2024-04-27 03:42:44, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003467 1691 bp mRNA linear PRI 15-JUL-2013 DEFINITION Homo sapiens chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 2, mRNA. ACCESSION NM_003467 VERSION NM_003467.2 GI:56790928 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1691) AUTHORS Arnolds,K.L., Lares,A.P. and Spencer,J.V. TITLE The US27 gene product of human cytomegalovirus enhances signaling of host chemokine receptor CXCR4 JOURNAL Virology 439 (2), 122-131 (2013) PUBMED 23490053 REMARK GeneRIF: Potentiation of CXCR4 signaling by US27 could represent a novel strategy by which human cytomegalovirus targets virus-infected cells to the bone marrow in order to expand the reservoir of latently infected cells. REFERENCE 2 (bases 1 to 1691) AUTHORS Mo,W., Chen,J., Patel,A., Zhang,L., Chau,V., Li,Y., Cho,W., Lim,K., Xu,J., Lazar,A.J., Creighton,C.J., Bolshakov,S., McKay,R.M., Lev,D., Le,L.Q. and Parada,L.F. TITLE CXCR4/CXCL12 mediate autocrine cell- cycle progression in NF1-associated malignant peripheral nerve sheath tumors JOURNAL Cell 152 (5), 1077-1090 (2013) PUBMED 23434321 REMARK GeneRIF: Study provides evidence that the CXCR4/CXCL12 axis is essential for Malignant peripheral nerve sheath tumors (MPNST) tumor progression. Specifically, the autocrine activation of CXCR4 by CXCL12 triggers intracellular PI3-kinase and beta-catenin signals to promote G1 to S phase transition in MPNST cells. REFERENCE 3 (bases 1 to 1691) AUTHORS Yuan,L., Zhang,H., Liu,J., Rubin,J.B., Cho,Y.J., Shu,H.K., Schniederjan,M. and MacDonald,T.J. TITLE Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes medulloblastoma migration JOURNAL Mol. Cancer 12, 18 (2013) PUBMED 23497290 REMARK GeneRIF: Growth factor receptor/PDGFR-Src-mediated dysregulation of CXCR4 signaling promotes medulloblastoma cell migration. Publication Status: Online-Only REFERENCE 4 (bases 1 to 1691) AUTHORS Ng,K.Y., Chew,K.K., Kaur,P., Kwan,J.Y., Khong,W.X., Lin,L., Chua,A., Tan,M.T., Quinn,T.C., Laeyendecker,O., Leo,Y.S. and Ng,O.T. TITLE High prevalence of CXCR4 usage among treatment-naive CRF01_AE and CRF51_01B-infected HIV-1 subjects in Singapore JOURNAL BMC Infect. Dis. 13, 90 (2013) PUBMED 23421710 REMARK GeneRIF: CRF51_01B and CRF01_AE-infected individuals have higher prevalence of CXCR4-usage compared to subtype B infected individuals. Publication Status: Online-Only REFERENCE 5 (bases 1 to 1691) AUTHORS de Muga,S., Hernandez,S., Salido,M., Lorenzo,M., Agell,L., Juanpere,N., Lorente,J.A., Serrano,S. and Lloreta,J. TITLE CXCR4 mRNA overexpression in high grade prostate tumors: lack of association with TMPRSS2-ERG rearrangement JOURNAL Cancer Biomark 12 (1), 21-30 (2012) PUBMED 23321466 REMARK GeneRIF: CXCR4 overexpression is associated with high Gleason score prostate tumors, but that it is independent of the TMPRSS2-ERG rearrangement. REFERENCE 6 (bases 1 to 1691) AUTHORS Lu,Z.H., Wang,Z.X., Horuk,R., Hesselgesser,J., Lou,Y.C., Hadley,T.J. and Peiper,S.C. TITLE The promiscuous chemokine binding profile of the Duffy antigen/receptor for chemokines is primarily localized to sequences in the amino-terminal domain JOURNAL J. Biol. Chem. 270 (44), 26239-26245 (1995) PUBMED 7592830 REFERENCE 7 (bases 1 to 1691) AUTHORS Loetscher,M., Geiser,T., O'Reilly,T., Zwahlen,R., Baggiolini,M. and Moser,B. TITLE Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes JOURNAL J. Biol. Chem. 269 (1), 232-237 (1994) PUBMED 8276799 REFERENCE 8 (bases 1 to 1691) AUTHORS Nomura,H., Nielsen,B.W. and Matsushima,K. TITLE Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors JOURNAL Int. Immunol. 5 (10), 1239-1249 (1993) PUBMED 7505609 REFERENCE 9 (bases 1 to 1691) AUTHORS Jazin,E.E., Yoo,H., Blomqvist,A.G., Yee,F., Weng,G., Walker,M.W., Salon,J., Larhammar,D. and Wahlestedt,C. TITLE A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells JOURNAL Regul. Pept. 47 (3), 247-258 (1993) PUBMED 8234909 REFERENCE 10 (bases 1 to 1691) AUTHORS Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and Kaziro,Y. TITLE Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs JOURNAL J. Biol. Chem. 263 (14), 6656-6664 (1988) PUBMED 2834384 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC068492.2, D10924.1 and AF147204.1. This sequence is a reference standard in the RefSeqGene project. On Dec 23, 2004 this sequence version replaced gi:4503174. Summary: This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (b) has a shorter N-terminus when compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D10924.1, AK129916.