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2024-04-27 05:28:36, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003257 7165 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens tight junction protein 1 (TJP1), transcript variant 1,
mRNA.
ACCESSION NM_003257
VERSION NM_003257.3 GI:116875766
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7165)
AUTHORS Van Itallie,C.M., Aponte,A., Tietgens,A.J., Gucek,M.,
Fredriksson,K. and Anderson,J.M.
TITLE The N and C termini of ZO-1 are surrounded by distinct proteins and
functional protein networks
JOURNAL J. Biol. Chem. 288 (19), 13775-13788 (2013)
PUBMED 23553632
REMARK GeneRIF: Proteomic identification of ZO-1 binding partners and
associated proteins that form tight junction complexes.
REFERENCE 2 (bases 1 to 7165)
AUTHORS Wu,H.L., Gao,X., Jiang,Z.D., Duan,Z.T., Wang,S.K., He,B.S.,
Zhang,Z.Y. and Xie,H.G.
TITLE Attenuated expression of the tight junction proteins is involved in
clopidogrel-induced gastric injury through p38 MAPK activation
JOURNAL Toxicology 304, 41-48 (2013)
PUBMED 23220562
REMARK GeneRIF: It is concluded that attenuated expression of the TJ
proteins occludin and ZO-1 in human gastric epithelial cells could
be involved in clopidogrel-induced gastric mucosal injury through
activation of the p38 MAPK pathway
REFERENCE 3 (bases 1 to 7165)
AUTHORS Lu Y, Vitart V, Burdon KP, Khor CC, Bykhovskaya Y, Mirshahi A,
Hewitt AW, Koehn D, Hysi PG, Ramdas WD, Zeller T, Vithana EN,
Cornes BK, Tay WT, Tai ES, Cheng CY, Liu J, Foo JN, Saw SM,
Thorleifsson G, Stefansson K, Dimasi DP, Mills RA, Mountain J, Ang
W, Hoehn R, Verhoeven VJ, Grus F, Wolfs R, Castagne R, Lackner KJ,
Springelkamp H, Yang J, Jonasson F, Leung DY, Chen LJ, Tham CC,
Rudan I, Vatavuk Z, Hayward C, Gibson J, Cree AJ, MacLeod A, Ennis
S, Polasek O, Campbell H, Wilson JF, Viswanathan AC, Fleck B, Li X,
Siscovick D, Taylor KD, Rotter JI, Yazar S, Ulmer M, Li J, Yaspan
BL, Ozel AB, Richards JE, Moroi SE, Haines JL, Kang JH, Pasquale
LR, Allingham RR, Ashley-Koch A, Mitchell P, Wang JJ, Wright AF,
Pennell C, Spector TD, Young TL, Klaver CC, Martin NG, Montgomery
GW, Anderson MG, Aung T, Willoughby CE, Wiggs JL, Pang CP,
Thorsteinsdottir U, Lotery AJ, Hammond CJ, van Duijn CM, Hauser MA,
Rabinowitz YS, Pfeiffer N, Mackey DA, Craig JE, Macgregor S and
Wong TY.
CONSRTM NEIGHBOR Consortium
TITLE Genome-wide association analyses identify multiple loci associated
with central corneal thickness and keratoconus
JOURNAL Nat. Genet. 45 (2), 155-163 (2013)
PUBMED 23291589
REFERENCE 4 (bases 1 to 7165)
AUTHORS Clark,S.L., Souza,R.P., Adkins,D.E., Aberg,K., Bukszar,J.,
McClay,J.L., Sullivan,P.F. and van den Oord,E.J.
TITLE Genome-wide association study of patient-rated and clinician-rated
global impression of severity during antipsychotic treatment
JOURNAL Pharmacogenet. Genomics 23 (2), 69-77 (2013)
PUBMED 23241943
REMARK GeneRIF: Single nucleotide polymorphisms in TJP1 is associated with
response to antipsychotic agents in schizophrenia.
REFERENCE 5 (bases 1 to 7165)
AUTHORS Arora,A.I., Johar,K., Gajjar,D.U., Ganatra,D.A., Kayastha,F.B.,
Pal,A.K., Patel,A.R., Rajkumar,S. and Vasavada,A.R.
