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2024-04-20 07:07:33, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003502 3675 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens axin 1 (AXIN1), transcript variant 1, mRNA.
ACCESSION NM_003502
VERSION NM_003502.3 GI:313482857
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3675)
AUTHORS Yang,L.H., Xu,H.T., Li,Q.C., Jiang,G.Y., Zhang,X.P., Zhao,H.Y.,
Xu,K. and Wang,E.H.
TITLE Abnormal hypermethylation and clinicopathological significance of
Axin gene in lung cancer
JOURNAL Tumour Biol. 34 (2), 749-757 (2013)
PUBMED 23192643
REMARK GeneRIF: Abnormal hypermethylation of Axin gene is associated with
lung cancer.
REFERENCE 2 (bases 1 to 3675)
AUTHORS Tran,H., Bustos,D., Yeh,R., Rubinfeld,B., Lam,C., Shriver,S.,
Zilberleyb,I., Lee,M.W., Phu,L., Sarkar,A.A., Zohn,I.E.,
Wertz,I.E., Kirkpatrick,D.S. and Polakis,P.
TITLE HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with
polyubiquitin to promote the APC-axin interaction
JOURNAL J. Biol. Chem. 288 (6), 3753-3767 (2013)
PUBMED 23277359
REMARK GeneRIF: HectD1 promotes the APC-Axin interaction to negatively
regulate Wnt signaling.
REFERENCE 3 (bases 1 to 3675)
AUTHORS Hida,T., Yamashita,N., Usui,H., Nakamura,F., Sasaki,Y., Kikuchi,A.
and Goshima,Y.
TITLE GSK3beta/axin-1/beta-catenin complex is involved in semaphorin3A
signaling
JOURNAL J. Neurosci. 32 (35), 11905-11918 (2012)
PUBMED 22933777
REMARK GeneRIF: Phosphorylation of axin-1 by glycogen synthase
kinase(GSK)-3beta accelerates the association of axin-1 with
beta-catenin.
REFERENCE 4 (bases 1 to 3675)
AUTHORS Li,V.S., Ng,S.S., Boersema,P.J., Low,T.Y., Karthaus,W.R.,
Gerlach,J.P., Mohammed,S., Heck,A.J., Maurice,M.M., Mahmoudi,T. and
Clevers,H.
TITLE Wnt signaling through inhibition of beta-catenin degradation in an
intact Axin1 complex
JOURNAL Cell 149 (6), 1245-1256 (2012)
PUBMED 22682247
REMARK GeneRIF: Results demonstrate that beta-catenin is not only
phosphorylated inside the APC/Axin1 destruction complex, but also
ubiquinated and degraded via the proteasome, all within an intact
Axin1 complex.
REFERENCE 5 (bases 1 to 3675)
AUTHORS Biechele,T.L., Kulikauskas,R.M., Toroni,R.A., Lucero,O.M.,
Swift,R.D., James,R.G., Robin,N.C., Dawson,D.W., Moon,R.T. and
Chien,A.J.
TITLE Wnt/beta-catenin signaling and AXIN1 regulate apoptosis triggered
by inhibition of the mutant kinase BRAFV600E in human melanoma
JOURNAL Sci Signal 5 (206), RA3 (2012)
PUBMED 22234612
REMARK GeneRIF: Wnt/beta-catenin signaling and AXIN1 may regulate the
efficacy of inhibitors of BRAF(V600E), suggesting that manipulation
of the Wnt/beta-catenin pathway could be combined with BRAF
inhibitors to treat melanoma
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3675)
AUTHORS Han,Y., Zhang,Y., Yang,L.H., Mi,X.Y., Dai,S.D., Li,Q.C., Xu,H.T.,
Yu,J.H., Li,G., Zhao,J., Han,C., Yuan,X.M. and Wang,E.H.
