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2024-04-26 09:42:36, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003300 7654 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens TNF receptor-associated factor 3 (TRAF3), transcript
variant 3, mRNA.
ACCESSION NM_003300
VERSION NM_003300.3 GI:313661480
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7654)
AUTHORS Cai,X., Du,J., Liu,Y., Xia,W., Liu,J., Zou,M., Wang,Y., Wang,M.,
Su,H. and Xu,D.
TITLE Identification and characterization of receptor-interacting protein
2 as a TNFR-associated factor 3 binding partner
JOURNAL Gene 517 (2), 205-211 (2013)
PUBMED 23333941
REMARK GeneRIF: In an attempt to explore TRAF3 binding partners that may
be involved in TRAF3-regulated signaling, a yeast two-hybrid screen
of a human spleen cDNA library was undertaken. RIP2 was identified
as a TRAF3 binding partner.
REFERENCE 2 (bases 1 to 7654)
AUTHORS Wolf,K. and Fields,K.A.
TITLE Chlamydia pneumoniae impairs the innate immune response in infected
epithelial cells by targeting TRAF3
JOURNAL J. Immunol. 190 (4), 1695-1701 (2013)
PUBMED 23303668
REMARK GeneRIF: Levels of TRAF3 degradation correlate with number of cells
infected with Chlamydia pneumoniae, because more TRAF3 is detected
at a lower multiplicity of C. pneumoniae infection.
REFERENCE 3 (bases 1 to 7654)
AUTHORS Shen,J., Qiao,Y.Q., Ran,Z.H. and Wang,T.R.
TITLE Up-regulation and pre-activation of TRAF3 and TRAF5 in inflammatory
bowel disease
JOURNAL Int J Med Sci 10 (2), 156-163 (2013)
PUBMED 23329887
REMARK GeneRIF: TRAF3 and TRAF5 are overexpressed in inflammatory bowel
disease. Although the endoscopic appearance can be normal, TRAF3
and TRAF5 pre-activation can be detected in non-inflamed colonic
segments
REFERENCE 4 (bases 1 to 7654)
AUTHORS Belgnaoui,S.M., Paz,S., Samuel,S., Goulet,M.L., Sun,Q., Kikkert,M.,
Iwai,K., Dikic,I., Hiscott,J. and Lin,R.
TITLE Linear ubiquitination of NEMO negatively regulates the interferon
antiviral response through disruption of the MAVS-TRAF3 complex
JOURNAL Cell Host Microbe 12 (2), 211-222 (2012)
PUBMED 22901541
REMARK GeneRIF: Ubiquitination of NEMO negatively regulates the interferon
antiviral response through disruption of the MAVS-TRAF3 complex.
REFERENCE 5 (bases 1 to 7654)
AUTHORS van Zuylen,W.J., Doyon,P., Clement,J.F., Khan,K.A.,
D'Ambrosio,L.M., Do,F., St-Amant-Verret,M., Wissanji,T., Emery,G.,
Gingras,A.C., Meloche,S. and Servant,M.J.
TITLE Proteomic profiling of the TRAF3 interactome network reveals a new
role for the ER-to-Golgi transport compartments in innate immunity
JOURNAL PLoS Pathog. 8 (7), E1002747 (2012)
PUBMED 22792062
REMARK GeneRIF: model proposed where dsDNA and dsRNA sensing induces the
formation of membrane-bound compartments originating from the
Golgi, which mediate the dynamic association of TRAF3 with MAVS
leading to an optimal induction of innate immune responses
REFERENCE 6 (bases 1 to 7654)
AUTHORS Hsu,H., Shu,H.B., Pan,M.G. and Goeddel,D.V.
TITLE TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF
receptor 1 signal transduction pathways
JOURNAL Cell 84 (2), 299-308 (1996)
PUBMED 8565075
REFERENCE 7 (bases 1 to 7654)
AUTHORS Cheng,G., Cleary,A.M., Ye,Z.S., Hong,D.I., Lederman,S. and
Baltimore,D.
