Home |
Help |
Advanced search
2024-04-26 07:09:26, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003252 3894 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens TIA1 cytotoxic granule-associated RNA binding
protein-like 1 (TIAL1), transcript variant 1, mRNA.
ACCESSION NM_003252 XM_941936 XM_945550 XM_945552 XM_945554 XM_945556
XM_945560 XM_945564 XM_945566 XM_945569 XM_945570 XM_945572
XM_945573
VERSION NM_003252.3 GI:77695910
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3894)
AUTHORS Singh,N.N., Seo,J., Ottesen,E.W., Shishimorova,M., Bhattacharya,D.
and Singh,R.N.
TITLE TIA1 prevents skipping of a critical exon associated with spinal
muscular atrophy
JOURNAL Mol. Cell. Biol. 31 (5), 935-954 (2011)
PUBMED 21189287
REMARK GeneRIF: TIA1 and TIAR proteins are intron-associated positive
regulators of SMN2 exon 7 splicing.
REFERENCE 2 (bases 1 to 3894)
AUTHORS Gottschald,O.R., Malec,V., Krasteva,G., Hasan,D., Kamlah,F.,
Herold,S., Rose,F., Seeger,W. and Hanze,J.
TITLE TIAR and TIA-1 mRNA-binding proteins co-aggregate under conditions
of rapid oxygen decline and extreme hypoxia and suppress the
HIF-1alpha pathway
JOURNAL J Mol Cell Biol 2 (6), 345-356 (2010)
PUBMED 20980400
REMARK GeneRIF: Severe hypoxia caused co-aggregation of TIAR/TIA-1 and
these proteins suppressed HIF-1alpha expression.
REFERENCE 3 (bases 1 to 3894)
AUTHORS Bossowski,A., Czarnocka,B., Bardadin,K., Moniuszko,A.,
Lyczkowska,A., Czerwinska,J., Dadan,J. and Bossowska,A.
TITLE Identification of chosen apoptotic (TIAR and TIA-1) markers
expression in thyroid tissues from adolescents with immune and
non-immune thyroid diseases
JOURNAL Folia Histochem. Cytobiol. 48 (2), 178-184 (2010)
PUBMED 20675271
REMARK GeneRIF: Data show that apoptotic (TIAR and TIA-1) marker
expression in thyroid tissues from adolescents with immune thyroid
diseases is higher than in non-immune thyroid diseases.
REFERENCE 4 (bases 1 to 3894)
AUTHORS Wang,Z., Kayikci,M., Briese,M., Zarnack,K., Luscombe,N.M., Rot,G.,
Zupan,B., Curk,T. and Ule,J.
TITLE iCLIP predicts the dual splicing effects of TIA-RNA interactions
JOURNAL PLoS Biol. 8 (10), E1000530 (2010)
PUBMED 21048981
REMARK GeneRIF: Data show that TIA1 and TIAL1 bind at the same positions
on human RNAs, and are consistent with a model where TIA proteins
shorten the time available for definition of an alternative exon by
enhancing recognition of the preceding 5' splice site.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 3894)
AUTHORS Lu,L., Wang,S., Zheng,L., Li,X., Suswam,E.A., Zhang,X.,
Wheeler,C.G., Nabors,L.B., Filippova,N. and King,P.H.
TITLE Amyotrophic lateral sclerosis-linked mutant SOD1 sequesters Hu
antigen R (HuR) and TIA-1-related protein (TIAR): implications for
impaired post-transcriptional regulation of vascular endothelial
growth factor
JOURNAL J. Biol. Chem. 284 (49), 33989-33998 (2009)
PUBMED 19805546
REMARK GeneRIF: SOD1 sequesters Hu antigen R (HuR) and TIA-1-related
protein (TIAR) and has a role in impaired post-transcriptional
regulation of vascular endothelial growth factor
REFERENCE 6 (bases 1 to 3894)
AUTHORS Jin,K., Li,W., Nagayama,T., He,X., Sinor,A.D., Chang,J., Mao,X.,
Graham,S.H., Simon,R.P. and Greenberg,D.A.
TITLE Expression of the RNA-binding protein TIAR is increased in neurons
after ischemic cerebral injury
JOURNAL J. Neurosci. Res. 59 (6), 767-774 (2000)
PUBMED 10700014
REFERENCE 7 (bases 1 to 3894)
AUTHORS Doi,T., Minami,T., Itoh,M., Aburatani,H., Kawabe,Y., Kodama,T.,
Kondo,N., Satoh,Y., Asayama,T. and Imanishi,T.