TITLE X-radiation inhibits histone deacetylase 1 and 2, upregulates Axin
expression and induces apoptosis in non-small cell lung cancer
JOURNAL Radiat Oncol 7, 183 (2012)
PUBMED 23110995
REMARK GeneRIF: X-radiation and siRNA inhibit expression of HDAC1 and
HDAC2, weaken the inhibitory effect of HDAC on Axin, upregulate
Axin expression and induce apoptosis of lung cancer cells
Publication Status: Online-Only
REFERENCE 7 (bases 1 to 3675)
AUTHORS Ikeda,S., Kishida,S., Yamamoto,H., Murai,H., Koyama,S. and
Kikuchi,A.
TITLE Axin, a negative regulator of the Wnt signaling pathway, forms a
complex with GSK-3beta and beta-catenin and promotes
GSK-3beta-dependent phosphorylation of beta-catenin
JOURNAL EMBO J. 17 (5), 1371-1384 (1998)
PUBMED 9482734
REFERENCE 8 (bases 1 to 3675)
AUTHORS Vasicek,T.J., Zeng,L., Guan,X.J., Zhang,T., Costantini,F. and
Tilghman,S.M.
TITLE Two dominant mutations in the mouse fused gene are the result of
transposon insertions
JOURNAL Genetics 147 (2), 777-786 (1997)
PUBMED 9335612
REFERENCE 9 (bases 1 to 3675)
AUTHORS Zeng,L., Fagotto,F., Zhang,T., Hsu,W., Vasicek,T.J., Perry,W.L.
III, Lee,J.J., Tilghman,S.M., Gumbiner,B.M. and Costantini,F.
TITLE The mouse Fused locus encodes Axin, an inhibitor of the Wnt
signaling pathway that regulates embryonic axis formation
JOURNAL Cell 90 (1), 181-192 (1997)
PUBMED 9230313
REFERENCE 10 (bases 1 to 3675)
AUTHORS Flint,J., Thomas,K., Micklem,G., Raynham,H., Clark,K.,
Doggett,N.A., King,A. and Higgs,D.R.
TITLE The relationship between chromosome structure and function at a
human telomeric region
JOURNAL Nat. Genet. 15 (3), 252-257 (1997)
PUBMED 9054936
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB460285.1, AC005202.1,
AF009674.1, Z99754.1, Z69667.1 and BC035872.1.
This sequence is a reference standard in the RefSeqGene project.
On Dec 3, 2010 this sequence version replaced gi:31083149.
Summary: This gene encodes a cytoplasmic protein which contains a
regulation of G-protein signaling (RGS) domain and a dishevelled
and axin (DIX) domain. The encoded protein interacts with
adenomatosis polyposis coli, catenin beta-1, glycogen synthase
kinase 3 beta, protein phosphate 2, and itself. This protein
functions as a negative regulator of the wingless-type MMTV
integration site family, member 1 (WNT) signaling pathway and can
induce apoptosis. The crystal structure of a portion of this
protein, alone and in a complex with other proteins, has been
resolved. Mutations in this gene have been associated with
hepatocellular carcinoma, hepatoblastomas, ovarian endometriod
adenocarcinomas, and medullablastomas. Two transcript variants
encoding distinct isoforms have been identified for this gene.
[provided by RefSeq, Dec 2010].
