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2020-10-30 19:36:32, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_003177               5079 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens spleen tyrosine kinase (SYK), transcript variant 1,
            mRNA.
ACCESSION   NM_003177
VERSION     NM_003177.5  GI:293332490
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5079)
  AUTHORS   Yu,S., Huang,H., Iliuk,A., Wang,W.H., Jayasundera,K.B., Tao,W.A.,
            Post,C.B. and Geahlen,R.L.
  TITLE     Syk inhibits the activity of protein kinase A by phosphorylating
            tyrosine 330 of the catalytic subunit
  JOURNAL   J. Biol. Chem. 288 (15), 10870-10881 (2013)
   PUBMED   23447535
  REMARK    GeneRIF: PKA is a novel substrate of Syk, and its phosphorylation
            on Tyr-330 inhibits its participation in downstream signaling
            pathways.
REFERENCE   2  (bases 1 to 5079)
  AUTHORS   Kim,Y., Kong,M. and Lee,C.
  TITLE     Association of intronic sequence variant in the gene encoding
            spleen tyrosine kinase with susceptibility to vascular dementia
  JOURNAL   World J. Biol. Psychiatry 14 (3), 220-226 (2013)
   PUBMED   23480133
REFERENCE   3  (bases 1 to 5079)
  AUTHORS   Vallieres,F. and Girard,D.
  TITLE     IL-21 enhances phagocytosis in mononuclear phagocyte cells:
            identification of spleen tyrosine kinase as a novel molecular
            target of IL-21
  JOURNAL   J. Immunol. 190 (6), 2904-2912 (2013)
   PUBMED   23396946
  REMARK    GeneRIF: Spleen tyrosine kinase (Syk) is a novel and important
            target of interleukin (IL)-21 for enhancing phagocytosis.
REFERENCE   4  (bases 1 to 5079)
  AUTHORS   Hussain,A., Mohammad,D.K., Gustafsson,M.O., Uslu,M., Hamasy,A.,
            Nore,B.F., Mohamed,A.J. and Smith,C.I.
  TITLE     Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK
            (spleen tyrosine kinase) fusion kinase is dependent on adapter
            SLP-76 and on the adapter function of the kinases SYK and ZAP70
  JOURNAL   J. Biol. Chem. 288 (10), 7338-7350 (2013)
   PUBMED   23293025
  REMARK    GeneRIF: Data indicate that the intracellular signaling of ITK-SYK
            requires both SLP-76 and the adapter function of SYK/ZAP-70
            kinases.
REFERENCE   5  (bases 1 to 5079)
  AUTHORS   Romero-Camarero,I., Jiang,X., Natkunam,Y., Lu,X.,
            Vicente-Duenas,C., Gonzalez-Herrero,I., Flores,T., Garcia,J.L.,
            McNamara,G., Kunder,C., Zhao,S., Segura,V., Fontan,L.,
            Martinez-Climent,J.A., Garcia-Criado,F.J., Theis,J.D., Dogan,A.,
            Campos-Sanchez,E., Green,M.R., Alizadeh,A.A., Cobaleda,C.,
            Sanchez-Garcia,I. and Lossos,I.S.
  TITLE     Germinal centre protein HGAL promotes lymphoid hyperplasia and
            amyloidosis via BCR-mediated Syk activation
  JOURNAL   Nat Commun 4, 1338 (2013)
   PUBMED   23299888
  REMARK    GeneRIF: the germinal centre protein human germinal
            centre-associated lymphoma regulates B-cell receptor signalling in
            B-lymphocytes which, without appropriate control, may lead to
            B-cell lymphoproliferation.
REFERENCE   6  (bases 1 to 5079)
  AUTHORS   Chan,A.C., Iwashima,M., Turck,C.W. and Weiss,A.
  TITLE     ZAP-70: a 70 kd protein-tyrosine kinase that associates with the
            TCR zeta chain
  JOURNAL   Cell 71 (4), 649-662 (1992)
   PUBMED   1423621
REFERENCE   7  (bases 1 to 5079)
  AUTHORS   Hutchcroft,J.E., Harrison,M.L. and Geahlen,R.L.
  TITLE     Association of the 72-kDa protein-tyrosine kinase PTK72 with the B
            cell antigen receptor
  JOURNAL   J. Biol. Chem. 267 (12), 8613-8619 (1992)
   PUBMED   1569106
REFERENCE   8  (bases 1 to 5079)
  AUTHORS   Yannoukakos,D., Meyer,H.E., Vasseur,C., Driancourt,C., Wajcman,H.
            and Bursaux,E.
  TITLE     Three regions of erythrocyte band 3 protein are phosphorylated on
            tyrosines: characterization of the phosphorylation sites by solid
            phase sequencing combined with capillary electrophoresis
  JOURNAL   Biochim. Biophys. Acta 1066 (1), 70-76 (1991)
   PUBMED   2065070
REFERENCE   9  (bases 1 to 5079)
  AUTHORS   Yannoukakos,D., Vasseur,C., Piau,J.P., Wajcman,H. and Bursaux,E.
