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2024-04-16 14:54:43, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003292 9727 bp mRNA linear PRI 12-MAY-2013
DEFINITION Homo sapiens translocated promoter region, nuclear basket protein
(TPR), mRNA.
ACCESSION NM_003292
VERSION NM_003292.2 GI:114155141
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 9727)
AUTHORS Li,F., Zhai,Y.P., Tang,Y.M., Wang,L.P. and Wan,P.J.
TITLE Identification of a novel partner gene, TPR, fused to FGFR1 in 8p11
myeloproliferative syndrome
JOURNAL Genes Chromosomes Cancer 51 (9), 890-897 (2012)
PUBMED 22619110
REMARK GeneRIF: Exon 23 of the translocated promoter region gene was fused
to exon 13 of FGFR1 resulting in 8p11 myeloproliferative syndrome.
REFERENCE 2 (bases 1 to 9727)
AUTHORS Funasaka,T., Tsuka,E. and Wong,R.W.
TITLE Regulation of autophagy by nucleoporin Tpr
JOURNAL Sci Rep 2, 878 (2012)
PUBMED 23170199
REMARK GeneRIF: Tpr depletion increased p53 nuclear accumulation and
facilitated autophagy.
REFERENCE 3 (bases 1 to 9727)
AUTHORS Rajanala,K. and Nandicoori,V.K.
TITLE Localization of nucleoporin Tpr to the nuclear pore complex is
essential for Tpr mediated regulation of the export of unspliced
RNA
JOURNAL PLoS ONE 7 (1), E29921 (2012)
PUBMED 22253824
REMARK GeneRIF: Perinuclear localization of Tpr at the nucleopore complex
is crucial for regulating intron containing mRNA export.
REFERENCE 4 (bases 1 to 9727)
AUTHORS Coyle,J.H., Bor,Y.C., Rekosh,D. and Hammarskjold,M.L.
TITLE The Tpr protein regulates export of mRNAs with retained introns
that traffic through the Nxf1 pathway
JOURNAL RNA 17 (7), 1344-1356 (2011)
PUBMED 21613532
REMARK GeneRIF: Tpr plays an important role in quality control of mRNA
trafficked on the Nxf1 pathway.
REFERENCE 5 (bases 1 to 9727)
AUTHORS David-Watine,B.
TITLE Silencing nuclear pore protein Tpr elicits a senescent-like
phenotype in cancer cells
JOURNAL PLoS ONE 6 (7), E22423 (2011)
PUBMED 21811608
REMARK GeneRIF: Depletion of Tpr by RNA interference triggers G0-G1 arrest
and ultimately induces a senescent-like phenotype dependent on the
presence of p53.
REFERENCE 6 (bases 1 to 9727)
AUTHORS Mitchell,P.J. and Cooper,C.S.
TITLE The human tpr gene encodes a protein of 2094 amino acids that has
extensive coiled-coil regions and an acidic C-terminal domain
JOURNAL Oncogene 7 (11), 2329-2333 (1992)
PUBMED 1437155
REFERENCE 7 (bases 1 to 9727)
AUTHORS Mitchell,P.J. and Cooper,C.S.
TITLE Nucleotide sequence analysis of human tpr cDNA clones
JOURNAL Oncogene 7 (2), 383-388 (1992)
PUBMED 1549355
REFERENCE 8 (bases 1 to 9727)
AUTHORS Greco,A., Pierotti,M.A., Bongarzone,I., Pagliardini,S., Lanzi,C.
and Della Porta,G.
TITLE TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK
genes in human papillary thyroid carcinomas
JOURNAL Oncogene 7 (2), 237-242 (1992)
PUBMED 1532241
REFERENCE 9 (bases 1 to 9727)
AUTHORS Galland,F., Stefanova,M., Lafage,M. and Birnbaum,D.
TITLE Localization of the 5' end of the MCF2 oncogene to human chromosome
15q15----q23
JOURNAL Cytogenet. Cell Genet. 60 (2), 114-116 (1992)
PUBMED 1611909
REFERENCE 10 (bases 1 to 9727)
AUTHORS Gonzatti-Haces,M., Seth,A., Park,M., Copeland,T., Oroszlan,S. and
Vande Woude,G.F.