Transcript Variant: This variant (1) represents the longer
transcript, and encodes the longer isoform (a). An upstream
in-frame AUG is present that could extend the N-terminus of this
isoform by 49 aa; however, there is no evidence that the upstream
AUG is used, so the shorter N-terminus is being annotated.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF009674.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025083, ERS025084 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
CDS uses downstream in-frame AUG :: lack of evidence for use of
upstream AUG
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-247 DB460285.1 3-249
248-253 AC005202.1 24253-24258 c
254-277 DB460285.1 255-278
278-370 AF009674.1 1-93
371-1151 AC005202.1 18093-18873 c
1152-1467 AF009674.1 875-1190
1468-1468 Z99754.1 16157-16157 c
1469-1740 AF009674.1 1192-1463
1741-1833 Z99754.1 4209-4301 c
1834-2188 AF009674.1 1560-1914
2189-2189 Z99754.1 3358-3358 c
2190-2389 AF009674.1 1916-2115
2390-2390 Z69667.1 31273-31273 c
2391-3349 AF009674.1 2117-3075
3350-3409 Z69667.1 25291-25350 c
3410-3675 BC035872.1 2451-2716
FEATURES Location/Qualifiers
source 1..3675
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16p13.3"
gene 1..3675
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/note="axin 1"
/db_xref="GeneID:8312"
/db_xref="HGNC:903"
/db_xref="HPRD:04819"
/db_xref="MIM:603816"
exon 1..308
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/inference="alignment:Splign:1.39.8"
exon 309..1267
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/inference="alignment:Splign:1.39.8"
STS 310..559
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/standard_name="REN95633"
/db_xref="UniSTS:420431"
CDS 390..2978
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/note="isoform a is encoded by transcript variant 1; axis
inhibitor 1; fused, mouse, homolog of; axin-1; axis
inhibition protein 1; protein phosphatase 1, regulatory
subunit 49"
/codon_start=1
/product="axin-1 isoform a"
/protein_id="NP_003493.1"
/db_xref="GI:27501450"
/db_xref="CCDS:CCDS10405.1"
/db_xref="GeneID:8312"
/db_xref="HGNC:903"
/db_xref="HPRD:04819"
/db_xref="MIM:603816"
/translation="
MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMEEEGEDGDPSSGPPGPCHKLPPAPAWHHFPPRCVDMGCAGLRDAHEENPESILDEHVQRVLRTPGRQSPGPGHRSPDSGHVAKMPVALGGAASGHGKHVPKSGAKLDAAGLHHHRHVHHHVHHSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGVACKRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRTGHGSSGTRKPQPHENSRPLSLEHPWAGPQLRTSVQPSHLFIQDPTMPPHPAPNPLTQLEEARRRLEEEEKRASRAPSKQRYVQEVMRRGRACVRPACAPVLHVVPAVSDMELSETETRSQRKVGGGSAQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD
"
misc_feature 420..629
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/note="Tankyrase binding N-terminal segment of axin;
Region: Axin_TNKS_binding; cd11582"
/db_xref="CDD:211424"
misc_feature order(441..443,447..479,573..575,585..596,600..617,
621..623)
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/note="TNKS binding site [polypeptide binding]; other
site"
/db_xref="CDD:211424"
misc_feature 447..476
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O15169.2);
Region: Tankyrase-binding motif"
misc_feature 612..614
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CK1; propagated from
UniProtKB/Swiss-Prot (O15169.2); phosphorylation site"
misc_feature 618..620
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CK1; propagated from
UniProtKB/Swiss-Prot (O15169.2); phosphorylation site"
misc_feature 654..1016
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/note="Regulator of G protein signaling (RGS) domain found
in the Axin protein; Region: RGS_Axin; cd08707"
/db_xref="CDD:188662"
misc_feature order(666..677,684..686,735..737,744..749,756..761,
765..767,804..809,813..821,825..830)
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/note="APC binding site [polypeptide binding]; other site"
/db_xref="CDD:188662"
misc_feature 1014..1403
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O15169.2);
Region: Interaction with TP53 (By similarity)"
misc_feature 1038..1040
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CK1; propagated from