TITLE Cx43, ZO-1, alpha-catenin and beta-catenin in cataractous lens
epithelial cells
JOURNAL J. Biosci. 37 (6), 979-987 (2012)
PUBMED 23151788
REMARK GeneRIF: findings suggest that ZO-1 and alpha-catenin are important
for gap junctions containing Cx43 in the LECs
REFERENCE 6 (bases 1 to 7165)
AUTHORS Van Itallie,C.M., Balda,M.S. and Anderson,J.M.
TITLE Epidermal growth factor induces tyrosine phosphorylation and
reorganization of the tight junction protein ZO-1 in A431 cells
JOURNAL J. Cell. Sci. 108 (PT 4), 1735-1742 (1995)
PUBMED 7542259
REFERENCE 7 (bases 1 to 7165)
AUTHORS Furuse,M., Itoh,M., Hirase,T., Nagafuchi,A., Yonemura,S.,
Tsukita,S. and Tsukita,S.
TITLE Direct association of occludin with ZO-1 and its possible
involvement in the localization of occludin at tight junctions
JOURNAL J. Cell Biol. 127 (6 PT 1), 1617-1626 (1994)
PUBMED 7798316
REFERENCE 8 (bases 1 to 7165)
AUTHORS Willott,E., Balda,M.S., Fanning,A.S., Jameson,B., Van Itallie,C.
and Anderson,J.M.
TITLE The tight junction protein ZO-1 is homologous to the Drosophila
discs-large tumor suppressor protein of septate junctions
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (16), 7834-7838 (1993)
PUBMED 8395056
REFERENCE 9 (bases 1 to 7165)
AUTHORS Balda,M.S. and Anderson,J.M.
TITLE Two classes of tight junctions are revealed by ZO-1 isoforms
JOURNAL Am. J. Physiol. 264 (4 PT 1), C918-C924 (1993)
PUBMED 7682777
REFERENCE 10 (bases 1 to 7165)
AUTHORS Willott,E., Balda,M.S., Heintzelman,M., Jameson,B. and
Anderson,J.M.
TITLE Localization and differential expression of two isoforms of the
tight junction protein ZO-1
JOURNAL Am. J. Physiol. 262 (5 PT 1), C1119-C1124 (1992)
PUBMED 1590354
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
L14837.1, BC111712.1, DA752892.1, AC022613.13 and BX640879.1.
On Oct 31, 2006 this sequence version replaced gi:28416399.
Summary: This gene encodes a protein located on a cytoplasmic
membrane surface of intercellular tight junctions. The encoded
protein may be involved in signal transduction at cell-cell
junctions. Two transcript variants encoding distinct isoforms have
been identified for this gene. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) represents the longer
transcript, and encodes the longer isoform a. Isoform a is found in
most epithelial cell junctions.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC111712.1, AK304758.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-229 L14837.1 716-944
230-4602 BC111712.1 132-4504
4603-4635 DA752892.1 276-308
4636-4636 AC022613.13 72158-72158 c
4637-4846 DA752892.1 310-519
4847-6064 BC111712.1 4749-5966
6065-7165 BX640879.1 5665-6765
FEATURES Location/Qualifiers
source 1..7165
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q13"
gene 1..7165
/gene="TJP1"
/gene_synonym="ZO-1"
/note="tight junction protein 1"
/db_xref="GeneID:7082"
/db_xref="HGNC:11827"
/db_xref="MIM:601009"
exon 1..502
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
misc_feature 404..406
/gene="TJP1"
/gene_synonym="ZO-1"
/note="upstream in-frame stop codon"
CDS 476..5722
/gene="TJP1"
/gene_synonym="ZO-1"
/note="isoform a is encoded by transcript variant 1; zona
occludens 1; zonula occludens 1 protein; tight junction
protein ZO-1; zona occludens protein 1; zonula occludens
protein 1"
/codon_start=1
/product="tight junction protein ZO-1 isoform a"
/protein_id="NP_003248.3"
/db_xref="GI:116875767"
/db_xref="CCDS:CCDS42007.1"
/db_xref="GeneID:7082"
/db_xref="HGNC:11827"
/db_xref="MIM:601009"
/translation="
MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
"
misc_feature 539..796
/gene="TJP1"
/gene_synonym="ZO-1"
/note="PDZ domain found in a variety of Eumetazoan
signaling molecules, often in tandem arrangements. May be
responsible for specific protein-protein interactions, as
most PDZ domains bind C-terminal polypeptides, and binding
to internal (non-C-terminal)...; Region: PDZ_signaling;
cd00992"
/db_xref="CDD:29049"
misc_feature order(572..583,587..589,746..751,758..763)
/gene="TJP1"