TITLE Characterization of the TPR-MET oncogene p65 and the MET
protooncogene p140 protein-tyrosine kinases
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85 (1), 21-25 (1988)
PUBMED 3277171
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from X66397.1, U69668.1, AL596220.9,
AL133553.9 and AA688415.1.
This sequence is a reference standard in the RefSeqGene project.
On Sep 7, 2006 this sequence version replaced gi:4507658.
Summary: This gene encodes a large coiled-coil protein that forms
intranuclear filaments attached to the inner surface of nuclear
pore complexes (NPCs). The protein directly interacts with several
components of the NPC. It is required for the nuclear export of
mRNAs and some proteins. Oncogenic fusions of the 5' end of this
gene with several different kinase genes occur in some neoplasias.
[provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U69668.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-209 X66397.1 1-209
210-2631 U69668.1 1-2422
2632-4010 X66397.1 2632-4010
4011-5891 U69668.1 3802-5682
5892-5892 AL596220.9 4304-4304 c
5893-7534 U69668.1 5684-7325
7535-9309 AL133553.9 16076-17850
9310-9727 AA688415.1 1-418 c
FEATURES Location/Qualifiers
source 1..9727
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q25"
gene 1..9727
/gene="TPR"
/note="translocated promoter region, nuclear basket
protein"
/db_xref="GeneID:7175"
/db_xref="HGNC:12017"
/db_xref="MIM:189940"
exon 1..448
/gene="TPR"
/inference="alignment:Splign:1.39.8"
misc_feature 103..105
/gene="TPR"
/note="upstream in-frame stop codon"
CDS 298..7389
/gene="TPR"
/note="nuclear pore complex-associated protein TPR; tumor
potentiating region; translocated promoter region (to
activated MET oncogene); megator; NPC-associated
intranuclear protein; translocated promoter region
protein"
/codon_start=1
/product="nucleoprotein TPR"
/protein_id="NP_003283.2"
/db_xref="GI:114155142"
/db_xref="CCDS:CCDS41446.1"
/db_xref="GeneID:7175"
/db_xref="HGNC:12017"
/db_xref="MIM:189940"
/translation="
MAAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSVRSTSPNVQPSISQPILTVQQQTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQGDYTPMEDSEETSQSLQIDLGPLQSDQQTTTSSQDGQGKGDDVIVIDSDDEEEDDDENDGEHEDYEEDEEDDDDDEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAADSQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRAPQSPRRPPHPLPPRLTIHAPPQELGPPVQRIQMTRRQSVGRGLQLTPGIGGMQQHFFDDEDRTVPSTPTLVVPHRTDGFAEAIHSPQVAGVPRFRFGPPEDMPQTSSSHSDLGQLASQGGLGMYETPLFLAHEEESGGRSVPTTPLQVAAPVTVFTESTTSDASEHASQSVPMVTTSTGTLSTTNETATGDDGDEVFVEAESEGISSEAGLEIDSQQEEEPVQASDESDLPSTSQDPPSSSSVDTSSSQPKPFRRVRLQTTLRQGVRGRQFNRQRGVSHAMGGRGGINRGNIN
"
misc_feature 301..303
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylalanine; propagated from
UniProtKB/Swiss-Prot (P12270.3); acetylation site"
misc_feature 304..336
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P12270.3);
Region: Sufficient for interaction with TPR"
misc_feature 337..648
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P12270.3);
Region: Necessary for interaction with HSF1"
misc_feature 868..870
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="Breakpoint for translocation to form TRK-T1;
propagated from UniProtKB/Swiss-Prot (P12270.3); other
site"
misc_feature 1051..1053
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P12270.3); acetylation site"
misc_feature 1231..1233
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P12270.3); acetylation site"
misc_feature 1330..1332
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P12270.3); acetylation site"
misc_feature 1432..1434
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P12270.3); phosphorylation site"
misc_feature 1438..1440
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1579..1581
