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2024-03-29 15:41:34, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_003164               1834 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens syntaxin 5 (STX5), transcript variant 1, mRNA.
ACCESSION   NM_003164 XM_938340
VERSION     NM_003164.4  GI:347658917
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1834)
  AUTHORS   Nabeta,M., Abe,Y., Takaoka,Y., Kusanagi,Y. and Ito,M.
  TITLE     Identification of anti-syntaxin 5 autoantibody as a novel serum
            marker of endometriosis
  JOURNAL   J. Reprod. Immunol. 91 (1-2), 48-55 (2011)
   PUBMED   21715015
  REMARK    GeneRIF: serum anti-STX5 autoantibody, which was discovered by a
            proteomic approach, is a potential new serum marker for the
            diagnosis of endometriosis.
REFERENCE   2  (bases 1 to 1834)
  AUTHORS   Renna,M., Schaffner,C., Winslow,A.R., Menzies,F.M., Peden,A.A.,
            Floto,R.A. and Rubinsztein,D.C.
  TITLE     Autophagic substrate clearance requires activity of the syntaxin-5
            SNARE complex
  JOURNAL   J. Cell. Sci. 124 (PT 3), 469-482 (2011)
   PUBMED   21242315
  REMARK    GeneRIF: Depletion of syntaxin-5 complex components results in the
            accumulation of autophagosomes as a result of lysosomal
            dysfunction, leading to decreased degradation of autophagic
            substrates.
REFERENCE   3  (bases 1 to 1834)
  AUTHORS   Laufman,O., Kedan,A., Hong,W. and Lev,S.
  TITLE     Direct interaction between the COG complex and the SM protein,
            Sly1, is required for Golgi SNARE pairing
  JOURNAL   EMBO J. 28 (14), 2006-2017 (2009)
   PUBMED   19536132
  REMARK    GeneRIF: Study shows that the SM protein, Sly1, interacts directly
            with the conserved oligomeric Golgi (COG) tethering complex;
            Sly1-COG interaction is mediated by the Cog4 subunit, which also
            interacts with Syntaxin 5 through a different binding site.
REFERENCE   4  (bases 1 to 1834)
  AUTHORS   Diao,A., Frost,L., Morohashi,Y. and Lowe,M.
  TITLE     Coordination of golgin tethering and SNARE assembly: GM130 binds
            syntaxin 5 in a p115-regulated manner
  JOURNAL   J. Biol. Chem. 283 (11), 6957-6967 (2008)
   PUBMED   18167358
  REMARK    GeneRIF: depletion of GM130 by RNA interference slows the rate of
            ER to Golgi trafficking in vivo; interactions of GM130 with
            syntaxin 5 and Rab1 are regulated by mitotic phosphorylation
REFERENCE   5  (bases 1 to 1834)
  AUTHORS   Shestakova,A., Suvorova,E., Pavliv,O., Khaidakova,G. and
            Lupashin,V.
  TITLE     Interaction of the conserved oligomeric Golgi complex with t-SNARE
            Syntaxin5a/Sed5 enhances intra-Golgi SNARE complex stability
  JOURNAL   J. Cell Biol. 179 (6), 1179-1192 (2007)
   PUBMED   18086915
REFERENCE   6  (bases 1 to 1834)
  AUTHORS   Nichols,B.J. and Pelham,H.R.
  TITLE     SNAREs and membrane fusion in the Golgi apparatus
  JOURNAL   Biochim. Biophys. Acta 1404 (1-2), 9-31 (1998)
   PUBMED   9714710
  REMARK    Review article
REFERENCE   7  (bases 1 to 1834)
  AUTHORS   Hay,J.C., Klumperman,J., Oorschot,V., Steegmaier,M., Kuo,C.S. and
            Scheller,R.H.
  TITLE     Localization, dynamics, and protein interactions reveal distinct
            roles for ER and Golgi SNAREs
  JOURNAL   J. Cell Biol. 141 (7), 1489-1502 (1998)
   PUBMED   9647643
  REMARK    Erratum:[J Cell Biol 1998 Aug 10;142(3):following 881]
REFERENCE   8  (bases 1 to 1834)
  AUTHORS   Rabouille,C., Kondo,H., Newman,R., Hui,N., Freemont,P. and
            Warren,G.
  TITLE     Syntaxin 5 is a common component of the NSF- and p97-mediated
            reassembly pathways of Golgi cisternae from mitotic Golgi fragments
            in vitro
  JOURNAL   Cell 92 (5), 603-610 (1998)
   PUBMED   9506515
REFERENCE   9  (bases 1 to 1834)
  AUTHORS   Hay,J.C., Chao,D.S., Kuo,C.S. and Scheller,R.H.
