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2020-10-24 07:17:58, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_003088               2812 bp    mRNA    linear   PRI 01-JUL-2013
DEFINITION  Homo sapiens fascin homolog 1, actin-bundling protein
            (Strongylocentrotus purpuratus) (FSCN1), mRNA.
ACCESSION   NM_003088
VERSION     NM_003088.3  GI:347360903
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2812)
  AUTHORS   Ma,Y., Li,A., Faller,W.J., Libertini,S., Fiorito,F.,
            Gillespie,D.A., Sansom,O.J., Yamashiro,S. and Machesky,L.M.
  TITLE     Fascin 1 is transiently expressed in mouse melanoblasts during
            development and promotes migration and proliferation
  JOURNAL   Development 140 (10), 2203-2211 (2013)
   PUBMED   23633513
  REMARK    GeneRIF: fascin 1 promotes cell migration and has a role in growth
            and cell cycle progression
REFERENCE   2  (bases 1 to 2812)
  AUTHORS   Hanker,L.C., Karn,T., Holtrich,U., Graeser,M., Becker,S.,
            Reinhard,J., Ruckhaberle,E., Gevensleben,H. and Rody,A.
  TITLE     Prognostic impact of fascin-1 (FSCN1) in epithelial ovarian cancer
  JOURNAL   Anticancer Res. 33 (2), 371-377 (2013)
   PUBMED   23393326
  REMARK    GeneRIF: FSCN1 is frequently expressed in primary epithelial
            ovarian cancer
REFERENCE   3  (bases 1 to 2812)
  AUTHORS   Kim,S.J., Kim,D.C., Kim,M.C., Jung,G.J., Kim,K.H., Jang,J.S.,
            Kwon,H.C., Kim,Y.M. and Jeong,J.S.
  TITLE     Fascin expression is related to poor survival in gastric cancer
  JOURNAL   Pathol. Int. 62 (12), 777-784 (2012)
   PUBMED   23252866
  REMARK    GeneRIF: fascin expression was related to worse survival rates and
            can be an independent poor prognostic factor in gastric cancer.
REFERENCE   4  (bases 1 to 2812)
  AUTHORS   Hashimoto,Y., Kim,D.J. and Adams,J.C.
  TITLE     The roles of fascins in health and disease
  JOURNAL   J. Pathol. 224 (3), 289-300 (2011)
   PUBMED   21618240
  REMARK    Review article
REFERENCE   5  (bases 1 to 2812)
  AUTHORS   Bros,M., Ross,X.L., Pautz,A., Reske-Kunz,A.B. and Ross,R.
  TITLE     The human fascin gene promoter is highly active in mature dendritic
            cells due to a stage-specific enhancer
  JOURNAL   J. Immunol. 171 (4), 1825-1834 (2003)
   PUBMED   12902483
  REMARK    GeneRIF: Fascin regulatory sequences are found solely in the
            5'-flanking promoter region; the promoter exerts robust activity in
            dendritic cells (DC) and a fascin-positive neuronal cell line;
            promoter activity in DC markedly increases with maturation of DC.
REFERENCE   6  (bases 1 to 2812)
  AUTHORS   Pinkus,G.S., Pinkus,J.L., Langhoff,E., Matsumura,F., Yamashiro,S.,
            Mosialos,G. and Said,J.W.
  TITLE     Fascin, a sensitive new marker for Reed-Sternberg cells of
            hodgkin's disease. Evidence for a dendritic or B cell derivation?
  JOURNAL   Am. J. Pathol. 150 (2), 543-562 (1997)
   PUBMED   9033270
REFERENCE   7  (bases 1 to 2812)
  AUTHORS   Mosialos,G., Yamashiro,S., Baughman,R.W., Matsudaira,P., Vara,L.,
            Matsumura,F., Kieff,E. and Birkenbach,M.