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P12270.3); acetylation site"
misc_feature 1606..1836
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P12270.3);
Region: Necessary for association to the NPC"
misc_feature 1666..1668
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P12270.3); acetylation site"
misc_feature 1864..1866
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1876..1878
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1879..1881
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1882..1884
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1885..1887
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2245..2247
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2434..2436
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P12270.3); acetylation site"
misc_feature 2464..2466
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P12270.3); acetylation site"
misc_feature 2539..2541
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P12270.3); acetylation site"
misc_feature 2560..2562
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P12270.3); acetylation site"
misc_feature 3055..3057
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3403..3798
/gene="TPR"
/note="TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2;
pfam07926"
/db_xref="CDD:149160"
misc_feature 3850..3852
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P12270.3); phosphorylation site"
misc_feature 3850..3852
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3949..4257
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P12270.3);
Region: Necessary for interaction with HSF1"
misc_feature 5371..5373
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (P12270.3); phosphorylation site"
misc_feature 5731..5898
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P12270.3);
Region: Sufficient and essential for mediating its nuclear
import"
misc_feature 6397..6399
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 6406..6408
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 6439..6441
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P12270.3); phosphorylation site"
misc_feature 6445..6447
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P12270.3); phosphorylation site"
misc_feature 6445..6447
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 6514..6516
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P12270.3); phosphorylation site"
misc_feature 6514..6516
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 6760..6762
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P12270.3); phosphorylation site"
misc_feature 6760..6762
/gene="TPR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 449..553
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 554..627
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 628..724
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 725..828
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 829..993
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 994..1086
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 1087..1167
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 1168..1255
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 1256..1396
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 1397..1488
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 1489..1686
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 1687..1794
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 1795..2021
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 2022..2185
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 2186..2319
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 2320..2468
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 2469..2631
/gene="TPR"
/inference="alignment:Splign:1.39.8"