  TITLE     Protein interactions regulating vesicle transport between the
            endoplasmic reticulum and Golgi apparatus in mammalian cells
  JOURNAL   Cell 89 (1), 149-158 (1997)
   PUBMED   9094723
REFERENCE   10 (bases 1 to 1834)
  AUTHORS   Ravichandran,V. and Roche,P.A.
  TITLE     Cloning and identification of human syntaxin 5 as a
            synaptobrevin/VAMP binding protein
  JOURNAL   J. Mol. Neurosci. 8 (2), 159-161 (1997)
   PUBMED   9188044
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB155395.1, U26648.1 and
            BE409085.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Sep 24, 2011 this sequence version replaced gi:94400931.
            
            Summary: This gene encodes a member of the syntaxin or t-SNARE
            (target-SNAP receptor) family. These proteins are found on cell
            membranes and serve as the targets for v-SNAREs (vesicle-SNAP
            receptors), permitting specific synaptic vesicle docking and
            fusion. The encoded protein regulates endoplasmic reticulum to
            Golgi transport and plays a critical role in autophagy.
            Autoantibodies targeting the encoded protein may be a diagnostic
            marker for endometriosis. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537426.1, BC012137.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-628               CB155395.1         1-628
            629-1553            U26648.1           336-1260
            1554-1834           BE409085.1         1-281               c
FEATURES             Location/Qualifiers
     source          1..1834
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..1834
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /note="syntaxin 5"
                     /db_xref="GeneID:6811"
                     /db_xref="HGNC:11440"
                     /db_xref="MIM:603189"
     exon            1..138
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    98..100
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /note="upstream in-frame stop codon"
     exon            139..382
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /inference="alignment:Splign:1.39.8"
     CDS             158..1225
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     syntaxin 5A"
                     /codon_start=1
                     /product="syntaxin-5 isoform 1"
                     /protein_id="NP_003155.2"
                     /db_xref="GI:94400932"
                     /db_xref="CCDS:CCDS8038.2"
                     /db_xref="GeneID:6811"
                     /db_xref="HGNC:11440"
                     /db_xref="MIM:603189"
                     /translation="
MIPRKRYGSKNTDQGVYLGLSKTQVLSPATAGSSSSDIAPLPPPVTLVPPPPDTMSCRDRTQEFLSACKSLQTRQNGIQTNKPALRAVRQRSEFTLMAKRIGKDLSNTFAKLEKLTILAKRKSLFDDKAVEIEELTYIIKQDINSLNKQIAQLQDFVRAKGSQSGRHLQTHSNTIVVSLQSKLASMSNDFKSVLEVRTENLKQQRSRREQFSRAPVSALPLAPNHLGGGAVVLGAESHASKDVAIDMMDSRTSQQLQLIDEQDSYIQSRADTMQNIESTIVELGSIFQQLAHMVKEQEETIQRIDENVLGAQLDVEAAHSEILKYFQSVTSNRWLMVKIFLILIVFFIIFVVFLA
"
     misc_feature    425..739
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /note="Syntaxin; Region: Syntaxin; pfam00804"
                     /db_xref="CDD:201451"
     misc_feature    953..1132
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /note="Soluble NSF (N-ethylmaleimide-sensitive fusion
                     protein)-Attachment protein (SNAP) REceptor domain; these
                     alpha-helical motifs form twisted and parallel
                     heterotetrameric helix bundles; the core complex contains
                     one helix from a protein that is anchored in...; Region:
                     t_SNARE; cd00193"
                     /db_xref="CDD:29155"
     misc_feature    order(1037..1039,1058..1060,1067..1069)
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /note="flanking leucine-zipper layers; other site"
                     /db_xref="CDD:29155"
     misc_feature    1046..1048
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /note="zero layer; other site"
                     /db_xref="CDD:29155"
     misc_feature    1157..1219
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13190.2);
                     transmembrane region"
     STS             186..306
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /standard_name="RH48793"
                     /db_xref="UniSTS:11266"
     variation       309
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3802945"
     exon            383..453
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /inference="alignment:Splign:1.39.8"
     exon            454..509
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /inference="alignment:Splign:1.39.8"
     exon            510..580
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /inference="alignment:Splign:1.39.8"
     exon            581..697
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /inference="alignment:Splign:1.39.8"
     variation       631