  TITLE     Epstein-Barr virus infection induces expression in B lymphocytes of
            a novel gene encoding an evolutionarily conserved 55-kilodalton
            actin-bundling protein
  JOURNAL   J. Virol. 68 (11), 7320-7328 (1994)
   PUBMED   7933116
REFERENCE   8  (bases 1 to 2812)
  AUTHORS   Duh,F.M., Latif,F., Weng,Y., Geil,L., Modi,W., Stackhouse,T.,
            Matsumura,F., Duan,D.R., Linehan,W.M., Lerman,M.I. et al.
  TITLE     cDNA cloning and expression of the human homolog of the sea urchin
            fascin and Drosophila singed genes which encodes an actin-bundling
            protein
  JOURNAL   DNA Cell Biol. 13 (8), 821-827 (1994)
   PUBMED   8068206
REFERENCE   9  (bases 1 to 2812)
  AUTHORS   Yamashiro-Matsumura,S. and Matsumura,F.
  TITLE     Intracellular localization of the 55-kD actin-bundling protein in
            cultured cells: spatial relationships with actin, alpha-actinin,
            tropomyosin, and fimbrin
  JOURNAL   J. Cell Biol. 103 (2), 631-640 (1986)
   PUBMED   3525578
REFERENCE   10 (bases 1 to 2812)
  AUTHORS   Yamashiro-Matsumura,S. and Matsumura,F.
  TITLE     Purification and characterization of an F-actin-bundling
            55-kilodalton protein from HeLa cells
  JOURNAL   J. Biol. Chem. 260 (8), 5087-5097 (1985)
   PUBMED   3886649
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI546742.1, AK095254.1,
            BC000521.2 and BU629782.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Sep 20, 2011 this sequence version replaced gi:49472815.
            
            Summary: This gene encodes a member of the fascin family of
            actin-binding proteins. Fascin proteins organize F-actin into
            parallel bundles, and are required for the formation of actin-based
            cellular protrusions. The encoded protein plays a critical role in
            cell migration, motility, adhesion and cellular interactions.
            Expression of this gene is known to be regulated by several
            microRNAs, and overexpression of this gene may play a role in the
            metastasis of multiple types of cancer by increasing cell motility.
            Expression of this gene is also a marker for Reed-Sternberg cells
            in Hodgkin's lymphoma. A pseudogene of this gene is located on the
            long arm of chromosome 15. [provided by RefSeq, Sep 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006304.2, U03057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BI546742.1         1-3
            4-123               AK095254.1         1-120
            124-2795            BC000521.2         15-2686
            2796-2812           BU629782.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2812
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22"
     gene            1..2812
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /note="fascin homolog 1, actin-bundling protein
                     (Strongylocentrotus purpuratus)"
                     /db_xref="GeneID:6624"
                     /db_xref="HGNC:11148"
                     /db_xref="HPRD:04068"
                     /db_xref="MIM:602689"
     exon            1..964
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    12
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /note="transcription initiation site"
     variation       18
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374232009"
     variation       80
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11557814"
     variation       100
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11557817"
     variation       115
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113466135"
     variation       124
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369511249"
     CDS             133..1614
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /note="55 kDa actin-bundling protein; singed-like (fascin
                     homolog, sea urchin)"
                     /codon_start=1
                     /product="fascin"
                     /protein_id="NP_003079.1"
                     /db_xref="GI:4507115"
                     /db_xref="CCDS:CCDS5342.1"
                     /db_xref="GeneID:6624"
                     /db_xref="HGNC:11148"
                     /db_xref="HPRD:04068"
                     /db_xref="MIM:602689"
                     /translation="
MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY
"
     misc_feature    136..138
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N-acetylthreonine; propagated from
                     UniProtKB/Swiss-Prot (Q16658.3); acetylation site"
     misc_feature    169..534
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /note="Fascin-like domain; members include
                     actin-bundling/crosslinking proteins facsin,
                     histoactophilin and singed;  identified in sea urchin,
                     Drosophila, Xenopus, rodents, and humans; The fascin-like
                     domain adopts a beta-trefoil topology and contains an...;
                     Region: Fascin; cd00257"
                     /db_xref="CDD:29332"
     misc_feature    244..246
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q16658.3); phosphorylation site"
     misc_feature    247..249
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /note="PKC phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:29332"
