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2024-04-20 11:58:08, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003576 4539 bp mRNA linear PRI 08-JUN-2013
DEFINITION Homo sapiens serine/threonine kinase 24 (STK24), transcript variant
1, mRNA.
ACCESSION NM_003576
VERSION NM_003576.3 GI:110349736
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4539)
AUTHORS Eggers,C.M., Kline,E.R., Zhong,D., Zhou,W. and Marcus,A.I.
TITLE STE20-related kinase adaptor protein alpha (STRADalpha) regulates
cell polarity and invasion through PAK1 signaling in LKB1-null
cells
JOURNAL J. Biol. Chem. 287 (22), 18758-18768 (2012)
PUBMED 22493453
REMARK GeneRIF: results show that a STRADalpha-rac1-PAK1 pathway regulates
cell polarity and invasion in LKB1-null cells. It also suggests
that while the function of LKB1 and STRADalpha undoubtedly overlap,
they may also have mutually exclusive roles
REFERENCE 2 (bases 1 to 4539)
AUTHORS Fuller,S.J., McGuffin,L.J., Marshall,A.K., Giraldo,A.,
Pikkarainen,S., Clerk,A. and Sugden,P.H.
TITLE A novel non-canonical mechanism of regulation of MST3 (mammalian
Sterile20-related kinase 3)
JOURNAL Biochem. J. 442 (3), 595-610 (2012)
PUBMED 22229648
REMARK GeneRIF: mechanism of regulation of MST3
REFERENCE 3 (bases 1 to 4539)
AUTHORS Logue,M.W., Schu,M., Vardarajan,B.N., Buros,J., Green,R.C.,
Go,R.C., Griffith,P., Obisesan,T.O., Shatz,R., Borenstein,A.,
Cupples,L.A., Lunetta,K.L., Fallin,M.D., Baldwin,C.T. and
Farrer,L.A.
CONSRTM Multi-Institutional Research on Alzheimer Genetic Epidemiology
(MIRAGE) Study Group
TITLE A comprehensive genetic association study of Alzheimer disease in
African Americans
JOURNAL Arch. Neurol. 68 (12), 1569-1579 (2011)
PUBMED 22159054
REFERENCE 4 (bases 1 to 4539)
AUTHORS Wu,H.Y., Lin,C.Y., Chen,T.C., Pan,S.T. and Yuan,C.J.
TITLE Mammalian Ste20-like protein kinase 3 plays a role in
hypoxia-induced apoptosis of trophoblast cell line 3A-sub-E
JOURNAL Int. J. Biochem. Cell Biol. 43 (5), 742-750 (2011)
PUBMED 21277991
REMARK GeneRIF: Mst3 is up-regulated and plays an important role in
hypoxia-induced apoptosis of human trophoblasts.
REFERENCE 5 (bases 1 to 4539)
AUTHORS Gordon,J., Hwang,J., Carrier,K.J., Jones,C.A., Kern,Q.L.,
Moreno,C.S., Karas,R.H. and Pallas,D.C.
TITLE Protein phosphatase 2a (PP2A) binds within the oligomerization
domain of striatin and regulates the phosphorylation and activation
of the mammalian Ste20-Like kinase Mst3
JOURNAL BMC Biochem. 12, 54 (2011)
PUBMED 21985334
REMARK GeneRIF: Striatin orchestrates the regulation of Mst3 by PP2A.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 4539)
AUTHORS Lee,W.S., Hsu,C.Y., Wang,P.L., Huang,C.Y., Chang,C.H. and Yuan,C.J.
TITLE Identification and characterization of the nuclear import and
export signals of the mammalian Ste20-like protein kinase 3
JOURNAL FEBS Lett. 572 (1-3), 41-45 (2004)
PUBMED 15304321
REMARK GeneRIF: Mst3 contains signals which may cooperate to control the
subcellular distribution of Mst3.
