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2020-10-24 07:24:16, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_003299               2879 bp    mRNA    linear   PRI 02-JUN-2013
DEFINITION  Homo sapiens heat shock protein 90kDa beta (Grp94), member 1
            (HSP90B1), mRNA.
ACCESSION   NM_003299
VERSION     NM_003299.2  GI:399567818
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2879)
  AUTHORS   Martins,M., Custodio,R., Camejo,A., Almeida,M.T., Cabanes,D. and
            Sousa,S.
  TITLE     Listeria monocytogenes triggers the cell surface expression of Gp96
            protein and interacts with its N terminus to support cellular
            infection
  JOURNAL   J. Biol. Chem. 287 (51), 43083-43093 (2012)
   PUBMED   23109341
  REMARK    GeneRIF: The Listeria-induced surface expression of Gp96 and the
            topology of its insertion on the plasma membrane, is reported.
REFERENCE   2  (bases 1 to 2879)
  AUTHORS   Li,G., Cai,M., Fu,D., Chen,K., Sun,M., Cai,Z. and Cheng,B.
  TITLE     Heat shock protein 90B1 plays an oncogenic role and is a target of
            microRNA-223 in human osteosarcoma
  JOURNAL   Cell. Physiol. Biochem. 30 (6), 1481-1490 (2012)
   PUBMED   23208072
  REMARK    GeneRIF: Hsp90B1 is a direct target of miR-223 and miR- 223 may
            have a tumor suppressor function in osteosarcoma through the
            PI3K/Akt/mTOR pathway.
REFERENCE   3  (bases 1 to 2879)
  AUTHORS   Zuehlke,A. and Johnson,J.L.
  TITLE     Hsp90 and co-chaperones twist the functions of diverse client
            proteins
  JOURNAL   Biopolymers 93 (3), 211-217 (2010)
   PUBMED   19697319
  REMARK    Review article
REFERENCE   4  (bases 1 to 2879)
  AUTHORS   Chen,B., Piel,W.H., Gui,L., Bruford,E. and Monteiro,A.
  TITLE     The HSP90 family of genes in the human genome: insights into their
            divergence and evolution
  JOURNAL   Genomics 86 (6), 627-637 (2005)
   PUBMED   16269234
REFERENCE   5  (bases 1 to 2879)
  AUTHORS   Prasadarao,N.V., Srivastava,P.K., Rudrabhatla,R.S., Kim,K.S.,
            Huang,S.H. and Sukumaran,S.K.
  TITLE     Cloning and expression of the Escherichia coli K1 outer membrane
            protein A receptor, a gp96 homologue
  JOURNAL   Infect. Immun. 71 (4), 1680-1688 (2003)
   PUBMED   12654781
  REMARK    GeneRIF: OmpA of E. coli K1 interacts with a gp96-like molecule on
            HBMECs for invasion (Ecgp: 96-kDa human brain microvascular
            endothelial cell (HBMEC) glycoprotein)
REFERENCE   6  (bases 1 to 2879)
  AUTHORS   Maki,R.G., Eddy,R.L. Jr., Byers,M., Shows,T.B. and Srivastava,P.K.
  TITLE     Mapping of the genes for human endoplasmic reticular heat shock
            protein gp96/grp94
  JOURNAL   Somat. Cell Mol. Genet. 19 (1), 73-81 (1993)
   PUBMED   8460400
REFERENCE   7  (bases 1 to 2879)
  AUTHORS   Schaiff,W.T., Hruska,K.A. Jr., McCourt,D.W., Green,M. and
            Schwartz,B.D.
  TITLE     HLA-DR associates with specific stress proteins and is retained in
            the endoplasmic reticulum in invariant chain negative cells
  JOURNAL   J. Exp. Med. 176 (3), 657-666 (1992)
   PUBMED   1512535
REFERENCE   8  (bases 1 to 2879)
  AUTHORS   Liu,E.S. and Lee,A.S.
  TITLE     Common sets of nuclear factors binding to the conserved promoter
            sequence motif of two coordinately regulated ER protein genes,
            GRP78 and GRP94
  JOURNAL   Nucleic Acids Res. 19 (19), 5425-5431 (1991)
   PUBMED   1923827
REFERENCE   9  (bases 1 to 2879)
  AUTHORS   Maki,R.G., Old,L.J. and Srivastava,P.K.
