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2024-04-27 10:54:13, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003337 2631 bp mRNA linear PRI 08-JUN-2013
DEFINITION Homo sapiens ubiquitin-conjugating enzyme E2B (UBE2B), mRNA.
ACCESSION NM_003337
VERSION NM_003337.2 GI:32967281
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2631)
AUTHORS Gerard,B., Sanders,M.A., Visscher,D.W., Tait,L. and Shekhar,M.P.
TITLE Lysine 394 is a novel Rad6B-induced ubiquitination site on
beta-catenin
JOURNAL Biochim. Biophys. Acta 1823 (10), 1686-1696 (2012)
PUBMED 22705350
REMARK GeneRIF: beta-catenin and Rad6B interacting regions, were
identified.
Erratum:[Biochim Biophys Acta. 2013 May;1833(5):1280-1]
REFERENCE 2 (bases 1 to 2631)
AUTHORS Yoon,J.H., Prakash,S. and Prakash,L.
TITLE Requirement of Rad18 protein for replication through DNA lesions in
mouse and human cells
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (20), 7799-7804 (2012)
PUBMED 22547805
REMARK GeneRIF: The Rad6-Rad18 enzyme plays an essential role in promoting
replication through DNA lesions by translesion synthesis in
mammalian cells.
REFERENCE 3 (bases 1 to 2631)
AUTHORS Chen,S., Wang,D.L., Liu,Y., Zhao,L. and Sun,F.L.
TITLE RAD6 regulates the dosage of p53 by a combination of
transcriptional and posttranscriptional mechanisms
JOURNAL Mol. Cell. Biol. 32 (2), 576-587 (2012)
PUBMED 22083959
REMARK GeneRIF: RAD6 can form a ternary complex with MDM2 and p53 that
contributes to the degradation of p53.
REFERENCE 4 (bases 1 to 2631)
AUTHORS Huang,A., Hibbert,R.G., de Jong,R.N., Das,D., Sixma,T.K. and
Boelens,R.
TITLE Symmetry and asymmetry of the RING-RING dimer of Rad18
JOURNAL J. Mol. Biol. 410 (3), 424-435 (2011)
PUBMED 21549715
REMARK GeneRIF: Data show that the homodimeric Rad18 RING domain can
recruit two Rad6b E2 enzymes, whereas the full-length Rad18
homodimer binds only to a single Rad6b molecule.
REFERENCE 5 (bases 1 to 2631)
AUTHORS Kumar,B., Lecompte,K.G., Klein,J.M. and Haas,A.L.
TITLE Ser(120) of Ubc2/Rad6 regulates ubiquitin-dependent N-end rule
targeting by E3{alpha}/Ubr1
JOURNAL J. Biol. Chem. 285 (53), 41300-41309 (2010)
PUBMED 21041297
REMARK GeneRIF: Ubc2/Rad6 ser(120) regulates ubiquitin-dependent N-end
rule targeting by E3{alpha}/Ubr1
REFERENCE 6 (bases 1 to 2631)
AUTHORS Koken,M.H., Hoogerbrugge,J.W., Jasper-Dekker,I., de Wit,J.,
Willemsen,R., Roest,H.P., Grootegoed,J.A. and Hoeijmakers,J.H.
TITLE Expression of the ubiquitin-conjugating DNA repair enzymes HHR6A
and B suggests a role in spermatogenesis and chromatin modification
JOURNAL Dev. Biol. 173 (1), 119-132 (1996)
PUBMED 8575614
REFERENCE 7 (bases 1 to 2631)
AUTHORS Koken,M.H., Smit,E.M., Jaspers-Dekker,I., Oostra,B.A.,
Hagemeijer,A., Bootsma,D. and Hoeijmakers,J.H.
TITLE Localization of two human homologs, HHR6A and HHR6B, of the yeast
DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31
JOURNAL Genomics 12 (3), 447-453 (1992)
PUBMED 1559696
REFERENCE 8 (bases 1 to 2631)
AUTHORS Koken,M.H., Reynolds,P., Jaspers-Dekker,I., Prakash,L., Prakash,S.,
Bootsma,D. and Hoeijmakers,J.H.