REFERENCE 7 (bases 1 to 4539)
AUTHORS Huang,C.Y., Wu,Y.M., Hsu,C.Y., Lee,W.S., Lai,M.D., Lu,T.J.,
Huang,C.L., Leu,T.H., Shih,H.M., Fang,H.I., Robinson,D.R.,
Kung,H.J. and Yuan,C.J.
TITLE Caspase activation of mammalian sterile 20-like kinase 3 (Mst3).
Nuclear translocation and induction of apoptosis
JOURNAL J. Biol. Chem. 277 (37), 34367-34374 (2002)
PUBMED 12107159
REMARK GeneRIF: Proteolytic activation of Mst3 by caspases.
REFERENCE 8 (bases 1 to 4539)
AUTHORS Christian,S.L., McDonough,J., Liu Cy,C.Y., Shaikh,S., Vlamakis,V.,
Badner,J.A., Chakravarti,A. and Gershon,E.S.
TITLE An evaluation of the assembly of an approximately 15-Mb region on
human chromosome 13q32-q33 linked to bipolar disorder and
schizophrenia
JOURNAL Genomics 79 (5), 635-656 (2002)
PUBMED 11991713
REFERENCE 9 (bases 1 to 4539)
AUTHORS Zhou,T.H., Ling,K., Guo,J., Zhou,H., Wu,Y.L., Jing,Q., Ma,L. and
Pei,G.
TITLE Identification of a human brain-specific isoform of mammalian
STE20-like kinase 3 that is regulated by cAMP-dependent protein
kinase
JOURNAL J. Biol. Chem. 275 (4), 2513-2519 (2000)
PUBMED 10644707
REFERENCE 10 (bases 1 to 4539)
AUTHORS Schinkmann,K. and Blenis,J.
TITLE Cloning and characterization of a human STE20-like protein kinase
with unusual cofactor requirements
JOURNAL J. Biol. Chem. 272 (45), 28695-28703 (1997)
PUBMED 9353338
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DA386652.1, AF083420.1 and AL137249.29.
On Jul 14, 2006 this sequence version replaced gi:20070157.
Summary: The yeast 'Sterile 20' gene (STE20) functions upstream of
the mitogen-activated protein kinase (MAPK) cascade. In mammals,
protein kinases related to STE20 can be divided into 2 subfamilies
based on their structure and regulation. Members of the PAK
subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic
domain and an N-terminal regulatory domain that has a CDC42 (MIM
116952)-binding domain. In contrast, members of the GCK subfamily
(see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an
N-terminal catalytic domain and a C-terminal regulatory domain
without a CDC42-binding domain. STK24 belongs to the GCK subfamily
of STE20-like kinases (Zhou et al., 2000 [PubMed
10644707]).[supplied by OMIM, Mar 2008].
Transcript Variant: This variant (1) encodes the longer protein
(isoform a).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF083420.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-313 DA386652.1 1-313
314-1850 AF083420.1 224-1760
1851-4539 AL137249.29 56459-59147 c
FEATURES Location/Qualifiers
source 1..4539
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="13"
/map="13q31.2-q32.3"
gene 1..4539
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/note="serine/threonine kinase 24"
/db_xref="GeneID:8428"
/db_xref="HGNC:11403"
/db_xref="HPRD:10385"
/db_xref="MIM:604984"
exon 1..313
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/inference="alignment:Splign:1.39.8"
misc_feature 206..208
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/note="upstream in-frame stop codon"
CDS 236..1567
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/EC_number="2.7.11.1"
/note="isoform a is encoded by transcript variant 1;
STE20-like kinase 3; sterile 20-like kinase 3;
serine/threonine kinase 24 (STE20 homolog, yeast);
serine/threonine-protein kinase 24; STE20-like kinase
MST3; mammalian STE20-like protein kinase 3"
/codon_start=1
/product="serine/threonine-protein kinase 24 isoform a"
/protein_id="NP_003567.2"
/db_xref="GI:20070158"
/db_xref="CCDS:CCDS9488.1"
/db_xref="GeneID:8428"
/db_xref="HGNC:11403"
/db_xref="HPRD:10385"
/db_xref="MIM:604984"
/translation="
MDSRAQLWGLALNKRRATLPHPGGSTNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYSLSGGGTSSH
"
misc_feature 287..289
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by PKA; propagated from
UniProtKB/Swiss-Prot (Q9Y6E0.1); phosphorylation site"