  TITLE     Phosphorylation sites in human erythrocyte band 3 protein
  JOURNAL   Biochim. Biophys. Acta 1061 (2), 253-266 (1991)
   PUBMED   1998697
REFERENCE   10 (bases 1 to 5079)
  AUTHORS   Kim,J.W., Sim,S.S., Kim,U.H., Nishibe,S., Wahl,M.I., Carpenter,G.
            and Rhee,S.G.
  TITLE     Tyrosine residues in bovine phospholipase C-gamma phosphorylated by
            the epidermal growth factor receptor in vitro
  JOURNAL   J. Biol. Chem. 265 (7), 3940-3943 (1990)
   PUBMED   1689310
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB458719.1, AK290927.1,
            BC011399.1, BC001645.2, AL354862.12 and W33104.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Apr 2, 2010 this sequence version replaced gi:205277433.
            
            Summary: This gene encodes a member of the family of non-receptor
            type Tyr protein kinases. This protein is widely expressed in
            hematopoietic cells and is involved in coupling activated
            immunoreceptors to downstream signaling events that mediate diverse
            cellular responses, including proliferation, differentiation, and
            phagocytosis. It is thought to be a modulator of epithelial cell
            growth and a potential tumour suppressor in human breast
            carcinomas. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Mar 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1 and 3 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001645.2, L28824.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               DB458719.1         51-156
            107-1701            AK290927.1         1-1595
            1702-2436           BC011399.1         1532-2266
            2437-2715           BC001645.2         2379-2657
            2716-4937           AL354862.12        145283-147504
            4938-5079           W33104.1           1-142               c
FEATURES             Location/Qualifiers
     source          1..5079
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22"
     gene            1..5079
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="spleen tyrosine kinase"
                     /db_xref="GeneID:6850"
                     /db_xref="HGNC:11491"
                     /db_xref="HPRD:02514"
                     /db_xref="MIM:600085"
     exon            1..164
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       69
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199721697"
     variation       77
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200712879"
     variation       92
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201472772"
     variation       126
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199778155"
     variation       145
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200900798"
     variation       156
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142604132"
     variation       162
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199939971"
     exon            165..622
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       177
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200237145"
     variation       185
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201338526"
     variation       193
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201341126"
     variation       194
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200373424"
     misc_feature    200..202
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="upstream in-frame stop codon"
     CDS             206..2113
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tyrosine-protein kinase SYK"
                     /codon_start=1
                     /product="tyrosine-protein kinase SYK isoform 1"
                     /protein_id="NP_003168.2"
                     /db_xref="GI:21361553"
                     /db_xref="CCDS:CCDS6688.1"
                     /db_xref="GeneID:6850"
                     /db_xref="HGNC:11491"
                     /db_xref="HPRD:02514"
                     /db_xref="MIM:600085"
                     /translation="
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
"
     misc_feature    242..553
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="N-terminal Src homology 2 (SH2) domain found in
                     Zeta-chain-associated protein kinase 70 (ZAP-70) and
                     Spleen tyrosine kinase (Syk) proteins; Region:
                     SH2_N-SH2_Zap70_Syk_like; cd09938"
                     /db_xref="CDD:198191"
     misc_feature    order(269..271,329..331,392..394,398..400)
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198191"
     misc_feature    287..289
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    335..337
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P43405.1); phosphorylation site"
     misc_feature    344..346
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    order(395..397,431..436,440..442,497..502)
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198191"
     misc_feature    527..706
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P43405.1);
                     Region: Interdomain A"
     misc_feature    596..598
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    596..598
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01301"
     misc_feature    596..598
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02514"
     misc_feature    695..991
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="C-terminal Src homology 2 (SH2) domain found in
                     Spleen tyrosine kinase (Syk) proteins; Region:
                     SH2_C-SH2_Syk_like; cd10401"
                     /db_xref="CDD:198264"
     misc_feature    order(728..730,788..790,794..796,848..850,854..856)
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198264"
     misc_feature    809..811
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P43405.1); phosphorylation site"
     misc_feature    order(851..853,887..889,896..898,953..955)
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198264"
     misc_feature    971..973
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    983..1315
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P43405.1);
                     Region: Interdomain B"
     misc_feature    1088..1090
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P43405.1); phosphorylation site"
     misc_feature    1091..1093
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1091..1093
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1094..1096
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P43405.1); phosphorylation site"
     misc_feature    1151..1153
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P43405.1); phosphorylation site"
     misc_feature    1154..1156
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1160..1162
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P43405.1); phosphorylation site"
     misc_feature    1172..1174
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by LYN; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1172..1174
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02514"
     misc_feature    1238..1240
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1247..1249
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1247..1249
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02514"
     misc_feature    1253..1255
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P43405.1); phosphorylation site"
     misc_feature    1259..1261
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1259..1261
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02514"
     misc_feature    1295..1297
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1325..2083
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="Protein tyrosine kinase; Region: Pkinase_Tyr;
                     pfam07714"
                     /db_xref="CDD:203736"
     misc_feature    1328..2098
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Spleen tyrosine kinase; Region: PTKc_Syk; cd05116"
                     /db_xref="CDD:133247"
     misc_feature    order(1334..1348,1358..1360,1403..1405,1409..1411,
                     1502..1504,1547..1558,1565..1570,1685..1687,1697..1702,
                     1706..1708,1739..1741,1796..1810,1835..1837,1937..1939)
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="active site"
                     /db_xref="CDD:133247"
     misc_feature    order(1334..1339,1358..1360,1403..1405,1409..1411,
                     1502..1504,1547..1558,1565..1570,1697..1702,1706..1708,