TITLE Involvement of CRAF1, a relative of TRAF, in CD40 signaling
JOURNAL Science 267 (5203), 1494-1498 (1995)
PUBMED 7533327
REFERENCE 8 (bases 1 to 7654)
AUTHORS Mosialos,G., Birkenbach,M., Yalamanchili,R., VanArsdale,T., Ware,C.
and Kieff,E.
TITLE The Epstein-Barr virus transforming protein LMP1 engages signaling
proteins for the tumor necrosis factor receptor family
JOURNAL Cell 80 (3), 389-399 (1995)
PUBMED 7859281
REFERENCE 9 (bases 1 to 7654)
AUTHORS Sato,T., Irie,S. and Reed,J.C.
TITLE A novel member of the TRAF family of putative signal transducing
proteins binds to the cytosolic domain of CD40
JOURNAL FEBS Lett. 358 (2), 113-118 (1995)
PUBMED 7530216
REFERENCE 10 (bases 1 to 7654)
AUTHORS Hu,H.M., O'Rourke,K., Boguski,M.S. and Dixit,V.M.
TITLE A novel RING finger protein interacts with the cytoplasmic domain
of CD40
JOURNAL J. Biol. Chem. 269 (48), 30069-30072 (1994)
PUBMED 7527023
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from U21092.1, AL132801.5,
BX247977.1, AL117209.7 and BQ000015.1.
On Dec 7, 2010 this sequence version replaced gi:22027615.
Summary: The protein encoded by this gene is a member of the TNF
receptor associated factor (TRAF) protein family. TRAF proteins
associate with, and mediate the signal transduction from, members
of the TNF receptor (TNFR) superfamily. This protein participates
in the signal transduction of CD40, a TNFR family member important
for the activation of the immune response. This protein is found to
be a critical component of the lymphotoxin-beta receptor (LTbetaR)
signaling complex, which induces NF-kappaB activation and cell
death initiated by LTbeta ligation. Epstein-Barr virus encoded
latent infection membrane protein-1 (LMP1) can interact with this
and several other members of the TRAF family, which may be
essential for the oncogenic effects of LMP1. Several alternatively
spliced transcript variants encoding three distinct isoforms have
been reported. [provided by RefSeq, Dec 2010].
Transcript Variant: This variant (3) differs in the 5' UTR compared
to variant 1. Variants 1 and 3 both encode the same isoform (1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U21092.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025092 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-81 U21092.1 4-84
82-106 AL132801.5 21810-21834 c
107-288 U21092.1 110-291
289-2398 BX247977.1 274-2383
2399-7632 AL117209.7 122476-127709
7633-7654 BQ000015.1 1-22 c
FEATURES Location/Qualifiers
source 1..7654
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q32.32"
gene 1..7654
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/note="TNF receptor-associated factor 3"
/db_xref="GeneID:7187"
/db_xref="HGNC:12033"
/db_xref="MIM:601896"
exon 1..197
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/inference="alignment:Splign:1.39.8"
variation 131
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1051750"
exon 198..459
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/inference="alignment:Splign:1.39.8"
variation 207
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370752725"
variation 209
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:190521973"
CDS 215..1921
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/note="isoform 1 is encoded by transcript variant 3; CD40
binding protein; CD40 receptor associated factor 1; CD40
associated protein 1; LMP1-associated protein 1"
/codon_start=1
/product="TNF receptor-associated factor 3 isoform 1"
/protein_id="NP_003291.2"
/db_xref="GI:22027616"
/db_xref="CCDS:CCDS9975.1"
/db_xref="GeneID:7187"
/db_xref="HGNC:12033"
/db_xref="MIM:601896"
/translation="
MESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIKDDTIFIKVIVDTSDLPDP
"
misc_feature 368..499
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/note="RING-finger (Really Interesting New Gene) domain, a
specialized type of Zn-finger of 40 to 60 residues that
binds two atoms of zinc; defined by the 'cross-brace'
motif C-X2-C-X(9-39)-C-X(1-3)-
H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved
in...; Region: RING; cd00162"
/db_xref="CDD:29102"
misc_feature order(371..373,380..382,416..418,422..424,431..433,
440..442,476..478,485..487)
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/note="cross-brace motif; other site"
/db_xref="CDD:29102"
misc_feature 620..790
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/note="TRAF-type zinc finger; Region: zf-TRAF; pfam02176"
/db_xref="CDD:190233"
misc_feature 803..967
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/note="TRAF-type zinc finger; Region: zf-TRAF; pfam02176"
/db_xref="CDD:190233"
misc_feature 1346..1903