misc_feature 287..289
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[9]
misc_feature 335..1156
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/note="Catalytic domain of Mammalian Ste20-like protein
kinase 3-like Protein Serine/Threonine Kinases; Region:
STKc_MST3_like; cd06609"
/db_xref="CDD:132940"
misc_feature 341..1093
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature order(359..373,383..385,422..424,428..430,479..481,
518..520,566..577,584..589,596..598,701..703,707..718,
722..724,755..757,764..766,806..817,821..823,902..904,
929..931)
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/note="active site"
/db_xref="CDD:132940"
misc_feature order(359..373,383..385,422..424,428..430,479..481,
518..520,566..577,584..589,596..598,713..718,722..724,
755..757)
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:132940"
misc_feature order(368..373,701..703,707..715,764..766,806..817,
821..823,902..904,929..931)
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:132940"
misc_feature order(752..787,791..823)
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/note="activation loop (A-loop); other site"
/db_xref="CDD:132940"
misc_feature 785..787
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 803..805
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (Q9Y6E0.1); phosphorylation site"
misc_feature 1067..1111
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9Y6E0.1);
Region: Bipartite nuclear localization signal"
misc_feature 1166..1168
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1178..1180
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1181..1183
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1184..1186
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1193..1195
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9Y6E0.1); phosphorylation site"
misc_feature 1193..1195
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1205..1207
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1208..1213
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/experiment="experimental evidence, no additional details
recorded"
/note="Cleavage, by caspase-3, caspase-7 and caspase-8;
propagated from UniProtKB/Swiss-Prot (Q9Y6E0.1); cleavage
site"
misc_feature 1238..1393
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9Y6E0.1);
Region: Nuclear export signal (NES)"
misc_feature 1241..1243
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/citation=[7]
/db_xref="HPRD:02799"
misc_feature 1361..>1522
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/note="Protein of unknown function (DUF1241); Region:
DUF1241; pfam06840"
/db_xref="CDD:191619"
exon 314..544
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/inference="alignment:Splign:1.39.8"
exon 545..601
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/inference="alignment:Splign:1.39.8"
exon 602..710
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/inference="alignment:Splign:1.39.8"
exon 711..868
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/inference="alignment:Splign:1.39.8"
exon 869..1054
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/inference="alignment:Splign:1.39.8"
variation 941
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:3198689"
exon 1055..1200
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/inference="alignment:Splign:1.39.8"
STS 1126..1254
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/standard_name="RH48488"
/db_xref="UniSTS:57654"
exon 1201..1324
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/inference="alignment:Splign:1.39.8"
exon 1325..1393
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/inference="alignment:Splign:1.39.8"
exon 1394..1530
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/inference="alignment:Splign:1.39.8"
variation 1459
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:11544741"
exon 1531..4539