                     1736..1741)
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:133247"
     misc_feature    1340..1342
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P43405.1); phosphorylation site"
     misc_feature    1355..1357
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1655..1657
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    order(1685..1687,1697..1699,1796..1810,1835..1837,
                     1937..1939)
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:133247"
     misc_feature    1724..1726
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1736..1816
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:133247"
     misc_feature    1778..1780
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1778..1780
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02514"
     misc_feature    1781..1783
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1781..1783
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02514"
     misc_feature    1793..1795
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1907..1909
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1940..1942
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P43405.1); phosphorylation site"
     misc_feature    1949..1951
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    2090..2092
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    2093..2095
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    2096..2098
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     variation       209
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201301123"
     variation       217
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199823436"
     variation       218
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146743944"
     variation       222
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201350143"
     variation       232
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201458538"
     variation       233
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199606629"
     variation       256
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200626943"
     variation       270
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140421546"
     variation       271
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139401525"
     variation       286
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200577589"
     variation       302
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201364101"
     STS             306..530
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /standard_name="STS-S80267"
                     /db_xref="UniSTS:70625"
     variation       334
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35758162"
     variation       339
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:16906862"
     variation       340
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201774526"
     variation       352
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:140490837"
     variation       358
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200928765"
     variation       367
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150440676"
     variation       368
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200078199"
     variation       376
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371908826"
     variation       397
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138271353"
     variation       399
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149603234"
     variation       417
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:146786995"
     variation       420
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200175081"
     variation       427
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139316651"
     variation       433
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202064642"
     variation       436
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200362424"
     variation       447
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201374653"
     variation       456
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199818587"
     variation       461
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201455170"
     variation       464
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201177148"
     variation       468
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78791900"
     variation       475
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199646361"
     variation       495
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200223184"
     variation       516
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200453337"
     variation       533
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202043759"
     variation       534
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375028044"
     variation       541
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143342183"
     variation       615
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200097669"
     variation       619
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142980255"
     exon            623..783
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       634
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199932327"
     variation       637
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370551918"
     variation       644
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373730562"
     variation       679
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200921683"
     variation       712
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147347882"
     variation       749
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200476529"
     variation       775
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:148413110"
     variation       778
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201529865"
     exon            784..922
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       832
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202000893"
     variation       850
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201867954"
     variation       892
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199938327"
     variation       893
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200498885"
     variation       912
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201857010"
     variation       913
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200087795"
     exon            923..1001
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       937
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201907766"
     variation       942
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184127752"
     variation       964
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34489331"
     variation       980
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201538038"
     variation       989
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:112619650"
     variation       992
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199886319"
     exon            1002..1051
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       1021
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201662709"
     variation       1023
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139520862"
     variation       1024
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55920107"
     variation       1027
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200859639"
     variation       1049
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377620701"
     variation       1050
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201994789"
     variation       1051
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199908671"
     exon            1052..1120
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       1063
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200313175"
     variation       1068
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143341039"
     variation       1110
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201228592"
     exon            1121..1208
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       1126
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146732805"
     variation       1137
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199612745"
     variation       1142
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200684262"
     variation       1143