/gene_synonym="ZO-1"
/note="protein binding site [polypeptide binding]; other
site"
/db_xref="CDD:29049"
misc_feature 848..850
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q07157.3); phosphorylation site"
misc_feature 848..850
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 866..868
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 869..871
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 971..973
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 977..979
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 998..1000
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q07157.3); phosphorylation site"
misc_feature 1007..1009
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q07157.3); phosphorylation site"
misc_feature 1010..1012
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q07157.3); phosphorylation site"
misc_feature 1025..1258
/gene="TJP1"
/gene_synonym="ZO-1"
/note="PDZ domain found in a variety of Eumetazoan
signaling molecules, often in tandem arrangements. May be
responsible for specific protein-protein interactions, as
most PDZ domains bind C-terminal polypeptides, and binding
to internal (non-C-terminal)...; Region: PDZ_signaling;
cd00992"
/db_xref="CDD:29049"
misc_feature 1028..1030
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q07157.3); phosphorylation site"
misc_feature order(1064..1075,1079..1081,1208..1213,1220..1225)
/gene="TJP1"
/gene_synonym="ZO-1"
/note="protein binding site [polypeptide binding]; other
site"
/db_xref="CDD:29049"
misc_feature 1298..1300
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1304..1306
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q07157.3); phosphorylation site"
misc_feature 1304..1306
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1313..1315
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1325..1327
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1343..1345
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1355..1357
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1364..1366
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q07157.3); phosphorylation site"
misc_feature 1373..1375
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q07157.3); phosphorylation site"
misc_feature 1442..1444
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1460..1462
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q07157.3); phosphorylation site"
misc_feature 1460..1462
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1475..1477
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q07157.3); phosphorylation site"
misc_feature 1484..1486
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q07157.3); phosphorylation site"
misc_feature 1484..1486
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1532..1534
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q07157.3); phosphorylation site"
misc_feature 1742..1978
/gene="TJP1"
/gene_synonym="ZO-1"
/note="PDZ domain found in a variety of Eumetazoan
signaling molecules, often in tandem arrangements. May be
responsible for specific protein-protein interactions, as
most PDZ domains bind C-terminal polypeptides, and binding
to internal (non-C-terminal)...; Region: PDZ_signaling;
cd00992"
/db_xref="CDD:29049"
misc_feature order(1769..1780,1784..1786,1922..1927,1934..1939)
/gene="TJP1"
/gene_synonym="ZO-1"
/note="protein binding site [polypeptide binding]; other
site"
/db_xref="CDD:29049"
misc_feature 2024..2218
/gene="TJP1"
/gene_synonym="ZO-1"
/note="Src homology 3 domain of the Tight junction
protein, Zonula occludens protein 1; Region: SH3_ZO-1;
cd12026"
/db_xref="CDD:212959"
misc_feature order(2024..2032,2114..2122,2135..2137,2144..2146,
2201..2203)
/gene="TJP1"
/gene_synonym="ZO-1"
/note="PDZ interface; other site"
/db_xref="CDD:212959"
misc_feature order(2030..2050,2087..2092,2099..2101,2144..2146,
2168..2173,2195..2203,2213..2218)
/gene="TJP1"
/gene_synonym="ZO-1"
/note="GuK interface [polypeptide binding]; other site"
/db_xref="CDD:212959"
misc_feature order(2048..2050,2054..2056,2063..2065,2075..2077,
