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2024-04-23 21:09:32, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003161 5368 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens ribosomal protein S6 kinase, 70kDa, polypeptide 1
(RPS6KB1), transcript variant 1, mRNA.
ACCESSION NM_003161
VERSION NM_003161.3 GI:440546393
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5368)
AUTHORS Yoshida,S., Matsumoto,K., Arao,T., Taniguchi,H., Goto,I.,
Hanafusa,T., Nishio,K. and Yamada,Y.
TITLE Gene amplification of ribosomal protein S6 kinase-1 and -2 in
gastric cancer
JOURNAL Anticancer Res. 33 (2), 469-475 (2013)
PUBMED 23393338
REMARK GeneRIF: No amplification of S6K1 was detected in gastric cancer
tissues
REFERENCE 2 (bases 1 to 5368)
AUTHORS Ben-Hur,V., Denichenko,P., Siegfried,Z., Maimon,A., Krainer,A.,
Davidson,B. and Karni,R.
TITLE S6K1 alternative splicing modulates its oncogenic activity and
regulates mTORC1
JOURNAL Cell Rep 3 (1), 103-115 (2013)
PUBMED 23273915
REFERENCE 3 (bases 1 to 5368)
AUTHORS Zhao,X.F., Zhao,M.Y., Chai,L., Kukuruga,D., Tan,M. and Stass,S.A.
TITLE Amplified RPS6KB1 and CDC2 genes are potential biomarkers for
aggressive HIV+/EBV+ diffuse large B-cell lymphomas
JOURNAL Int J Clin Exp Pathol 6 (2), 148-154 (2013)
PUBMED 23330000
REMARK GeneRIF: HIV+/EBV+ aggressive diffuse large B-cell lymphoma could
be potentially treated by targeting RPS6KB1 and CDC2 genes.
REFERENCE 4 (bases 1 to 5368)
AUTHORS Rosner,M. and Hengstschlager,M.
TITLE Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms
p85 and p31, is regulated by TSC2/mTOR
JOURNAL Oncogene 30 (44), 4509-4522 (2011)
PUBMED 21602892
REFERENCE 5 (bases 1 to 5368)
AUTHORS Fenton,T.R. and Gout,I.T.
TITLE Functions and regulation of the 70kDa ribosomal S6 kinases
JOURNAL Int. J. Biochem. Cell Biol. 43 (1), 47-59 (2011)
PUBMED 20932932
REMARK GeneRIF: Dysregulation of S6 kinases contributes to the
pathogenesis of human diseases.
Review article
REFERENCE 6 (bases 1 to 5368)
AUTHORS Karni,R., de Stanchina,E., Lowe,S.W., Sinha,R., Mu,D. and
Krainer,A.R.
TITLE The gene encoding the splicing factor SF2/ASF is a proto-oncogene
JOURNAL Nat. Struct. Mol. Biol. 14 (3), 185-193 (2007)
PUBMED 17310252
REFERENCE 7 (bases 1 to 5368)
AUTHORS Couch,F.J., Wang,X.Y., Wu,G.J., Qian,J., Jenkins,R.B. and
James,C.D.
TITLE Localization of PS6K to chromosomal region 17q23 and determination
of its amplification in breast cancer
JOURNAL Cancer Res. 59 (7), 1408-1411 (1999)
PUBMED 10197603
REFERENCE 8 (bases 1 to 5368)
AUTHORS Moser,B.A., Dennis,P.B., Pullen,N., Pearson,R.B., Williamson,N.A.,
Wettenhall,R.E., Kozma,S.C. and Thomas,G.
TITLE Dual requirement for a newly identified phosphorylation site in
p70s6k
JOURNAL Mol. Cell. Biol. 17 (9), 5648-5655 (1997)
PUBMED 9271440
REFERENCE 9 (bases 1 to 5368)
AUTHORS Proud,C.G.