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201840933"
     variation       1144
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199745532"
     variation       1171
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200697355"
     variation       1191
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201358181"
     exon            1209..1386
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       1209
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139388374"
     variation       1212
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200099811"
     variation       1214
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144168552"
     variation       1218
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56071116"
     variation       1224
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200994798"
     variation       1226
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200409467"
     variation       1249
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142936514"
     variation       1261
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41274652"
     variation       1262
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200167353"
     variation       1263
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201479078"
     variation       1264
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377587992"
     variation       1270
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2290890"
     variation       1280
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200418715"
     variation       1286
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201460357"
     variation       1305
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199772052"
     variation       1312
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376461830"
     variation       1317
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369986984"
     variation       1318
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151053124"
     variation       1328
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201179887"
     variation       1348
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:67128367"
     exon            1387..1596
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       1399
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375613854"
     variation       1409
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:79190821"
     variation       1423
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202093746"
     STS             1438..1694
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /standard_name="SYK-1"
                     /db_xref="UniSTS:513716"
     variation       1439
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201438493"
     variation       1474
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200930117"
     variation       1498
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141000507"
     variation       1501
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202166418"
     variation       1507
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2290888"
     variation       1513
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201416422"
     variation       1522
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202191431"
     variation       1523
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200202947"
     variation       1543
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2290887"
     variation       1561
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199712945"
     variation       1570
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143304676"
     exon            1597..1786
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       1614
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201930376"
     variation       1630
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200072255"
     variation       1636
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56285406"
     variation       1637
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201724218"
     variation       1649
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200456955"
     variation       1653
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147125933"
     variation       1690
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200991736"
     variation       1702
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2306042"
     variation       1726
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2306041"
     variation       1732
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201341572"
     variation       1735
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202069669"
     variation       1738
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200251333"
     variation       1744
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34231418"
     variation       1750
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2306040"
     variation       1763
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200320837"
     exon            1787..1927
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       1798
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200628553"
     variation       1815
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371627100"
     variation       1822
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201650753"
     variation       1828
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201516360"
     variation       1843
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201065688"
     variation       1860
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199801793"
     variation       1864
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141667926"
     variation       1915
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200957611"
     variation       1926
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201765057"
     exon            1928..2040
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       1930
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201336985"
     variation       1951
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139024468"
     variation       1952
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369492720"
     variation       1975
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149469439"
     variation       2012
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200438123"
     variation       2038
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201360872"
     exon            2041..5073
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     STS             2046..2793
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /standard_name="SYK_1884"
                     /db_xref="UniSTS:281037"
     variation       2056
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202024803"
     variation       2057
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200612476"
     variation       2062
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374945682"
     variation       2063
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139348511"
     variation       2068
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:145685109"
     variation       2086
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200834108"
     variation       2088
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150998279"
     variation       2101
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201364356"
     variation       2104
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200148300"
     variation       2107
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200682995"
     variation       2115
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201520390"
     variation       2116
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199607948"
     variation       2139
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201191948"
     variation       2147
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201001425"
     variation       2154
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202243160"
     variation       2183
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200070739"
     variation       2208
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201179148"
     variation       2212
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202035242"
     variation       2213
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191082286"
     variation       2230
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201474800"
     variation       2247
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202088785"
     variation       2294
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200443955"
     variation       2301
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201367588"
     variation       2302
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113175204"
     variation       2313
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200786369"
     variation       2314
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201177252"
     variation       2328
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199644752"
     variation       2333
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56139234"
     variation       2339
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1804251"
     variation       2353
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201615361"
     variation       2362
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200080967"
     variation       2378
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200817268"
     variation       2379
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182865904"
     variation       2401
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187420975"
     variation       2434
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199888968"
     variation       2435
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201168587"
     variation       2437
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1049164"
     STS             2443..2583
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /standard_name="WI-18899"
                     /db_xref="UniSTS:28988"
     variation       2455
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199927091"
     STS             2470..2599
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /standard_name="RH69035"
                     /db_xref="UniSTS:21128"
     variation       2504
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200937477"
     variation       2528
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202179400"
     variation       2530
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200478377"
     variation       2533
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41309340"
     variation       2553
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201184094"
     variation       2563
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202018238"
     variation       2579
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:14979"
     variation       2583
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1804252"
     variation       2586
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201236332"
     variation       2587
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41313849"
     variation       2613..2614
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34237652"
     variation       2627
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:3087507"
     polyA_signal    2629..2634
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
     variation       2635
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113304691"
     variation       2649
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201054834"
     variation       2650
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3087508"
     variation       2656
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3087506"
     polyA_site      2660
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
     variation       2671
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199807708"
     variation       2716..2717
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:113920845"
     variation       2716
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200854897"
     variation       2719
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:57651872"
     variation       2720
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201993887"
     variation       2749
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199584610"
     variation       2751
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113580142"
     variation       2760
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201935229"
     variation       2771
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200082519"
     variation       2801
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200996064"
     variation       2818
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:192822491"
     variation       2827
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201640049"
     variation       2830
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199893313"
     variation       2831
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201228319"
     variation       2846
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202208832"
     variation       2859
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200250756"
     variation       2865
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200788246"
     variation       2872
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201901573"
     variation       2924
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200306296"
     variation       2971
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201170015"
     variation       2972
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199593787"
     variation       2978
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200233293"
     variation       3000
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201530364"
     variation       3010
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199757614"
     variation       3017
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200639366"
     variation       3025
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201656525"
     variation       3026
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140271666"
     variation       3044
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200271297"
     variation       3046
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201996237"
     variation       3059
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199910798"
     variation       3060
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201033897"
     variation       3072
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201904421"
     variation       3078
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200062335"
     variation       3085
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:158688"
     variation       3104
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201766681"
     variation       3119
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184864847"
     variation       3128
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201197144"
     variation       3132
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202205240"
     variation       3176
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200418572"
     variation       3177
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201475559"
     variation       3178
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376917555"
     variation       3181
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202172624"
     variation       3183
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12344755"
     variation       3209
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:158687"
     variation       3240
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199614233"
     variation       3242
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:74847439"
     variation       3251
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138070207"
     variation       3265
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:10512203"
     variation       3267
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113367349"
     variation       3303
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200684900"
     variation       3305
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201846169"
     variation       3310
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:158686"
     variation       3311
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200678129"
     variation       3313
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201507403"
     variation       3329
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199954919"
     variation       3331