STS 2546..2638
/gene="TPR"
/standard_name="G19412"
/db_xref="UniSTS:38371"
exon 2632..2766
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 2767..2907
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 2908..3073
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 3074..3240
/gene="TPR"
/inference="alignment:Splign:1.39.8"
variation 3176
/gene="TPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:3753565"
variation 3228
/gene="TPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:3753566"
exon 3241..3393
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 3394..3510
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 3511..3714
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 3715..3899
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 3900..4047
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 4048..4185
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 4186..4317
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 4318..4448
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 4449..4659
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 4660..4803
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 4804..5002
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 5003..5208
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 5209..5270
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 5271..5479
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 5480..5752
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 5753..5901
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 5902..5985
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 5986..6186
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 6187..6318
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 6319..6409
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 6410..6594
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 6595..6663
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 6664..6758
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 6759..6865
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 6866..6961
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 6962..7118
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 7119..7237
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 7238..7333
/gene="TPR"
/inference="alignment:Splign:1.39.8"
exon 7334..9708
/gene="TPR"
/inference="alignment:Splign:1.39.8"
STS 7338..7587
/gene="TPR"
/standard_name="RH80846"
/db_xref="UniSTS:87439"
polyA_signal 7510..7515
/gene="TPR"
polyA_site 7534
/gene="TPR"
STS 8762..8873
/gene="TPR"
/standard_name="G62041"
/db_xref="UniSTS:139135"
STS 8790..8905
/gene="TPR"
/standard_name="G31461"
/db_xref="UniSTS:73106"
variation 8947
/gene="TPR"
/replace="a"
/replace="t"
/db_xref="dbSNP:9272"
polyA_signal 8974..8979
/gene="TPR"
polyA_site 9001
/gene="TPR"
variation 9164
/gene="TPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:1293985"
polyA_site 9708
/gene="TPR"
ORIGIN
gcgcaagaggatcagggatagcctctgagctcgggttcccagggttcgtagcttccaacggctgcgcgcgcacttcggtcgcgggcggtgaggtgctgttgctgaaacgctgccgctgagggtggactcgatttcccagggtcccgccgcgggagtctccggcgggcgggcgcgcgcgagccaccgagcgaggtgatagaggcggcggcccaggcgtctgggtcctgctggtcttcgcctttcttctccgcttctaccccgtcggccgctgccactggggtccctggccccaccgacatggcggcggtgttgcagcaagtcctggagcgcacggagctgaacaagctgcccaagtctgtccagaacaaacttgaaaagttccttgctgatcagcaatccgagatcgatggcctgaaggggcggcatgagaaatttaaggtggagagcgaacaacagtattttgaaatagaaaagaggttgtcccacagtcaggagagacttgtgaatgaaacccgagagtgtcaaagcttgcggcttgagctagagaaactcaacaatcaactgaaggcactaactgagaaaaacaaagaacttgaaattgctcaggatcgcaatattgccattcagagccaatttacaagaacaaaggaagaattagaagctgagaaaagagacttaattagaaccaatgagagactatctcaagaacttgaatacttaacagaggatgttaaacgtctgaatgaaaaacttaaagaaagcaatacaacaaagggtgaacttcagttaaaattggatgaacttcaagcttctgatgtttctgttaagtatcgagaaaaacgcttggagcaagaaaaggaattgctacatagtcagaatacatggctgaatacagagttgaaaaccaaaactgatgaacttctggctcttggaagagaaaaagggaatgagattctagagcttaaatgtaatcttgaaaataaaaaagaagaggtttctagactggaagaacaaatgaatggcttaaaaacatcaaatgaacatcttcaaaagcatgtggaggatctgttgaccaaattaaaagaggccaaggaacaacaggccagtatggaagagaaattccacaatgaattaaatgcccacataaaactttctaatttgtacaagagtgccgctgatgactcagaagcaaagagcaatgaactaacccgggcagtagaggaactacacaaacttttgaaagaagctggtgaagccaacaaagcaatacaagatcatcttctagaggtggagcaatccaaagatcaaatggaaaaagaaatgcttgagaaaatagggagattggagaaggaattagagaatgcaaatgaccttctttctgccacaaaacgtaaaggagccatattgtctgaagaagagcttgccgccatgtctcctactgcagcagctgtagctaagatagtgaaacctgggatgaaactaactgagctctataatgcttatgtggaaactcaggatcagttgcttttggagaaactagagaacaaaagaattaataagtacctagatgaaatagtgaaagaagtggaagccaaagcaccaattttgaaacgccagcgtgaggaatatgaacgtgcacagaaagctgtagcaagtttatctgttaagcttgaacaagctatgaaggagattcagcgattgcaggaggacactgataaagccaacaagcaatcatctgtacttgagagagataatcgaagaatggaaatacaagtaaaagatctttcacaacagattagagtgcttttgatggaacttgaagaagcaaggggtaaccacgtaattcgtgatgaggaagtaagctctgctgatataagtagttcatctgaggtaatatcacagcatctagtatcttacagaaatattgaagagcttcaacaacaaaatcaacgtctcttagtggcccttagagagcttggggaaaccagagaaagagaagaacaagaaacaacttcatccaaaatcactgagcttcagctcaaacttgagagtgcccttactgaactagaacaactccgcaaatcacgacagcatcaaatgcagcttgttgattccatagttcgtcagcgtgatatgtaccgtattttattgtcacaaacaacaggagttgccattccattacatgcttcaagcttagatgatgtttctcttgcatcaactccaaaacgtccaagtacatcacagactgtttccactcctgctccagtacctgttattgaatcaacagaggctatagaggctaaggctgcccttaaacagttgcaggaaatttttgagaactacaaaaaagaaaaagcagaaaatgaaaaaatacaaaatgagcagcttgagaaacttcaagaacaagttacagatttgcgatcacaaaataccaaaatttctacccagctagattttgcttctaaacgttatgaaatgctgcaagataatgttgaaggatatcgtcgagaaataacatcacttcatgagagaaatcagaaactcactgccacaactcaaaagcaagaacagattatcaatacgatgactcaagatttgagaggagcaaatgagaagctagctgtcgcagaagtaagagcagaaaatttgaagaaggaaaaggaaatgcttaaattgtctgaagttcgtctttctcagcaaagagagtctttgttagctgaacaaagggggcaaaacttactgctaactaatctgcaaacaattcagggaatactggagcgatctgaaacagaaaccaaacaaaggcttagtagccagatagaaaaactggaacatgagatctctcatctaaagaagaagttggaaaatgaggtggaacaaaggcatacacttactagaaatctagatgttcaacttttagatacaaagagacaactggatacagagacaaatcttcatcttaacacaaaagaactattaaaaaatgctcaaaaagaaattgccacattgaaacagcacctcagtaatatggaagtccaagttgcttctcagtcttcacagagaactggtaaaggtcagcctagcaacaaagaagatgtggatgatcttgtgagtcagctaagacagacagaagagcaggtgaatgacttaaaggagagactcaaaacaagtacgagcaatgtggaacaatatcaagcaatggttactagtttagaagaatccctgaacaaggaaaaacaggtgacagaagaagtgcgtaagaatattgaagttcgtttaaaagagtcagctgaatttcagacacagttggaaaagaagttgatggaagtagagaaggaaaaacaagaacttcaggatgataaaagaagagccatagagagcatggaacaacagttatctgaattgaagaaaacactttctagtgttcagaatgaagtacaagaagctcttcagagagcaagcacagctttaagtaatgagcagcaagccagacgtgactgtcaggaacaagctaaaatagctgtggaagctcagaataagtatgagagagaattgatgctgcatgctgctgatgttgaagctctacaagctgcgaaggagcaggtttcaaaaatggcatcagtccgtcagcatttggaagaaacaacacagaaagcagaatcacagttgttggagtgtaaagcatcttgggaggaaagagagagaatgttaaaggatgaagtttccaaatgtgtatgtcgctgtgaagatctggagaaacaaaacagattacttcatgatcagatcgaaaaattaagtgacaaggtcgttgcctctgtgaaggaaggtgtacaaggtccactgaatgtatctctcagtgaagaaggaaaatctcaagaacaaattttggaaattctcagatttatacgacgagaaaaagaaattgctgaaactaggtttgaggtggctcaggttgagagtctgcgttatcgacaaagggttgaacttttagaaagagagctgcaggaactgcaagatagtctaaatgctgaaagggagaaagtccaggtaactgcaaaaacaatggctcagcatgaagaactgatgaagaaaactgaaacaatgaatgtagttatggagaccaataaaatgctaagagaagagaaggagagactagaacaggatctacagcaaatgcaagcaaaggtgaggaaactggagttagatattttacccttacaagaagcaaatgctgagctgagtgagaaaagcggtatgttgcaggcagagaagaagctcttagaagaggatgtcaaacgttggaaagcacgtaaccagcatctagtaagtcaacagaaagatccagatacagaagaatatcggaagctcctttctgaaaaggaagttcatactaagcgtattcaacaattgacagaagaaattggtagacttaaagctgaaattgcaagatcaaatgcatctttgactaacaaccagaacttaattcagagtctgaaggaagatctaaataaagtaagaactgaaaaggaaaccatccagaaggacttagatgccaaaataattgatatccaagaaaaagtcaaaactattactcaagttaagaaaattggacgtaggtacaagactcaatatgaagaacttaaagcacaacaggataaggttatggagacatcggctcagtcctctggagaccatcaggagcagcatgtttcagtccaggaaatgcaggaactcaaagaaacgctcaaccaagctgaaacaaaatcaaaatcacttgaaagtcaagtagagaatctgcagaagacattatctgaaaaagagacagaagcaagaaatctccaggaacagactgtgcaacttcagtctgaactttcacgacttcgtcaggatcttcaagatagaaccacacaggaggagcagctccgacaacagataactgaaaaggaagaaaaaaccagaaaggctattgtagcagcaaagtcaaaaattgcacacttagctggtgtaaaagatcagctaactaaagaaaatgaggagcttaaacaaaggaatggagccttagatcagcagaaagatgaattggatgttcgcattactgcgctaaagtcccaatatgaaggtcgaattagtcgcttggaaagagaactcagggagcatcaagagagacaccttgagcagagagatgagcctcaagaaccttctaataaggtccctgaacagcagagacagatcacattgaaaacaactccagcttctggtgaaagaggaattgccagcacatcagacccaccaacagccaatatcaagccaactcctgttgtgtctactccaagtaaagtgacagctgcagctatggctggaaataagtcaacacccagggctagtatccgcccaatggttacacctgcaactgttacaaatcccactactaccccaacagctacagtgatgcccactacacaagtggaatcacaggaagctatgcagtcagaagggcctgtggaacatgttccagtttttggaagcacaagtggatccgttcgttctactagtcctaatgtccagccttctatctctcaacctattttaactgttcagcaacaaacacaggctacagcttttgtgcaacccactcaacagagtcatcctcagattgagcctgccaatcaagagttatcttcaaacatagtagaggttgttcagagttcaccagttgagcggccttctacttccacagcagtatttggcacagtttcggctacccccagttcttctttgccaaagcgtacacgtgaagaggaagaggatagcaccatagaagcatcagaccaagtctctgatgatacagtggaaatgcctcttccaaagaagttgaaaagtgtcacacctgtaggaactgaggaagaagttatggcagaagaaagtactgatggagaggtagagactcaggtatacaaccaggattctcaagattccattggagaaggagttacccagggagattatacacctatggaagacagtgaagaaacctctcagtctctacaaatagatcttgggccacttcaatcagatcagcagacgacaacttcatcccaggatggtcaaggcaaaggagatgatgtcattgtaattgacagtgatgatgaagaagaggatgatgatgaaaatgatggagaacatgaggattatgaagaggatgaggaagatgatgatgatgatgaagatgacacagggatgggagatgagggtgaagatagtaatgaaggaactggtagtgccgatggcaatgatggttatgaagctgatgatgctgagggtggtgatgggactgatccaggtacagaaacagaagaaagtatgggtggaggtgaaggtaatcacagagctgctgattctcaaaacagtggtgaaggaaatacaggtgctgcagaatcttctttttctcaggaggtttctagagaacaacagccatcatcagcatctgaaagacaggcccctcgagcacctcagtcaccgagacgcccaccacatccacttcccccaagactgaccattcatgccccacctcaggagttgggaccaccagttcagagaattcagatgacccgaaggcagtctgtaggacgtggccttcagttgactccaggaataggtggcatgcaacagcatttttttgatgatgaagacagaacagttccaagtactccaactcttgtggtgccacatcgtactgatggatttgctgaagcaattcattcgccgcaggttgctggtgtccctagattccggtttgggccacctgaagatatgccacaaacaagttctagtcactctgatcttggccagcttgcttctcaaggaggtttaggaatgtatgaaacacccctgttcctagctcatgaagaagagtcaggtggccgaagtgttcccactactccactacaagtagcagccccagtgactgtatttactgagagcaccacctctgatgcttcggaacatgcctctcaatctgttccaatggtgactacatccactggcactttatctacaacaaatgaaacagcaacaggtgatgatggagatgaagtatttgtggaggcagaatctgaaggtattagttcagaagcaggcctagaaattgatagccagcaggaagaagagccggttcaagcatctgatgagtcagatctcccctccaccagccaggatcctccttctagctcatctgtagatactagtagtagtcaaccaaagcctttcagacgagtaagacttcagacaacattgagacaaggtgtccgtggtcgtcagtttaacagacagagaggtgtgagccatgcaatgggagggagaggaggaataaacagaggaaatattaattaaatggtctgtaaacaataacaactgtgaataagattatcaaatctgttttagtgtaatgattgtcaagtttaaaaacatttttatatataaactggtatactcatgtcaatattctttattaataaaatgtttttcagtgtcaaaatttattattcatttcttcattagttgactcctcctttgctcatcagtctaaggacagttgtaccagactttggataaggtctgcccagaacgagtagtaattgctcttgctgttctactaggcacatcaatgttatagtattgatctaaatggaagagaaaacatttttttagttaaaaagaaaacaatgcccaaactaaaaaataacttatgttgactattatgctcaaagacaatgtttatcattttaatagagatgtttttactaattaatttgaactttataacaaaaagaaaaacaattgcctagacttttcagcttttttgatgtttcaaaagattgacatttcaccatctttttgtaaaatcaggttcagctctcctttatgaagtaaacattaaagagtaaccaagtttgaaaaataatttacttggggttattccttttaaaaaatacatgccaatgtcattcatattatgaaattacaggcagaataacttagatttctgggcatttcaaagaaaagcatcctgagtaatataatttaattaataaaattagtttctcaggaacttctttctgatcttacagactctgcagtgatgcaaatcattataaccttgtgccaaacaaggtatctgttaaatgccacaaatgatagaagtaaaatactattgtcagtagcaagtttactctagtaactggatgttttatcgtaatctcatgaaggttagagcagaattgaattgcagtgccatcattttaattgaaattaaagcaaaagtcttaactcttttccacagcaattagaataagtaccgtagtgtaacttctcacattcagtcatcattgcagccagcatttttactttatcttcatgttttcacaaatgatatcacctccttgggaaactgttagttaataccttacctttagaaaaggcatagtaatcatagccgtcaggttttctgatgttgggcagtgatatagctgaggtaaccacatttggaagtcctctccacagtatactcactttaacttcattatgaaggacacctgtaagtggcatgtttaataaaagataccagattaaaaggcaatgtactatcttggaaagagccagacatctgagttttaatctcagttttagccctctgatgtagaactattgagggttatagactggtatataatgttcttggtaagaagtacttgataaatagtattggttataactaacaaacctgaacaaactgctttacttacccacaaggaaaaagaaagtattggtctttggttattcactaaggcaagtggatgagtttttcatcagtaagcttaaattattagggctgtttgatcagtatccatatttcataagccttactgtataagaaactgtattacatctacttatgtttaaggatttttttaacacaataaaaatgttacctttgtcttgataagccagtctggcaggtgaatattgaattctgatggtgtgtgtttgagaaggtcctatagcacgttcaaagcgacgtctcctaacctgtgtcgtttctccatacactggataatttagagcaggccttcttccagggcacttctgtacaggttcctgtttataaatatactgctgaatgctgccacctgttatgtattagaatatcacatggaaaatgaaaattaattttaataccctcagaaaaggtggaaaacaacttttacaatgtataggaaacagttttgttctcatttttcatataatatattgatattaataatggctattagtcaagggtattataaaaataattattaaactgaaatacttgttgaatgaatagatgcagcaaattacatagttatatatttaatttcaattgaaagtgacaagtgctcagtttggcagcacatatactaaaactggaatgatacagagattagcatggcccttgtgcaaggatgacatgcacatttgtgaagcgaaagtaaatgacattctatcagtgacctgaaaactcaaatgaattgtgacttgcctgtgaagaaatgaaaataaaaattgagggcaataagaatactaccctcaatattgatttttttcactgaaaatatttgatttcagccattaaagatatcttttgacagtaaagtcaataataaatgaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7175 -> Molecular function: GO:0003682 [chromatin binding] evidence: IDA
GeneID:7175 -> Molecular function: GO:0003729 [mRNA binding] evidence: IDA
GeneID:7175 -> Molecular function: GO:0004828 [serine-tRNA ligase activity] evidence: IEA
GeneID:7175 -> Molecular function: GO:0005215 [transporter activity] evidence: IMP
GeneID:7175 -> Molecular function: GO:0005487 [nucleocytoplasmic transporter activity] evidence: IDA
GeneID:7175 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7175 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:7175 -> Molecular function: GO:0015631 [tubulin binding] evidence: IDA
GeneID:7175 -> Molecular function: GO:0031072 [heat shock protein binding] evidence: IDA
GeneID:7175 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IDA
GeneID:7175 -> Molecular function: GO:0043495 [protein anchor] evidence: IMP
GeneID:7175 -> Molecular function: GO:0051019 [mitogen-activated protein kinase binding] evidence: IDA
GeneID:7175 -> Molecular function: GO:0070840 [dynein complex binding] evidence: IDA
GeneID:7175 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IMP
GeneID:7175 -> Biological process: GO:0000189 [MAPK import into nucleus] evidence: IMP
GeneID:7175 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:7175 -> Biological process: GO:0005975 [carbohydrate metabolic process] evidence: TAS
GeneID:7175 -> Biological process: GO:0006404 [RNA import into nucleus] evidence: IDA
GeneID:7175 -> Biological process: GO:0006405 [RNA export from nucleus] evidence: IMP
GeneID:7175 -> Biological process: GO:0006434 [seryl-tRNA aminoacylation] evidence: IEA
GeneID:7175 -> Biological process: GO:0006606 [protein import into nucleus] evidence: IDA
GeneID:7175 -> Biological process: GO:0006606 [protein import into nucleus] evidence: IMP
GeneID:7175 -> Biological process: GO:0006611 [protein export from nucleus] evidence: IMP
GeneID:7175 -> Biological process: GO:0006999 [nuclear pore organization] evidence: IMP
GeneID:7175 -> Biological process: GO:0007067 [mitosis] evidence: IEA
GeneID:7175 -> Biological process: GO:0007077 [mitotic nuclear envelope disassembly] evidence: TAS
GeneID:7175 -> Biological process: GO:0007094 [mitotic spindle assembly checkpoint] evidence: IMP
GeneID:7175 -> Biological process: GO:0008645 [hexose transport] evidence: TAS