TITLE p70 S6 kinase: an enigma with variations
JOURNAL Trends Biochem. Sci. 21 (5), 181-185 (1996)
PUBMED 8871403
REMARK Review article
REFERENCE 10 (bases 1 to 5368)
AUTHORS Grove,J.R., Banerjee,P., Balasubramanyam,A., Coffer,P.J.,
Price,D.J., Avruch,J. and Woodgett,J.R.
TITLE Cloning and expression of two human p70 S6 kinase polypeptides
differing only at their amino termini
JOURNAL Mol. Cell. Biol. 11 (11), 5541-5550 (1991)
PUBMED 1922062
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BP359158.1, AK312875.1,
AC004686.2, AK297147.1 and CA444907.1.
This sequence is a reference standard in the RefSeqGene project.
On Jan 5, 2013 this sequence version replaced gi:55925648.
Summary: This gene encodes a member of the ribosomal S6 kinase
family of serine/threonine kinases. The encoded protein responds to
mTOR (mammalian target of rapamycin) signaling to promote protein
synthesis, cell growth, and cell proliferation. Activity of this
gene has been associated with human cancer. Alternatively spliced
transcript variants have been observed. The use of alternative
translation start sites results in isoforms with longer or shorter
N-termini which may differ in their subcellular localizations.
There are two pseudogenes for this gene on chromosome 17. [provided
by RefSeq, Jan 2013].
Transcript Variant: This variant (1) can initiate translation from
two alternate in-frame AUG start codons. The isoform represented in
this RefSeq (a, also known as p85 or alpha I) is derived from the
first AUG start codon, and is the longest isoform.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: M60724.1, AK312875.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-94 BP359158.1 1-94
95-610 AK312875.1 1-516
611-611 AC004686.2 28745-28745 c
612-1420 AK312875.1 518-1326
1421-2110 AK297147.1 1357-2046
2111-4918 AC004686.2 5281-8088 c
4919-5368 CA444907.1 1-450 c
FEATURES Location/Qualifiers
source 1..5368
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q23.1"
gene 1..5368
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="ribosomal protein S6 kinase, 70kDa, polypeptide 1"
/db_xref="GeneID:6198"
/db_xref="HGNC:10436"
/db_xref="HPRD:10202"
/db_xref="MIM:608938"
exon 1..280
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
misc_feature 86..88
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="upstream in-frame stop codon"
variation 134
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="g"
/replace="t"
/db_xref="dbSNP:373348379"
CDS 140..1717
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/EC_number="2.7.11.1"
/note="p85, alpha I; isoform a is encoded by transcript
variant 1; serine/threonine kinase 14 alpha; ribosomal
protein S6 kinase beta-1; ribosomal protein S6 kinase I;
p70 S6 kinase, alpha; serine/threonine-protein kinase 14A"
/codon_start=1
/product="ribosomal protein S6 kinase beta-1 isoform a"
/protein_id="NP_003152.1"
/db_xref="GI:4506737"
/db_xref="CCDS:CCDS11621.1"
/db_xref="GeneID:6198"
/db_xref="HGNC:10436"
/db_xref="HPRD:10202"
/db_xref="MIM:608938"
/translation="
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
"
misc_feature 209..211
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="p70, alpha II, isoform e; Region: Alternative start
codon"
misc_feature 221..235
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P23443.2);
Region: TOS motif"
misc_feature 410..1195
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:214567"
misc_feature 419..1387
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="Catalytic domain of the Protein Serine/Threonine
Kinase, 70 kDa ribosomal protein S6 kinase; Region:
STKc_p70S6K; cd05584"
/db_xref="CDD:173675"
misc_feature order(428..442,452..454,500..502,506..508,605..607,
653..658,662..664,674..676,680..682,791..793,797..799,
803..808,812..814,842..847,854..856,896..913,992..994,
1010..1012,1019..1021)
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="active site"
/db_xref="CDD:173675"
misc_feature order(428..442,452..454,500..502,506..508,605..607,
656..664,674..676,791..793,797..799,803..808,812..814,
842..847)
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173675"
misc_feature order(440..442,674..676,680..682,791..793,797..799,
803..805,854..856,896..913,992..994,1010..1012,1019..1021)
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173675"