2138..2143,2198..2200,2204..2209)
/gene="TJP1"
/gene_synonym="ZO-1"
/note="peptide ligand binding site [polypeptide binding];
other site"
/db_xref="CDD:212959"
misc_feature 2324..2326
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q07157.3); phosphorylation site"
misc_feature 2324..2326
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2330..2857
/gene="TJP1"
/gene_synonym="ZO-1"
/note="Guanylate kinase homologues; Region: GuKc;
smart00072"
/db_xref="CDD:197501"
misc_feature 2339..2341
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q07157.3); phosphorylation site"
misc_feature 3077..3079
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3104..3106
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3128..3130
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3131..3133
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3155..3157
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3158..3160
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3209..3211
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q07157.3); phosphorylation site"
misc_feature 3377..3379
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q07157.3); phosphorylation site"
misc_feature 3821..3823
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 4571..4573
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q07157.3); phosphorylation site"
misc_feature 4571..4573
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 5108..5110
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q07157.3); phosphorylation site"
misc_feature 5324..5326
/gene="TJP1"
/gene_synonym="ZO-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q07157.3); phosphorylation site"
misc_feature 5369..5641
/gene="TJP1"
/gene_synonym="ZO-1"
/note="ZU5 domain; Region: ZU5; pfam00791"
/db_xref="CDD:189721"
exon 503..559
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
exon 560..684
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
exon 685..787
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
exon 788..1064
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
exon 1065..1168
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
exon 1169..1337
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
exon 1338..1485
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
variation 1396
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200368203"
exon 1486..1625
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
variation 1561
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2229513"
exon 1626..1731
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
exon 1732..1882
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
variation 1741
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2229514"
variation 1822
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:45602341"
exon 1883..1991
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
variation 1887
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2229517"
exon 1992..2211
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
exon 2212..2396
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
exon 2397..2492
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
exon 2493..2575
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
exon 2576..2786
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
exon 2787..2887
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
variation 2843
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2229515"
variation 2878
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2229516"
exon 2888..3238
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
variation 3194
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:34771010"
exon 3239..3478
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
variation 3264
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:45529137"
variation 3403
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="a"
/replace="c"
/db_xref="dbSNP:45575741"
STS 3451..3606
/gene="TJP1"
/gene_synonym="ZO-1"