UniProtKB/Swiss-Prot (O15169.2); phosphorylation site"
misc_feature 1053..1055
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:15942"
misc_feature 1431..1688
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O15169.2);
Region: Interaction with GSK3B (By similarity)"
misc_feature 1689..1895
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O15169.2);
Region: Interaction with CTNNB1 (By similarity)"
misc_feature 1779..1877
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/note="Axin beta-catenin binding domain; Region:
Axin_b-cat_bind; pfam08833"
/db_xref="CDD:149783"
misc_feature 1794..1796
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CK1; propagated from
UniProtKB/Swiss-Prot (O15169.2); phosphorylation site"
misc_feature 1908..2660
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O15169.2);
Region: Interaction with RNF111"
misc_feature 2112..2756
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O15169.2);
Region: Interaction with PPP2CA"
misc_feature 2229..2231
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05418"
misc_feature 2418..2645
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O15169.2);
Region: Interaction with HIPK2 (By similarity)"
misc_feature 2736..2975
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/note="DIX domain; Region: DIX; pfam00778"
/db_xref="CDD:189714"
misc_feature 2958..2960
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/experiment="experimental evidence, no additional details
recorded"
/note="sumoylation site; modified site"
misc_feature 2967..2969
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/experiment="experimental evidence, no additional details
recorded"
/note="sumoylation site; modified site"
STS 536..799
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/standard_name="REN95632"
/db_xref="UniSTS:420430"
variation 611
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/replace="c"
/replace="t"
/db_xref="dbSNP:1805104"
STS 785..1032
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/standard_name="REN95631"
/db_xref="UniSTS:420429"
variation 997
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/replace="a"
/replace="t"
/db_xref="dbSNP:35289539"
STS 1016..1254
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/standard_name="REN95630"
/db_xref="UniSTS:420428"
variation 1151
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/replace="c"
/replace="t"
/db_xref="dbSNP:1805105"
variation 1176
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/replace="a"
/replace="c"
/db_xref="dbSNP:35216805"
exon 1268..1408
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/inference="alignment:Splign:1.39.8"
exon 1409..1505
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/inference="alignment:Splign:1.39.8"
variation 1435
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/replace="a"
/replace="g"
/db_xref="dbSNP:36045489"
exon 1506..1643
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/inference="alignment:Splign:1.39.8"
variation 1575
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/replace="a"
/replace="c"
/db_xref="dbSNP:34440193"
exon 1644..2173
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/inference="alignment:Splign:1.39.8"
STS 1780..2019
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/standard_name="REN95449"
/db_xref="UniSTS:420247"
variation 1853
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/replace="g"
/replace="t"
/db_xref="dbSNP:1805103"
variation 1964
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/replace="c"
/replace="t"
/db_xref="dbSNP:1805102"
exon 2174..2344
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/inference="alignment:Splign:1.39.8"
exon 2345..2575
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/inference="alignment:Splign:1.39.8"
exon 2576..2683
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/inference="alignment:Splign:1.39.8"
exon 2684..2851
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/inference="alignment:Splign:1.39.8"
exon 2852..3660
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/inference="alignment:Splign:1.39.8"