misc_feature 842..913
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173675"
misc_feature 893..895
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by PDPK1; propagated from
UniProtKB/Swiss-Prot (P23443.2); phosphorylation site"
misc_feature 893..895
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[8]
/db_xref="HPRD:05556"
misc_feature 1049..1051
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P23443.2); acetylation site"
misc_feature 1307..1309
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[8]
misc_feature 1307..1309
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03134"
misc_feature 1307..1309
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01382"
misc_feature 1307..1309
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03954"
misc_feature 1319..1321
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="turn motif phosphorylation site [posttranslational
modification]; other site"
/db_xref="CDD:173675"
misc_feature 1319..1321
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P23443.2); phosphorylation site"
misc_feature 1319..1321
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03134"
misc_feature 1319..1321
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[8]
/db_xref="HPRD:00302"
misc_feature 1361..1378
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/note="hydrophobic motif (HM); other site"
/db_xref="CDD:173675"
misc_feature 1373..1375
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[8]
/db_xref="HPRD:05556"
misc_feature 1373..1375
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03134"
misc_feature 1409..1714
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P23443.2);
Region: Autoinhibitory domain"
misc_feature 1418..1420
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[8]
misc_feature 1439..1441
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[8]
/db_xref="HPRD:00302"
misc_feature 1460..1462
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P23443.2); phosphorylation site"
misc_feature 1460..1462
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[8]
misc_feature 1469..1471
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (P23443.2); phosphorylation site"
misc_feature 1478..1480
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P23443.2); phosphorylation site"
misc_feature 1493..1495
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P23443.2); phosphorylation site"
misc_feature 1547..1549
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[8]
variation 164
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:139530428"
variation 168
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="t"
/db_xref="dbSNP:201606773"
variation 248
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:142855919"
variation 250
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="c"
/db_xref="dbSNP:376390460"
variation 253
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:200955904"
variation 256
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:369943341"
variation 274
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:56376112"
exon 281..330
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
exon 331..451
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 332
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:200282847"
variation 338
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:369352640"
variation 394
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="c"
/db_xref="dbSNP:201788760"
exon 452..520
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 486
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:377332462"
variation 490
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:56010534"
exon 521..668
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 571
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="g"
/replace="t"
/db_xref="dbSNP:373972797"
variation 573
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:183590386"
variation 635
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:367762054"
exon 669..726
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 682
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:149835132"
variation 704
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:371239209"
exon 727..827
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 772