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/note="Tumor Necrosis Factor Receptor (TNFR)-Associated
Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF
molecules serve as adapter proteins that link TNFRs and
downstream kinase cascades resulting in the activation of
transcription factors and the...; Region: MATH_TRAF3;
cd03777"
/db_xref="CDD:58108"
misc_feature order(1409..1411,1418..1420,1442..1444,1448..1450,
1469..1471,1475..1477,1559..1564,1655..1657,1664..1666,
1715..1717)
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/note="trimer interface [polypeptide binding]; other site"
/db_xref="CDD:58108"
misc_feature order(1583..1585,1589..1591,1601..1603,1607..1609,
1634..1636,1748..1750,1757..1759,1772..1774,1802..1813)
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/note="TNFR binding site; other site"
/db_xref="CDD:58108"
variation 223
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:377427517"
variation 248
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139127242"
variation 250
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199639339"
variation 261..262
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace=""
/replace="c"
/db_xref="dbSNP:376342002"
variation 267
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:145456077"
variation 288
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370955205"
variation 289
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1051749"
variation 290
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:375545964"
variation 330
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147686384"
variation 352
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:201415483"
variation 399
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:183443558"
variation 403
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142350527"
exon 460..511
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/inference="alignment:Splign:1.39.8"
variation 460
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:146435455"
variation 481
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:147871145"
variation 484
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:149018928"
exon 512..616
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/inference="alignment:Splign:1.39.8"
variation 555
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:12896018"
variation 561
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372370114"
variation 566
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143813189"
variation 591
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="t"
/db_xref="dbSNP:377142394"
variation 600
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1131877"
exon 617..784
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/inference="alignment:Splign:1.39.8"
variation 663
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141920055"
variation 697
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374166578"
variation 721
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:145367471"
variation 776
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:137916856"
exon 785..865
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/inference="alignment:Splign:1.39.8"
variation 796
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:368161114"
variation 799
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:186117694"
variation 800
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142439625"
variation 840
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199989168"
variation 842
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145947234"
variation 861
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139458877"
exon 866..940
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/inference="alignment:Splign:1.39.8"
variation 920
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368804411"
variation 932
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200118821"
exon 941..1033
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/inference="alignment:Splign:1.39.8"
variation 944
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="t"
/db_xref="dbSNP:149327017"
variation 988
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144578195"
variation 1020
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369640883"
variation 1021
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:201211273"
exon 1034..1174
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/inference="alignment:Splign:1.39.8"
variation 1052..1053
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace=""
/replace="a"
/db_xref="dbSNP:35228820"
variation 1168