TITLE Structural and functional conservation of two human homologs of the
yeast DNA repair gene RAD6
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (20), 8865-8869 (1991)
PUBMED 1717990
REFERENCE 9 (bases 1 to 2631)
AUTHORS Woffendin,C., Chen,Z.Y., Staskus,K., Retzel,E.F. and Plagemann,P.G.
TITLE Mammalian mRNAs encoding protein closely related to
ubiquitin-conjugating enzyme encoded by yeast DNA repair gene RAD6
JOURNAL Biochim. Biophys. Acta 1090 (1), 81-85 (1991)
PUBMED 1883845
REFERENCE 10 (bases 1 to 2631)
AUTHORS Schneider,R., Eckerskorn,C., Lottspeich,F. and Schweiger,M.
TITLE The human ubiquitin carrier protein E2(Mr = 17,000) is homologous
to the yeast DNA repair gene RAD6
JOURNAL EMBO J. 9 (5), 1431-1435 (1990)
PUBMED 2158443
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from M74525.1 and T88933.1.
On Jul 18, 2003 this sequence version replaced gi:4507770.
Summary: The modification of proteins with ubiquitin is an
important cellular mechanism for targeting abnormal or short-lived
proteins for degradation. Ubiquitination involves at least three
classes of enzymes: ubiquitin-activating enzymes, or E1s,
ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein
ligases, or E3s. This gene encodes a member of the E2
ubiquitin-conjugating enzyme family. This enzyme is required for
post-replicative DNA damage repair. Its protein sequence is 100%
identical to the mouse, rat, and rabbit homologs, which indicates
that this enzyme is highly conserved in eukaryotic evolution.
[provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: M74525.1, BC005979.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
FEATURES Location/Qualifiers
source 1..2631
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q31.1"
gene 1..2631
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/note="ubiquitin-conjugating enzyme E2B"
/db_xref="GeneID:7320"
/db_xref="HGNC:12473"
/db_xref="HPRD:01533"
/db_xref="MIM:179095"
exon 1..461
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/inference="alignment:Splign:1.39.8"
variation 7
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="g"
/replace="t"
/db_xref="dbSNP:367568607"
misc_feature 100..102
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/note="upstream in-frame stop codon"
variation 125
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="g"
/replace="t"
/db_xref="dbSNP:17167484"
variation 135
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="c"
/replace="g"
/db_xref="dbSNP:375781135"
variation 137
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370174699"
variation 203
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="c"
/replace="t"
/db_xref="dbSNP:367696276"
variation 296..298
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace=""
/replace="cgg"
/db_xref="dbSNP:376526735"
variation 296
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="a"
/replace="c"
/db_xref="dbSNP:34835090"
variation 323
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="c"
/replace="t"
/db_xref="dbSNP:34553375"
variation 327..328
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace=""
/replace="gcg"
/db_xref="dbSNP:34763898"
variation 379
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace=""
/replace="t"
/db_xref="dbSNP:35950497"
variation 387
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="c"
/replace="t"
/db_xref="dbSNP:35674764"
variation 398
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="c"
/replace="g"
/db_xref="dbSNP:369451577"
variation 399
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="c"
/replace="t"
/db_xref="dbSNP:373780934"
variation 406
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="c"
/replace="g"
/db_xref="dbSNP:371691768"
variation 416
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375951755"
CDS 418..876
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/EC_number="6.3.2.19"
/note="ubiquitin-conjugating enzyme E2B (RAD6 homolog); E2
protein; ubiquitin-protein ligase B; ubiquitin carrier
protein B; RAD6 homolog B; ubiquitin-conjugating enzyme
E2-17 kDa"
/codon_start=1
/product="ubiquitin-conjugating enzyme E2 B"
/protein_id="NP_003328.1"