TITLE An alternative form of nucleolysin binds to a T-cluster DNA in the
silencer element of platelet factor 4 gene
JOURNAL Biochem. Biophys. Res. Commun. 235 (3), 625-630 (1997)
PUBMED 9207209
REFERENCE 8 (bases 1 to 3894)
AUTHORS Dember,L.M., Kim,N.D., Liu,K.Q. and Anderson,P.
TITLE Individual RNA recognition motifs of TIA-1 and TIAR have different
RNA binding specificities
JOURNAL J. Biol. Chem. 271 (5), 2783-2788 (1996)
PUBMED 8576255
REFERENCE 9 (bases 1 to 3894)
AUTHORS Taupin,J.L., Tian,Q., Kedersha,N., Robertson,M. and Anderson,P.
TITLE The RNA-binding protein TIAR is translocated from the nucleus to
the cytoplasm during Fas-mediated apoptotic cell death
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (5), 1629-1633 (1995)
PUBMED 7533298
REFERENCE 10 (bases 1 to 3894)
AUTHORS Kawakami,A., Tian,Q., Duan,X., Streuli,M., Schlossman,S.F. and
Anderson,P.
TITLE Identification and functional characterization of a TIA-1-related
nucleolysin
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (18), 8681-8685 (1992)
PUBMED 1326761
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC030025.1, AL833106.1,
AC012468.10, AK125264.1 and AA972022.1.
On or before Mar 4, 2006 this sequence version replaced
gi:89033597, gi:89033599, gi:89033601, gi:89033603, gi:89033605,
gi:89033607, gi:89033609, gi:89033611, gi:89033613, gi:89033615,
gi:89033617, gi:89033619, gi:13435392.
Summary: The protein encoded by this gene is a member of a family
of RNA-binding proteins, has three RNA recognition motifs (RRMs),
and binds adenine and uridine-rich elements in mRNA and pre-mRNAs
of a wide range of genes. It regulates various activities including
translational control, splicing and apoptosis. Alternate
transcriptional splice variants, encoding different isoforms, have
been characterized. The different isoforms have been show to
function differently with respect to post-transcriptional
silencing. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) represents the shorter
transcript and encodes the shorter isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK290695.1, AK291239.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-65 BC030025.1 6-70
66-793 AL833106.1 2-729
794-935 BC030025.1 799-940
936-1301 AL833106.1 872-1237
1302-1425 AC012468.10 37686-37809 c
1426-1565 AC012468.10 37217-37356 c
1566-1915 AC012468.10 36048-36397 c
1916-3659 AK125264.1 19-1762
3660-3894 AA972022.1 1-235 c
FEATURES Location/Qualifiers
source 1..3894
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q"
gene 1..3894
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/note="TIA1 cytotoxic granule-associated RNA binding
protein-like 1"
/db_xref="GeneID:7073"
/db_xref="HGNC:11804"
/db_xref="HPRD:04563"
/db_xref="MIM:603413"
exon 1..596
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
variation 116
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/replace="a"
/replace="c"
/db_xref="dbSNP:17516000"
misc_feature 289..291
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/note="upstream in-frame stop codon"
CDS 565..1692
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/note="isoform 1 is encoded by transcript variant 1;
TIA-1-related nucleolysin; T-cluster binding protein;
nucleolysin TIAR; aging-associated gene 7 protein"
/codon_start=1
/product="nucleolysin TIAR isoform 1"
/protein_id="NP_003243.1"
/db_xref="GI:4507499"
/db_xref="CCDS:CCDS7613.1"
/db_xref="GeneID:7073"
/db_xref="HGNC:11804"
/db_xref="HPRD:04563"
/db_xref="MIM:603413"
/translation="
MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ
"
misc_feature 592..834
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/note="RNA recognition motif 1 in nucleolysin TIAR and
similar proteins; Region: RRM1_TIAR; cd12616"
/db_xref="CDD:241060"
misc_feature 712..714
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 850..1089
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/note="RNA recognition motif 2 in nucleolysin TIAR and
similar proteins; Region: RRM2_TIAR; cd12617"
/db_xref="CDD:241061"