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:182757817"
exon 1175..1349
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/inference="alignment:Splign:1.39.8"
variation 1176
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148461790"
variation 1183
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:1131876"
variation 1201
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372134660"
variation 1237
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145200267"
variation 1274
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369697250"
variation 1306
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201374351"
variation 1313
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147610812"
variation 1324
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1051743"
variation 1326
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:144719184"
exon 1350..7637
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/inference="alignment:Splign:1.39.8"
variation 1399
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376141594"
variation 1408
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:151258452"
variation 1414
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370697221"
variation 1438
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:140423891"
variation 1441
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150483724"
variation 1453
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:111762207"
variation 1468
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201486992"
variation 1483
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:377168511"
variation 1510
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:145391228"
variation 1528
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:3742448"
STS 1558..2448
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/standard_name="TRAF3_v555"
/db_xref="UniSTS:277842"
variation 1567
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1051742"
variation 1597
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141356642"
variation 1621
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200974693"
variation 1630
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150561735"
variation 1699
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199868254"
variation 1702
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:145126372"
variation 1723
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138943371"
variation 1728
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:186844617"
variation 1741
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:202084269"
variation 1756
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374255469"
variation 1792
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:142501447"
variation 1841
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:372089179"
variation 1848
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144637377"
variation 1858
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370725073"
variation 1903
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148195281"
variation 1912
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:377148855"
variation 1938
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369453811"
STS 1959..2090
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/standard_name="RH69049"
/db_xref="UniSTS:33196"
variation 1977
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373244439"
variation 2026
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:191258518"
variation 2039
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377143104"
variation 2051
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139584485"
STS 2075..2312
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/standard_name="G15867"
/db_xref="UniSTS:12048"
variation 2271..2272
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace=""
/replace="ac"
/db_xref="dbSNP:371921986"
variation 2272..2273
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace=""
/replace="ac"
/db_xref="dbSNP:142806500"
variation 2272
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:201568881"
variation 2375
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:184183944"
variation 2804
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:188857207"
variation 2831..2832
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace=""
/replace="a"
/db_xref="dbSNP:57120368"
variation 2865
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142745057"
variation 2877
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:192894065"
variation 2898
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:147370186"