/db_xref="GI:4507771"
/db_xref="CCDS:CCDS4174.1"
/db_xref="GeneID:7320"
/db_xref="HGNC:12473"
/db_xref="HPRD:01533"
/db_xref="MIM:179095"
/translation="
MSTPARRRLMRDFKRLQEDPPVGVSGAPSENNIMQWNAVIFGPEGTPFEDGTFKLVIEFSEEYPNKPPTVRFLSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWNDS
"
misc_feature 436..840
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc)
domain. This is part of the ubiquitin-mediated protein
degradation pathway in which a thiol-ester linkage forms
between a conserved cysteine and the C-terminus of
ubiquitin and complexes with ubiquitin...; Region: UBCc;
cd00195"
/db_xref="CDD:238117"
misc_feature order(436..438,607..612,709..714)
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/note="E3 interaction residues; other site"
/db_xref="CDD:238117"
misc_feature order(640..645,655..660,664..666,676..684,688..693,
703..708,715..717,730..732,739..741,748..750,757..762,
766..768,772..777)
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/note="Ub thioester intermediate interaction residues;
other site"
/db_xref="CDD:238117"
misc_feature 679..681
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/note="active site cysteine"
/db_xref="CDD:238117"
variation 423
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="c"
/replace="g"
/db_xref="dbSNP:201989843"
variation 427
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="c"
/replace="t"
/db_xref="dbSNP:373518433"
variation 432
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201423355"
exon 462..542
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/inference="alignment:Splign:1.39.8"
exon 543..568
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/inference="alignment:Splign:1.39.8"
variation 568
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201619957"
exon 569..658
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/inference="alignment:Splign:1.39.8"
variation 639
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1803727"
exon 659..747
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/inference="alignment:Splign:1.39.8"
variation 723
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="a"
/replace="g"
/db_xref="dbSNP:142325838"
variation 742
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370904887"
exon 748..2631
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/inference="alignment:Splign:1.39.8"
variation 786
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374719729"
variation 795
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="a"
/replace="g"
/db_xref="dbSNP:368553903"
variation 849
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="a"
/replace="t"
/db_xref="dbSNP:61749632"
variation 866
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370961649"
variation 915
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200085190"
variation 990..991
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace=""
/replace="a"
/db_xref="dbSNP:71802004"
variation 1108..1109
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace=""
/replace="t"
/db_xref="dbSNP:66724509"
variation 1215
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="c"
/replace="t"
/db_xref="dbSNP:184830298"
variation 1272
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="a"
/replace="c"
/db_xref="dbSNP:34620273"
polyA_site 1302
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/experiment="experimental evidence, no additional details
recorded"
polyA_site 1307
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/experiment="experimental evidence, no additional details
recorded"
variation 1477
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="a"
/replace="c"
/db_xref="dbSNP:36072121"
STS 1575..1677
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/standard_name="WI-16140"
/db_xref="UniSTS:6847"
variation 1598
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="c"
/replace="t"
/db_xref="dbSNP:376028663"
STS 1635..1783
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/standard_name="D5S1596E"
/db_xref="UniSTS:151018"
STS 1726..1955
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/standard_name="WI-20684"
/db_xref="UniSTS:66147"
variation 1869