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-19 AC068492.2 101850-101868 20-1437 D10924.1 1-1418 1438-1691 AF147204.1 1697-1950 FEATURES Location/Qualifiers source 1..1691 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="2" /map="2q21" gene 1..1691 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /note="chemokine (C-X-C motif) receptor 4" /db_xref="GeneID:7852" /db_xref="HGNC:2561" /db_xref="HPRD:01217" /db_xref="MIM:162643" exon 1..110 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /inference="alignment:Splign:1.39.8" misc_feature 30..32 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /note="upstream in-frame stop codon" CDS 96..1154 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /note="isoform b is encoded by transcript variant 2; leukocyte-derived seven-transmembrane-domain receptor; seven-transmembrane-segment receptor, spleen; lipopolysaccharide-associated protein 3; stromal cell-derived factor 1 receptor; CD184 antigen; C-X-C chemokine receptor type 4; neuropeptide Y receptor Y3; fusin; seven transmembrane helix receptor; CXC-R4; CXCR-4; SDF-1 receptor; leukocyte-derived seven transmembrane domain receptor" /codon_start=1 /product="C-X-C chemokine receptor type 4 isoform b" /protein_id="NP_003458.1" /db_xref="GI:4503175" /db_xref="CCDS:CCDS46420.1" /db_xref="GeneID:7852" /db_xref="HGNC:2561" /db_xref="HPRD:01217" /db_xref="MIM:162643" /translation="
MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
" misc_feature 96..158 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P61073.1); Region: Important for chemokine binding, signaling and HIV-1 coreceptor activity" misc_feature 111..209 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /note="CXCR4 Chemokine receptor N terminal; Region: CXCR4_N; pfam12109" /db_xref="CDD:152544" misc_feature 114..116 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="Sulfotyrosine, partial; propagated from UniProtKB/Swiss-Prot (P61073.1); sulfatation site" misc_feature 126..128 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="glycosylation site" misc_feature 129..131 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="Sulfotyrosine, partial; propagated from UniProtKB/Swiss-Prot (P61073.1); sulfatation site" misc_feature 147..149 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="sulfatation site" misc_feature 156..158 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="Sulfotyrosine; propagated from UniProtKB/Swiss-Prot (P61073.1); sulfatation site" misc_feature 156..158 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="sulfatation site" misc_feature 210..284 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P61073.1); transmembrane region" misc_feature 276..1001 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /note="7 transmembrane receptor (rhodopsin family); Region: 7tm_1; pfam00001" /db_xref="CDD:200918" misc_feature 327..392 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P61073.1); transmembrane region" misc_feature 375..386 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P61073.1); Region: Chemokine binding" misc_feature 426..485 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P61073.1); transmembrane region" misc_feature 432..446 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P61073.1); Region: Chemokine binding" misc_feature 492..500 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P61073.1); Region: Important for signaling" misc_feature 498..536 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P61073.1); Region: Involved in dimerization, when bound to chemokine" misc_feature 558..617 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P61073.1); transmembrane region" misc_feature 651..665 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P61073.1); Region: Chemokine binding, important for signaling and HIV-1 coreceptor activity" misc_feature 666..725 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P61073.1); Region: Involved in dimerization" misc_feature 681..743 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P61073.1); transmembrane region" misc_feature 819..878 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P61073.1); transmembrane region" misc_feature 891..899 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P61073.1); Region: Involved in dimerization" misc_feature 942..1001 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P61073.1); transmembrane region" misc_feature 1047..1049 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1050..1052 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P61073.1); phosphorylation site" misc_feature 1056..1058 