variation 2902
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:185305434"
variation 2945
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139583976"
variation 2988
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144980713"
variation 2990
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:80216614"
variation 3033
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:190155467"
variation 3151
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374592471"
variation 3202
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:75249707"
variation 3219..3220
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace=""
/replace="atct"
/db_xref="dbSNP:375424663"
variation 3234
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:72704737"
variation 3433
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373295670"
variation 3438
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372051148"
variation 3495
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:112261683"
variation 3533
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376429109"
variation 3540..3541
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace=""
/replace="ca"
/db_xref="dbSNP:201700309"
variation 3674
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:182212093"
variation 3707
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:148584503"
variation 3775
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367719643"
variation 3845
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142988351"
variation 3858..3859
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace=""
/replace="a"
/db_xref="dbSNP:34474027"
variation 3874
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:151084914"
variation 3877
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:186127559"
variation 3926
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:141331668"
variation 3960
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:117897999"
variation 3967
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:117475076"
variation 4026
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:188198787"
variation 4120
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:114392221"
variation 4183
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376100146"
variation 4200
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:145120246"
variation 4242
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:117653635"
variation 4243
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:117106738"
variation 4269
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:7152158"
variation 4363
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace=""
/replace="c"
/db_xref="dbSNP:34578787"
variation 4421
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:116178840"
variation 4471
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374825187"
variation 4477
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:180688846"
variation 4510
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11160707"
variation 4684
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11552465"
variation 4861
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:185075993"
variation 4887
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146802843"
variation 4900
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:191356380"
variation 4937
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372945156"
variation 4962
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:183222973"
variation 4994
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:45517731"
variation 5067
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376995306"
variation 5130
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:45585743"
variation 5194
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:78630751"
variation 5227
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201281332"
variation 5246
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:186841343"
variation 5274
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:80197834"
variation 5306
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:191683954"
variation 5314
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:183394545"
variation 5340
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:74082969"
variation 5389
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:187691773"
variation 5394
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="t"
/db_xref="dbSNP:4906271"
variation 5503
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375292813"
variation 5616
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:35360806"
variation 5718