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="g"
/replace="t"
/db_xref="dbSNP:35406150"
variation 1884
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="a"
/replace="c"
/db_xref="dbSNP:11538104"
variation 1907
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="a"
/replace="t"
/db_xref="dbSNP:80070849"
variation 2038..2039
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace=""
/replace="g"
/db_xref="dbSNP:34880639"
variation 2135
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="a"
/replace="g"
/db_xref="dbSNP:3777373"
variation 2175
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="a"
/replace="g"
/db_xref="dbSNP:189252870"
variation 2256
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="c"
/replace="t"
/db_xref="dbSNP:181009937"
variation 2333
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace=""
/replace="t"
/db_xref="dbSNP:72406055"
variation 2383
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="a"
/replace="g"
/db_xref="dbSNP:34556130"
variation 2445
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="c"
/replace="t"
/db_xref="dbSNP:184299705"
polyA_signal 2493..2498
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
STS 2498..2631
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/standard_name="SGC32120"
/db_xref="UniSTS:99850"
STS 2500..2576
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/standard_name="WI-20661"
/db_xref="UniSTS:78272"
variation 2504
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/replace="c"
/replace="t"
/db_xref="dbSNP:36033883"
polyA_site 2515
/gene="UBE2B"
/gene_synonym="E2-17kDa; HHR6B; HR6B; RAD6B; UBC2"
/experiment="experimental evidence, no additional details
recorded"
ORIGIN
cgtccctctttctccaccccgccgagcctaaactagtgacggggagggagacgggatagtgtttctgtttcgtggtctttgaatccacaacctctagtctgaacacagagaacacaaatttgtctattacttcaggaagcccagggggaaccgcgccccgctgaagggctcggggaaggcgcgctcccgcgtcccgccccctcctcccccagcactcacactgtggtagcggcggagggcggagggatccggaggcggcggagggagacgtcattgcagggttgtttgtcagtctcggcggcggcggcggcggcggcggcggcggcgatccacagtgattcggccgccgcgccggggggtgggggggctgcgcgggactttttttttttcagactgaccgcggggcagctgcggagcatgtcgaccccggcccggaggaggctcatgcgggatttcaagcggttacaagaggacccacctgtgggtgtcagtggcgcaccatctgaaaacaacatcatgcagtggaatgcagttatatttggaccagaagggacaccttttgaagatggtacttttaaactagtaatagaattttctgaagaatatccaaataaaccaccaactgttaggtttttatccaaaatgtttcatccaaatgtgtatgctgatggtagcatatgtttagatatccttcagaatcgatggagtccaacatatgatgtatcttctatcttaacatcaattcagtctctgctggatgaaccgaatcctaacagtccagccaatagccaggcagcacagctttatcaggaaaacaaacgagaatatgagaaaagagtttcggccattgttgaacaaagctggaatgattcataatagacaactggtctgttaatctttttcatcattgttgtgtataatttacctctcattagaaaggctaacaaattttaagtgccacaggttttaaggattctgcagaaaaaaaagaaaaaagtccttcagtttagaacctacaaaagcttgtgtatcttgattaatgtactttttattgcatggtgtgaactaagttattgctgcataaatttgtaatatatcctgtttgtatttttttccaagtgtataatgttggtgtggagttttcatgacagaatatacacattttgtaaatctgtacttttttcaaatattgaatgccttatttttgaattctttagatttttaaattggagaaaagcacttaaagttttttatatatgaatattacatgtaaagctgttaaaatacataacttcagtgcaagagactttgtcacttatttccttatgtgtgtaggaggggttaataagtctctagctctccatctattgatagtttcatttacaatttcaaaagaacattcttatattttatcaaggaagtcttcaaatttgattctaaatagcgattataatctccaactttattttgaatgtacctctattagtttcaattgagtaattctagacataactggtttgactctgtccaactctgtatttaggccatttgttacagtttcttcatgcattacttactgttaaaactgtaccttttgcgatttcacagttggcacttctgccatgagcagagaactgatgcgacttgttttgctgcttggtagcactttaaaaaattttttgattaatgaagaaagtaaaaccataaacatttgccaaaaattcatgccccagtattagcaatgaattagttgcattggtttgagaaaggcacatattggagggaaatcttggtgtaacttaaatatttgaaaattacctttaatgcaatgcatatctgtttattctgggaaatgttttaatgccagggcctgctgagttgcttcttcttgtggagattttttttttaatctcctgagttgtataaaagttgtactgcatcttagtttactggataaatttaaaacacagtattgtagaaagctaatacaaaactatcctatgccttcaaatagtatagaaaatggaaaatatacaagtaaattctgttgaaccacctgtgtagtctctctagtagttaaaacagctattttagtaaccccaagagtttcttctcatatccataaaattggattacagtatggcaatatctacagcttctattcattatgcaacgtttaacattgattggataaatgcttataggctgggccaggtggctcccacctgtagtcccagcactttgggaggcaaaggcgggaggatcacttgaggccaggactttgagaccagccagggcaacataataagacttttctctactttaaattttttaaaaaattagttgggcatagtggcacttgcctgtagtctcagctacttaggaggctgaggtggcagaatagcttatgcctaggaggttgaggctgcagtgagctgtgattatgccattgcactccagcctgggtgacagagcaataccctgtctttaaaaataaaagctattacttggcaaattctgaggtaagtgtatgatcttagggaactttgatacaaatgggaattcactcactggaatcgtggctcccaaaaagatgctttaattgtgtggtgcttttatagtttagctcca