misc_feature 928..930
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q01085.1); acetylation site"
misc_feature 1165..1167
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q01085.1); phosphorylation site"
misc_feature 1177..1395
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/note="RNA recognition motif 3 in nucleolysin TIAR and
similar proteins; Region: RRM3_TIAR; cd12620"
/db_xref="CDD:241064"
exon 597..693
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
exon 694..792
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
exon 793..847
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
exon 848..935
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
STS 894..1493
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/standard_name="Tial1"
/db_xref="UniSTS:479295"
exon 936..1011
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
exon 1012..1120
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
exon 1121..1216
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
exon 1217..1301
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
exon 1302..1425
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
exon 1426..1565
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
exon 1566..3892
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/inference="alignment:Splign:1.39.8"
STS 1677..1908
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/standard_name="RH81093"
/db_xref="UniSTS:84885"
STS 1680..1871
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/standard_name="RH80809"
/db_xref="UniSTS:86914"
polyA_signal 1926..1931
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
polyA_signal 1935..1940
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
polyA_site 1945
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/experiment="experimental evidence, no additional details
recorded"
polyA_site 1973
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/experiment="experimental evidence, no additional details
recorded"
STS 2005..2813
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/standard_name="TIAL1_1101"
/db_xref="UniSTS:277814"
STS 2190..2337
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/standard_name="RH78958"
/db_xref="UniSTS:75095"
STS 2513..2633
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/standard_name="STS-N39410"
/db_xref="UniSTS:56407"
polyA_signal 2642..2647
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
polyA_site 2665
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/experiment="experimental evidence, no additional details
recorded"
polyA_signal 3659..3664
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
polyA_site 3678
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
/experiment="experimental evidence, no additional details
recorded"
polyA_signal 3855..3860
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
polyA_site 3889
/gene="TIAL1"
/gene_synonym="TCBP; TIAR"
ORIGIN
tcttcacgtcccagcgcgggtgggcgccggcggctcctcttaaccacaggttccagaagtcctctgcagaagtgcttccctctctcatttccaggaccacaattcccagagacttcggcttcacgacgtttctctttttgcccgatctctcccggagctggctgggcttcggccggccagaggcccacagcgacgacgtgatccgtcgtgagcgggtcccagggtttcctcggcggcccttttttctctcccctcggtcgtcccccttgcaggctgtcgcggctggcctgagcggtgacctggcgggtcgcgcctgcgctctgccctgtttcctgcctggctggtggcggcggccattttgttcatcctcctcctcctcctgctcctcctggttggagcgcagtgtccggagcgggctggggggagagagcccgagagcagggttcggtgccttttcctctgtccccagccggtgcccagagcccccctccccttcctccccaccccctcccctccccaaccctgccctcccccttgtcccgggatcgctccgtcgcacccaccatgatggaagacgacgggcagccccggactctatacgtaggtaacctttccagagatgtgacagaagtccttatacttcagttgttcagtcagattggaccctgtaaaagctgtaaaatgataacagagcatacaagcaatgacccatattgctttgtggaattttatgaacacagagatgcagctgctgcattagctgctatgaatgggagaaaaattttgggaaaggaggtcaaagtaaactgggcaaccacaccaagtagccagaaaaaagatacttccaatcacttccatgtgtttgttggggatttgagtccagaaattacaacagaagatatcaaatcagcatttgccccctttggtaaaatatcggatgcccgggtagttaaagacatggcaactggaaaatccaaaggctatggttttgtatctttttataacaaactggatgcagaaaatgcgattgtgcatatgggcggtcagtggttgggtggtcgtcaaatccgaaccaattgggccactcgtaaaccacctgcacctaaaagtacacaagaaaacaacactaagcagttgagatttgaagatgtagtaaaccagtcaagtccaaaaaattgtactgtgtactgtggaggaattgcgtctgggttaacagatcagcttatgagacagacattctcaccatttggacaaattatggaaataagagttttcccagaaaagggctattcatttgtcagattttcaacccatgaaagtgcagcccatgccattgtttcggtgaacggtactacgattgaaggacatgtggttaaatgctattggggtaaagaatctcctgatatgactaaaaacttccaacaggttgactatagtcaatggggccaatggagccaagtgtatggaaacccacaacagtatggacagtatatggcaaatgggtggcaagtaccgccttatggagtatacgggcaaccatggaatcaacaaggatttggagtagatcaatcaccttctgctgcttggatgggtggatttggtgctcagcctccccaaggacaagctcctccccctgtaatacctcctcctaaccaagccggatatggtatggcaagttaccaaacacagtgagccgggactctaaaaaaaaattgtaattcatgataggcttcgatttcctgtgacactctgaagacatgaaagtagacatcggaaaatgaaaatatttattttaaaaattgaaatgtttggaacctttagcacagatttgctttggtgaaggacacgtgtcttctagttctgcctttttaagtttttgttcatgatggatatgaacatgatttttctttatgtacaaaaactaaaataaagtcaataaagacaattctgactacaaattttgatataataggaaaaatggctaatacattttgattcttagatactattccatttttatcttgctgttcagtattttaactcactgtgtttttaaaagagcaaaaaagggaggatcgtgaaaacctgggaatcacatataagttcatcctgaatcctgatactcccctccccttccctgaggtggaccacatttgaagtcagcagagaaaaagtgtgatattcagaagaaatgcgtgattttggagtcgctttggaggaaatattttctttctctatgcctaaagaaactgaagccagactgaagttttgcaccctaaaaaaggaacagcattgtttgagttacttgagcaaatgttggtggtccacgttaagacatatttttaaaacttccaaaagtgtcgattattaaaattgtagtattttacatttcattttggggggaaatccaagtatggtgtttgtattgaagtcagacagtcatacttgtgcttttacatgaagtttaaatgatacatattgtaaatattcaataactacagtgtttaaaaagcatgcttcaacatagaagtagcagcaatgtaattatttgaagtaacacttaacacactccgctgcattgaatgcagtggattgatcagaatgttaagactgacatttccaaggttggctactatgtaaaattaaaattacacaaattgtgcagaaaaagccttaattttaatttcatacaatctttgatgcattagtatgttctaaaatgtcattgggaattagttttttgtttttgtttttttttttttttttttttgctttacattacttggtatgtaaataccttgattaaaaccttgtaaaccaatttcaaggttactataagttgtatagtacaagtgttttttaaaaatcttggggtgtttttaaaaattaagatatattttgcccaagaatttttttaacaagattgctaaaaacatcttatttagacacttcaatgtaccaatttataattggatattcagtttaaatagtacacagagttgtggcttttattttcaattaatttttttccttgtgggcagtgtgcatggtataataagcctgagcagaggcttaagttgtatgtgtgcagagtttgtaaaggaatcaattggaagatgcagaagaccgaggtttgctttcaaggtatttttcaggctgtgtgggtaaaatttgcctcaaatttctatcaaacaggaatgtaaaatagataaaatcctatgtatttgaattgtcagagctagggagtgcaaatgttttggcaatgtattcaaaatgctggcctgggcaccaaagagaaaatagccttttacagttacatagtaagatgcgattagtacccacaaattactgttttctaaacatttgaagttttacgattagctttaaaataatgattttataaattggtggtcacaataattttggtattactttcctccttttcccacttagcaatatagccaaatgtattcaacataaaaattcatagggtctgaaattcatagctgggccaaattttttatggcaccttagttttaccataatggtcatctattacactcttctgttataaaatatacccttatttcttttgtttatagtatctttgaggaatgtttttggaaaagttaatttatattttatagggagaacactcaataaattatgttaactgtgcccccgagttaaaaattttatgagtatatgtgaaacttgaacaactgaagactttttttaattgataaaaatgcttagtatgcctgttttggtctgccagtaaattaagtagcttattgagataactaacagctaaatatagctgtagtgtttcctgactgtatattctatgatttaataaaattatccagactagttatattgccacagtaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7073 -> Molecular function: GO:0000166 [nucleotide binding] evidence: IEA
GeneID:7073 -> Molecular function: GO:0003723 [RNA binding] evidence: TAS
GeneID:7073 -> Molecular function: GO:0017091 [AU-rich element binding] evidence: IEA
GeneID:7073 -> Biological process: GO:0006357 [regulation of transcription from RNA polymerase II promoter] evidence: TAS
GeneID:7073 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:7073 -> Biological process: GO:0006917 [induction of apoptosis] evidence: TAS
GeneID:7073 -> Biological process: GO:0006952 [defense response] evidence: TAS
GeneID:7073 -> Biological process: GO:0007281 [germ cell development] evidence: IEA
GeneID:7073 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IEA
GeneID:7073 -> Biological process: GO:0017145 [stem cell division] evidence: IEA
GeneID:7073 -> Cellular component: GO:0005634 [nucleus] evidence: ISS
GeneID:7073 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS
GeneID:7073 -> Cellular component: GO:0005764 [lysosome] evidence: TAS
GeneID:7073 -> Cellular component: GO:0010494 [cytoplasmic stress granule] evidence: ISS
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.