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368940960"
variation 5831
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:4906272"
variation 5885
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375381789"
variation 5929
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138179996"
variation 5952
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:117406867"
variation 5957
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:149530934"
variation 5989
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143203754"
variation 5994
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:191019034"
variation 6039
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369985542"
variation 6058
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11620870"
variation 6082
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:182443319"
variation 6095
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:186731083"
variation 6125
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:192760623"
variation 6186
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:117597898"
variation 6194
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138947290"
variation 6207
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142791534"
variation 6280
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147406100"
variation 6284
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:4906273"
variation 6324
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="t"
/db_xref="dbSNP:373563762"
variation 6360
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138001318"
variation 6378
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376776135"
variation 6401
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370848396"
variation 6432
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:45478597"
variation 6438
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:188439936"
variation 6574
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374197709"
variation 6587
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:193031191"
variation 6590
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369332741"
variation 6628
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:4900558"
variation 6668
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377603736"
variation 6699
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:184726526"
variation 6832
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370260743"
variation 6866
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143573604"
variation 6867
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374968722"
variation 6932
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377708288"
variation 7056
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150503115"
variation 7121
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:10133111"
variation 7125
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1046299"
variation 7149
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:45528941"
variation 7154
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:11552464"
variation 7262
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:79926472"
variation 7271
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368377660"
variation 7277
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:117858701"
STS 7499..7607
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/standard_name="WI-13969"
/db_xref="UniSTS:60858"
variation 7520
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:115804335"
variation 7542
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="t"
/db_xref="dbSNP:78211216"
polyA_signal 7614..7619
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
polyA_site 7637
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
ORIGIN
gggagcgcggcgcggccgccgcgtgcgcgagccggggttgcagcccagccgggactttccagccggcggcagccgcggcggccgccggctcttccccgccccccgccatggggcagcccggggagcagaacgctgcggaccgcggcggaggacgcgcccggcgcccctgagccggccgagcggcgacggaccgcgagaactcctctttcctaaaatggagtcgagtaaaaagatggactctcctggcgcgctgcagactaacccgccgctaaagctgcacactgaccgcagtgctgggacgccagtttttgtccctgaacaaggaggttacaaggaaaagtttgtgaagaccgtggaggacaagtacaagtgtgagaagtgccacctggtgctgtgcagcccgaagcagaccgagtgtgggcaccgcttctgcgagagctgcatggcggccctgctgagctcttcaagtccaaaatgtacagcgtgtcaagagagcatcgttaaagataaggtgtttaaggataattgctgcaagagagaaattctggctcttcagatctattgtcggaatgaaagcagaggttgtgcagagcagttaatgctgggacatctgctggtgcatttaaaaaatgattgccattttgaagaacttccatgtgtgcgtcctgactgcaaagaaaaggtcttgaggaaagacctgcgagaccacgtggagaaggcgtgtaaataccgggaagccacatgcagccactgcaagagtcaggttccgatgatcgcgctgcagaaacacgaagacaccgactgtccctgcgtggtggtgtcctgccctcacaagtgcagcgtccagactctcctgaggagcgagttgagtgcacacttgtcagagtgtgtcaatgcccccagcacctgtagttttaagcgctatggctgcgtttttcaggggacaaaccagcagatcaaggcccacgaggccagctccgccgtgcagcacgtcaacctgctgaaggagtggagcaactcgctcgaaaagaaggtttccttgttgcagaatgaaagtgtagaaaaaaacaagagcatacaaagtttgcacaatcagatatgtagctttgaaattgaaattgagagacaaaaggaaatgcttcgaaataatgaatccaaaatccttcatttacagcgagtgatagacagccaagcagagaaactgaaggagcttgacaaggagatccggcccttccggcagaactgggaggaagcagacagcatgaagagcagcgtggagtccctccagaaccgcgtgaccgagctggagagcgtggacaagagcgcggggcaagtggctcggaacacaggcctgctggagtcccagctgagccggcatgaccagatgctgagtgtgcacgacatccgcctagccgacatggacctgcgcttccaggtcctggagaccgccagctacaatggagtgctcatctggaagattcgcgactacaagcggcggaagcaggaggccgtcatggggaagaccctgtccctttacagccagcctttctacactggttactttggctataagatgtgtgccagggtctacctgaacggggacgggatggggaaggggacgcacttgtcgctgttttttgtcatcatgcgtggagaatatgatgccctgcttccttggccgtttaagcagaaagtgacactcatgctgatggatcaggggtcctctcgacgtcatttgggagatgcattcaagcccgaccccaacagcagcagcttcaagaagcccactggagagatgaatatcgcctctggctgcccagtctttgtggcccaaactgttctagaaaatgggacatatattaaagatgatacaatttttattaaagtcatagtggatacttcggatctgcccgatccctgataagtagctggggaggtggatttagcagaaggcaactcctctgggggatttgaaccggtctgtcttcactgaggtcctcgcgctcagaaaaggaccttgtgagacggaggaagcggcagaaggcggacgcgtgccggcgggaggagccacgcgtgagcacacctgacacgttttataatagactagccacacttcactctgaagaattatttatccttcaacaagataaatattgctgtcagagaaggttttcattttcatttttaaagatctagttaattaaggtggaaaacatatatgctaaacaaaagaaacatgatttttcttccttaaacttgaacaccaaaaaaacacacacacacacacacgtggggatagctggacatgtcagcatgttaagtaaaaggagaatttatgaaatagtaatgcaattctgatatcttctttctaaaattcaagagtgcaattttgtttcaaatacagtatattgtctatttttaaggcctcatctggtctctgttttaataatttgtttgtcagaagaccctgaagtatatacctaggtcttttttttgaaagtctctaaattcagaatcattttttaatttaaagttctacaaataattgttactgcaaacattttattttaaaacgttgatagactgatatttcttggaagaaaatataaaatatcaaacactggttatcacttgtgataggaaagagaatattcaacctgttgttatttctcgttagaaatgtaaaccttcaaatatctgtcgtagttaatgacacgacttcacaattctgaacggagcctcgctcatggatgctgtgcatcattttcagatttataattgttttcaccctaaaatagggcatccgttgaactttggagttctaaacaaaatcctgtaggtgtttggattctgccccatgtgttcggacgagctctctgttgctgacagcaccggccttcggtctccatgtcaggggtgggcgggtgactgctgagggaggcccgcaggtgtgtttctccatcccgtcatcttgctgcatgccgtcaacggtctccgaaagcaacgttgtgcgtagagctggtggcatacggcccacgtgccttagatgggacatgctgcttctccaccctgggtttgcattgagcatcattctagaaagtgctagtttaaccagacttttctctccaccactagatctttgtctctacaagggccctcagacacctctgcacctgctgaggggaagccaggctccaccgtcggcttctggagcctccgctgcttaattaccacagattccaaatctctaggccccacgagtgagccgcctggtccaagtacggcctggtcccaccctgagggaggcaggtgtggaacagaagccgagcctctccgtgtccccaccggggccgtgggcacccccacagcccgaagcagaaccctctgagcattccagagaccgctgctcgggggcctgcccaggctgaccaacgggcgctcctgaccaccaccctggcgggaagggtggccacggggcccgtcgtcccagcctgtgcctgcccagatggcattttctcaactcactgtttactgtctctcagtgtccaactgtgattagaagcctggagcctgccccctgcaccccttttgctatgcaccacgcttcatggtgctcttaccactgatgggtgctacacgcgacgggtgcttcttaggcaaaaccaatgtgtgcgaactgtcacacctgtgccactcgcccacaagccgcgcccacaattggccagctgggccgtgcacgtcagactgcctgcctcggctctccccgtggccgcgcggggacagcttggtgggtgcccggtggcccacctgtctctggtgctgccatctgtcctgggtgtgccttcgccccagtgcctgctggaagtgccctccgtcgcacccctgtgccctgagctcccgtgaggggcccgccgcgccctttcgcggtcgaagcgttccgttgttcttatctgcctttcctttccccgctctcctgggattactttgggggaatgagtatccttggttctgccctgtgagggagtcgtgtgtccctgctcataaaggaaggacttcctgcagaagctgcggaaaactactgttccctcgaaggtgtcccccacctgaggcctgtcccctacctgccctcaggtagttttcctgaggccaggggttaacaacagggacatccctgcaacttccccttcacaaaatgtataatattagatgaaggatatgcaacatcttggtctagtaagaaccgtttcctcccctctgggttgaagtcctggtgtggcccccagaagcagcagtgcgtgtcactgggacgtctccagtagcccttcccaggcagacgctcctggcgggacgccatggggcccacctgagggtcccacagacgtaacctgagtgacaggagtccttgaggatgggatggcctatgtcacacactttgtccttgaacctgagtgatgggggtccttgaggatgggatggcctgtgtcacgcgctttgtctttgtgtttggttgtatcggggtctctgttctgagtgtgtcttcctctcatgtactcaacacagtgggcagcagcctgggacggcgtcccctctcccggcggcgggcaagccttgcgctgctccaccctcggcctgggcaccctcacttggcgctggccacctgggccagcctggggccatggtctctctgcagctgaggcccagtggccccttgggcagtgatcggccctccccgcatcacagggccctggcagcaagcgggaaatgggggcgcacactgtgtgcttgggggtgctgcttgtttaccacacatgaccagactcccagcaggacagagctgctcagtactttacagaaaccaactgagtcgtttgtgcatgaattaagccggtctgcttccccgtcaccttcgtaacaaaacaacgtcccctctcccctcgcctcgagcagtttcttcaggacaccgtggctcgggctgctccctgctgccaggcacgctggttggctggcctgggcccggctcacgtgaagggcactggctcttgtgaccacactgagccacgtgcaagccgcagccgggcctggaagcctgaccctctggttctagggcttgtcccgcggagcctgcagagctagacgttggggtgtgtccgtgatgatatgggggccaggctgggagtagggcctttctagcagggttgggtggctcagtgagggtgtggaagtgggggacccacggggcctggctttgggactagacatgccagccccagctgggctggagggagcctgagtgagccccgacatacgctgggcctttcagctcgccgtgctctggtgacacacaggcggccaggttgggatttgtgtcaattctaggagccatcaagcatgaatgtggttctgtctcctgagcgcaagcctcgccggacccctgggcgaaggcctggacttgcagatgtgtgttccctgtgcgggtggacagagggggcccttatgacccacattgcagccccattccaccaccccttcctccccagagcagtctctgccgagggacagcacctgtgtcccttcgatgccacaacagccagttgaacaggggagccctttgctcaggcagcttctcctgcctctccctcctttctccttccctgccccatccccgtgcccttcttggcctgtggcgctggggagccatggtgtggcatactggggctcctgctccttgggccacttcctcagcccgggccccacaggcccaccacctgccagggctcccactgcactggctgtggcaggaggcttccccatgaccccgtgtggcccagctcggtgaggatgcagttctaggcacagcccctgggacagccagctgcctcccagaccacgtcagcctgctccagggtcctcagtcaccctgggccaggggccacgtgtcccatggatgtcgaccatgccaacgtcacattccagcaccccttttgcttgatggcgtctggtggtagtcagcatggtggacccacatcctacagccagaggtgatgttggacaaaggaaggggagtctggatgggtccttaaacgaccattctgtccgcagcggggtcattccttgtcagcccaagggagggccggggagtacactgatcccaacagctgggctgacacctcctttctcccctgcacggggaggattggcctgaggaccgtcaccctgtgcacagccccagtagggtggcagtgccactgtctccttgggccgttgcaggattgggcgggtgcagactccccttgcgggccccttgctcaatccccggccctcccagactcctccctctactgggggtaatttgtgtgtcagaagggctctggcagagctgtaaaatactgttttttaaaaattttagtccagatctttacttattagactgcagaaggagagctagggagagtgggggaagcccccttgcttttgtatctgtgaggtgaatgagggtctgtcacccaaatctacttctcagcccatgaccatagttctgttttccgtttgcaaatctcagtagctctgttttctccaaagtagaatgtgcgcaccggggtcctagccaggcgaggtcagtgtcggcaggctacctggtcattattgctgcctcgtccaggctgatgctgatggtcacaggcacggtggcatcagggagccgggccagcaggcggcgtgaggcggggccagcagctcactgcaagggcattttccacctgatcctggtgtgccccacatgcggtggcagggcagacgtgtgaagcctcggccgtctcggggctggcaggtgtgcgggtgaggaggccccggtggccaagcagagcctgcgtttcatttctcctgctgcactgtgtctagtctgtcttgtgaactctcaccgtgaaaagaggctagaagtccaggatcgctgtaccgctcctgtaattaggtgatgactggatttgacaacttagtcccctcagacaagtaagataccctccaacagcaaattcaatgacttaattggaaaacacacaagctggcatgatgtccggtgatttctgtaagaaatgcctgtaggagaaggtctgtgaagtgtggagggcagtgtcgacgctgcacagcatctgcagattcgcagcctcttctctgccggtgcctctgttcggttctgttacccaaaaacaaagaccaaagaaggccaatctctcatttgaccctgtctttttaatctgcctgttttaaaagttgcgtctgtagtagccgcttgctgtgaagacacatcttgacagtccaagtgattttgtgaccagtgatttgggtcctgttttccgctcttctaagaaaaaacaaaaagaccgtgagttattgcccagcaataatcatgttgttactgtgagttagcaacatgcctgacttcctgatagcattactgttttctagttttgtttattgtatattatgtgtggttttatttggtatttatttgtgttttgaggtcttgcaatgtttttgtgtttctgatgctaataactaaagtttgtaagactgtagaatgcaaaactcggagatgctaaactgtcttattagaggaaaataaatctgattatggagtctcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7187 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: TAS
GeneID:7187 -> Molecular function: GO:0004871 [signal transducer activity] evidence: TAS
GeneID:7187 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7187 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:7187 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IEA
GeneID:7187 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI
GeneID:7187 -> Molecular function: GO:0031996 [thioesterase binding] evidence: IPI
GeneID:7187 -> Biological process: GO:0001817 [regulation of cytokine production] evidence: ISS
GeneID:7187 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: ISS
GeneID:7187 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
GeneID:7187 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
GeneID:7187 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:7187 -> Biological process: GO:0006917 [induction of apoptosis] evidence: TAS
GeneID:7187 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:7187 -> Biological process: GO:0008063 [Toll signaling pathway] evidence: IEA
GeneID:7187 -> Biological process: GO:0030162 [regulation of proteolysis] evidence: IMP
GeneID:7187 -> Biological process: GO:0032088 [negative regulation of NF-kappaB transcription factor activity] evidence: IMP
GeneID:7187 -> Biological process: GO:0032480 [negative regulation of type I interferon production] evidence: TAS
GeneID:7187 -> Biological process: GO:0032648 [regulation of interferon-beta production] evidence: ISS
GeneID:7187 -> Biological process: GO:0033209 [tumor necrosis factor-mediated signaling pathway] evidence: IMP
GeneID:7187 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
GeneID:7187 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
GeneID:7187 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:7187 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:7187 -> Biological process: GO:0050688 [regulation of defense response to virus] evidence: ISS
GeneID:7187 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
GeneID:7187 -> Cellular component: GO:0005768 [endosome] evidence: IEA
GeneID:7187 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:7187 -> Cellular component: GO:0009898 [internal side of plasma membrane] evidence: ISS
GeneID:7187 -> Cellular component: GO:0035631 [CD40 receptor complex] evidence: ISS
by
@meso_cacase at
DBCLS
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