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P61073.1); phosphorylation site" misc_feature 1056..1058 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1065..1067 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by PKC and GRK6; propagated from UniProtKB/Swiss-Prot (P61073.1); phosphorylation site" misc_feature 1065..1067 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1068..1070 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by PKC and GRK6; propagated from UniProtKB/Swiss-Prot (P61073.1); phosphorylation site" misc_feature 1068..1070 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1083..1085 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by GRK6; propagated from UniProtKB/Swiss-Prot (P61073.1); phosphorylation site" misc_feature 1110..1112 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by GRK6; propagated from UniProtKB/Swiss-Prot (P61073.1); phosphorylation site" misc_feature 1131..1133 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1137..1139 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P61073.1); phosphorylation site" misc_feature 1137..1139 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1146..1148 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P61073.1); phosphorylation site" misc_feature 1149..1151 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" exon 111..1674 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /inference="alignment:Splign:1.39.8" STS 158..538 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /standard_name="PMC109444P3" /db_xref="UniSTS:270168" STS 238..825 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /standard_name="Cxcr4" /db_xref="UniSTS:528302" STS 410..711 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /standard_name="PMC109434P1" /db_xref="UniSTS:270163" STS 437..1286 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /standard_name="CXCR4_564" /db_xref="UniSTS:277147" variation 440 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /replace="c" /replace="t" /db_xref="dbSNP:1051557" variation 509 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /replace="c" /replace="t" /db_xref="dbSNP:2228014" STS 539..872 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /standard_name="PMC109895P1" /db_xref="UniSTS:270179" STS 636..1154 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /standard_name="PMC149544P1" /db_xref="UniSTS:271047" STS 656..845 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /standard_name="CXCR4" /db_xref="UniSTS:480008" STS 980..1605 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /standard_name="PMC112647P1" /db_xref="UniSTS:270237" variation 1183 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /replace="a" /replace="g" /db_xref="dbSNP:17848059" variation 1220 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /replace="g" /replace="t" /db_xref="dbSNP:1804029" STS 1239..1445 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /standard_name="SHGC-31461" /db_xref="UniSTS:80512" STS 1378..1626 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /standard_name="PMC110622P1" /db_xref="UniSTS:270191" STS 1443..1632 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /standard_name="RH17365" /db_xref="UniSTS:9776" STS 1498..1626 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /standard_name="RH78321" /db_xref="UniSTS:35222" variation 1571 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /replace="a" /replace="g" /db_xref="dbSNP:148300422" variation 1584 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" /replace="a" /replace="t" /db_xref="dbSNP:17848060" polyA_signal 1652..1657 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" polyA_site 1674 /gene="CXCR4" /gene_synonym="CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM" ORIGIN
aacttcagtttgttggctgcggcagcaggtagcaaagtgacgccgagggcctgagtgctccagtagccaccgcatctggagaaccagcggttaccatggaggggatcagtatatacacttcagataactacaccgaggaaatgggctcaggggactatgactccatgaaggaaccctgtttccgtgaagaaaatgctaatttcaataaaatcttcctgcccaccatctactccatcatcttcttaactggcattgtgggcaatggattggtcatcctggtcatgggttaccagaagaaactgagaagcatgacggacaagtacaggctgcacctgtcagtggccgacctcctctttgtcatcacgcttcccttctgggcagttgatgccgtggcaaactggtactttgggaacttcctatgcaaggcagtccatgtcatctacacagtcaacctctacagcagtgtcctcatcctggccttcatcagtctggaccgctacctggccatcgtccacgccaccaacagtcagaggccaaggaagctgttggctgaaaaggtggtctatgttggcgtctggatccctgccctcctgctgactattcccgacttcatctttgccaacgtcagtgaggcagatgacagatatatctgtgaccgcttctaccccaatgacttgtgggtggttgtgttccagtttcagcacatcatggttggccttatcctgcctggtattgtcatcctgtcctgctattgcattatcatctccaagctgtcacactccaagggccaccagaagcgcaaggccctcaagaccacagtcatcctcatcctggctttcttcgcctgttggctgccttactacattgggatcagcatcgactccttcatcctcctggaaatcatcaagcaagggtgtgagtttgagaacactgtgcacaagtggatttccatcaccgaggccctagctttcttccactgttgtctgaaccccatcctctatgctttccttggagccaaatttaaaacctctgcccagcacgcactcacctctgtgagcagagggtccagcctcaagatcctctccaaaggaaagcgaggtggacattcatctgtttccactgagtctgagtcttcaagttttcactccagctaacacagatgtaaaagacttttttttatacgataaataacttttttttaagttacacatttttcagatataaaagactgaccaatattgtacagtttttattgcttgttggatttttgtcttgtgtttctttagtttttgtgaagtttaattgacttatttatataaattttttttgtttcatattgatgtgtgtctaggcaggacctgtggccaagttcttagttgctgtatgtctcgtggtaggactgtagaaaagggaactgaacattccagagcgtgtagtgaatcacgtaaagctagaaatgatccccagctgtttatgcatagataatctctccattcccgtggaacgtttttcctgttcttaagacgtgattttgctgtagaagatggcacttataaccaaagcccaaagtggtatagaaatgctggtttttcagttttcaggagtgggttgatttcagcacctacagtgtacagtcttgtattaagttgttaataaaagtacatgttaaacttaaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:7852 -> Molecular function: GO:0003779 [actin binding] evidence: IDA GeneID:7852 -> Molecular function: GO:0004930 [G-protein coupled receptor activity] evidence: TAS GeneID:7852 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:7852 -> Molecular function: GO:0015026 [coreceptor activity] evidence: TAS GeneID:7852 -> Molecular function: GO:0016494 [C-X-C chemokine receptor activity] evidence: NAS GeneID:7852 -> Molecular function: GO:0019955 [cytokine binding] evidence: IEA GeneID:7852 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI GeneID:7852 -> Molecular function: GO:0032027 [myosin light chain binding] evidence: IDA GeneID:7852 -> Molecular function: GO:0043130 [ubiquitin binding] evidence: IDA GeneID:7852 -> Biological process: GO:0000187 [activation of MAPK activity] evidence: TAS GeneID:7852 -> Biological process: GO:0001569 [patterning of blood vessels] evidence: IEA GeneID:7852 -> Biological process: GO:0001666 [response to hypoxia] evidence: IEP GeneID:7852 -> Biological process: GO:0001667 [ameboidal cell migration] evidence: IEA GeneID:7852 -> Biological process: GO:0001764 [neuron migration] evidence: IEA GeneID:7852 -> Biological process: GO:0002407 [dendritic cell chemotaxis] evidence: TAS GeneID:7852 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:7852 -> Biological process: GO:0006954 [inflammatory response] evidence: TAS GeneID:7852 -> Biological process: GO:0007186 [G-protein coupled receptor signaling pathway] evidence: IDA GeneID:7852 -> Biological process: GO:0007204 [elevation of cytosolic calcium ion concentration] evidence: TAS GeneID:7852 -> Biological process: GO:0007281 [germ cell development] evidence: IEA GeneID:7852 -> Biological process: GO:0007420 [brain development] evidence: IEA GeneID:7852 -> Biological process: GO:0008045 [motor neuron axon guidance] evidence: IEA GeneID:7852 -> Biological process: GO:0008354 [germ cell migration] evidence: IEA GeneID:7852 -> Biological process: GO:0009615 [response to virus] evidence: TAS GeneID:7852 -> Biological process: GO:0016032 [viral process] evidence: TAS GeneID:7852 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA GeneID:7852 -> Biological process: GO:0019722 [calcium-mediated signaling] evidence: IMP GeneID:7852 -> Biological process: GO:0030260 [entry into host cell] evidence: TAS GeneID:7852 -> Biological process: GO:0030334 [regulation of cell migration] evidence: IEA GeneID:7852 -> Biological process: GO:0042098 [T cell proliferation] evidence: IEA GeneID:7852 -> Biological process: GO:0042119 [neutrophil activation] evidence: IEA GeneID:7852 -> Biological process: GO:0043217 [myelin maintenance] evidence: ISS GeneID:7852 -> Biological process: GO:0048714 [positive regulation of oligodendrocyte differentiation] evidence: ISS GeneID:7852 -> Biological process: GO:0050920 [regulation of chemotaxis] evidence: IMP GeneID:7852 -> Biological process: GO:0061351 [neural precursor cell proliferation] evidence: IEA GeneID:7852 -> Cellular component: GO:0005737 [cytoplasm] evidence: TAS GeneID:7852 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS GeneID:7852 -> Cellular component: GO:0009897 [external side of plasma membrane] evidence: IEA GeneID:7852 -> Cellular component: GO:0009986 [cell surface] evidence: IDA GeneID:7852 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA GeneID:7852 -> Cellular component: GO:0016023 [cytoplasmic membrane-bounded vesicle] evidence: IDA GeneID:7852 -> Cellular component: GO:0030426 [growth cone] evidence: IEA GeneID:7852 -> Cellular component: GO:0031252 [cell leading edge] evidence: IDA GeneID:7852 -> Cellular component: GO:0031410 [cytoplasmic vesicle] evidence: IDA
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