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/inference="alignment:Splign:1.39.8"
variation 1599
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:8481"
variation 1692
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:12463"
STS 1744..1849
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/standard_name="RH44984"
/db_xref="UniSTS:67071"
variation 2305
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:6956"
STS 2396..2506
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/standard_name="D13S678E"
/db_xref="UniSTS:153211"
STS 2426..2553
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/standard_name="WI-12444"
/db_xref="UniSTS:13144"
polyA_signal 2560..2565
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
polyA_site 2581
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
variation 2824
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:3742134"
variation 2851
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/replace="c"
/replace="t"
/db_xref="dbSNP:3742135"
polyA_signal 3373..3378
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
polyA_site 3394
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
variation 4306
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/replace=""
/replace="t"
/db_xref="dbSNP:184907551"
variation 4387
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/replace="a"
/replace="g"
/db_xref="dbSNP:3742136"
variation 4516
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
/replace=""
/replace="g"
/db_xref="dbSNP:3832885"
polyA_signal 4519..4524
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
polyA_site 4539
/gene="STK24"
/gene_synonym="MST3; MST3B; STE20; STK3"
ORIGIN
ggagccaggctgcagtggtggggaggaccgggcaggtccagatgactttgaagggactccagaggaaggagagagtggaggaggagggctttgggttagggagagtgctttcgtttgttttaaatgggagaaactggagcatgttgccaagggcagagagccagcagagaggggtgaatggaagaaggagcgagaagggggttactgacgaagccttatcctggaggagagaaggatggactccagagcccagctttggggactggccttgaataaaaggagggccactctacctcatcctggagggagcacgaacctaaaggcagacccagaagagctttttacaaaactagagaaaattgggaagggctcctttggagaggtgttcaaaggcattgacaatcggactcagaaagtggttgccataaagatcattgatctggaagaagctgaagatgagatagaggacattcaacaagaaatcacagtgctgagtcagtgtgacagtccatatgtaaccaaatattatggatcctatctgaaggatacaaaattatggataataatggaatatcttggtggaggctccgcactagatctattagaacctggcccattagatgaaacccagatcgctactatattaagagaaatactgaaaggactcgattatctccattcggagaagaaaatccacagagacattaaagcggccaacgtcctgctgtctgagcatggcgaggtgaagctggcggactttggcgtggctggccagctgacagacacccagatcaaaaggaacaccttcgtgggcaccccattctggatggcacccgaggtcatcaaacagtcggcctatgactcgaaggcagacatctggtccctgggcataacagctattgaacttgcaagaggggaaccacctcattccgagctgcaccccatgaaagttttattcctcattccaaagaacaacccaccgacgttggaaggaaactacagtaaacccctcaaggagtttgtggaggcctgtttgaataaggagccgagctttagacccactgctaaggagttattgaagcacaagtttatactacgcaatgcaaagaaaacttcctacttgaccgagctcatcgacaggtacaagagatggaaggccgagcagagccatgacgactcgagctccgaggattccgacgcggaaacagatggccaagcctcggggggcagtgattctggggactggatcttcacaatccgagaaaaagatcccaagaatctcgagaatggagctcttcagccatcggacttggacagaaataagatgaaagacatcccaaagaggcctttctctcagtgtttatctacaattatttctcctctgtttgcagagttgaaggagaagagccaggcgtgcggagggaacttggggtccattgaagagctgcgaggggccatctacctagcggaggaggcgtgccctggcatctccgacaccatggtggcccagctcgtgcagcggctccagagatactctctaagtggtggaggaacttcatcccactgaaattcctttggcatttggggttttgtttttccttttttccttcttcatcctcctccttttttaaaagtcaacgagagccttcgctgactccaccgaagaggtgcgccactgggagccaccccagcgccaggcgcccgtccagggacacacacagtcttcactgtgctgcagccagatgaagtctctcagatgggtggggagggtcagctccttccagcgatcattttattttattttattacttttgtttttaattttaaccatagtgcacatattccaggaaagtgtctttaaaaacaaaaacaaaccctgaaatgtatatttgggattatgataaggcaactaaagacatgaaacctcaggtatcctgctttaagttgataactccctctgggagctggagaatcgctctggtggatgggtgtacagatttgtatataatgtcatttttacggaaaccctttcggcgtgcataaggaatcactgtgtacaaactggccaagtgcttctgtagataacgtcagtggagtaaatattcgacaggccataacttgagtctattgccttgcctttattacatgtacattttgaattctgtgaccagtgatttgggttttattttgtatttgcagggtttgtcattaataattaatgcccctctcttacagaacactcctatttgtacctcaacaaatgcaaattttccccgtttgccctacgccccttttggtacacctagaggttgatttcctttttcatcgatggtactatttcttagtgttttaaattggaacatatcttgcctcatgaagctttaaattataattttcagtttctccccatgaagcgctctcgtctgacatttgtttggaatcgtgccactgctggtctgcgccagatgtaccgtcctttccaatacgattttctgttgcaccttgtagtggattctgcatatcatctttcccacctaaaaatgtctgaatgcttacacaaataaattttataacacgcttattttgcatactccttgaaatgtgactcttcagaggacagggcacctgctgtgtatgtgtggccgtgcgtgtgtactcgtggctgtgtgtgtgtgatgagacactttggaagactccagggagaagtccccaggcctggagctgccgagtgcccaggtcagcgccctggactgcttgcgcacttgctcaccgagatgatgcagttggaggttgctgatctgtgcgattgctgtagcggttgccggggaccttaagagttattttgcttctctggaaggggcctatgcttgctaggcaggcagccagtgtgtctgtttttcttggtttgctgtgggaccttgcttggcgagggggaaaatctctgggtttctggagtgggagggttcgtgcagcagctgttgactggtacatgaagcattcttttatgtttgttgaagctgatgattgacatctcccgtgggtgtgccagttcttgtggagttaagacaggatttttggaagcaaggaagttagtgggtgagcttggggatgtagctcagctatctgctggtctagtggcctctaagctatagggaggggacagagccctgagctacagatgcttgagtgggttattgtgtcggtttgctagtgcagtctggtttttaagctctaaaattgaggtattttattagaagtggatttgggttgaactcttaatttgtataagggatatattttggttggggaaatagaactgagttgctaattcttattgtactcattactccatacaagaatgttatgttgaataataaaattggagaagatttcattttgtgtttccagggagtattctgtgtggggaactgtttccttacgtgaggccggcggcataagtcaaagatgagttttgtccttgcgaatcacacagattgagtctgtgttccccagggtgtgccgttacctgatttttaagtgagccagggcggacagcagcttttctgatttacagagttcttcagatttacaaatggacaatgacatcacagtttttagcactgaagccagtctcatgctagtaacagtgggtgagccgctcgagggactgggttctaatgaatactggtatgaacggggagtctctgcagtcgccagacaaatcatactcagccccttcccccgtagagcaacaagtggttcttttagagttgactggcagcatttcctgtcgggggaggtggggtttgatggagttagaaagctcgcctctgtgtacattctctcctgggctgttactttctgtagacgcacaaaatcagccccaatgtttttaagggcatcttagccaaggaagctggcttttgtgtcgccacttccaggcctgcattaagagagagcccaggcaccagggctaccactggaacctgcctcagcgtcaactgctgctggtctgtagccaggcccagcctttgagacgggtttactgtcaccagtagcctctcagtgccagccctgagctgctcctggctcagctgcccagagcctgcagcctggggaggtactcagcctctgggagacgagggccgtggactgggtggctggtagctcctgcgtttttgagctgtgtcctggctggctgctgccaatgaggtggacaccagtgtggtttggggtgcactggccacttcttgctgggttctgattttcttggaagtgcatctgccttccttatccaatagttttatccctgcattgctcttgtgaagtggctggtttggttctgtatgtagcattttgtacctttcctctggcaaaacactgtcagtttataaacattttttatatttccctcctttaaaaacagcttgtgtatttctgctataaaatgtgtcagcaaaggcagagtgacctaatagggcatgttcttaagcacagggactgtatcatgcaggggccaataaagctcaagaaaacgag
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:8428 -> Molecular function: GO:0004672 [protein kinase activity] evidence: TAS
GeneID:8428 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:8428 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:8428 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:8428 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:8428 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:8428 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:8428 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
GeneID:8428 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:8428 -> Biological process: GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] evidence: IMP
GeneID:8428 -> Biological process: GO:0030336 [negative regulation of cell migration] evidence: IMP
GeneID:8428 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
GeneID:8428 -> Biological process: GO:0048679 [regulation of axon regeneration] evidence: IMP
GeneID:8428 -> Biological process: GO:0097194 [execution phase of apoptosis] evidence: IMP
GeneID:8428 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:8428 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:8428 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:8428 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:8428 -> Cellular component: GO:0016020 [membrane] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_003567 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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