2024-04-26 02:19:04, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003183 3572 bp mRNA linear PRI 15-JUL-2013 DEFINITION Homo sapiens ADAM metallopeptidase domain 17 (ADAM17), mRNA. ACCESSION NM_003183 VERSION NM_003183.4 GI:73747888 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3572) AUTHORS Romee,R., Foley,B., Lenvik,T., Wang,Y., Zhang,B., Ankarlo,D., Luo,X., Cooley,S., Verneris,M., Walcheck,B. and Miller,J. TITLE NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17) JOURNAL Blood 121 (18), 3599-3608 (2013) PUBMED 23487023 REMARK GeneRIF: Over-activation of ADAM17 in NK cells may be detrimental to their effector functions by down-regulating surface expression of CD16 and CD62L. REFERENCE 2 (bases 1 to 3572) AUTHORS Dobel,T., Kunze,A., Babatz,J., Trankner,K., Ludwig,A., Schmitz,M., Enk,A. and Schakel,K. TITLE FcgammaRIII (CD16) equips immature 6-sulfo LacNAc-expressing dendritic cells (slanDCs) with a unique capacity to handle IgG-complexed antigens JOURNAL Blood 121 (18), 3609-3618 (2013) PUBMED 23460612 REMARK GeneRIF: CD16 is rapidly shed from the surface of maturing 6-sulfo LacNAc-expressing dendritic cells, resulting from the combined action of the metalloproteinases ADAM10 and ADAM17. REFERENCE 3 (bases 1 to 3572) AUTHORS Tsubota,Y., Frey,J.M., Tai,P.W., Welikson,R.E. and Raines,E.W. TITLE Monocyte ADAM17 promotes diapedesis during transendothelial migration: identification of steps and substrates targeted by metalloproteinases JOURNAL J. Immunol. 190 (8), 4236-4244 (2013) PUBMED 23479224 REMARK GeneRIF: Monocyte ADAM17 facilitates the completion of transendothelial migration by accelerating the rate of diapedesis. REFERENCE 4 (bases 1 to 3572) AUTHORS Chen,X., Chen,L., Zhang,R., Yi,Y., Ma,Y., Yan,K., Jiang,X. and Wang,X. TITLE ADAM17 regulates self-renewal and differentiation of U87 glioblastoma stem cells JOURNAL Neurosci. Lett. 537, 44-49 (2013) PUBMED 23356982 REMARK GeneRIF: ADAM17 may maintain the stemness of glioblastoma stem cells by promoting their self-renewal and inhibiting their differentiation via Notch signaling. REFERENCE 5 (bases 1 to 3572) AUTHORS Li,Y.Q., Yan,J.P., Xu,W.L., Wang,H., Xia,Y.J., Wang,H.J., Zhu,Y.Y. and Huang,X.J. TITLE ADAM17 mediates MMP9 expression in lung epithelial cells JOURNAL PLoS ONE 8 (1), E51701 (2013) PUBMED 23341882 REMARK GeneRIF: Lentiviral ADAM17 RNA interference inhibited MMP9 expression, IkappaBalpha phosphorylation and the expression of phosphorylation p65 protein in response to lipopolysaccharides. REFERENCE 6 (bases 1 to 3572) AUTHORS Schroeter,E.H., Kisslinger,J.A. and Kopan,R. TITLE Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain JOURNAL Nature 393 (6683), 382-386 (1998) PUBMED 9620803 REFERENCE 7 (bases 1 to 3572) AUTHORS Patel,I.R., Attur,M.G., Patel,R.N., Stuchin,S.A., Abagyan,R.A., Abramson,S.B. and Amin,A.R. TITLE TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha JOURNAL J. Immunol. 160 (9), 4570-4579 (1998) PUBMED 9574564 REFERENCE 8 (bases 1 to 3572) AUTHORS Maskos,K., Fernandez-Catalan,C., Huber,R., Bourenkov,G.P., Bartunik,H., Ellestad,G.A., Reddy,P., Wolfson,M.F., Rauch,C.T., Castner,B.J., Davis,R., Clarke,H.R., Petersen,M., Fitzner,J.N., Cerretti,D.P., March,C.J., Paxton,R.J., Black,R.A. and Bode,W. TITLE Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (7), 3408-3412 (1998) PUBMED 9520379 REFERENCE 9 (bases 1 to 3572) AUTHORS Moss,M.L., Jin,S.L., Milla,M.E., Bickett,D.M., Burkhart,W., Carter,H.L., Chen,W.J., Clay,W.C., Didsbury,J.R., Hassler,D., Hoffman,C.R., Kost,T.A., Lambert,M.H., Leesnitzer,M.A., McCauley,P., McGeehan,G., Mitchell,J., Moyer,M., Pahel,G., Rocque,W., Overton,L.K., Schoenen,F., Seaton,T., Su,J.L., Becherer,J.D. et al. TITLE Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha JOURNAL Nature 385 (6618), 733-736 (1997) PUBMED 9034191 REMARK Erratum:[Nature 1997 Apr 17;386(6626):738] REFERENCE 10 (bases 1 to 3572) AUTHORS Black,R.A., Rauch,C.T., Kozlosky,C.J., Peschon,J.J., Slack,J.L., Wolfson,M.F., Castner,B.J., Stocking,K.L., Reddy,P., Srinivasan,S., Nelson,N., Boiani,N., Schooley,K.A., Gerhart,M., Davis,R., Fitzner,J.N., Johnson,R.S., Paxton,R.J., March,C.J. and Cerretti,D.P. TITLE A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells JOURNAL Nature 385 (6618), 729-733 (1997) PUBMED 9034190 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN258241.1, U86755.1, BX339672.2, U92649.1, U69611.1, BM725368.1 and BQ186514.1. This sequence is a reference standard in the RefSeqGene project. On Aug 24, 2005 this sequence version replaced gi:11497003. Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: GQ402545.1, U92649.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084, ERS025088 [ECO:0000348] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-20 CN258241.1 3-22 21-2716 U86755.1 1-2696 2717-2941 BX339672.2 720-944 2942-3046 U92649.1 2922-3026 3047-3083 U69611.1 2978-3014 3084-3134 U92649.1 3063-3113 3135-3374 BM725368.1 207-446 c 3375-3572 BQ186514.1 7-204 c FEATURES Location/Qualifiers source 1..3572 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="2" /map="2p25" gene 1..3572 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /note="ADAM metallopeptidase domain 17" /db_xref="GeneID:6868" /db_xref="HGNC:195" /db_xref="MIM:603639" exon 1..280 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="alignment:Splign:1.39.8" variation 30 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /replace="a" /replace="c" /db_xref="dbSNP:55790676" misc_feature 82..84 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /note="upstream in-frame stop codon" CDS 184..2658 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /EC_number="3.4.24.86" /note="snake venom-like protease; tumor necrosis factor, alpha, converting enzyme; TNF-alpha converting enzyme; disintegrin and metalloproteinase domain-containing protein 17; ADAM metallopeptidase domain 18; TNF-alpha convertase" /codon_start=1 /product="disintegrin and metalloproteinase domain-containing protein 17 preproprotein" /protein_id="NP_003174.3" /db_xref="GI:73747889" /db_xref="CCDS:CCDS1665.1" /db_xref="GeneID:6868" /db_xref="HGNC:195" /db_xref="MIM:603639" /translation="
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC
" sig_peptide 184..234 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="COORDINATES: ab initio prediction:SignalP:4.0" proprotein 235..2655 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /product="disintegrin and metalloproteinase domain-containing protein 17 proprotein" misc_feature 340..684 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /note="Reprolysin family propeptide; Region: Pep_M12B_propep; pfam01562" /db_xref="CDD:201861" misc_feature 727..750 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P78536.1); Region: Cysteine switch (By similarity)" mat_peptide 832..2655 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /product="disintegrin and metalloproteinase domain-containing protein 17" misc_feature 850..1614 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /note="Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha; Region: ZnMc_TACE_like; cd04270" /db_xref="CDD:58571" misc_feature 1318..1320 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1327..1329 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature order(1396..1401,1408..1410,1426..1428) /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /note="active site" /db_xref="CDD:58571" misc_feature 1633..1863 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /note="Homologues of snake disintegrins; Region: DISIN; smart00050" /db_xref="CDD:197489" misc_feature 1894..1989 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /note="Region: EGF-like domain" misc_feature 1990..2196 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P78536.1); Region: Crambin-like" misc_feature 2197..2265 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /note="Region: transmembrane domain" misc_feature 2197..2259 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P78536.1); transmembrane region" misc_feature 2266..2655 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /note="Region: cytoplasmic domain" misc_feature 2386..2388 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine, by MAPK14; propagated from UniProtKB/Swiss-Prot (P78536.1); phosphorylation site" misc_feature 2554..2556 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /experiment="experimental evidence, no additional details recorded" /note="dephosphorylation site; modified site" misc_feature 2554..2556 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P78536.1); phosphorylation