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:368534737"
variation 791..792
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="c"
/db_xref="dbSNP:34994293"
exon 828..918
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 844
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:372457945"
variation 871
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:376961948"
exon 919..1009
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 967
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:201582805"
variation 974
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:370044721"
variation 981
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:147955400"
exon 1010..1117
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 1054
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="c"
/db_xref="dbSNP:184521347"
variation 1069
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:373846364"
variation 1071
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:200443093"
exon 1118..1180
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 1120
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:370608471"
variation 1121
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="c"
/db_xref="dbSNP:373201580"
variation 1147
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:141890234"
exon 1181..1258
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 1255
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:367688464"
exon 1259..1366
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
exon 1367..1479
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 1472
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:201316437"
variation 1475
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:146927684"
exon 1480..5355
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/inference="alignment:Splign:1.39.8"
variation 1480
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:369106764"
variation 1589
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:137873345"
variation 1601
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:201664077"
STS 1632..1806
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/standard_name="D17S1554"
/db_xref="UniSTS:61668"
variation 1634
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:149039467"
variation 1642
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:143055403"
variation 1648
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:148223136"
variation 1684
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:373473920"
variation 1690
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:371306904"
variation 1754
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="g"
/replace="t"
/db_xref="dbSNP:369442815"
variation 1792..1793
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="aa"
/db_xref="dbSNP:76853887"
variation 1792
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="c"
/db_xref="dbSNP:200620649"
variation 1793..1794
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="a"
/replace="aa"
/db_xref="dbSNP:67846207"
variation 1793
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:25548"
variation 1821
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:144814059"
variation 1843
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:180515"
variation 1875
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="c"
/db_xref="dbSNP:193186563"
variation 1891..1892
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="aa"
/db_xref="dbSNP:71685029"
variation 1892
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:1051424"
variation 1914
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:112530345"
STS 1943..2292
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/standard_name="D17S1994"
/db_xref="UniSTS:6637"
STS 2068..2438
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/standard_name="MARC_10535-10536:1000147856:1"
/db_xref="UniSTS:267161"
variation 2225
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="t"
/db_xref="dbSNP:200194783"
variation 2290
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:11549046"
polyA_signal 2364..2369
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
polyA_site 2390
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
variation 2402
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="g"