/standard_name="RH48761"
/db_xref="UniSTS:53877"
exon 3479..4351
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
variation 3502
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:45562135"
variation 3586
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="c"
/replace="g"
/db_xref="dbSNP:36012099"
variation 3722
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35392254"
variation 3804
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:45567033"
variation 3808
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="g"
/replace="t"
/db_xref="dbSNP:35120167"
exon 4352..4449
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
exon 4450..4677
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
variation 4603
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2229518"
exon 4678..4847
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
exon 4848..5325
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
variation 5289
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:45578638"
exon 5326..5543
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
exon 5544..5627
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
exon 5628..7165
/gene="TJP1"
/gene_synonym="ZO-1"
/inference="alignment:Splign:1.39.8"
variation 5924
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:45443392"
variation 5974
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:45467499"
STS 6483..6698
/gene="TJP1"
/gene_synonym="ZO-1"
/standard_name="G10656"
/db_xref="UniSTS:70582"
variation 6575
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200994469"
variation 6679
/gene="TJP1"
/gene_synonym="ZO-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:45472197"
STS 6744..6995
/gene="TJP1"
/gene_synonym="ZO-1"
/standard_name="STS-L14837"
/db_xref="UniSTS:2427"
STS 6818..6991
/gene="TJP1"
/gene_synonym="ZO-1"
/standard_name="EST10C1"
/db_xref="UniSTS:263026"
STS 6901..7008
/gene="TJP1"
/gene_synonym="ZO-1"
/standard_name="TJP1"
/db_xref="UniSTS:479948"
STS 6903..6992
/gene="TJP1"
/gene_synonym="ZO-1"
/standard_name="TJP1"
/db_xref="UniSTS:266199"
ORIGIN
cgggcatgctcagtgggccgggccggcaggtttgcgtggccgctgagttgccggcgccggctgagccagcggacgccgcgttccttggcggccgccggttcccgggaagttacgtggcgaagccggcttccgaggagacgccgggaggccacgggtgctgctgacgggcgggcgaccgggcgaggccgacgtggccgggctgcgaaagctgcgggaggccgagtgggtggccgcgctcggagggaggtgccggtcgggcgcgccccgtggagaagacccgggcggggcgggcgcttcccggacttttgtccgagttgaattccctccccctgggccgggcccttccggccgcccccgcccgtgccccgctcgctctcgggagatgtttatttgggctgtggcgtgaggagcgggcgggccagcgccgcggagtttcgggtccgaggagcctcgcgcggcgctggagagagacaagatgtccgccagagctgcggccgccaagagcacagcaatggaggaaacagctatatgggaacaacatacagtgacgcttcacagggctcctggatttggatttggaattgcaatatctggtggacgagataatcctcattttcagagtggggaaacgtcaatagtgatttcagatgtgctgaaaggaggaccagctgaaggacagctacaggaaaatgaccgagttgcaatggttaacggagtttcaatggataatgttgaacatgcttttgctgttcagcaactaaggaaaagtgggaaaaatgcaaaaattacaattagaaggaagaagaaagttcaaataccagtaagtcgtcctgatcctgaaccagtatctgataatgaagaagatagttatgatgaggaaatacatgatccaagaagtggccggagtggtgtggttaacagaaggagtgagaagatttggccgagggatagaagtgcaagtagagagaggagcttgtccccgcggtcagacaggcggtcagtggcttccagccagcctgctaaacctactaaagtcacactggtgaaatcccggaaaaatgaagaatatggtcttcgattggcaagccatatatttgttaaggaaatttcacaagatagtttggcagcaagagatggcaatattcaagaaggtgatgttgtattgaagataaatggtactgtgacagaaaatatgtcattgacagatgcaaagacattgatagaaaggtctaaaggcaaattaaaaatggtagttcaaagagatgaacgggctacgctattgaatgtccctgatctttctgacagcatccactctgctaatgcctctgagagagacgacatttcagaaattcagtcactggcatcagatcattctggtcgatcacacgataggcctccccgccgcagccggtcacgatctcctgaccagcggtcagagccttctgatcattccaggcactcgccgcagcagccaagcaatggcagtctccggagtagagatgaagagagaatttctaaacctggggctgtctcaactcctgtaaagcatgctgatgatcacacacctaaaacagtggaagaagttacagttgaaagaaatgagaaacaaacaccttctcttccagaaccaaagcctgtgtatgcccaagttgggcaaccagatgtggatttacctgtcagtccatctgatggtgtcctacctaattcaactcatgaagatgggattcttcggcccagcatgaaattggtaaaattcagaaaaggagatagtgtgggtttgcggctggctggtggaaatgatgttggaatatttgtagctggcgttctagaagatagccctgcagccaaggaaggcttagaggaaggtgatcaaattctcagggtaaacaacgtagattttacaaatatcataagagaagaagccgtccttttcctgcttgacctccctaaaggagaagaagtgaccatattggctcagaagaagaaggatgtttatcgtcgcattgtagaatcagatgtaggagattctttctatattagaacccattttgaatatgaaaaggaatctccctatggacttagttttaacaaaggagaggtgttccgtgttgtggataccttgtacaatggaaaactgggctcttggcttgctattcgaattggtaaaaatcataaggaggtagaacgaggcatcatccctaataagaacagagctgagcagctagccagtgtacagtatacacttccaaaaacagcaggcggagaccgtgctgacttctggagattcagaggtcttcgcagctccaagagaaatcttcgaaaaagcagagaggatttgtccgctcagcctgttcaaacaaagtttccagcttatgaaagagtggttcttcgagaagctggatttctgaggcctgtaaccatttttggaccaatagctgatgttgccagagaaaagctggcaagagaagaaccagatatttatcaaattgcaaagagtgaaccacgagacgctggaactgaccaacgtagctctggcattattcgcctgcatacaataaagcaaatcatagatcaagacaaacatgctttattagatgtaacaccaaatgcagttgatcgtcttaactatgcccagtggtatccaattgttgtatttcttaaccctgattctaagcaaggagtaaaaacaatgagaatgaggttatgtccagaatctcggaaaagtgccaggaagttatacgagcgatctcataaacttcgtaaaaataatcaccatctttttacaactacaattaacttaaattcaatgaatgatggttggtatggtgcgctgaaagaagcaattcaacaacagcaaaaccagctggtatgggtttccgagggaaaggcggatggtgctacaagtgatgaccttgatttgcatgatgatcgtctgtcctacctgtcagctccaggtagtgaatactcaatgtatagcacggacagtagacacacttctgactatgaagacacagacacagaaggcggggcctacactgatcaagaactagatgaaactcttaatgatgaggttgggactccaccggagtctgccattacacggtcctctgagcctgtaagagaggactcctctggaatgcatcatgaaaaccaaacatatcctccttactcaccacaagcgcagccacaaccaattcatagaatagactcccctggatttaagccagcctctcaacagaaagcagaagcttcatctccagtcccttacctttcgcctgaaacaaacccagcatcatcaacctctgctgttaatcataatgtaaatttaactaatgtcagactggaggagcccaccccagctccttccacctcttactcaccacaagctgattctttaagaacaccaagtactgaggcagctcacataatgctaagagatcaagaaccatcattgtcgtcgcatgtagatccaacaaaggtgtatagaaaggatccatatcccgaggaaatgatgaggcagaaccatgttttgaaacagccagccgttagtcacccagggcacaggccagacaaagagcctaatctgacctatgaaccccaactcccatacgtagagaaacaagccagcagagacctcgagcagcccacatacagatacgagtcctcaagctatacggaccagttttctcgaaactatgaacatcgtctgcgatacgaagatcgcgtccccatgtatgaagaacagtggtcatattatgatgacaaacagccctacccatctcggccaccttttgataatcagcactctcaagaccttgactccagacagcatcccgaagagtcctcagaacgagggtactttccacgttttgaagagccagcccctctgtcttacgacagcagaccacgttacgaacaggcacctagagcatccgccctgcggcacgaagagcagccagctcctgggtatgacacacatggtagactcagaccggaagcccagccccacccttcagcagggcccaagcctgcagagtccaagcagtattttgagcaatattcacgcagttacgagcaagtaccaccccaaggatttacctctagagcaggtcattttgagcctctccatggtgctgcagctgtccctccgctgataccttcatctcagcataagccagaagctctgccttcaaacaccaaaccactgcctccacccccaactcaaaccgaagaagaggaagatccagcaatgaagccacagtctgtactcaccagagttaagatgtttgaaaacaaaagatctgcatccttagagaccaagaaggatgtaaatgacactggcagttttaagcctccagaagtagcatctaaaccttcaggtgctcccatcattggtcccaaacccacttctcagaatcaattcagtgaacatgacaaaactctgtacaggatcccagaacctcaaaaacctcaactgaagccacctgaagatattgttcggtccaatcattatgaccctgaagaagatgaagaatattatcgaaaacagctgtcatactttgaccgaagaagttttgagaataagcctcctgcacacattgccgccagccatctctccgagcctgcaaagccagcgcattctcagaatcaatcaaatttttctagttattcttcaaagggaaagcctcctgaagctgatggtgtggatagatcatttggcgagaaacgctatgaacccatccaggccactccccctcctcctccattgccctcgcagtatgcccagccatctcagcctgtcaccagcgcgtctctccacatacattctaagggagcacatggtgaaggtaattcagtgtcattggattttcagaattccttagtgtccaaaccagacccacctccatctcagaataagccagcaactttcagaccaccaaaccgagaagatactgctcaggcagctttctatccccagaaaagttttccagataaagccccagttaatggaactgaacagactcagaaaacagtcactccagcatacaatcgattcacaccaaaaccatatacaagttctgcccgaccatttgaacgcaagtttgaaagtcctaaattcaatcacaatcttctgccaagtgaaactgcacataaacctgacttgtcttcaaaaactcccacttctccaaaaactcttgtgaaatcgcacagtttggcacagcctcctgagtttgacagtggagttgaaactttctctatccatgcagagaagcctaaatatcaaataaataatatcagcacagtgcctaaagctattcctgtgagtccttcagctgtggaagaggatgaagatgaagatggtcatactgtggtggccacagcccgaggcatatttaacagcaatgggggcgtgctgagttccatagaaactggtgttagtataattatccctcaaggagccattcccgaaggagttgagcaggaaatctatttcaaggtctgccgggacaacagcatccttccacctttagataaagagaaaggtgaaacactgctgagtcctttggtgatgtgtggtccccatggcctcaagttcctgaagcctgtggagctgcgcttaccacactgtgatcctaaaacctggcaaaacaagtgtcttcccggagatccaaattatctcgttggagcaaactgtgtttctgtccttattgaccacttttaactcttgaaatataggaacttaaataatgtgaaactggattaaacttaatctaaatggaaccactctatcaagtattataccttttttagagttgatactacagtttgttagtatgaggcatttgtttgaactgataaagatgagtgagcatgcccctgaaccatggtcggaaaacatgctacacactgcatgtttgtgattgacgggactgttggtattggctagaggttcaaagatattttgctttgtgatttttgtaatttttttatcgtcactgcttaacttcacatattgatttccgttaaaataccagccagtaaatgggggtgcatttgaggtctgttctttccaaagtacactgtttcaaactttactatggccctggcctagcatacgtacacattttattttattatgcatgaagtaatatgcacacattttttaaatgcacctggaatatataaccagtgttgtggatttaacagaaatgtacagcaaggagatttacaactgggggagggtgaagtgaagacaatgacttactgtacatgaaaacacatttttcttagggaaggatacaaaagcatgtgagactggttccatggcctcttcagatctctaacttcaccatattaccacagacatactaaccagcagaaatgccttaccctcatgttcttaattcttagctcattctccttgtgttactaagtttttatggcttttgtgcattatctagatactgtatcatgacaaagactgagtacgttgtgcatttggtggtttcagaaatgtgttatcacccagaagaaaatagtggtgtgatttggggatatttttttcttttcttttcttttctttttttttttttttgacaaggggcagtggtggttttctgttctttctggctatgcatttgaaaattttgatgttttaaggatgcttgtacataatgcgtgcataccacttttgttcttggtttgtaaattaacttttataaactttaccttttttatacataaacaagaccacgtttctaaaggctacctttgtattctctcctgtacctcttgagccttgaactttgacctctgcagcaataaagcagcgtttctatgacacatgcaaggtcattttttttaagaaaaaggatgcacagagttgttacatttttaagtgctgcatttaaaagatacagttactcagaattctctagtttgattaaattcttgcaaagtatccctactgtaatttgtgatacaatgctgtgccctaaagtgtatttttttactaatagacaatttattatggcacatcagcacgatttctgtttagataatacaccactacattctgttaatcattaggtgtgactgaatttcttttgccgttattaaaaatctcaaatttctaaatctccaaaataaaactttttaaaataaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7082 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7082 -> Molecular function: GO:0005516 [calmodulin binding] evidence: IEA
GeneID:7082 -> Molecular function: GO:0008022 [protein C-terminus binding] evidence: IEA
GeneID:7082 -> Molecular function: GO:0019904 [protein domain specific binding] evidence: IEA
GeneID:7082 -> Biological process: GO:0001825 [blastocyst formation] evidence: IEA
GeneID:7082 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:7082 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
GeneID:7082 -> Biological process: GO:0007043 [cell-cell junction assembly] evidence: TAS
GeneID:7082 -> Biological process: GO:0016044 [cellular membrane organization] evidence: TAS
GeneID:7082 -> Biological process: GO:0032496 [response to lipopolysaccharide] evidence: IEA
GeneID:7082 -> Biological process: GO:0035329 [hippo signaling cascade] evidence: TAS
GeneID:7082 -> Biological process: GO:0042493 [response to drug] evidence: IEA
GeneID:7082 -> Biological process: GO:0043116 [negative regulation of vascular permeability] evidence: IEA
GeneID:7082 -> Biological process: GO:0045471 [response to ethanol] evidence: IEA
GeneID:7082 -> Biological process: GO:0071000 [response to magnetism] evidence: IEA
GeneID:7082 -> Biological process: GO:0071333 [cellular response to glucose stimulus] evidence: IEA
GeneID:7082 -> Biological process: GO:1901350 [cell-cell signaling involved in cell-cell junction organization] evidence: NAS
GeneID:7082 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:7082 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:7082 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:7082 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:7082 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:7082 -> Cellular component: GO:0005913 [cell-cell adherens junction] evidence: IEA
GeneID:7082 -> Cellular component: GO:0005921 [gap junction] evidence: IEA
GeneID:7082 -> Cellular component: GO:0005923 [tight junction] evidence: IDA
GeneID:7082 -> Cellular component: GO:0014704 [intercalated disc] evidence: IEA
GeneID:7082 -> Cellular component: GO:0016323 [basolateral plasma membrane] evidence: IDA
GeneID:7082 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IEA
GeneID:7082 -> Cellular component: GO:0016327 [apicolateral plasma membrane] evidence: IEA
GeneID:7082 -> Cellular component: GO:0030054 [cell junction] evidence: IDA
GeneID:7082 -> Cellular component: GO:0043296 [apical junction complex] evidence: IDA
GeneID:7082 -> Cellular component: GO:0045177 [apical part of cell] evidence: IDA
GeneID:7082 -> Cellular component: GO:0046581 [intercellular canaliculus] evidence: IEA
by
@meso_cacase at
DBCLS
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