     misc_feature    247..249
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by PKC; propagated from
                     UniProtKB/Swiss-Prot (Q16658.3); phosphorylation site"
     misc_feature    247..249
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01501"
     misc_feature    547..900
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /note="Fascin-like domain; members include
                     actin-bundling/crosslinking proteins facsin,
                     histoactophilin and singed;  identified in sea urchin,
                     Drosophila, Xenopus, rodents, and humans; The fascin-like
                     domain adopts a beta-trefoil topology and contains an...;
                     Region: Fascin; cd00257"
                     /db_xref="CDD:29332"
     misc_feature    637..639
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /note="PKC phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:29332"
     misc_feature    910..1266
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /note="Fascin-like domain; members include
                     actin-bundling/crosslinking proteins facsin,
                     histoactophilin and singed;  identified in sea urchin,
                     Drosophila, Xenopus, rodents, and humans; The fascin-like
                     domain adopts a beta-trefoil topology and contains an...;
                     Region: Fascin; cd00257"
                     /db_xref="CDD:29332"
     misc_feature    991..993
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /note="PKC phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:29332"
     misc_feature    1279..1611
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /note="Fascin-like domain; members include
                     actin-bundling/crosslinking proteins facsin,
                     histoactophilin and singed;  identified in sea urchin,
                     Drosophila, Xenopus, rodents, and humans; The fascin-like
                     domain adopts a beta-trefoil topology and contains an...;
                     Region: Fascin; cd00257"
                     /db_xref="CDD:29332"
     misc_feature    1360..1362
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /note="PKC phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:29332"
     variation       175
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11557821"
     variation       207
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11557820"
     variation       303
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372943444"
     variation       344
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201797140"
     variation       392
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11557819"
     variation       402
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61732762"
     variation       410
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61732763"
     variation       411
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:140188726"
     variation       420
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145834301"
     variation       423
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369117139"
     variation       426
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146600697"
     variation       453
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:141452968"
     variation       459
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376016880"
     variation       471
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61731540"
     variation       486
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200701274"
     variation       492
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:61731541"
     variation       512
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11557818"
     variation       531
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145145668"
     variation       545
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138722128"
     variation       561
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201120266"
     variation       578
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:61731557"
     variation       594
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143649632"
     variation       624
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:61731558"
     variation       694
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371640415"
     variation       726
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374555702"
     variation       730
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61731559"
     variation       750
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:112714846"
     variation       775
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:61732760"
     variation       792
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:61732761"
     variation       807
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187465308"
     variation       864
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199712638"
     variation       921
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145153592"
     variation       948
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17764881"
     variation       963
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200989728"