  TITLE     Human homologue of murine tumor rejection antigen gp96:
            5'-regulatory and coding regions and relationship to stress-induced
            proteins
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (15), 5658-5662 (1990)
   PUBMED   2377606
  REMARK    GeneRIF: a paper describing a pathway in which this gene product
            functions
REFERENCE   10 (bases 1 to 2879)
  AUTHORS   Srivastava,P.K. and Old,L.J.
  TITLE     Identification of a human homologue of the murine tumor rejection
            antigen GP96
  JOURNAL   Cancer Res. 49 (6), 1341-1343 (1989)
   PUBMED   2924290
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC078819.24, X15187.1 and
            CA419931.1.
            On Aug 7, 2012 this sequence version replaced gi:4507676.
            
            Summary: This gene encodes a member of a family of adenosine
            triphosphate(ATP)-metabolizing molecular chaperones with roles in
            stabilizing and folding other proteins. The encoded protein is
            localized to melanosomes and the endoplasmic reticulum. Expression
            of this protein is associated with a variety of pathogenic states,
            including tumor formation. There is a microRNA gene located within
            the 5' exon of this gene. There are pseudogenes for this gene on
            chromosomes 1 and 15. [provided by RefSeq, Aug 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ890084.1, AK025459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC078819.24        6906-6982
            78-2857             X15187.1           1-2780
            2858-2879           CA419931.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..2879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.2-q24.3"
     gene            1..2879
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /note="heat shock protein 90kDa beta (Grp94), member 1"
                     /db_xref="GeneID:7184"
                     /db_xref="HGNC:12028"
                     /db_xref="HPRD:01860"
                     /db_xref="MIM:191175"
     exon            1..231
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /inference="alignment:Splign:1.39.8"
     variation       37
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2722187"
     misc_feature    48..50
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /note="upstream in-frame stop codon"
     variation       71
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2070908"
     variation       86
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74866968"
     variation       120..126
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace=""
                     /replace="ggggtgg"
                     /db_xref="dbSNP:62747560"
     variation       120
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372933336"
     variation       135
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374876307"
     variation       140
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369259960"
     variation       155
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17797090"
     variation       168
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201473633"
     CDS             183..2594
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /note="tumor rejection antigen (gp96) 1; endothelial cell
                     (HBMEC) glycoprotein; endoplasmin; 94 kDa
                     glucose-regulated protein; heat shock protein 90 kDa beta
                     member 1; tumor rejection antigen 1; stress-inducible
                     tumor rejection antigen gp96"
                     /codon_start=1
                     /product="endoplasmin precursor"
                     /protein_id="NP_003290.1"
                     /db_xref="GI:4507677"
                     /db_xref="CCDS:CCDS9094.1"
                     /db_xref="GeneID:7184"
                     /db_xref="HGNC:12028"
                     /db_xref="HPRD:01860"
                     /db_xref="MIM:191175"
                     /translation="
MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL
"
     sig_peptide     183..245
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P14625.1)"
     mat_peptide     246..2591
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /product="Endoplasmin"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P14625.1)"
     misc_feature    402..2420
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /note="heat shock protein 90; Provisional; Region:
                     PRK05218"
                     /db_xref="CDD:179965"
     misc_feature    474..839
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /note="Histidine kinase-like ATPases; This family includes
                     several ATP-binding proteins for example: histidine
                     kinase, DNA gyrase B, topoisomerases, heat shock protein
                     HSP90, phytochrome-like ATPases and DNA mismatch repair
                     proteins; Region: HATPase_c; cd00075"
                     /db_xref="CDD:28956"
     misc_feature    order(489..491,501..503,510..512,621..623,627..629,
                     633..635,639..644,768..779,813..815,819..821,834..839)
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:28956"
     misc_feature    501..503
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /note="Mg2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28956"
     misc_feature    order(633..635,639..641,768..770,774..776)
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /note="G-X-G motif; other site"
                     /db_xref="CDD:28956"
     misc_feature    1098..1100
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P14625.1); phosphorylation site"
     misc_feature    2211..2213
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    2580..2591
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P14625.1);
                     Region: Prevents secretion from ER"
     variation       187
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200731731"
     variation       188
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367697851"
     variation       198