site" misc_feature 2554..2556 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 2638..2640 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P78536.1); phosphorylation site" misc_feature 2638..2640 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" exon 281..413 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="alignment:Splign:1.39.8" exon 414..544 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="alignment:Splign:1.39.8" exon 545..633 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="alignment:Splign:1.39.8" exon 634..802 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="alignment:Splign:1.39.8" variation 667 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /replace="a" /replace="g" /db_xref="dbSNP:34431503" variation 787 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:2230818" exon 803..936 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="alignment:Splign:1.39.8" exon 937..1026 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="alignment:Splign:1.39.8" exon 1027..1140 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="alignment:Splign:1.39.8" exon 1141..1285 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="alignment:Splign:1.39.8" exon 1286..1374 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="alignment:Splign:1.39.8" exon 1375..1527 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="alignment:Splign:1.39.8" exon 1528..1727 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="alignment:Splign:1.39.8" variation 1654 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /replace="c" /replace="t" /db_xref="dbSNP:55937573" exon 1728..1831 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="alignment:Splign:1.39.8" exon 1832..1966 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="alignment:Splign:1.39.8" exon 1967..2097 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="alignment:Splign:1.39.8" variation 2007 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /replace="c" /replace="t" /db_xref="dbSNP:1048610" exon 2098..2176 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="alignment:Splign:1.39.8" exon 2177..2265 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="alignment:Splign:1.39.8" STS 2199..2658 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /standard_name="Adam17" /db_xref="UniSTS:471064" variation 2256 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /replace="c" /replace="t" /db_xref="dbSNP:34355677" exon 2266..2316 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="alignment:Splign:1.39.8" exon 2317..3572 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /inference="alignment:Splign:1.39.8" variation 2423 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /replace="c" /replace="t" /db_xref="dbSNP:55796712" variation 2719 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /replace="" /replace="a" /db_xref="dbSNP:3833563" STS 2760..2916 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /standard_name="RH70698" /db_xref="UniSTS:62215" variation 2948 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /replace="a" /replace="g" /db_xref="dbSNP:1130094" variation 3233 /gene="ADAM17" /gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE" /replace="a" /replace="g" /db_xref="dbSNP:10063" ORIGIN
acctgcacttctgggggcgtcgagcctggcggtagaatcttcccagtaggcggcgcgggagggaaaagaggattgaggggctaggccgggcggatcccgtcctcccccgatgtgagcagttttccgaaaccccgtcaggcgaaggctgcccagagaggtggagtcggtagcggggccgggaacatgaggcagtctctcctattcctgaccagcgtggttcctttcgtgctggcgccgcgacctccggatgacccgggcttcggcccccaccagagactcgagaagcttgattctttgctctcagactacgatattctctctttatctaatatccagcagcattcggtaagaaaaagagatctacagacttcaacacatgtagaaacactactaactttttcagctttgaaaaggcattttaaattatacctgacatcaagtactgaacgtttttcacaaaatttcaaggtcgtggtggtggatggtaaaaacgaaagcgagtacactgtaaaatggcaggacttcttcactggacacgtggttggtgagcctgactctagggttctagcccacataagagatgatgatgttataatcagaatcaacacagatggggccgaatataacatagagccactttggagatttgttaatgataccaaagacaaaagaatgttagtttataaatctgaagatatcaagaatgtttcacgtttgcagtctccaaaagtgtgtggttatttaaaagtggataatgaagagttgctcccaaaagggttagtagacagagaaccacctgaagagcttgttcatcgagtgaaaagaagagctgacccagatcccatgaagaacacgtgtaaattattggtggtagcagatcatcgcttctacagatacatgggcagaggggaagagagtacaactacaaattacttaatagagctaattgacagagttgatgacatctatcggaacacttcatgggataatgcaggttttaaaggctatggaatacagatagagcagattcgcattctcaagtctccacaagaggtaaaacctggtgaaaagcactacaacatggcaaaaagttacccaaatgaagaaaaggatgcttgggatgtgaagatgttgctagagcaatttagctttgatatagctgaggaagcatctaaagtttgcttggcacaccttttcacataccaagattttgatatgggaactcttggattagcttatgttggctctcccagagcaaacagccatggaggtgtttgtccaaaggcttattatagcccagttgggaagaaaaatatctatttgaatagtggtttgacgagcacaaagaattatggtaaaaccatccttacaaaggaagctgacctggttacaactcatgaattgggacataattttggagcagaacatgatccggatggtctagcagaatgtgccccgaatgaggaccagggagggaaatatgtcatgtatcccatagctgtgagtggcgatcacgagaacaataagatgttttcaaactgcagtaaacaatcaatctataagaccattgaaagtaaggcccaggagtgttttcaagaacgcagcaataaagtttgtgggaactcgagggtggatgaaggagaagagtgtgatcctggcatcatgtatctgaacaacgacacctgctgcaacagcgactgcacgttgaaggaaggtgtccagtgcagtgacaggaacagtccttgctgtaaaaactgtcagtttgagactgcccagaagaagtgccaggaggcgattaatgctacttgcaaaggcgtgtcctactgcacaggtaatagcagtgagtgcccgcctccaggaaatgctgaagatgacactgtttgcttggatcttggcaagtgtaaggatgggaaatgcatccctttctgcgagagggaacagcagctggagtcctgtgcatgtaatgaaactgacaactcctgcaaggtgtgctgcagggacctttctggccgctgtgtgccctatgtcgatgctgaacaaaagaacttatttttgaggaaaggaaagccctgtacagtaggattttgtgacatgaatggcaaatgtgagaaacgagtacaggatgtaattgaacgattttgggatttcattgaccagctgagcatcaatacttttggaaagtttttagcagacaacatcgttgggtctgtcctggttttctccttgatattttggattcctttcagcattcttgtccattgtgtggataagaaattggataaacagtatgaatctctgtctctgtttcaccccagtaacgtcgaaatgctgagcagcatggattctgcatcggttcgcattatcaaaccctttcctgcgccccagactccaggccgcctgcagcctgcccctgtgatcccttcggcgccagcagctccaaaactggaccaccagagaatggacaccatccaggaagaccccagcacagactcacatatggacgaggatgggtttgagaaggaccccttcccaaatagcagcacagctgccaagtcatttgaggatctcacggaccatccggtcaccagaagtgaaaaggctgcctcctttaaactgcagcgtcagaatcgtgttgacagcaaagaaacagagtgctaatttagttctcagctcttctgacttaagtgtgcaaaatatttttatagatttgacctacaaatcaatcacagcttgtattttgtgaagactgggaagtgacttagcagatgctggtcatgtgtttgaacttcctgcaggtaaacagttcttgtgtggtttggcccttctccttttgaaaaggtaaggtgaaggtgaatctagcttattttgaggctttcaggttttagtttttaaaatatcttttgacctgtggtgcaaaagcagaaaatacagctggattgggttatgaatatttacgtttttgtaaattaatcttttatattgataacagcactgactagggaaatgatcagtttttttttatacactgtaatgaaccgctgaatatgaggcatttggcatttatttgtgatgacaactggaatagttttttttttttttttttttttttgccttcaactaaaaacaaaggagataaatctagtatacattgtctctaaattgtgggtctatttctagttattacccagagtttttatgtagcagggaaaatatatatctaaatttagaaatcatttgggttaatatggctcttcataattctaagactaatgctctctagaaacctaaccacctaccttacagtgagggctatacatggtagccagttgaatttatggaatctaccaactgtttagggccctgatttgctgggcagtttttctgtattttataagtatcttcatgtatccctgttactgatagggatacatgctcttagaaaattcactattggctgggagtggtggctcatgcctgtaatcccagcacttggagaggctgaggttgcgccactacactccagcctgggtgacagagtgagactctgcctcaaaaaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:6868 -> Molecular function: GO:0004222 [metalloendopeptidase activity] evidence: IDA GeneID:6868 -> Molecular function: GO:0004222 [metalloendopeptidase activity] evidence: IMP GeneID:6868 -> Molecular function: GO:0004222 [metalloendopeptidase activity] evidence: TAS GeneID:6868 -> Molecular function: GO:0005138 [interleukin-6 receptor binding] evidence: IPI GeneID:6868 -> Molecular function: GO:0005178 [integrin binding] evidence: IPI GeneID:6868 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:6868 -> Molecular function: GO:0008237 [metallopeptidase activity] evidence: IDA GeneID:6868 -> Molecular function: GO:0008237 [metallopeptidase activity] evidence: IMP GeneID:6868 -> Molecular function: GO:0008237 [metallopeptidase activity] evidence: TAS GeneID:6868 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA GeneID:6868 -> Molecular function: GO:0017124 [SH3 domain binding] evidence: IEA GeneID:6868 -> Molecular function: GO:0030165 [PDZ domain binding] evidence: IPI GeneID:6868 -> Biological process: GO:0001666 [response to hypoxia] evidence: IDA GeneID:6868 -> Biological process: GO:0001934 [positive regulation of protein phosphorylation] evidence: IMP GeneID:6868 -> Biological process: GO:0002446 [neutrophil mediated immunity] evidence: IC GeneID:6868 -> Biological process: GO:0002467 [germinal center formation] evidence: ISS GeneID:6868 -> Biological process: GO:0002690 [positive regulation of leukocyte chemotaxis] evidence: IC GeneID:6868 -> Biological process: GO:0006509 [membrane protein ectodomain proteolysis] evidence: IDA GeneID:6868 -> Biological process: GO:0006509 [membrane protein ectodomain