variation 2911
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/replace="a"
/replace="g"
/db_xref="dbSNP:34015754"
STS 2959..3212
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/standard_name="REN95405"
/db_xref="UniSTS:420203"
STS 3100..3202
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/standard_name="PMC154232P1"
/db_xref="UniSTS:271301"
STS 3189..3437
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/standard_name="REN95404"
/db_xref="UniSTS:420202"
variation 3350
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/replace="c"
/replace="g"
/db_xref="dbSNP:395545"
STS 3431..3587
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/standard_name="RH11656"
/db_xref="UniSTS:67369"
STS 3520..3636
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
/standard_name="RH44784"
/db_xref="UniSTS:28633"
polyA_signal 3638..3643
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
polyA_site 3659
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
polyA_site 3660
/gene="AXIN1"
/gene_synonym="AXIN; PPP1R49"
ORIGIN
tctggctcgggctctggctcgggaggcgatcgtggccgctgccgccgccagagccggccggagtcggcccggagccgcgtccacgcggagcgggcgggtgggagctggcggctgggcccctgcggcgcccccgcggcctgccccgcgtccgcctccgggccgccgagccgcagccgccgagatgggggccgccccgggccgcgcccccgccgggtcccgcccgccgcgctgccgctgagcgcatgggcccggaccgcgccgcgccgctccgggagccgggcccggggtcccgccaccaccgcgcgcgggacagattgattcactttggagctgtaagtactgatgtattagggtgcagcgctcattgttccttgacgcagagtcccaaaatgaatatccaagagcagggtttccccttggacctcggagcaagtttcaccgaagatgctccccgacccccagtgcctggtgaggagggagaactggtgtccacagacccgaggcccgccagctacagtttctgctccgggaaaggtgttggcattaaaggtgagacttcgacggccactccgaggcgctcggatctggacctggggtatgagcctgagggcagtgcctcccccaccccaccatacttgaagtgggctgagtcactgcattccctgctggatgaccaagatgggataagcctgttcaggactttcctgaagcaggagggctgtgccgacttgctggacttctggtttgcctgcactggcttcaggaagctggagccctgtgactcgaacgaggagaagaggctgaagctggcgagagccatctaccgaaagtacattcttgataacaatggcatcgtgtcccggcagaccaagccagccaccaagagcttcataaagggctgcatcatgaagcagctgatcgatcctgccatgtttgaccaggcccagaccgaaatccaggccactatggaggaaaacacctatccctccttccttaagtctgatatttatttggaatatacgaggacaggctcggagagccccaaagtctgtagtgaccagagctctgggtcagggacagggaagggcatatctggatacctgccgaccttaaatgaagatgaggaatggaagtgtgaccaggacatggatgaggacgatggcagagacgctgctccccccggaagactccctcagaagctgctcctggagacagctgccccgagggtctcctccagtagacggtacagcgaaggcagagagttcaggtatggatcctggcgggagccagtcaacccctattatgtcaatgccggctatgccctggccccagccaccagtgccaacgacagcgagcagcagagcctgtccagcgatgcagacaccctgtccctcacggacagcagcgtggatgggatccccccatacaggatccgtaagcagcaccgcagggagatgcaggagagcgtgcaggtcaatgggcgggtgcccctacctcacattccccgcacgtaccgggtgccgaaggaggtccgcgtggagcctcagaagttcgcggaggagctcatccaccgcctggaggctgtgcagcgcacgcgggaggccgaggagaagctggaggagcggctgaagcgcgtgcgcatggaggaggaaggtgaggacggcgatccatcgtcagggcccccagggccgtgtcacaagctgcctcccgcccccgcttggcaccacttcccgccccgctgtgtggacatgggctgtgccgggctccgggatgcacacgaggagaaccctgagagcatcctggacgagcacgtacagcgtgtgctgaggacacctggccgccagtcgcctgggcctggccatcgctccccggacagtgggcacgtggccaagatgccagtggcactggggggtgccgcctcggggcacgggaagcacgtacccaagtcaggggcgaagctggacgcggccggcctgcaccaccaccgacacgtccaccaccacgtccaccacagcacagcccggcccaaggagcaggtggaggccgaggccacccgcagggcccagagcagcttcgcctggggcctggaaccacacagccatggggcaaggtcccgaggctactcagagagtgttggcgctgcccccaacgccagtgatggcctcgcccacagtgggaaggtgggcgtggcgtgcaaaagaaatgccaagaaggctgagtcggggaagagcgccagcaccgaggtgccaggtgcctcggaggatgcggagaagaaccagaaaatcatgcagtggatcattgagggggaaaaggagatcagcaggcaccgcaggaccggccacgggtcttcggggacgaggaagccacagccccatgagaactccagacccttgtcccttgagcacccctgggccggccctcagctccggacctccgtgcagccctcccacctcttcatccaagaccccaccatgccaccccacccagctcccaaccccctaacccagctggaggaggcgcgccgacgtctggaggaggaagaaaagagagccagccgagcaccctccaagcagaggtatgtgcaggaggttatgcggcggggacgcgcctgcgtcaggccagcgtgcgcgccggtgctgcacgtggtaccagccgtgtcggacatggagctctccgagacagagacaagatcgcagaggaaggtgggcggcgggagtgcccagccgtgtgacagcatcgttgtggcgtactacttctgcggggaacccatcccctaccgcaccctggtgaggggccgcgctgtcaccctgggccagttcaaggagctgctgaccaaaaagggcagctacagatactacttcaagaaagtgagcgacgagtttgactgtggggtggtgtttgaggaggttcgagaggacgaggccgtcctgcccgtctttgaggagaagatcatcggcaaagtggagaaggtggactgataggctggtgggctggccgctgtgccaggcgaggcccttggcgggcacgggtgtcacggccaggcagatgacctcgtactcaggagcccgatggggaacagtgttgggtgtaccacccatccctgtggtctacccgtgtctagaggcaggtagggggtccctccaagtggtccacaagcttctgtcctgcccccaaggaggcagcctggaccactcctcatagcaatacttggagggcccagcccaagtgaggcagccgaggtccctgctgccagcttcaggtgacccccccccatcccccggcacctcccttgggcacgtgtgctgggatctactttccctctgggatttgcccacgtacccaggtctgggtggggcccaggcccggatgcagaggcctgcagggcctctgtcaattgtacgcgccaccgagtgccttcaacacagcttgtctcttgcctgccactgtgtgaatcggcgacggagcactgcacctgcctccagccgccggctgtgcagtcctgggtcctcctttctgagggcccgtgtaaatatgtacatttctcaggctaggccagcaggggctgcccgagtctgtttttcatgcgatgacacttgtacaattaattatcttttcaaaggtacttggataataatgaaataaaactgtttttgaacctgcaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:8312 -> Molecular function: GO:0002039 [p53 binding] evidence: IDA
GeneID:8312 -> Molecular function: GO:0004871 [signal transducer activity] evidence: IDA
GeneID:8312 -> Molecular function: GO:0005096 [GTPase activator activity] evidence: IBA
GeneID:8312 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:8312 -> Molecular function: GO:0008013 [beta-catenin binding] evidence: IDA
GeneID:8312 -> Molecular function: GO:0008013 [beta-catenin binding] evidence: IPI
GeneID:8312 -> Molecular function: GO:0008022 [protein C-terminus binding] evidence: IEA
GeneID:8312 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
GeneID:8312 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IBA
GeneID:8312 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IDA
GeneID:8312 -> Molecular function: GO:0019901 [protein kinase binding] evidence: ISS
GeneID:8312 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI
GeneID:8312 -> Molecular function: GO:0032947 [protein complex scaffold] evidence: IDA
GeneID:8312 -> Molecular function: GO:0032947 [protein complex scaffold] evidence: IMP
GeneID:8312 -> Molecular function: GO:0042802 [identical protein binding] evidence: ISS
GeneID:8312 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: ISS
GeneID:8312 -> Molecular function: GO:0043621 [protein self-association] evidence: IEA
GeneID:8312 -> Molecular function: GO:0046332 [SMAD binding] evidence: IPI
GeneID:8312 -> Molecular function: GO:0070016 [armadillo repeat domain binding] evidence: IBA
GeneID:8312 -> Molecular function: GO:0070016 [armadillo repeat domain binding] evidence: ISS
GeneID:8312 -> Molecular function: GO:0070411 [I-SMAD binding] evidence: IPI
GeneID:8312 -> Molecular function: GO:0070412 [R-SMAD binding] evidence: IEA
GeneID:8312 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: IEA
GeneID:8312 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
GeneID:8312 -> Biological process: GO:0001743 [optic placode formation] evidence: IBA
GeneID:8312 -> Biological process: GO:0001934 [positive regulation of protein phosphorylation] evidence: IDA
GeneID:8312 -> Biological process: GO:0006913 [nucleocytoplasmic transport] evidence: IEA
GeneID:8312 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:8312 -> Biological process: GO:0007257 [activation of JUN kinase activity] evidence: IBA
GeneID:8312 -> Biological process: GO:0007368 [determination of left/right symmetry] evidence: IBA
GeneID:8312 -> Biological process: GO:0007605 [sensory perception of sound] evidence: IEA
GeneID:8312 -> Biological process: GO:0008219 [cell death] evidence: IBA
GeneID:8312 -> Biological process: GO:0009950 [dorsal/ventral axis specification] evidence: IBA
GeneID:8312 -> Biological process: GO:0010800 [positive regulation of peptidyl-threonine phosphorylation] evidence: IDA
GeneID:8312 -> Biological process: GO:0021797 [forebrain anterior/posterior pattern specification] evidence: IBA
GeneID:8312 -> Biological process: GO:0021881 [Wnt receptor signaling pathway involved in forebrain neuron fate commitment] evidence: IBA
GeneID:8312 -> Biological process: GO:0030163 [protein catabolic process] evidence: IEA
GeneID:8312 -> Biological process: GO:0030178 [negative regulation of Wnt receptor signaling pathway] evidence: IDA
GeneID:8312 -> Biological process: GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] evidence: IEA
GeneID:8312 -> Biological process: GO:0030910 [olfactory placode formation] evidence: IBA