     exon            965..1121
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /inference="alignment:Splign:1.39.8"
     variation       990
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373614334"
     variation       997
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113330783"
     variation       1000
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201645418"
     variation       1026
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147410388"
     variation       1027
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373803657"
     variation       1056
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:73052796"
     variation       1064
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111761155"
     variation       1079
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143738037"
     variation       1085
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150576558"
     variation       1092
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11557822"
     variation       1110
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374500646"
     exon            1122..1243
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /inference="alignment:Splign:1.39.8"
     variation       1140
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1640233"
     variation       1154
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377275041"
     variation       1162
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186765948"
     variation       1224
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148787065"
     exon            1244..1411
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /inference="alignment:Splign:1.39.8"
     variation       1250
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11557815"
     variation       1293
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:375630058"
     variation       1297
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369724252"
     variation       1311
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144434787"
     variation       1334
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139232758"
     variation       1368
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144028572"
     variation       1369
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146612530"
     variation       1389
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376197791"
     variation       1390
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369086654"
     variation       1395
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151247331"
     variation       1396
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202027851"
     exon            1412..2796
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /inference="alignment:Splign:1.39.8"
     variation       1450
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371109603"
     variation       1451
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17850070"
     variation       1468
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140594742"
     variation       1474
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371278589"
     variation       1531
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199567587"
     variation       1535
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373729143"
     variation       1545
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368024232"
     variation       1548
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201678383"
     variation       1560
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138127333"
     variation       1575
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376411605"
     variation       1577
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142450075"
     variation       1578
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113601886"
     variation       1594
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369926891"
     variation       1620
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374456091"
     variation       1623
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116867877"
     variation       1625
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116036920"
     variation       1634
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373433239"
     variation       1651
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376574679"
     variation       1707
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375923451"
     variation       1840
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:146589678"
     variation       1849
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368725715"
     variation       1888
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:137877258"
     STS             1923..2784
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /standard_name="FSCN1__6758"
                     /db_xref="UniSTS:466191"
     variation       2030
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185458134"
     variation       2054
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:73334479"
     variation       2126
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1054201"
     variation       2191
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3735288"