proteolysis] evidence: IMP GeneID:6868 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:6868 -> Biological process: GO:0007155 [cell adhesion] evidence: IDA GeneID:6868 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: IDA GeneID:6868 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS GeneID:6868 -> Biological process: GO:0007219 [Notch signaling pathway] evidence: IEA GeneID:6868 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IMP GeneID:6868 -> Biological process: GO:0010820 [positive regulation of T cell chemotaxis] evidence: IMP GeneID:6868 -> Biological process: GO:0022617 [extracellular matrix disassembly] evidence: TAS GeneID:6868 -> Biological process: GO:0030183 [B cell differentiation] evidence: ISS GeneID:6868 -> Biological process: GO:0030198 [extracellular matrix organization] evidence: TAS GeneID:6868 -> Biological process: GO:0030307 [positive regulation of cell growth] evidence: IMP GeneID:6868 -> Biological process: GO:0030335 [positive regulation of cell migration] evidence: IMP GeneID:6868 -> Biological process: GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] evidence: ISS GeneID:6868 -> Biological process: GO:0030574 [collagen catabolic process] evidence: TAS GeneID:6868 -> Biological process: GO:0031293 [membrane protein intracellular domain proteolysis] evidence: TAS GeneID:6868 -> Biological process: GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] evidence: IDA GeneID:6868 -> Biological process: GO:0032496 [response to lipopolysaccharide] evidence: IDA GeneID:6868 -> Biological process: GO:0032717 [negative regulation of interleukin-8 production] evidence: IMP GeneID:6868 -> Biological process: GO:0032722 [positive regulation of chemokine production] evidence: IMP GeneID:6868 -> Biological process: GO:0033025 [regulation of mast cell apoptotic process] evidence: ISS GeneID:6868 -> Biological process: GO:0033077 [T cell differentiation in thymus] evidence: ISS GeneID:6868 -> Biological process: GO:0033627 [cell adhesion mediated by integrin] evidence: IDA GeneID:6868 -> Biological process: GO:0035313 [wound healing, spreading of epidermal cells] evidence: IEP GeneID:6868 -> Biological process: GO:0035625 [epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway] evidence: IMP GeneID:6868 -> Biological process: GO:0042493 [response to drug] evidence: ISS GeneID:6868 -> Biological process: GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity] evidence: IDA GeneID:6868 -> Biological process: GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity] evidence: IMP GeneID:6868 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS GeneID:6868 -> Biological process: GO:0048536 [spleen development] evidence: ISS GeneID:6868 -> Biological process: GO:0048870 [cell motility] evidence: ISS GeneID:6868 -> Biological process: GO:0051088 [PMA-inducible membrane protein ectodomain proteolysis] evidence: IDA GeneID:6868 -> Biological process: GO:0051088 [PMA-inducible membrane protein ectodomain proteolysis] evidence: IMP GeneID:6868 -> Biological process: GO:0051272 [positive regulation of cellular component movement] evidence: ISS GeneID:6868 -> Biological process: GO:0055099 [response to high density lipoprotein particle stimulus] evidence: IDA GeneID:6868 -> Biological process: GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] evidence: TAS GeneID:6868 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS GeneID:6868 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA GeneID:6868 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS GeneID:6868 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: IDA GeneID:6868 -> Cellular component: GO:0005911 [cell-cell junction] evidence: IDA GeneID:6868 -> Cellular component: GO:0005925 [focal adhesion] evidence: IDA GeneID:6868 -> Cellular component: GO:0009986 [cell surface] evidence: IDA GeneID:6868 -> Cellular component: GO:0015629 [actin cytoskeleton] evidence: IDA GeneID:6868 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IDA GeneID:6868 -> Cellular component: GO:0032587 [ruffle membrane] evidence: IDA GeneID:6868 -> Cellular component: GO:0045121 [membrane raft] evidence: IDA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_003174 -> EC 3.4.24.86
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