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:149528402"
     variation       215
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371874127"
     variation       218
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375806115"
     variation       226
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34701102"
     exon            232..334
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /inference="alignment:Splign:1.39.8"
     variation       282
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201068970"
     variation       324
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148706377"
     exon            335..476
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /inference="alignment:Splign:1.39.8"
     variation       369
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377222712"
     variation       390
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370161871"
     variation       400
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372981677"
     variation       401
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11547724"
     STS             408..567
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /standard_name="MARC_26038-26039:1032450563:1"
                     /db_xref="UniSTS:268921"
     variation       429
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201119782"
     exon            477..593
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /inference="alignment:Splign:1.39.8"
     variation       533
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146331537"
     variation       558
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368880453"
     exon            594..925
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /inference="alignment:Splign:1.39.8"
     variation       622
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202077306"
     variation       677
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144387251"
     variation       753
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376154262"
     variation       779
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201423886"
     variation       786
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368251601"
     STS             790..917
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /standard_name="RH67937"
                     /db_xref="UniSTS:87570"
     variation       793
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200565749"
     variation       832
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371098260"
     variation       833
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373905083"
     variation       839
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:6615"
     variation       880
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199621152"
     variation       890
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144333332"
     variation       903
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372511163"
     exon            926..1037
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /inference="alignment:Splign:1.39.8"
     variation       926
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:149843361"
     variation       949
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201596968"
     variation       974
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145871780"
     variation       984
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375719261"
     exon            1038..1157
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /inference="alignment:Splign:1.39.8"
     variation       1059
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144242572"
     variation       1064
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375011875"
     variation       1081
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368915159"
     variation       1119
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200904772"
     variation       1144
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116891695"
     exon            1158..1274
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /inference="alignment:Splign:1.39.8"
     variation       1240
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375594636"
     exon            1275..1412
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /inference="alignment:Splign:1.39.8"
     variation       1361
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370436489"
     variation       1366
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141254870"
     variation       1380
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374437641"
     variation       1407
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377747819"
     exon            1413..1490
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /inference="alignment:Splign:1.39.8"
     variation       1422
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368374645"
     STS             1469..1703
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /standard_name="STS-H99801"
                     /db_xref="UniSTS:12740"
     exon            1491..1556
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /inference="alignment:Splign:1.39.8"
     exon            1557..1826
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /inference="alignment:Splign:1.39.8"
     variation       1586
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200554688"
     variation       1600
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146962447"
     variation       1630
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148024900"
     variation       1704
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374505761"
     variation       1712
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:368541065"
     variation       1736
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200418863"
     variation       1760
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372371380"
     variation       1778
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:55793710"
     variation       1784
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:34482425"
     variation       1799
