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2019-03-25 15:10:39, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_003631               4276 bp    mRNA    linear   PRI 08-JUN-2013
DEFINITION  Homo sapiens poly (ADP-ribose) glycohydrolase (PARG), mRNA.
ACCESSION   NM_003631 XM_495821
VERSION     NM_003631.2  GI:70610135
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4276)
  AUTHORS   Le May,N., Iltis,I., Ame,J.C., Zhovmer,A., Biard,D., Egly,J.M.,
            Schreiber,V. and Coin,F.
  TITLE     Poly (ADP-ribose) glycohydrolase regulates retinoic acid
            receptor-mediated gene expression
  JOURNAL   Mol. Cell 48 (5), 785-798 (2012)
   PUBMED   23102699
  REMARK    GeneRIF: Results define PARG as a coactivator regulating chromatin
            remodeling during retinoic acid receptor-dependent gene expression.
REFERENCE   2  (bases 1 to 4276)
  AUTHORS   Pan,J., Fauzee,N.J., Wang,Y.L., Sheng,Y.T., Tang,Y., Wang,J.Q.,
            Wu,W.Q., Yan,J.X. and Xu,J.
  TITLE     Effect of silencing PARG in human colon carcinoma LoVo cells on the
            ability of HUVEC migration and proliferation
  JOURNAL   Cancer Gene Ther. 19 (10), 715-722 (2012)
   PUBMED   22918473
  REMARK    GeneRIF: PARG silencing could inhibit the ability of HUVEC
            migration and proliferation by downregulating the activity of
            NF-kappaB in LoVo cells that in turn decreases angiogenic factors
            such as VEGF, b-FGF, ICAM-1, MMP-9, as well as phosphorylation of
            p38 and ERK.
REFERENCE   3  (bases 1 to 4276)
  AUTHORS   Niere,M., Mashimo,M., Agledal,L., Dolle,C., Kasamatsu,A., Kato,J.,
            Moss,J. and Ziegler,M.
  TITLE     ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose) glycohydrolase
            (PARG) isoforms, is responsible for degradation of mitochondrial
            matrix-associated poly(ADP-ribose)
  JOURNAL   J. Biol. Chem. 287 (20), 16088-16102 (2012)
   PUBMED   22433848
REFERENCE   4  (bases 1 to 4276)
  AUTHORS   Feng,X., Zhou,Y., Proctor,A.M., Hopkins,M.M., Liu,M. and Koh,D.W.
  TITLE     Silencing of Apoptosis-Inducing factor and poly(ADP-ribose)
            glycohydrolase reveals novel roles in breast cancer cell death
            after chemotherapy
  JOURNAL   Mol. Cancer 11, 48 (2012)
   PUBMED   22839996
  REMARK    GeneRIF: Silencing of Apoptosis-Inducing factor and
            poly(ADP-ribose) glycohydrolase reveals novel roles in breast
            cancer cell death after chemotherapy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4276)
  AUTHORS   Li,Q., Li,M., Wang,Y.L., Fauzee,N.J., Yang,Y., Pan,J., Yang,L. and
            Lazar,A.
  TITLE     RNA interference of PARG could inhibit the metastatic potency of
            colon carcinoma cells via PI3-kinase/Akt pathway
  JOURNAL   Cell. Physiol. Biochem. 29 (3-4), 361-372 (2012)
   PUBMED   22508044
  REMARK    GeneRIF: PARG knockdown, concomitant with inhibition of PARP,
            suppressed the metastatic potency of colon carcinoma cells by
            activation of PI3K/Akt signaling pathway.
REFERENCE   6  (bases 1 to 4276)
  AUTHORS   Affar,E.B., Germain,M., Winstall,E., Vodenicharov,M., Shah,R.G.,
            Salvesen,G.S. and Poirier,G.G.
  TITLE     Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase
            during apoptosis
  JOURNAL   J. Biol. Chem. 276 (4), 2935-2942 (2001)
   PUBMED   11053413
REFERENCE   7  (bases 1 to 4276)
  AUTHORS   Winstall,E., Affar,E.B., Shah,R., Bourassa,S., Scovassi,A.I. and
            Poirier,G.G.
  TITLE     Poly(ADP-ribose) glycohydrolase is present and active in mammalian
            cells as a 110-kDa protein
  JOURNAL   Exp. Cell Res. 246 (2), 395-398 (1999)
   PUBMED   9925755
REFERENCE   8  (bases 1 to 4276)
  AUTHORS   Ame,J.C., Apiou,F., Jacobson,E.L. and Jacobson,M.K.