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201129087"
     variation       3343
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202170530"
     variation       3356
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200092376"
     variation       3361
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201067892"
     STS             3366..3454
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
     variation       3368
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202049478"
     variation       3375
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200169491"
     variation       3376
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201483217"
     variation       3377
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:202087399"
     STS             3385..3495
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /standard_name="D10S275"
                     /db_xref="UniSTS:147992"
     variation       3393
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:192259837"
     variation       3396
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201450125"
     variation       3432
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199763889"
     variation       3433
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200961449"
     variation       3454
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201471258"
     variation       3472
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199623121"
     variation       3478
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200404562"
     variation       3479
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:158685"
     variation       3487
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200068159"
     variation       3489
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200689319"
     variation       3494
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138672587"
     variation       3509
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183960220"
     variation       3513
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189425165"
     variation       3526
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142720783"
     variation       3527
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199842566"
     variation       3535
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201341496"
     variation       3545
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201770050"
     variation       3558
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199924149"
     variation       3559..3563
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace=""
                     /replace="aactt"
                     /db_xref="dbSNP:368223574"
     variation       3559
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200933262"
     variation       3561
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202178674"
     variation       3566
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200488395"
     variation       3638
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201111768"
     variation       3639
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:5021552"
     variation       3659
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202189825"
     variation       3662
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371047374"
     variation       3663
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115363876"
     variation       3681
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192548937"
     variation       3684
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199783989"
     variation       3693
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184355645"
     variation       3714
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201058837"
     variation       3727
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:189146244"
     variation       3739
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199768164"
     variation       3752
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:181141508"
     variation       3759
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201774920"
     variation       3783
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186279193"
     variation       3789
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200592316"
     variation       3797
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201934148"
     variation       3815
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200079558"
     variation       3827
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112868894"
     variation       3894
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201711043"
     variation       3914
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199822713"
     variation       3917
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201323598"
     variation       3934
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202054985"
     variation       3938
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200437396"
     variation       3946
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:17568705"
     variation       3947
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201899168"
     variation       3963
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200311317"
     variation       3981
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201177408"
     variation       3985..3986
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:35758629"
     variation       4000
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199604777"
     variation       4011
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200219989"
     variation       4027
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201716941"
     variation       4033
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199714639"
     variation       4079
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148015317"
     variation       4080
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200634194"
     variation       4086
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201655256"
     variation       4092
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199537078"
     variation       4095
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371399205"
     variation       4097
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200782311"
     variation       4107
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201768739"
     variation       4118
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199976134"
     variation       4148
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200655648"
     variation       4176
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202076504"
     variation       4184
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:10217275"
     variation       4186
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200864082"
     variation       4187
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:111798674"
     variation       4200
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201771764"
     variation       4203
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199911137"
     variation       4207
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200984283"
     variation       4212
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202058374"
     variation       4216
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200440991"
     variation       4241
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115781501"
     variation       4248
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202241782"
     variation       4259
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200430210"
     variation       4260
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201413796"
     variation       4286
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199603436"
     variation       4294
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200481350"
     variation       4313
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201775735"
     variation       4319
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199695443"
     variation       4343
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200815743"
     variation       4350
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114553487"
     variation       4359
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199914885"
     variation       4365
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200680066"