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202050731"
     variation       1825
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113326059"
     exon            1827..2072
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /inference="alignment:Splign:1.39.8"
     STS             1842..2037
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /standard_name="TRA1"
                     /db_xref="UniSTS:254008"
     variation       1852
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373394058"
     variation       1984
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143727498"
     variation       1998
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141744749"
     variation       2068
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:114330942"
     exon            2073..2209
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /inference="alignment:Splign:1.39.8"
     variation       2088
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377323380"
     variation       2108
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:141949667"
     variation       2114
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146313005"
     variation       2127
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200619766"
     variation       2151
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3209749"
     variation       2180
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138296639"
     variation       2189
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142832694"
     exon            2210..2288
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /inference="alignment:Splign:1.39.8"
     variation       2218
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373656293"
     variation       2221
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:367709041"
     variation       2233
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144295543"
     variation       2257
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372636341"
     variation       2284
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374724193"
     exon            2289..2444
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /inference="alignment:Splign:1.39.8"
     variation       2295
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200307600"
     variation       2348
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148760324"
     variation       2378
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199559319"
     variation       2386
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369072974"
     variation       2423
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:188648559"
     variation       2426
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142406645"
     exon            2445..2564
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /inference="alignment:Splign:1.39.8"
     variation       2459
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:7645"
     variation       2464
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140225827"
     STS             2466..2685
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /standard_name="STS-X15187"
                     /db_xref="UniSTS:41934"
     variation       2470
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376271632"
     variation       2481
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370313687"
     variation       2482
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200650067"
     variation       2500
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17034989"
     variation       2513
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374034403"
     variation       2526
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144178041"
     variation       2544..2546
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace=""
                     /replace="gaa"
                     /db_xref="dbSNP:5800607"
     variation       2551
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace=""
                     /replace="aag"
                     /db_xref="dbSNP:3037197"
     variation       2553..2555
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace=""
                     /replace="gaa"
                     /db_xref="dbSNP:201427769"
     variation       2553
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199613394"
     variation       2555
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace=""
                     /replace="gaa"
                     /db_xref="dbSNP:60927295"
     exon            2565..2862
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /inference="alignment:Splign:1.39.8"
     variation       2566
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:372146745"
     STS             2605..2832
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /standard_name="SHGC-12717"
                     /db_xref="UniSTS:24559"
     variation       2605
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200512715"
     variation       2617
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373539366"
     variation       2625
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375456268"
     variation       2647
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:202143765"
     variation       2695
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1051185"
     variation       2740
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11547719"
     variation       2798
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace=""
                     /replace="actg"
                     /db_xref="dbSNP:35780385"
     variation       2799..2801
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace=""
                     /replace="gact"
                     /db_xref="dbSNP:2307842"
     variation       2834
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111996964"
     polyA_signal    2839..2844
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
     polyA_site      2862
                     /gene="HSP90B1"
                     /gene_synonym="ECGP; GP96; GRP94; TRA1"
ORIGIN      