/db_xref="dbSNP:67046002"
variation 2421..2422
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="g"
/db_xref="dbSNP:35627972"
variation 2477
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="a"
/db_xref="dbSNP:201868081"
variation 2496
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="g"
/replace="t"
/db_xref="dbSNP:372223764"
variation 3520
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="g"
/replace="t"
/db_xref="dbSNP:2158458"
variation 3562
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="c"
/db_xref="dbSNP:148571848"
variation 3590
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="a"
/db_xref="dbSNP:35485878"
variation 3599
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="t"
/db_xref="dbSNP:62081839"
variation 3600
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="t"
/db_xref="dbSNP:75120475"
variation 3735
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:183346732"
variation 3767..3768
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="a"
/db_xref="dbSNP:34975148"
variation 3856
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="c"
/db_xref="dbSNP:144391145"
variation 4240
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:375536815"
variation 4286
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:111430839"
variation 4356
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:11555598"
variation 4484
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="g"
/db_xref="dbSNP:369479523"
variation 4574
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="t"
/db_xref="dbSNP:34061743"
variation 4594
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="t"
/db_xref="dbSNP:34454406"
variation 4644
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:188457115"
variation 4774
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace=""
/replace="a"
/db_xref="dbSNP:139023905"
variation 4856
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:146705278"
variation 4913
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="t"
/db_xref="dbSNP:139176752"
STS 5018..5258
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/standard_name="RH69849"
/db_xref="UniSTS:15737"
variation 5065
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:192688444"
variation 5158
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:144027445"
variation 5256
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="c"
/replace="t"
/db_xref="dbSNP:373703630"
variation 5264
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:183658577"
polyA_signal 5328..5333
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
variation 5344
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
/replace="a"
/replace="g"
/db_xref="dbSNP:187967995"
polyA_site 5355
/gene="RPS6KB1"
/gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
ORIGIN
gtttggcttcacggaaccctgtacgcatgctcctacgctgaactttaggagccagtctaaggcctaggcgcagacgcactgagcctaagcagccggtgatggcggcagcggctgtggtggctgcggcgggtccgggcccatgaggcgacgaaggaggcgggacggcttttacccagccccggacttccgagacagggaagctgaggacatggcaggagtgtttgacatagacctggaccagccagaggacgcgggctctgaggatgagctggaggaggggggtcagttaaatgaaagcatggaccatgggggagttggaccatatgaacttggcatggaacattgtgagaaatttgaaatctcagaaactagtgtgaacagagggccagaaaaaatcagaccagaatgttttgagctacttcgggtacttggtaaagggggctatggaaaggtttttcaagtacgaaaagtaacaggagcaaatactgggaaaatatttgccatgaaggtgcttaaaaaggcaatgatagtaagaaatgctaaagatacagctcatacaaaagcagaacggaatattctggaggaagtaaagcatcccttcatcgtggatttaatttatgcctttcagactggtggaaaactctacctcatccttgagtatctcagtggaggagaactatttatgcagttagaaagagagggaatatttatggaagacactgcctgcttttacttggcagaaatctccatggctttggggcatttacatcaaaaggggatcatctacagagacctgaagccggagaatatcatgcttaatcaccaaggtcatgtgaaactaacagactttggactatgcaaagaatctattcatgatggaacagtcacacacacattttgtggaacaatagaatacatggcccctgaaatcttgatgagaagtggccacaatcgtgctgtggattggtggagtttgggagcattaatgtatgacatgctgactggagcacccccattcactggggagaatagaaagaaaacaattgacaaaatcctcaaatgtaaactcaatttgcctccctacctcacacaagaagccagagatctgcttaaaaagctgctgaaaagaaatgctgcttctcgtctgggagctggtcctggggacgctggagaagttcaagctcatccattctttagacacattaactgggaagaacttctggctcgaaaggtggagcccccctttaaacctctgttgcaatctgaagaggatgtaagtcagtttgattccaagtttacacgtcagacacctgtcgacagcccagatgactcaactctcagtgaaagtgccaatcaggtctttctgggttttacatatgtggctccatctgtacttgaaagtgtgaaagaaaagttttcctttgaaccaaaaatccgatcacctcgaagatttattggcagcccacgaacacctgtcagcccagtcaaattttctcctggggatttctggggaagaggtgcttcggccagcacagcaaatcctcagacacctgtggaatacccaatggaaacaagtggcatagagcagatggatgtgacaatgagtggggaagcatcggcaccacttccaatacgacagccgaactctgggccatacaaaaaacaagcttttcccatgatctccaaacggccagagcacctgcgtatgaatctatgacagagcaatgcttttaatgaatttaaggcaaaaaaggtggagagggagatgtgtgagcatcctgcaaggtgaaacgactcaaaatgacagtttcagagagtcaatgtcattacatagaacacttcagacacaggaaaaataaacgtggattttaaaaaatcaatcaatggtgcaaaaaaaaacttaaagcaaaatagtattgctgaactcttaggcacatcaattaattgattcctcgcgacatcttctcaaccttatcaaggattttcatgttgatgactcgaaactgacagtattaagggtaggatgttgcttctgaatcactgttgagttctgattgtgttgaagaagggttatcctttcattaggcaaagtacaaaattgcctataatacttgcaactaaggacaaattagcatgcaagcttggtcaaactttttccagcaaaatggaagcaaagacaaaagaaacttaccaattgatgttttacgtgcaaacaacctgaatcttttttttatataaatatatatttttcaaatagatttttgattcagctcattatgaaaaacatcccaaactttaaaatgcgaaattattggttggtgtgaagaaagccagacaacttctgtttcttctcttggtgaaataataaaatgcaaatgaatcattgttaaccacagctgtggctcgtttgagggattggggtggacctggggtttattttcagtaacccagctgcaatacctgtctgtaatatgagaaaaaaaaaatgaatctatttaatcatttctacttgcagtactgctatgtgctaagcttaactggaagccttggaatgggcataagttgtatgtcctacatttcatcattgtcccgggcctgcattgcactggaaaaaaaaatcgccacctgttcttacaccagtatttggttcaagacaccaaatgtcttcagcccatggctgaagaacaacagaagagagtcaggataaaaaatacatactgtggtcggcaaggtgagggagatagggatatccaggggaagagggtgttgctgtggcccactctctgtctaatctctttacagcaaattggtaagattttcagttttacttctttctactgtttctgctgtctaccttccttatatttttttcctcaacagttttaaaaagaaaaaaaggtctatttttttttctcctatacttgggctacattttttgattgtaaaaatatttgatggccttttgatgaatgtcttccacagtaaagaaaacttagtggcttaatttaggaaacatgttaacaggacactatgtttttgaaattgtaacaaaatctacataaatgatttacaggttaaaagaataaaaataaaggtaactttacctttcttaaatatttcctgccttaaagagagcatttccatgactttagctggtgaaagggtttaatatctgcagagctttataaaaatatatttcagtgcatactggtataatagatgatcatgcagttgcagttgagttgtatcaccttttttgtttgtcttttataatgtcttcagtctgagtgtgcaaagtcaatttgtaatattttgcaaccctaggatttttttaaatagatgctgcttgctatgttttcaaacctttttgagccataggatccaagccataaaattctttatgcatgttgaattcagtcagaaaagagcaaggctttgctttttgaaattgcaactcaaatgagatgggatgaaatcctatgacagtaagcaaaaacagaaccatgaaaaatgattggacatacaccttttcaattgtggcaataattgaaagaatcgataaaagttcatctttggacagaaagcctttaaaaaaaaaatcactccctcttccccctcctcccttattgcagcagcctactgagaactttgactgttgctggtaaattagaagctacaataataattaagggcagaaattatacttaaaaagtgcagatccttgttctttgacaatttgtgatgtctgaaaaaacagaacccgaaaagctatggtgatatgtacaggcattatttcagactgtaaatggcttgtgatactcttgatacttgttttcaaatatgtttactaactgtagtgttgactgcctgaccaaattccagtgaaacttatacaccaaaatattcttcctaggtcctatttgctagtaacatgagcactgtgattggctggctataaccaccccagttaaaccattttcataattagtagtgccagcaatagtggcaaacactgcaacttttctgcataaaaagcattaattgcacagctaccatccacacaaatacatagtttttctgacttcacatttattaagtgaaatttatttcccatgctgtggaaagtttattgagaacttgtttcataaatggatatccctactatgactgtgaaaacatgtcaagtgtcacattagtgtcacagacagaaagcacacacctatgcaatatggcttatctatatttatttgtaaaaatccaagcatagtttaaaatatgatgtcgatattactagtcttgagtttctaagagggttctttatgttataccaggtaagtgtataaaagagattaagtgcttttttttcatcacttgattattttctttaaaatcagctattacaggatatttttttattttatacatgctgttttttaattaaaatataatcactgaagtttactaatttgattttataaggtttgtagcattacagaataactaaactgggatttataaaccagctgtgattaacaatgtaaagtattaattattgaactttgaaccagatttttaggaaaattatgttctttttccccctttatggtcttaactaatttgaatccttcaagaaggatttttccatactattttttaagatagaagataatttgtgggcaggggtggaggatgcatgtatgatactccataaattcaacattctttactataggtaatgaatgattataaacaagatgcatcttagatagtattaatatactgagccttggattatatatttaatataggacctattttgaatattcagttaatcatatggttcctagcttacaagggctagatctaagattattcccatgagaaatgttgaatttatgaagaatagattttaaggctttgaaaatggttaatttctcaaaaacatcaatgtccaaacatctaccttttttcataggagtagacactagcaagctggacaaactatcacaaaagtatttgtcacacataacctgtggtctgttgctgattaatacagtactttttcttgtgtgattcttaacattatagcacaagtattatctcagtggattatccggaataacatctgaaagatgggttcatctatgtttgtgtttgctctttaaactattgtttctcctatcccaagttcgctttgcatctatcagtaaataaaattcttcagctgccttattaggagtgctatgagggtaacacctgttctgcttttcatcttgtatttagttgactgtattatttgatttcggattgaatgaatgtaaatagaaattaaatgcaaatttgaatgaacataaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6198 -> Molecular function: GO:0004672 [protein kinase activity] evidence: IDA
GeneID:6198 -> Molecular function: GO:0004711 [ribosomal protein S6 kinase activity] evidence: IEA
GeneID:6198 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6198 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:6198 -> Molecular function: GO:0042277 [peptide binding] evidence: IEA
