db_xref="CDD:165380"
     misc_feature    1576..1875
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /note="BTB And C-terminal Kelch; Region: BACK; pfam07707"
                     /db_xref="CDD:149006"
     misc_feature    2017..2151
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14682.2);
                     Region: Kelch 1"
     misc_feature    2116..2253
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /note="Kelch motif; Region: Kelch_1; pfam01344"
                     /db_xref="CDD:201739"
     misc_feature    2152..2295
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14682.2);
                     Region: Kelch 2"
     misc_feature    2296..2463
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14682.2);
                     Region: Kelch 3"
     misc_feature    2296..2454
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /note="Kelch domain; Region: Kelch; smart00612"
                     /db_xref="CDD:128874"
     misc_feature    2467..2607
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14682.2);
                     Region: Kelch 4"
     misc_feature    2572..2700
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /note="Kelch motif; Region: Kelch_1; pfam01344"
                     /db_xref="CDD:201739"
     misc_feature    2611..2745
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14682.2);
                     Region: Kelch 5"
     misc_feature    2710..2847
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /note="Kelch motif; Region: Kelch_1; pfam01344"
                     /db_xref="CDD:201739"
     misc_feature    2746..2886
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14682.2);
                     Region: Kelch 6"
     exon            2934..5520
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /inference="alignment:Splign:1.39.8"
     variation       3460
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11557038"
     STS             3806..3944
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /standard_name="D5S1949E"
                     /db_xref="UniSTS:473366"
     variation       4767
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1802334"
     STS             5198..5299
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /standard_name="D5S2420"
                     /db_xref="UniSTS:55536"
     STS             5289..5440
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
                     /standard_name="D5S1939"
                     /db_xref="UniSTS:154193"
     polyA_signal    5491..5496
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
     polyA_site      5517
                     /gene="ENC1"
                     /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10;
                     TP53I10"
ORIGIN

agagtccagccgggggtgccgcacccactggggagtggggagggaggacacataggaaatgcctggggctggagtctctttggctctctgccagcaagaaacttaaacgtcctggcttgctcaacccgagtgtccctaaactgtccagacttttgcccgtccattgccactatctctccccactctgggtgtcctacccaaggcgctgtctatgcgtgcccagggcctgtcctgcggatacccagctcgccccttgcagccctttttagagcatctcgcgggctctggcatcaccaagcgcacagccccgggctgcgctcccctaaggtgggtccctcagatccggggctgtccattaaccaggctggcccaaagaggcgcagacactcgaacccgggaaaacttattttattctcggttcccggggttgcagctgccagcggctgagacagtgcgtccgctttgtctctctgcactccccgcagcccccctctcccgcttcctctcccgattaactcccccgacacgctcttctctagctcctctcctcctcccactccttctcctcctcttcctcctcctacaccacaggccgcgctaatgcgcttcctccctcccccggtgtcggtctctttgcatacgcgccccctcccctccccgccgcgccacttatagcggggcgcacggcggcggggcgcagactgctctggcagccggagaggaggcggtgcggcggtggcgctgcggagacccggtccagacgcctggcggccgccggcacacaaggcgctttctagctccctcccccgagcgcacagcccgcctccttccgcggcgcctgcagtggcaggcttgctctgccctaccgtgacgcgctccggagacgctctgcgggtcctggacaccgggtccgcggcgtggggacgacagacggaggcgaacgccatcggtagccggtccgcgagccatcgttcggggcgcagtcctctccccggctggccctcctttctccggggcattcgccaccgcttccctgggctgagacgaccggttcgtcgcctccttgcccgtgaccgtcgctagaactcagttgtgcgttgcggccagtcgccactgctgagtggaaacaaaatgtcagtcagtgtgcatgagaaccgcaagtccagggccagcagcggctccattaacatctatctgtttcacaagtcctcctacgctgacagcgtcctcactcacctgaatcttttacgccagcagcgtctcttcactgacgtccttctccatgccggaaataggaccttcccttgccaccgggcagtgctggctgcatgcagtcgctactttgaggccatgttcagtggtggcctgaaagagagccaggacagtgaggtcaactttgacaattccatccacccagaagtcttggagctgctgcttgactatgcgtactcctcccgggtcatcatcaatgaagaaaatgcagaatcgctcctggaagctggtgacatgctggagtttcaagacatccgggatgcatgtgcagagttcctggaaaagaacctgcatcccaccaactgcctgggcatgctgctgctgtctgatgcacaccagtgcaccaagctgtacgaactatcttggagaatgtgtctcagcaacttccaaaccatcaggaagaatgaagatttcctccagctgccccaggacatggtagtgcaactcttgtccagtgaagagctggagacagaggatgaaaggcttgtgtacgagtctgcaattaactggatcagctatgacctgaagaagcgctattgctacctcccagaactgttgcagacagtaaggctggcacttctgccagccatctatctcatggagaatgtggccatggaggaactcatcaccaagcagagaaagagtaaggaaattgtggaagaggccatcaggtgcaaactgaaaatcctgcagaatgacggtgtggtaaccagcctctgtgcccgacctcggaaaactggccatgccctcttccttctgggaggacagactttcatgtgtgacaagttgtatctggtagaccagaaggccaaagaaatcattcccaaggctgacattcccagcccaagaaaagagtttagtgcatgtgcgattggctgcaaagtgtacattactggggggcgggggtctgaaaatggggtctcaaaagatgtctgggtttatgataccctgcacgaggagtggtccaaggctgcccccatgctggtggccaggtttggccatggctctgctgaactgaagcactgcctgtatgtggttggggggcacacggccgcaactggctgcctcccggcctccccctcagtctctctaaagcaggtagaacattatgaccccacaatcaacaaatggaccatggtggccccactccgagaaggcgttagcaacgccgcagtagtgagtgccaaacttaagttatttgctttcggaggtaccagtgtcagtcatgacaagctccccaaagttcagtgttacgatcagtgtgaaaacaggtggactgtaccggccacctgtccccagccctggcgttacacagcagcagctgtgctggggaaccagatttttattatggggggtgatacagaattctctgcctgctctgcttataaattcaacagtgagacttaccagtggaccaaggtgggagatgtgacagcaaagcgcatgagctgccatgctgtggcctctggaaacaaactctacgtggttggaggatactttggcattcagcgatgcaagactttggactgctacgatccaacattagacgtgtggaacagcatcaccactgtcccgtactcgctgattcctactgcatttgtcagcacctggaaacatctgccttcttaaatgcagtacattctaaagagagtgagcatgagctcactccatcactcgatgagataatatgagatttctacttcggagaggccaagtctaatgaagagaaaaaaaggaaaagaagttgcaagactcgaataaaatctgctgcaccttgtaaatgctctaactggacatgaaggaaaggggcgagggaggggggtgggatttttggtgcaagtagcacatggtttaaatatgaatgaacaaacctgtgatctagtccttgtcttgtaattgtggattaatgtcaatgttaatcagcccctcaaagggagagaaaagctggaccttttcccttgctgtaccatattcagcatttgatttccatgggccccaccatttatgtgtagaatttgaaatggttgtcacctctctctgaggacagagcttgaagcctccacaccagctgctgctggagattcaaagcccaactgtgggtccgagagggaagctggctgggctggctgaagaatgaagaccactggactctccgttaatctctaaggggtctgctccccaggaacgtttctgaacaatggggactttgttggtagccatttggtagatgttcttttctatttataagtgactttaaactttcccttggctgttaagaagtttgttatagatttagctatttattgttcgatgcctgcatgctgaaacaatgcctacagctgtcttcacatgtatggacgtgtgtgaatggttgtacgttttgcacattttgtggctgttgagatgtgctttgctgcacaaacatgaaaatttttgagttacaatttggagcataactggagggtgggttggggaggggtggatttttaaaatgtcaagacagggaaggatgacaaaatggaaatttaaatgacatcctagaggtagagaaaccgtggagatcgcttttctcagactcaccaacttttaatgggatttcatggggtttggttgtgctgatagggtaaggggaggctgctttctgcccttctccccactcccatctgatttacttaattcagtctcagctgctgaaatttggaaaggaccaaattgctttacagtttttttctttgtgtagtatcttgaaatcctggaaaattctatggaatagttctgtatatagggcacaagtaaaggcattgtccaaagtttatttatttatttattaccctaagaatgctttgccataaccacatttaatgggaaaaacggcagtatcacagatgtaaattaactcaccagatttactgggcctgaactcattctcttcttgctatatgatttagcaagttctagaaggtctccaagacaataattacattggcacaatgtatacttcagtgctcacccgtaggcaaatctctttttaaaaaactctttggtgcacaagtaacacatttggccacaaaacaccaaagaattgtaggcagtggcccctattgagaagttttccggtagagttggaaatcagttgtgaatacattctttgctagttggagtgcttgtttactaagcatgtgccgtcgtaggtattagtgctagtctcagataggtgcttcccctgaggtgcaggggaagaccaaagtttgcaactcgaactgctttcgtccatgtttctcacattgctgtattttagaaaataggggttaagactgataacaaccttttacattgtgactgtgtttgcattgtctaatgacagataaatccttaacatttctctccaccttagtactttagactaattgtgtttgtccgtccatgccatgaatgagtgggctgtagttgggcctaaataaatgagctgttggaagaaaagaatcacagtactttccagcagtcagtccctggttcctagatgtgttctaagcaatgcaaatgtctaattgtcccccagtgggcatagtcagtgtcgtttatattgtagcagttacagctctgtagtttatgatgcaaatctgccaagagagatgtatgtgtcactgcatggcttctgaaagcaggatgaattttctgcagctgtttcaaagttggggtctgttcttgaatcctctattaattactgtgtgtgagccagagggagctgtggtaagggttgggcccccagcctgtagggaactttctggactcccactctttgaatcgatataggcatttggtctcactacttgaccattctcaccctgtgaaacgtcccacactttgaagcaaatacaattcacagcacagtacacacaaaaaccttggcataagacagagaaggttcttcttattttgtgggctggttgctgtagaaacacataacaaagggcagccctccacttctggtataattgtgtagccccttttctttgggcttgacacctgtcttgaataagagtgattagagctgcataatgtccctctcttggctattgaccatgtggttcacgtacaaaactctgtataagttgaaggaaaatgttcatgttcatatgtacttgtttgctatgactacattttgaggttttgtaaaactgttatttttttttttttcacaatgtgaaactgaaggtcaataaattattagagattttctcttcatta

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