  TITLE     Assignment of the poly(ADP-ribose) glycohydrolase gene (PARG) to
            human chromosome 10q11.23 and mouse chromosome 14B by in situ
            hybridization
  JOURNAL   Cytogenet. Cell Genet. 85 (3-4), 269-270 (1999)
   PUBMED   10449915
REFERENCE   9  (bases 1 to 4276)
  AUTHORS   Lin,W., Ame,J.C., Aboul-Ela,N., Jacobson,E.L. and Jacobson,M.K.
  TITLE     Isolation and characterization of the cDNA encoding bovine
            poly(ADP-ribose) glycohydrolase
  JOURNAL   J. Biol. Chem. 272 (18), 11895-11901 (1997)
   PUBMED   9115250
REFERENCE   10 (bases 1 to 4276)
  AUTHORS   Uchida,K., Suzuki,H., Maruta,H., Abe,H., Aoki,K., Miwa,M. and
            Tanuma,S.
  TITLE     Preferential degradation of protein-bound (ADP-ribose)n by nuclear
            poly(ADP-ribose) glycohydrolase from human placenta
  JOURNAL   J. Biol. Chem. 268 (5), 3194-3200 (1993)
   PUBMED   8428996
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY258587.1 and BC050560.1.
            On Jul 8, 2005 this sequence version replaced gi:4505608.
            
            Summary:  Poly(ADP-ribose) glycohydrolase (PARG) is the major
            enzyme responsible for the catabolism of poly(ADP-ribose), a
            reversible covalent-modifier of chromosomal proteins.  The protein
            is found in many tissues and may be subject to proteolysis
            generating smaller, active products. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050560.1, DQ867088.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025084 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1814              AY258587.1         1-1814
            1815-4276           BC050560.1         1782-4243
FEATURES             Location/Qualifiers
     source          1..4276
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.23"
     gene            1..4276
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /note="poly (ADP-ribose) glycohydrolase"
                     /db_xref="GeneID:8505"
                     /db_xref="HGNC:8605"
                     /db_xref="MIM:603501"
     exon            1..478
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    205..207
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /note="upstream in-frame stop codon"
     CDS             262..3192
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /EC_number="3.2.1.143"
                     /note="poly(ADP-ribose) glycohydrolase 60 kDa isoform;
                     mitochondrial poly(ADP-ribose) glycohydrolase"
                     /codon_start=1
                     /product="poly(ADP-ribose) glycohydrolase"
                     /protein_id="NP_003622.2"
                     /db_xref="GI:70610136"
                     /db_xref="GeneID:8505"
                     /db_xref="HGNC:8605"
                     /db_xref="MIM:603501"
                     /translation="
MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT
"
     misc_feature    262..1629
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86W56.1);
                     Region: A-domain"
     misc_feature    289..309
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86W56.1);
                     Region: Nuclear localization signal"
     misc_feature    487..510
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86W56.1);
                     Region: PIP-box (PCNA interacting peptide)"
     misc_feature    658..660
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q86W56.1); phosphorylation site"
     misc_feature    670..672
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q86W56.1); phosphorylation site"
     misc_feature    850..852
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q86W56.1); phosphorylation site"
     misc_feature    856..858
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (Q86W56.1); phosphorylation site"
     misc_feature    1153..1155
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q86W56.1); phosphorylation site"
     misc_feature    1165..1167
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q86W56.1); phosphorylation site"
     misc_feature    1207..1209
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1990..2997
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /note="Poly (ADP-ribose) glycohydrolase (PARG); Region:
                     PARG_cat; pfam05028"
                     /db_xref="CDD:191169"