GeneID:8312 -> Biological process: GO:0031122 [cytoplasmic microtubule organization] evidence: IBA
GeneID:8312 -> Biological process: GO:0031398 [positive regulation of protein ubiquitination] evidence: IDA
GeneID:8312 -> Biological process: GO:0032147 [activation of protein kinase activity] evidence: IDA
GeneID:8312 -> Biological process: GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] evidence: IEA
GeneID:8312 -> Biological process: GO:0033138 [positive regulation of peptidyl-serine phosphorylation] evidence: IDA
GeneID:8312 -> Biological process: GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter] evidence: IEA
GeneID:8312 -> Biological process: GO:0035412 [regulation of catenin import into nucleus] evidence: IBA
GeneID:8312 -> Biological process: GO:0036342 [post-anal tail morphogenesis] evidence: IEA
GeneID:8312 -> Biological process: GO:0038032 [termination of G-protein coupled receptor signaling pathway] evidence: IEA
GeneID:8312 -> Biological process: GO:0043547 [positive regulation of GTPase activity] evidence: IBA
GeneID:8312 -> Biological process: GO:0043623 [cellular protein complex assembly] evidence: IDA
GeneID:8312 -> Biological process: GO:0045599 [negative regulation of fat cell differentiation] evidence: IBA
GeneID:8312 -> Biological process: GO:0045732 [positive regulation of protein catabolic process] evidence: IC
GeneID:8312 -> Biological process: GO:0045732 [positive regulation of protein catabolic process] evidence: IDA
GeneID:8312 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IMP
GeneID:8312 -> Biological process: GO:0046330 [positive regulation of JNK cascade] evidence: ISS
GeneID:8312 -> Biological process: GO:0048048 [embryonic eye morphogenesis] evidence: IBA
GeneID:8312 -> Biological process: GO:0048320 [axial mesoderm formation] evidence: IBA
GeneID:8312 -> Biological process: GO:0051248 [negative regulation of protein metabolic process] evidence: IEA
GeneID:8312 -> Biological process: GO:0051260 [protein homooligomerization] evidence: IEA
GeneID:8312 -> Biological process: GO:0051443 [positive regulation of ubiquitin-protein ligase activity] evidence: IMP
GeneID:8312 -> Biological process: GO:0055001 [muscle cell development] evidence: IBA
GeneID:8312 -> Biological process: GO:0060070 [canonical Wnt receptor signaling pathway] evidence: IC
GeneID:8312 -> Biological process: GO:0060272 [embryonic skeletal joint morphogenesis] evidence: IBA
GeneID:8312 -> Biological process: GO:0060823 [canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation] evidence: IBA
GeneID:8312 -> Biological process: GO:0071407 [cellular response to organic cyclic compound] evidence: IBA
GeneID:8312 -> Biological process: GO:0071514 [genetic imprinting] evidence: IEA
GeneID:8312 -> Biological process: GO:0090090 [negative regulation of canonical Wnt receptor signaling pathway] evidence: IBA
GeneID:8312 -> Biological process: GO:0090244 [Wnt receptor signaling pathway involved in somitogenesis] evidence: IBA
GeneID:8312 -> Biological process: GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] evidence: ISS
GeneID:8312 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:8312 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:8312 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:8312 -> Cellular component: GO:0005881 [cytoplasmic microtubule] evidence: IBA
GeneID:8312 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:8312 -> Cellular component: GO:0005938 [cell cortex] evidence: IBA
GeneID:8312 -> Cellular component: GO:0014069 [postsynaptic density] evidence: IBA
GeneID:8312 -> Cellular component: GO:0016023 [cytoplasmic membrane-bounded vesicle] evidence: IBA
GeneID:8312 -> Cellular component: GO:0016328 [lateral plasma membrane] evidence: IDA
GeneID:8312 -> Cellular component: GO:0030877 [beta-catenin destruction complex] evidence: IDA
GeneID:8312 -> Cellular component: GO:0031410 [cytoplasmic vesicle] evidence: ISS
GeneID:8312 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IDA
GeneID:8312 -> Cellular component: GO:0071944 [cell periphery] evidence: IDA
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