gattggtgggttcatgtttcccgtcccccgcccgcgggaagtgggggtgaaaagcggcccgacctgcttgcggtgtagtgggcggaccgcgcggctggaggtgtgaggatccgaacccaggggtggggggtggaggcggctcctgcgatcgaaggggacttgagactcaccggccgcacgccatgagggccctgtgggtgctgggcctctgctgcgtcctgctgaccttcgggtcggtcagagctgacgatgaagttgatgtggatggtacagtagaagaggatctgggtaaaagtagagaaggatcaaggacggatgatgaagtagtacagagagaggaagaagctattcagttggatggattaaatgcatcacaaataagagaacttagagagaagtcggaaaagtttgccttccaagccgaagttaacagaatgatgaaacttatcatcaattcattgtataaaaataaagagattttcctgagagaactgatttcaaatgcttctgatgctttagataagataaggctaatatcactgactgatgaaaatgctctttctggaaatgaggaactaacagtcaaaattaagtgtgataaggagaagaacctgctgcatgtcacagacaccggtgtaggaatgaccagagaagagttggttaaaaaccttggtaccatagccaaatctgggacaagcgagtttttaaacaaaatgactgaagcacaggaagatggccagtcaacttctgaattgattggccagtttggtgtcggtttctattccgccttccttgtagcagataaggttattgtcacttcaaaacacaacaacgatacccagcacatctgggagtctgactccaatgaattttctgtaattgctgacccaagaggaaacactctaggacggggaacgacaattacccttgtcttaaaagaagaagcatctgattaccttgaattggatacaattaaaaatctcgtcaaaaaatattcacagttcataaactttcctatttatgtatggagcagcaagactgaaactgttgaggagcccatggaggaagaagaagcagccaaagaagagaaagaagaatctgatgatgaagctgcagtagaggaagaagaagaagaaaagaaaccaaagactaaaaaagttgaaaaaactgtctgggactgggaacttatgaatgatatcaaaccaatatggcagagaccatcaaaagaagtagaagaagatgaatacaaagctttctacaaatcattttcaaaggaaagtgatgaccccatggcttatattcactttactgctgaaggggaagttaccttcaaatcaattttatttgtacccacatctgctccacgtggtctgtttgacgaatatggatctaaaaagagcgattacattaagctctatgtgcgccgtgtattcatcacagacgacttccatgatatgatgcctaaatacctcaattttgtcaagggtgtggtggactcagatgatctccccttgaatgtttcccgcgagactcttcagcaacataaactgcttaaggtgattaggaagaagcttgttcgtaaaacgctggacatgatcaagaagattgctgatgataaatacaatgatactttttggaaagaatttggtaccaacatcaagcttggtgtgattgaagaccactcgaatcgaacacgtcttgctaaacttcttaggttccagtcttctcatcatccaactgacattactagcctagaccagtatgtggaaagaatgaaggaaaaacaagacaaaatctacttcatggctgggtccagcagaaaagaggctgaatcttctccatttgttgagcgacttctgaaaaagggctatgaagttatttacctcacagaacctgtggatgaatactgtattcaggcccttcccgaatttgatgggaagaggttccagaatgttgccaaggaaggagtgaagttcgatgaaagtgagaaaactaaggagagtcgtgaagcagttgagaaagaatttgagcctctgctgaattggatgaaagataaagcccttaaggacaagattgaaaaggctgtggtgtctcagcgcctgacagaatctccgtgtgctttggtggccagccagtacggatggtctggcaacatggagagaatcatgaaagcacaagcgtaccaaacgggcaaggacatctctacaaattactatgcgagtcagaagaaaacatttgaaattaatcccagacacccgctgatcagagacatgcttcgacgaattaaggaagatgaagatgataaaacagttttggatcttgctgtggttttgtttgaaacagcaacgcttcggtcagggtatcttttaccagacactaaagcatatggagatagaatagaaagaatgcttcgcctcagtttgaacattgaccctgatgcaaaggtggaagaagagcccgaagaagaacctgaagagacagcagaagacacaacagaagacacagagcaagacgaagatgaagaaatggatgtgggaacagatgaagaagaagaaacagcaaaggaatctacagctgaaaaagatgaattgtaaattatactctcaccatttggatcctgtgtggagagggaatgtgaaatttacatcatttctttttgggagagacttgttttggatgccccctaatccccttctcccctgcactgtaaaatgtgggattatgggtcacaggaaaaagtgggttttttagttgaattttttttaacattcctcatgaatgtaaatttgtactatttaactgactattcttgatgtaaaatcttgtcatgtgtataaaaataaaaaagatcccaaatactcaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:7184 -> Molecular function: GO:0003723 [RNA binding] evidence: IDA
            GeneID:7184 -> Molecular function: GO:0005509 [calcium ion binding] evidence: TAS
            GeneID:7184 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:7184 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:7184 -> Molecular function: GO:0019903 [protein phosphatase binding] evidence: IDA
            GeneID:7184 -> Molecular function: GO:0046790 [virion binding] evidence: IPI
            GeneID:7184 -> Molecular function: GO:0050750 [low-density lipoprotein particle receptor binding] evidence: IDA
            GeneID:7184 -> Molecular function: GO:0051082 [unfolded protein binding] evidence: IEA
            GeneID:7184 -> Biological process: GO:0001666 [response to hypoxia] evidence: IDA
            GeneID:7184 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
            GeneID:7184 -> Biological process: GO:0006457 [protein folding] evidence: IEA
            GeneID:7184 -> Biological process: GO:0006987 [activation of signaling protein activity involved in unfolded protein response] evidence: TAS
            GeneID:7184 -> Biological process: GO:0015031 [protein transport] evidence: NAS
            GeneID:7184 -> Biological process: GO:0030433 [ER-associated protein catabolic process] evidence: IMP
            GeneID:7184 -> Biological process: GO:0030968 [endoplasmic reticulum unfolded protein response] evidence: TAS
            GeneID:7184 -> Biological process: GO:0031247 [actin rod assembly] evidence: IDA
            GeneID:7184 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IMP
            GeneID:7184 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
            GeneID:7184 -> Biological process: GO:0043666 [regulation of phosphoprotein phosphatase activity] evidence: IDA
            GeneID:7184 -> Biological process: GO:0044267 [cellular protein metabolic process] evidence: TAS
            GeneID:7184 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:7184 -> Biological process: GO:0051208 [sequestering of calcium ion] evidence: NAS
            GeneID:7184 -> Biological process: GO:0071318 [cellular response to ATP] evidence: IDA
            GeneID:7184 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS
            GeneID:7184 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IDA
            GeneID:7184 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: TAS
            GeneID:7184 -> Cellular component: GO:0005788 [endoplasmic reticulum lumen] evidence: IDA
            GeneID:7184 -> Cellular component: GO:0005788 [endoplasmic reticulum lumen] evidence: TAS
            GeneID:7184 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: IDA
            GeneID:7184 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
            GeneID:7184 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
            GeneID:7184 -> Cellular component: GO:0030496 [midbody] evidence: IDA
            GeneID:7184 -> Cellular component: GO:0042470 [melanosome] evidence: IEA
            GeneID:7184 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IDA
            GeneID:7184 -> Cellular component: GO:0071682 [endocytic vesicle lumen] evidence: TAS

by @meso_cacase at DBCLS
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