     variation       2372
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:77878566"
     variation       2471
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35340467"
     variation       2581
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:111913918"
     STS             2664..2768
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /standard_name="G62033"
                     /db_xref="UniSTS:139123"
     STS             2664..2751
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /standard_name="RH28419"
                     /db_xref="UniSTS:84106"
     variation       2740
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8772"
     polyA_signal    2769..2774
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
     polyA_site      2789
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
     variation       2790
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113634843"
     polyA_site      2796
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
ORIGIN      
agctgggctttgtggagcgctgcggagggtgcgtgcgggccgcggcagccgaacaaaggagcaggggcgccgccgcagggacccgccacccacctcccggggccgcgcagcggcctctcgtctactgccaccatgaccgccaacggcacagccgaggcggtgcagatccagttcggcctcatcaactgcggcaacaagtacctgacggccgaggcgttcgggttcaaggtgaacgcgtccgccagcagcctgaagaagaagcagatctggacgctggagcagccccctgacgaggcgggcagcgcggccgtgtgcctgcgcagccacctgggccgctacctggcggcggacaaggacggcaacgtgacctgcgagcgcgaggtgcccggtcccgactgccgtttcctcatcgtggcgcacgacgacggtcgctggtcgctgcagtccgaggcgcaccggcgctacttcggcggcaccgaggaccgcctgtcctgcttcgcgcagacggtgtcccccgccgagaagtggagcgtgcacatcgccatgcaccctcaggtcaacatctacagcgtcacccgtaagcgctacgcgcacctgagcgcgcggccggccgacgagatcgccgtggaccgcgacgtgccctggggcgtcgactcgctcatcaccctcgccttccaggaccagcgctacagcgtgcagaccgccgaccaccgcttcctgcgccacgacgggcgcctggtggcgcgccccgagccggccactggctacacgctggagttccgctccggcaaggtggccttccgcgactgcgagggccgttacctggcgccgtcggggcccagcggcacgctcaaggcgggcaaggccaccaaggtgggcaaggacgagctctttgctctggagcagagctgcgcccaggtcgtgctgcaggcggccaacgagaggaacgtgtccacgcgccagggtatggacctgtctgccaatcaggacgaggagaccgaccaggagaccttccagctggagatcgaccgcgacaccaaaaagtgtgccttccgtacccacacgggcaagtactggacgctgacggccaccgggggcgtgcagtccaccgcctccagcaagaatgccagctgctactttgacatcgagtggcgtgaccggcgcatcacactgagggcgtccaatggcaagtttgtgacctccaagaagaatgggcagctggccgcctcggtggagacagcaggggactcagagctcttcctcatgaagctcatcaaccgccccatcatcgtgttccgcggggagcatggcttcatcggctgccgcaaggtcacgggcaccctggacgccaaccgctccagctatgacgtcttccagctggagttcaacgatggcgcctacaacatcaaagactccacaggcaaatactggacggtgggcagtgactccgcggtcaccagcagcggcgacactcctgtggacttcttcttcgagttctgcgactataacaaggtggccatcaaggtgggcgggcgctacctgaagggcgaccacgcaggcgtcctgaaggcctcggcggaaaccgtggaccccgcctcgctctgggagtactagggccggcccgtccttccccgcccctgcccacatggcggctcctgccaaccctccctgctaaccccttctccgccaggtgggctccagggcgggaggcaagcccccttgcctttcaaactggaaaccccagagaaaacggtgcccccacctgtcgcccctatggactccccactctcccctccgcccgggttccctactcccctcgggtcagcggctgcggcctggccctgggagggatttcagatgcccctgccctcttgtctgccacggggcgagtctggcacctctttcttctgacctcagacggctctgagccttatttctctggaagcggctaagggacggttgggggctgggagccctgggcgtgtagtgtaactggaatcttttgcctctcccagccacctcctcccagccccccaggagagctgggcacatgtcccaagcctgtcagtggccctccctggtgcactgtccccgaaacccctgcttgggaagggaagctgtcgggtgggctaggactgacccttgtggtgtttttttgggtggtggctggaaacagcccctctcccacgtggcagaggctcagcctggctcccttccctggagcggcagggcgtgacggccacagggtctgcccgctgcacgttctgccaaggtggtggtggcgggcgggtaggggtgtgggggccgtcttcctcctgtctctttcctttcaccctagcctgactggaagcagaaaatgaccaaatcagtattttttttaatgaaatattattgctggaggcgtcccaggcaagcctggctgtagtagcgagtgatctggcggggggcgtctcagcaccctccccagggggtgcatctcagccccctctttccgtccttcccgtccagccccagccctgggcctgggctgccgacacctgggccagagcccctgctgtgattggtgctccctgggcctcccgggtggatgaagccaggcgtcgccccctccgggagccctggggtgagccgccggggcccccctgctgccagcctcccccgtccccaacatgcatctcactctgggtgtcttggtcttttattttttgtaagtgtcatttgtataactctaaacgcccatgatagtagcttcaaactggaaatagcgaaataaaataactcagtctgcagccccagaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:6624 -> Molecular function: GO:0003779 [actin binding] evidence: IDA
            GeneID:6624 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:6624 -> Molecular function: GO:0008144 [drug binding] evidence: IDA
            GeneID:6624 -> Molecular function: GO:0030674 [protein binding, bridging] evidence: IEA
            GeneID:6624 -> Molecular function: GO:0051015 [actin filament binding] evidence: IDA
            GeneID:6624 -> Biological process: GO:0008283 [cell proliferation] evidence: TAS
            GeneID:6624 -> Biological process: GO:0016477 [cell migration] evidence: IMP
            GeneID:6624 -> Biological process: GO:0030036 [actin cytoskeleton organization] evidence: IDA
            GeneID:6624 -> Biological process: GO:0048870 [cell motility] evidence: IDA
            GeneID:6624 -> Biological process: GO:0051017 [actin filament bundle assembly] evidence: IDA
            GeneID:6624 -> Cellular component: GO:0001725 [stress fiber] evidence: IDA
            GeneID:6624 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
            GeneID:6624 -> Cellular component: GO:0015629 [actin cytoskeleton] evidence: IDA
            GeneID:6624 -> Cellular component: GO:0030054 [cell junction] evidence: IEA
            GeneID:6624 -> Cellular component: GO:0030175 [filopodium] evidence: IDA
            GeneID:6624 -> Cellular component: GO:0071437 [invadopodium] evidence: IDA

by @meso_cacase at DBCLS
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