     misc_feature    2089..2646
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86W56.1);
                     Region: Catalytic"
     misc_feature    2437..2442
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86W56.1);
                     Region: Substrate binding (By similarity)"
     misc_feature    2866..2883
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86W56.1);
                     Region: Substrate binding (By similarity)"
     exon            479..545
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="alignment:Splign:1.39.8"
     exon            546..1532
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="alignment:Splign:1.39.8"
     variation       674
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4412715"
     variation       870
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111469919"
     exon            1533..1716
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="alignment:Splign:1.39.8"
     exon            1717..1839
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1785)
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55651805"
     exon            1840..1923
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="alignment:Splign:1.39.8"
     exon            1924..1998
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="alignment:Splign:1.39.8"
     exon            1999..2091
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="alignment:Splign:1.39.8"
     exon            2092..2249
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="alignment:Splign:1.39.8"
     exon            2250..2329
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="alignment:Splign:1.39.8"
     exon            2330..2390
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="alignment:Splign:1.39.8"
     exon            2391..2466
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="alignment:Splign:1.39.8"
     exon            2467..2614
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="alignment:Splign:1.39.8"
     exon            2615..2693
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="alignment:Splign:1.39.8"
     exon            2694..2802
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="alignment:Splign:1.39.8"
     exon            2803..2908
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="alignment:Splign:1.39.8"
     exon            2909..3037
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="alignment:Splign:1.39.8"
     exon            3038..4253
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /inference="alignment:Splign:1.39.8"
     STS             3297..4216
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /standard_name="PARG_8819"
                     /db_xref="UniSTS:468583"
     STS             4083..4217
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /standard_name="RH69997"
                     /db_xref="UniSTS:58118"
     polyA_signal    4125..4130
                     /gene="PARG"
                     /gene_synonym="PARG99"
     polyA_site      4145
                     /gene="PARG"
                     /gene_synonym="PARG99"
                     /experiment="experimental evidence, no additional details
                     recorded"
     polyA_signal    4228..4233
                     /gene="PARG"
                     /gene_synonym="PARG99"
     polyA_site      4253
                     /gene="PARG"
                     /gene_synonym="PARG99"
ORIGIN      
cggtggtgggaaagtgaacgaatcccgaatcaaagcggcgcattgaggcaggtggggtgccagtggaagagagaaagcaggcgagtgtttacggcctgacttgggaggccggcggatcagcaattgcagaagcaggcagcggcagagagggaatggtgcaggcaggcgctgagaaggacgcgcagtccatctctctcaggttagtgaaatgaggctctccgcccggggccggcccggggacagtgcgctgctggtcccagcatgaatgcgggccccggctgtgaaccctgcaccaagcgaccccgctggggcgccgctacaacttcgccggctgcttcggacgcccggagctttcccagcaggcagaggcgcgtcctcgaccccaaggacgctcacgtgcagttcagggtcccaccgtcctcgccagcctgcgtcccagggcgggcgggacagcacagaggcagcgccacctcgcttgttttcaaacaaaagactattaccagttggatggacactaaaggaatcaagacagcggaatcagaaagtttggatagtaaagaaaacaacaatacaagaatagaatccatgatgagttctgtacaaaaagataacttttaccaacataatgtagaaaaattagaaaatgtttctcagctaagtcttgataagtcacccactgaaaaaagtacacagtatttgaaccagcatcagactgcagcaatgtgtaagtggcaaaatgaagggaaacacacggagcagcttttggaaagtgaacctcaaacagtaaccctggtaccagagcagtttagtaatgctaacattgatcggtcacctcaaaatgatgatcacagtgacacagatagtgaagagaatagagacaatcaacagtttctcacaactgtaaagcttgcaaatgcaaagcagactacggaagatgaacaggccagagaagccaaaagccaccagaagtgcagcaagtcttgcgatcctggggaagactgtgcaagttgtcagcaagatgagatagatgtggtgccagagagtccattgtcagatgttggctctgaggatgttggtactgggccaaaaaatgacaacaaattgactagacaagaaagttgcctaggaaattctcctccatttgagaaggaaagtgaacccgagtcaccgatggatgtggataattctaaaaatagttgtcaagactcagaagcagatgaggagacaagtccaggttttgatgaacaagaagatggtagttcctcccaaacagcaaataaaccttcaaggttccaagcaagagacgctgacattgaatttaggaaacggtactctactaagggcggtgaagttagattacatttccaatttgaaggaggagagagtcgcactggaatgaatgatttaaatgctaaactacctggaaatatttctagcctgaatgtagaatgcagaaattctaagcaacatggaaaaaaggattctaaaatcacagatcatttcatgagactgcccaaagcagaggacagaagaaaagaacagtgggaaaccaaacatcaaagaacagaaaggaagatccctaaatacgttccacctcacctttctccagataagaagtggcttggaactcccattgaggagatgagaagaatgcctcggtgtgggatccggctgcctctcttgagaccatctgccaatcacacagtaactattcgggtagatcttttgcgagcaggagaagttcctaaaccttttccaacacattataaagatttgtgggataacaagcatgttaaaatgccttgttcagaacaaaatttgtacccagtggaagatgagaatggtgagcgaactgcggggagccggtgggagctcattcagactgcacttctcaacaaatttacacgaccccaaaacttgaaggatgctattctgaaatacaatgtggcatattctaagaaatgggactttacagctttgatcgatttctgggataaggtacttgaagaagcagaagctcaacatttatatcagtccatcttgcctgatatggtgaaaattgcactctgtctgccaaatatttgcacccagccaataccactcctgaaacagaagatgaatcattccatcacaatgtcgcaggaacagattgccagtcttttagctaatgctttcttctgcacatttccacgacgaaatgctaagatgaaatcggagtattctagttacccagacattaacttcaatcgattgtttgagggacgttcatcaaggaaaccggagaaacttaaaacgctcttctgctactttagaagagtcacagagaaaaaacctactgggttggtgacatttacaagacagagtcttgaagattttccagaatgggaaagatgtgaaaaacccttgacacgattgcatgtcacttacgaaggtaccatagaagaaaatggccaaggcatgctacaggtggattttgcaaatcgttttgttggaggtggtgtaaccagtgcaggacttgtgcaagaagaaatccgctttttaatcaatcctgagttgattatttcacggctcttcactgaggtgctggatcacaatgaatgtctaattatcacaggtactgagcagtacagtgaatacacaggctatgctgagacatatcgttggtcccggagccacgaagatgggagtgaaagggacgactggcagcggcgctgcactgagatcgttgccatcgatgctcttcacttcagacgctacctcgatcagtttgtgcctgagaaaatgagacgcgagctgaacaaggcttactgtggatttctccgtcctggagtttcttcagagaatctttctgcagtggccacaggaaactggggctgtggtgcctttgggggtgatgccaggttaaaagccttaatacagatattggcagctgctgcagctgagcgagatgtggtttatttcacctttggggactcagaattgatgagagacatttacagcatgcacattttccttactgaaaggaaactcactgttggagatgtgtataagctgttgctacgatactacaatgaagaatgcagaaactgttccacccctggaccagacatcaagctttatccattcatataccatgctgtcgagtcctgtgcagagaccgctgaccattcagggcaaaggacagggacctgaggagccgagcgaatagcatctcctcccacctcccaccagagacgtcctgtttgagctgtcaggtgtaatatatgaattgacttaagttaatataaatgtgtacataatccacatttgtagtcaaggacgcaatctcttccacacatgtgcagttgtcagttggtacatctaaactccctccatcctgactcacgtggacttagatatgttttgtttctattttcttctatttcagtttttcattctttgatgtttatttcttttgtccatcagatctcttgtgaaatcccatggaaggttgtgctcagcctgtcgggtctctttcttcctgcccatatattataccagttgcttctgcagcccgcagatgccagcgatgccaggaaacaagttgaaatccaggaatctctttaactgattttgctaaaaatctccctgtgagccttccactcaactcttaatatgcttgcattgtttaagtttttaaattctgaaaattaataattagggtttttttcatatgtgttgcataatgcaaacctcctaggttaaaatagtttctttatttaagatagaataatttccagaaattgtacttttgaggtatcatttttatctgtaatggtttgtctgtcttttttcctctgatcagtatttttttataccagttttggagactggctgagatgaaaggaaatgtggaataaaaggaggttttcctgatgtggtgtaaagaaaacagattcaagagaattgaagattttttttgtttcttggtacttttttctttttaaattaggactaatgtttcttttgtggtgcttgaggcatattcatataaccaaagtttgagaactgggaacttcatgctgatttgtacatattgaagtttctctggtattcaaaggttatatagtgaatgaattttcattaataaatcactttgtcagaaactcccatatcatctatattttatatatgtatatataaacgtatgctctttaagtgtgtctatatgtgagcacataaaatctaaataaaattggactggtgggaaacaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:8505 -> Molecular function: GO:0004649 [poly(ADP-ribose) glycohydrolase activity] evidence: IDA
            GeneID:8505 -> Biological process: GO:0005975 [carbohydrate metabolic process] evidence: IEA
            GeneID:8505 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IEA
            GeneID:8505 -> Biological process: GO:0016045 [detection of bacterium] evidence: IEA
            GeneID:8505 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:8505 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:8505 -> Cellular component: GO:0005737 [cytoplasm] evidence: TAS
            GeneID:8505 -> Cellular component: GO:0005759 [mitochondrial matrix] evidence: IEA
            GeneID:8505 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
            GeneID:8505 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_003622 -> EC 3.2.1.143

by @meso_cacase at DBCLS
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