GeneID:6198 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: IMP
GeneID:6198 -> Biological process: GO:0003009 [skeletal muscle contraction] evidence: IEA
GeneID:6198 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:6198 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:6198 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:6198 -> Biological process: GO:0007281 [germ cell development] evidence: IEA
GeneID:6198 -> Biological process: GO:0007568 [aging] evidence: IEA
GeneID:6198 -> Biological process: GO:0007584 [response to nutrient] evidence: IEA
GeneID:6198 -> Biological process: GO:0007616 [long-term memory] evidence: IEA
GeneID:6198 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: TAS
GeneID:6198 -> Biological process: GO:0009408 [response to heat] evidence: IEA
GeneID:6198 -> Biological process: GO:0009611 [response to wounding] evidence: IEA
GeneID:6198 -> Biological process: GO:0009612 [response to mechanical stimulus] evidence: IEA
GeneID:6198 -> Biological process: GO:0009636 [response to toxic substance] evidence: IEA
GeneID:6198 -> Biological process: GO:0009749 [response to glucose stimulus] evidence: IEA
GeneID:6198 -> Biological process: GO:0014732 [skeletal muscle atrophy] evidence: IEA
GeneID:6198 -> Biological process: GO:0014878 [response to electrical stimulus involved in regulation of muscle adaptation] evidence: IEA
GeneID:6198 -> Biological process: GO:0014911 [positive regulation of smooth muscle cell migration] evidence: IEA
GeneID:6198 -> Biological process: GO:0016477 [cell migration] evidence: IEA
GeneID:6198 -> Biological process: GO:0031929 [TOR signaling cascade] evidence: IDA
GeneID:6198 -> Biological process: GO:0032496 [response to lipopolysaccharide] evidence: IEA
GeneID:6198 -> Biological process: GO:0033574 [response to testosterone stimulus] evidence: IEA
GeneID:6198 -> Biological process: GO:0033762 [response to glucagon stimulus] evidence: IEA
GeneID:6198 -> Biological process: GO:0034612 [response to tumor necrosis factor] evidence: IEA
GeneID:6198 -> Biological process: GO:0042493 [response to drug] evidence: IEA
GeneID:6198 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IMP
GeneID:6198 -> Biological process: GO:0043201 [response to leucine] evidence: IEA
GeneID:6198 -> Biological process: GO:0043491 [protein kinase B signaling cascade] evidence: IEA
GeneID:6198 -> Biological process: GO:0045471 [response to ethanol] evidence: IEA
GeneID:6198 -> Biological process: GO:0045727 [positive regulation of translation] evidence: IMP
GeneID:6198 -> Biological process: GO:0045931 [positive regulation of mitotic cell cycle] evidence: IMP
GeneID:6198 -> Biological process: GO:0045948 [positive regulation of translational initiation] evidence: IMP
GeneID:6198 -> Biological process: GO:0046324 [regulation of glucose import] evidence: IEA
GeneID:6198 -> Biological process: GO:0046627 [negative regulation of insulin receptor signaling pathway] evidence: IMP
GeneID:6198 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: TAS
GeneID:6198 -> Biological process: GO:0048633 [positive regulation of skeletal muscle tissue growth] evidence: IEA
GeneID:6198 -> Biological process: GO:0048661 [positive regulation of smooth muscle cell proliferation] evidence: IEA
GeneID:6198 -> Biological process: GO:0051384 [response to glucocorticoid stimulus] evidence: IEA
GeneID:6198 -> Biological process: GO:0071363 [cellular response to growth factor stimulus] evidence: IDA
GeneID:6198 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:6198 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:6198 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:6198 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
GeneID:6198 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: IEA
GeneID:6198 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:6198 -> Cellular component: GO:0009986 [cell surface] evidence: IEA
GeneID:6198 -> Cellular component: GO:0030054 [cell junction] evidence: IEA
GeneID:6198 -> Cellular component: GO:0043005 [neuron projection] evidence: IEA
GeneID:6198 -> Cellular component: GO:0045202 [synapse] evidence: IEA
GeneID:6198 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_003152 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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