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7320 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IDA
GeneID:7320 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IMP
GeneID:7320 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7320 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:7320 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI
GeneID:7320 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: IMP
GeneID:7320 -> Biological process: GO:0001666 [response to hypoxia] evidence: IEA
GeneID:7320 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
GeneID:7320 -> Biological process: GO:0006281 [DNA repair] evidence: IGI
GeneID:7320 -> Biological process: GO:0006301 [postreplication repair] evidence: IDA
GeneID:7320 -> Biological process: GO:0006301 [postreplication repair] evidence: NAS
GeneID:7320 -> Biological process: GO:0006344 [maintenance of chromatin silencing] evidence: IEA
GeneID:7320 -> Biological process: GO:0006511 [ubiquitin-dependent protein catabolic process] evidence: IDA
GeneID:7320 -> Biological process: GO:0006511 [ubiquitin-dependent protein catabolic process] evidence: NAS
GeneID:7320 -> Biological process: GO:0006513 [protein monoubiquitination] evidence: IMP
GeneID:7320 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IDA
GeneID:7320 -> Biological process: GO:0007283 [spermatogenesis] evidence: TAS
GeneID:7320 -> Biological process: GO:0007288 [sperm axoneme assembly] evidence: IEA
GeneID:7320 -> Biological process: GO:0009411 [response to UV] evidence: IGI
GeneID:7320 -> Biological process: GO:0010845 [positive regulation of reciprocal meiotic recombination] evidence: IEA
GeneID:7320 -> Biological process: GO:0016567 [protein ubiquitination] evidence: IDA
GeneID:7320 -> Biological process: GO:0032869 [cellular response to insulin stimulus] evidence: IEA
GeneID:7320 -> Biological process: GO:0033128 [negative regulation of histone phosphorylation] evidence: IEA
GeneID:7320 -> Biological process: GO:0033522 [histone H2A ubiquitination] evidence: IMP
GeneID:7320 -> Biological process: GO:0042493 [response to drug] evidence: IDA
GeneID:7320 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
GeneID:7320 -> Biological process: GO:0043161 [proteasomal ubiquitin-dependent protein catabolic process] evidence: IDA
GeneID:7320 -> Biological process: GO:0043951 [negative regulation of cAMP-mediated signaling] evidence: IDA
GeneID:7320 -> Biological process: GO:0050821 [protein stabilization] evidence: IMP
GeneID:7320 -> Biological process: GO:0051026 [chiasma assembly] evidence: IEA
GeneID:7320 -> Biological process: GO:0051865 [protein autoubiquitination] evidence: IDA
GeneID:7320 -> Biological process: GO:0060070 [canonical Wnt receptor signaling pathway] evidence: ISS
GeneID:7320 -> Biological process: GO:0070076 [histone lysine demethylation] evidence: IEA
GeneID:7320 -> Biological process: GO:0070193 [synaptonemal complex organization] evidence: IEA
GeneID:7320 -> Biological process: GO:0070534 [protein K63-linked ubiquitination] evidence: IDA
GeneID:7320 -> Biological process: GO:0070936 [protein K48-linked ubiquitination] evidence: IDA
GeneID:7320 -> Biological process: GO:0070979 [protein K11-linked ubiquitination] evidence: IDA
GeneID:7320 -> Cellular component: GO:0000785 [chromatin] evidence: ISS
GeneID:7320 -> Cellular component: GO:0000790 [nuclear chromatin] evidence: IEA
GeneID:7320 -> Cellular component: GO:0001741 [XY body] evidence: IEA
GeneID:7320 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:7320 -> Cellular component: GO:0005657 [replication fork] evidence: IDA
GeneID:7320 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:7320 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
GeneID:7320 -> Cellular component: GO:0033503 [HULC complex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_003328 -> EC 6.3.2.19
by
@meso_cacase at
DBCLS
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