GeneID:7175 -> Biological process: GO:0010793 [regulation of mRNA export from nucleus] evidence: IMP
GeneID:7175 -> Biological process: GO:0010827 [regulation of glucose transport] evidence: TAS
GeneID:7175 -> Biological process: GO:0010965 [regulation of mitotic sister chromatid separation] evidence: IMP
GeneID:7175 -> Biological process: GO:0015758 [glucose transport] evidence: TAS
GeneID:7175 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:7175 -> Biological process: GO:0019221 [cytokine-mediated signaling pathway] evidence: TAS
GeneID:7175 -> Biological process: GO:0031453 [positive regulation of heterochromatin assembly] evidence: IMP
GeneID:7175 -> Biological process: GO:0031647 [regulation of protein stability] evidence: IMP
GeneID:7175 -> Biological process: GO:0031990 [mRNA export from nucleus in response to heat stress] evidence: IDA
GeneID:7175 -> Biological process: GO:0034605 [cellular response to heat] evidence: IDA
GeneID:7175 -> Biological process: GO:0035457 [cellular response to interferon-alpha] evidence: ISS
GeneID:7175 -> Biological process: GO:0042306 [regulation of protein import into nucleus] evidence: IMP
GeneID:7175 -> Biological process: GO:0042307 [positive regulation of protein import into nucleus] evidence: IMP
GeneID:7175 -> Biological process: GO:0043578 [nuclear matrix organization] evidence: IMP
GeneID:7175 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:7175 -> Biological process: GO:0045947 [negative regulation of translational initiation] evidence: IMP
GeneID:7175 -> Biological process: GO:0046825 [regulation of protein export from nucleus] evidence: IMP
GeneID:7175 -> Biological process: GO:0046827 [positive regulation of protein export from nucleus] evidence: ISS
GeneID:7175 -> Biological process: GO:0046832 [negative regulation of RNA export from nucleus] evidence: IDA
GeneID:7175 -> Biological process: GO:0046832 [negative regulation of RNA export from nucleus] evidence: IMP
GeneID:7175 -> Biological process: GO:0051292 [nuclear pore complex assembly] evidence: IMP
GeneID:7175 -> Biological process: GO:0051301 [cell division] evidence: IEA
GeneID:7175 -> Biological process: GO:0055085 [transmembrane transport] evidence: TAS
GeneID:7175 -> Biological process: GO:0070849 [response to epidermal growth factor stimulus] evidence: IDA
GeneID:7175 -> Biological process: GO:0090267 [positive regulation of mitotic cell cycle spindle assembly checkpoint] evidence: IMP
GeneID:7175 -> Biological process: GO:0090316 [positive regulation of intracellular protein transport] evidence: IMP
GeneID:7175 -> Biological process: GO:1901673 [regulation of spindle assembly involved in mitosis] evidence: IMP
GeneID:7175 -> Cellular component: GO:0000776 [kinetochore] evidence: IDA
GeneID:7175 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:7175 -> Cellular component: GO:0005635 [nuclear envelope] evidence: IDA
GeneID:7175 -> Cellular component: GO:0005643 [nuclear pore] evidence: IDA
GeneID:7175 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:7175 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:7175 -> Cellular component: GO:0005868 [cytoplasmic dynein complex] evidence: IDA
GeneID:7175 -> Cellular component: GO:0019898 [extrinsic to membrane] evidence: IDA
GeneID:7175 -> Cellular component: GO:0031965 [nuclear membrane] evidence: IDA
GeneID:7175 -> Cellular component: GO:0034399 [nuclear periphery] evidence: IDA
GeneID:7175 -> Cellular component: GO:0042405 [nuclear inclusion body] evidence: IDA
GeneID:7175 -> Cellular component: GO:0044615 [nuclear pore nuclear basket] evidence: IDA
GeneID:7175 -> Cellular component: GO:0072686 [mitotic spindle] evidence: IDA
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