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2228627"
     exon            698..754
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /inference="alignment:Splign:1.39.8"
     exon            755..836
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /inference="alignment:Splign:1.39.8"
     exon            837..943
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /inference="alignment:Splign:1.39.8"
     exon            944..1065
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /inference="alignment:Splign:1.39.8"
     exon            1066..1834
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /inference="alignment:Splign:1.39.8"
     STS             1124..1814
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /standard_name="STX5A_8658"
                     /db_xref="UniSTS:468726"
     variation       1141
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:2228626"
     STS             1236..1476
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /standard_name="RH80822"
                     /db_xref="UniSTS:87760"
     variation       1430
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11557825"
     STS             1448..1594
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /standard_name="STS-U26648"
                     /db_xref="UniSTS:69568"
     STS             1464..1606
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /standard_name="G62080"
                     /db_xref="UniSTS:139223"
     variation       1579
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:10484"
     polyA_site      1797
                     /gene="STX5"
                     /gene_synonym="SED5; STX5A"
ORIGIN      
actgggggtggggttacgtgtaggtgacgtggccgcttccagtctttggtcgggtttcggcggcttcagtgctcggggaggaggcagtgacggccggtgagattggaagtggcggcggcggcaggcggcagaggggagtccgaggttatgcgtctcaatgatcccgcggaaacgctacgggtctaagaacacggatcagggtgtctacctgggtctctcaaagacacaggtcctgtcccctgcaactgctggcagtagcagcagcgacatcgcccctctgccccccccagtgaccctcgtccctccccctcccgacaccatgtcctgccgggatcggacccaggagtttctgtctgcctgcaagtcgctgcagacccgtcagaatggaatccagacaaataagccagctttgcgtgctgtccgacaacgcagtgaattcaccctcatggccaagcgcattgggaaagaccttagcaacacatttgccaagctggagaagctgacaatcttggcaaagcgcaagtccctctttgatgataaagcagtggaaattgaagagctaacatatatcatcaaacaggacatcaatagcctcaacaaacaaattgctcagctccaggatttcgtgagagccaagggcagccagagtggccggcacctgcagacccactccaacaccattgtggtctccttgcagtcgaaactggcttctatgtccaatgacttcaaatcggttttagaagtgaggacagagaacctgaagcagcagaggagccggagagagcagttctcccgggcacctgtgtcagccctgccccttgcccctaaccacctgggcggtggtgctgtggttctgggggcagagtcccatgcctccaaggatgtcgccatcgacatgatggactctcggaccagccagcagctgcagctcattgacgagcaggattcctacatccagagtcgggcagacaccatgcagaacattgagtcgacaattgttgagttgggctccatctttcagcagttggcacacatggttaaggaacaggaggaaaccattcagaggatcgacgagaacgtgctaggagcccagctggacgttgaggccgcccattcagagatcctcaagtacttccagtctgtcacctccaaccggtggctcatggtcaaaatcttcctcatcctcattgtcttcttcatcatctttgtggtcttccttgcttgaaccctctctactctgaggcactctgttggggtttgggaccctcctgggaaggcaagtggccagtgctgccactgagcctgtgcagggtacttgggagaaaggccctgtttccctggaactgctaagaatgaccactgcccctgatcccccaccccttgcctctggccaccctgtcctccccccaccaccctcaggcctatgaaacacacagggttctagatttgaactctgctgtgaagtgactggaagggagcagaggccagctgggggccagtgggggaggttgtttccactaggagatttttataaaccctctccagcctctcccaaaggaagcgttggcagcaaagggagatgatgcccttacccaccttcctgtgagtgaagagaggaagcagccccagggaccaattttcccaattgacctctttcttcctctttcaccatgtgaggcagggagccctgagcccttcagctgcctgcacaacccctgacattggctgctggtgactcaatctgccaaatgtgctgcagctcgttttctcccaattacagcaagactgtcagcctcactagccatgtcatcatttctgggtgggagcgtcgaag
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:6811 -> Molecular function: GO:0005484 [SNAP receptor activity] evidence: IDA
            GeneID:6811 -> Molecular function: GO:0047485 [protein N-terminus binding] evidence: IPI
            GeneID:6811 -> Biological process: GO:0006886 [intracellular protein transport] evidence: IEA
            GeneID:6811 -> Biological process: GO:0006888 [ER to Golgi vesicle-mediated transport] evidence: IEA
            GeneID:6811 -> Biological process: GO:0006903 [vesicle targeting] evidence: TAS
            GeneID:6811 -> Biological process: GO:0042147 [retrograde transport, endosome to Golgi] evidence: IDA
            GeneID:6811 -> Biological process: GO:0048280 [vesicle fusion with Golgi apparatus] evidence: IEA
            GeneID:6811 -> Cellular component: GO:0000139 [Golgi membrane] evidence: IEA
            GeneID:6811 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:6811 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:6811 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IEA
            GeneID:6811 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
            GeneID:6811 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
            GeneID:6811 -> Cellular component: GO:0031201 [SNARE complex] evidence: TAS
            GeneID:6811 -> Cellular component: GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] evidence: IEA

by @meso_cacase at DBCLS
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