     variation       4375
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201514338"
     variation       4389
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199958969"
     variation       4422
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200795833"
     variation       4436
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73650275"
     variation       4505
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368631722"
     variation       4506
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200073109"
     variation       4514
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201185795"
     variation       4516
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202006211"
     variation       4540
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13559"
     variation       4542
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:72729087"
     variation       4548
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201467820"
     variation       4550
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202131391"
     variation       4557
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200305022"
     variation       4572
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201342619"
     variation       4610
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199804824"
     variation       4621
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200863208"
     variation       4622
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201618755"
     variation       4628
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199633431"
     variation       4629
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:117866558"
     variation       4631
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201616726"
     variation       4638
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199774700"
     variation       4643
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141926409"
     variation       4664
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201639704"
     variation       4665
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199863553"
     variation       4679
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201200597"
     variation       4702
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201761264"
     variation       4728
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199956562"
     variation       4729
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200907814"
     variation       4743
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202165739"
     variation       4751
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200362937"
     variation       4758
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201255894"
     variation       4773
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202010594"
     variation       4780
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200244210"
     variation       4783
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201537770"
     variation       4790
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199792221"
     variation       4794
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200278333"
     variation       4797
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:189965276"
     variation       4798
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199848843"
     variation       4816
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200863059"
     variation       4850
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367775503"
     STS             4854..4989
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /standard_name="RH91425"
                     /db_xref="UniSTS:84312"
     variation       4875
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201987311"
     variation       4882
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199576591"
     STS             4892..5025
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /standard_name="D9S2062"
                     /db_xref="UniSTS:2175"
     variation       4916
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77417541"
     variation       4938
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:8773"
     variation       4978
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200056866"
     variation       5002
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150672706"
     variation       5028
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201710784"
     variation       5031
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199868385"
     variation       5034
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201205439"
     variation       5037
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202207011"
     variation       5040
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200425328"
     polyA_signal    5044..5049
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
     polyA_site      5073
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
ORIGIN      
acactgggaggaagtgcgggccgcctgcccgggcgcgttaaggaagttgcccaaaatgaggaagagccgcgggcccggcggctgaggccaccccggcggcggctggagagcgaggaggagcgggtggccccgcgctgcgcccgccctcgcctcacctggcgcaggtggacacctgcgcaggtgtgtgccctccggcccctgaagcatggccagcagcggcatggctgacagcgccaaccacctgcccttctttttcggcaacatcacccgggaggaggcagaagattacctggtccaggggggcatgagtgatgggctttatttgctgcgccagagccgcaactacctgggtggcttcgccctgtccgtggcccacgggaggaaggcacaccactacaccatcgagcgggagctgaatggcacctacgccatcgccggtggcaggacccatgccagccccgccgacctctgccactaccactcccaggagtctgatggcctggtctgcctcctcaagaagcccttcaaccggccccaaggggtgcagcccaagactgggccctttgaggatttgaaggaaaacctcatcagggaatatgtgaagcagacatggaacctgcagggtcaggctctggagcaggccatcatcagtcagaagcctcagctggagaagctgatcgctaccacagcccatgaaaaaatgccttggttccatggaaaaatctctcgggaagaatctgagcaaattgtcctgataggatcaaagacaaatggaaagttcctgatccgagccagagacaacaacggctcctacgccctgtgcctgctgcacgaagggaaggtgctgcactatcgcatcgacaaagacaagacagggaagctctccatccccgagggaaagaagttcgacacgctctggcagctagtcgagcattattcttataaagcagatggtttgttaagagttcttactgtcccatgtcaaaaaatcggcacacagggaaatgttaattttggaggccgtccacaacttccaggttcccatcctgcgacttggtcagcgggtggaataatctcaagaatcaaatcatactccttcccaaagcctggccacagaaagtcctcccctgcccaagggaaccggcaagagagtactgtgtcattcaatccgtatgagccagaacttgcaccctgggctgcagacaaaggcccccagagagaagccctacccatggacacagaggtgtacgagagcccctacgcggaccccgaggagatcaggcccaaggaggtttacctggaccgaaagctgctgacgctggaagacaaagaactgggctctggtaattttggaactgtgaaaaagggctactaccaaatgaaaaaagttgtgaaaaccgtggctgtgaaaatactgaaaaacgaggccaatgaccccgctcttaaagatgagttattagcagaagcaaatgtcatgcagcagctggacaacccgtacatcgtgcggatgatcgggatatgcgaggccgagtcctggatgctggttatggagatggcagaacttggtcccctcaataagtatttgcagcagaacagacatgtcaaggataagaacatcatagaactggttcatcaggtttccatgggcatgaagtacttggaggagagcaattttgtgcacagagatctggctgcaagaaatgtgttgctagttacccaacattacgccaagatcagtgatttcggactttccaaagcactgcgtgctgatgaaaactactacaaggcccagacccatggaaagtggcctgtcaagtggtacgctccggaatgcatcaactactacaagttctccagcaaaagcgatgtctggagctttggagtgttgatgtgggaagcattctcctatgggcagaagccatatcgagggatgaaaggaagtgaagtcaccgctatgttagagaaaggagagcggatggggtgccctgcagggtgtccaagagagatgtacgatctcatgaatctgtgctggacatacgatgtggaaaacaggcccggattcgcagcagtggaactgcggctgcgcaattactactatgacgtggtgaactaaccgctcccgcacctgtcggtggctgcctttgatcacaggagcaatcacaggaaaatgtatccagaggaattgattgtcagccacctccctctgccagtcgggagagccaggcttggatggaacatgcccacaacttgtcacccaaagcctgtcccaggactcaccctccacaaagcaaaggcagtcccgggagaaaagacggatggcaggatccaaggggctagctggatttgtttgttttcttgtctgtgtgattttcatacaggttatttttacgatctgtttccaaatccctttcatgtctttccacttctctgggtcccggggtgcatttgttactcatcgggcccagggacattgcagagtggcctagagcactctcaccccaagcggccttttccaaatgcccaaggatgccttagcatgtgactcctgaagggaaggcaaaggcagaggaatttggctgcttctacggccatgagactgatccctggccactgaaaagctttcctgacaataaaaatgttttgaggctttaaaaagaaaatcaagtttgaccagtgcagtttctaagcatgtagccagttaaggaaagaaagaaagaaaaaaaaaaaaggcctggatactgcttttgctgtctctgttatgagatggaagacttacatgtttgtgataaaaggggaccatgagaatgaattggcttggcttactttccccctgaaatcctctctcctgcagactgtcttgaagacctggtgactggtaaataaagccctgcatggaggctgcacagcaggggcaagaggcccatcccccagcatctcactgaggacagcttcaggctgccttcctctgaacgtggtccacaccttcctctcctccacagagagggtgccgccagaatcccctgtcgctttctgtgtctgcaatggggggcagcacagggatcaaagccatctaaagagtttccaaagaaagtattaattcagaacaagccaaagaccctgagcctcaccacaaacaggccttttggagtgtgaatttgagttgaagatacaagatcggagaatgattttctggtcttaactaatcctcatcttcatgtttgatctttaagaagtcatcacccattgatttcagttttgctgtacctcttgaaagttaaagagacatctcagcactttaggaggccgaggcgggtggatcacttgaggtaaggagtttgagactagcctggccaatatggtaaaaccccatctctactaaaaatacaaaaattagccgggcatggtggcatgtgtctgtagtcccagctactcgggaggctgaggcaggagaatcgcttgaacccaggaaacggaggtcgcagtgagccaagatcatgccactgcactccagcttgggcatcacagcgagactctgtcaaaacaaacaaacaaaaaaacaacttaaagaggtaatttagccatcattcttatgccagcagatataaataaacttggacccatctggtcttcagctaaacctgagacattttaaagtgcatggacagccatggacagcaggccctcctctaacaggggatgcaaggcatggagaaagacaatcagtacccaagctcagccacagaagacaggagtcactcatataacttgtgtttagaagtttttggtagccacgcacactttctgaaatcacactatctggtggtttaatcatatttttaaagacagaatccctgagtgctgagcagattctcaaaacacatttagaatccctgaaattagaaagatcaatgacaaaatatctgtcagccaggccacaaacaggtgtaaaattatgaaaggagtggttggatgtgccaagtttggtaaagtggtgactgcatctgagaaagaggctgtgaggctgaactcttggtggcttccttctgtaacttccagagggagtcttcaacacaggccccgtgctcgtaggaatacggtagcacctatgtaggaagtgcgtggagttttctgtcttctttctgtgtgatttttggcctttttatcagcacttctcccctcccaggagcctggggatgccaaacatccagaatgtgatgggacaagatgggggcaggggcctcacctccctgcagaggtccggccaggtctccttgtccctggacaatctcctgagcctctctgcttggtggagcaggcacctgtgtgcagaattcccactgtggccagcacgaggaagtcttttctagtgaaaatgtgtcttgtggtcaggaataattatcctttcccctgtagccaccaaggagggcaaatagagaaaggtaacctaattgaaggattggtcatgtgaaaagggctacatttgggaagctgggaaaggcctccaggcttctagagcagctagcttgggctggattctcatacccaggctgccccttggattgttctacccaagcttttccctggggtctgggctcactccataaggtaaggtgccttttaccttatggtccttctttagcaggtaacaaaggagcatcaggggcaggctgccctggtggcatcacactggctagtgaggccgtgaatatcttgtcccccagcagggccgacagtttctatcacagaaaacagtgtgttcagtggtgaaaatcgttgcatgcatgttttcatctgagcgtgtccttctcccatactccctatcagccagccctgcctgtagctgctgtatggtgattgcacttggacatcagtccaatgactgcaagtcggcctggattttcacttgcagaggctacagctgcattgtcaggtctcccagccctgcagagagctccctccactggttagcagtgtgttgtgttttccattcatttcagaagagctacattgtgtcactggacatttttaaaaactgtgatttttaataaaaatttaaaatttgctttgtgatgaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:6850 -> Molecular function: GO:0004672 [protein kinase activity] evidence: NAS
            GeneID:6850 -> Molecular function: GO:0004713 [protein tyrosine kinase activity] evidence: EXP
            GeneID:6850 -> Molecular function: GO:0004713 [protein tyrosine kinase activity] evidence: TAS
            GeneID:6850 -> Molecular function: GO:0004715 [non-membrane spanning protein tyrosine kinase activity] evidence: IDA
            GeneID:6850 -> Molecular function: GO:0004715 [non-membrane spanning protein tyrosine kinase activity] evidence: TAS
            GeneID:6850 -> Molecular function: GO:0004716 [receptor signaling protein tyrosine kinase activity] evidence: IEA
            GeneID:6850 -> Molecular function: GO:0005178 [integrin binding] evidence: IPI
            GeneID:6850 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:6850 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:6850 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IEA
            GeneID:6850 -> Biological process: GO:0001525 [angiogenesis] evidence: IEA
            GeneID:6850 -> Biological process: GO:0001945 [lymph vessel development] evidence: ISS
            GeneID:6850 -> Biological process: GO:0002250 [adaptive immune response] evidence: ISS
            GeneID:6850 -> Biological process: GO:0002281 [macrophage activation involved in immune response] evidence: ISS
            GeneID:6850 -> Biological process: GO:0002283 [neutrophil activation involved in immune response] evidence: ISS
            GeneID:6850 -> Biological process: GO:0002366 [leukocyte activation involved in immune response] evidence: ISS
            GeneID:6850 -> Biological process: GO:0002554 [serotonin secretion by platelet] evidence: ISS
            GeneID:6850 -> Biological process: GO:0006468 [protein phosphorylation] evidence: ISS
            GeneID:6850 -> Biological process: GO:0007159 [leukocyte cell-cell adhesion] evidence: IDA
            GeneID:6850 -> Biological process: GO:0007167 [enzyme linked receptor protein signaling pathway] evidence: IEA
            GeneID:6850 -> Biological process: GO:0007229 [integrin-mediated signaling pathway] evidence: ISS
            GeneID:6850 -> Biological process: GO:0007229 [integrin-mediated signaling pathway] evidence: NAS
            GeneID:6850 -> Biological process: GO:0007257 [activation of JUN kinase activity] evidence: IEA
            GeneID:6850 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
            GeneID:6850 -> Biological process: GO:0008283 [cell proliferation] evidence: TAS
            GeneID:6850 -> Biological process: GO:0009887 [organ morphogenesis] evidence: TAS
            GeneID:6850 -> Biological process: GO:0010543 [regulation of platelet activation] evidence: ISS
            GeneID:6850 -> Biological process: GO:0018108 [peptidyl-tyrosine phosphorylation] evidence: IEA
            GeneID:6850 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
            GeneID:6850 -> Biological process: GO:0019370 [leukotriene biosynthetic process] evidence: IEA
            GeneID:6850 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
            GeneID:6850 -> Biological process: GO:0030593 [neutrophil chemotaxis] evidence: IDA
            GeneID:6850 -> Biological process: GO:0032928 [regulation of superoxide anion generation] evidence: ISS
            GeneID:6850 -> Biological process: GO:0033630 [positive regulation of cell adhesion mediated by integrin] evidence: ISS
            GeneID:6850 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
            GeneID:6850 -> Biological process: GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] evidence: TAS
            GeneID:6850 -> Biological process: GO:0042742 [defense response to bacterium] evidence: ISS
            GeneID:6850 -> Biological process: GO:0043306 [positive regulation of mast cell degranulation] evidence: IEA
            GeneID:6850 -> Biological process: GO:0043313 [regulation of neutrophil degranulation] evidence: ISS
            GeneID:6850 -> Biological process: GO:0043366 [beta selection] evidence: IEA
            GeneID:6850 -> Biological process: GO:0045087 [innate immune response] evidence: ISS
            GeneID:6850 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:6850 -> Biological process: GO:0045401 [positive regulation of interleukin-3 biosynthetic process] evidence: IEA
            GeneID:6850 -> Biological process: GO:0045425 [positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process] evidence: IEA
            GeneID:6850 -> Biological process: GO:0045579 [positive regulation of B cell differentiation] evidence: IEA
            GeneID:6850 -> Biological process: GO:0045588 [positive regulation of gamma-delta T cell differentiation] evidence: IEA
            GeneID:6850 -> Biological process: GO:0045780 [positive regulation of bone resorption] evidence: ISS
            GeneID:6850 -> Biological process: GO:0046638 [positive regulation of alpha-beta T cell differentiation] evidence: IEA
            GeneID:6850 -> Biological process: GO:0046641 [positive regulation of alpha-beta T cell proliferation] evidence: IEA
            GeneID:6850 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IEA
            GeneID:6850 -> Biological process: GO:0048514 [blood vessel morphogenesis] evidence: ISS
            GeneID:6850 -> Biological process: GO:0050715 [positive regulation of cytokine secretion] evidence: IEA
            GeneID:6850 -> Biological process: GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] evidence: IEA
            GeneID:6850 -> Biological process: GO:0050764 [regulation of phagocytosis] evidence: ISS
            GeneID:6850 -> Biological process: GO:0050850 [positive regulation of calcium-mediated signaling] evidence: IEA
            GeneID:6850 -> Biological process: GO:0050853 [B cell receptor signaling pathway] evidence: ISS
            GeneID:6850 -> Biological process: GO:0070372 [regulation of ERK1 and ERK2 cascade] evidence: ISS
            GeneID:6850 -> Biological process: GO:0071226 [cellular response to molecule of fungal origin] evidence: ISS
            GeneID:6850 -> Biological process: GO:0090237 [regulation of arachidonic acid secretion] evidence: ISS
            GeneID:6850 -> Biological process: GO:0090330 [regulation of platelet aggregation] evidence: ISS
            GeneID:6850 -> Cellular component: GO:0005829 [cytosol] evidence: IC
            GeneID:6850 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:6850 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:6850 -> Cellular component: GO:0019815 [B cell receptor complex] evidence: IEA
            GeneID:6850 -> Cellular component: GO:0032009 [early phagosome] evidence: ISS
            GeneID:6850 -> Cellular component: GO:0042101 [T cell receptor complex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_003168 -> EC 2.7.10.2

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.