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2024-04-20 01:05:22, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003069 4102 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens SWI/SNF related, matrix associated, actin dependent
regulator of chromatin, subfamily a, member 1 (SMARCA1), transcript
variant 1, mRNA.
ACCESSION NM_003069
VERSION NM_003069.3 GI:164419747
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4102)
AUTHORS Eckey,M., Kuphal,S., Straub,T., Rummele,P., Kremmer,E.,
Bosserhoff,A.K. and Becker,P.B.
TITLE Nucleosome remodeler SNF2L suppresses cell proliferation and
migration and attenuates Wnt signaling
JOURNAL Mol. Cell. Biol. 32 (13), 2359-2371 (2012)
PUBMED 22508985
REMARK GeneRIF: The effect of SNF2L depletion on gene expression portray
the cell in a state of activated Wnt signaling with increased
proliferation and locomotion. High levels of SNF2L expression in
normal melanocytes contrast with undetectable expression in
melanoma.
REFERENCE 2 (bases 1 to 4102)
AUTHORS Shain,A.H., Giacomini,C.P., Matsukuma,K., Karikari,C.A.,
Bashyam,M.D., Hidalgo,M., Maitra,A. and Pollack,J.R.
TITLE Convergent structural alterations define SWItch/Sucrose
NonFermentable (SWI/SNF) chromatin remodeler as a central tumor
suppressive complex in pancreatic cancer
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (5), E252-E259 (2012)
PUBMED 22233809
REMARK GeneRIF: expression profiling analyses revealed that SWI/SNF likely
antagonizes Polycomb repressive complex 2, implicating this as one
possible mechanism of tumor suppression
REFERENCE 3 (bases 1 to 4102)
AUTHORS Erdel,F. and Rippe,K.
TITLE Binding kinetics of human ISWI chromatin-remodelers to DNA repair
sites elucidate their target location mechanism
JOURNAL Nucleus 2 (2), 105-112 (2011)
PUBMED 21738833
REMARK GeneRIF: ISWI proteins Snf2H, Snf2L as well as Acf1 accumulate at
UV-induced DNA damage sites within tens of seconds and reach a
plateau after a few minutes.
REFERENCE 4 (bases 1 to 4102)
AUTHORS Ye,Y., Xiao,Y., Wang,W., Wang,Q., Yearsley,K., Wani,A.A., Yan,Q.,
Gao,J.X., Shetuni,B.S. and Barsky,S.H.
TITLE Inhibition of expression of the chromatin remodeling gene, SNF2L,
selectively leads to DNA damage, growth inhibition, and cancer cell
death
JOURNAL Mol. Cancer Res. 7 (12), 1984-1999 (2009)
PUBMED 19996304
REMARK GeneRIF: Cancers are sensitive to SNF2L knockdown because, unlike
their normal counterparts, they lack sufficient compensation from
other family members.
REFERENCE 5 (bases 1 to 4102)
AUTHORS Lazzaro,M.A., Todd,M.A., Lavigne,P., Vallee,D., De Maria,A. and
Picketts,D.J.
TITLE Characterization of novel isoforms and evaluation of SNF2L/SMARCA1
as a candidate gene for X-linked mental retardation in 12 families
linked to Xq25-26
JOURNAL BMC Med. Genet. 9, 11 (2008)
PUBMED 18302774
REMARK GeneRIF: SNF2L mutations are not a cause of X-linked mental
retardation in our cohort of patients, although we cannot exclude
the possibility that regulatory mutations might exist
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 4102)
AUTHORS Barak,O., Lazzaro,M.A., Cooch,N.S., Picketts,D.J. and
Shiekhattar,R.
TITLE A tissue-specific, naturally occurring human SNF2L variant
inactivates chromatin remodeling
JOURNAL J. Biol. Chem. 279 (43), 45130-45138 (2004)
PUBMED 15310751
REMARK GeneRIF: a neuronal SNF2L variant inactivates chromatin remodeling
REFERENCE 7 (bases 1 to 4102)
AUTHORS Barak,O., Lazzaro,M.A., Lane,W.S., Speicher,D.W., Picketts,D.J. and
Shiekhattar,R.
TITLE Isolation of human NURF: a regulator of Engrailed gene expression
JOURNAL EMBO J. 22 (22), 6089-6100 (2003)
PUBMED 14609955
REFERENCE 8 (bases 1 to 4102)
AUTHORS Maguire,P.B., Wynne,K.J., Harney,D.F., O'Donoghue,N.M., Stephens,G.
and Fitzgerald,D.J.
TITLE Identification of the phosphotyrosine proteome from thrombin
activated platelets
JOURNAL Proteomics 2 (6), 642-648 (2002)
PUBMED 12112843
REFERENCE 9 (bases 1 to 4102)
AUTHORS Bozhenok,L., Wade,P.A. and Varga-Weisz,P.
TITLE WSTF-ISWI chromatin remodeling complex targets heterochromatic
replication foci
JOURNAL EMBO J. 21 (9), 2231-2241 (2002)
PUBMED 11980720
REMARK Erratum:[EMBO J 2002 Jun 17;21(12):3212]
REFERENCE 10 (bases 1 to 4102)
AUTHORS Okabe,I., Bailey,L.C., Attree,O., Srinivasan,S., Perkel,J.M.,
Laurent,B.C., Carlson,M., Nelson,D.L. and Nussbaum,R.L.
TITLE Cloning of human and bovine homologs of SNF2/SWI2: a global
activator of transcription in yeast S. cerevisiae
JOURNAL Nucleic Acids Res. 20 (17), 4649-4655 (1992)
PUBMED 1408766
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AW614102.1, BC117447.1 and
BQ006393.1.
This sequence is a reference standard in the RefSeqGene project.
On Jan 2, 2008 this sequence version replaced gi:21071043.
Summary: This gene encodes a member of the SWI/SNF family of
proteins. Members of this family have helicase and ATPase
activities and are thought to regulate transcription of certain
genes by altering the chromatin structure around those genes.
Alternatively spliced transcript variants encoding different
isoforms have been found for this gene. [provided by RefSeq, Jul
2008].
Transcript Variant: This variant (1) encodes the longer isoform
(a).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC117447.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-78 AW614102.1 158-235 c
79-3741 BC117447.1 1-3663
3742-4102 BQ006393.1 1-361 c
FEATURES Location/Qualifiers
source 1..4102
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq25"
gene 1..4102
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/note="SWI/SNF related, matrix associated, actin dependent
regulator of chromatin, subfamily a, member 1"
/db_xref="GeneID:6594"
/db_xref="HGNC:11097"
/db_xref="HPRD:02055"
/db_xref="MIM:300012"
exon 1..287
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
misc_feature 30..32
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/note="upstream in-frame stop codon"
CDS 114..3278
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/note="isoform a is encoded by transcript variant 1;
global transcription activator homologous sequence;
SNF2-like 1; sucrose nonfermenting 2-like protein 1;
SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin a1; probable global transcription
activator SNF2L1; SWI/SNF-related matrix-associated
actin-dependent regulator of chromatin subfamily A member
1; ATP-dependent helicase SMARCA1; nucleosome-remodeling
factor subunit SNF2L"
/codon_start=1
/product="probable global transcription activator SNF2L1
isoform a"
/protein_id="NP_003060.2"
/db_xref="GI:21071044"
/db_xref="CCDS:CCDS14612.1"
/db_xref="GeneID:6594"
/db_xref="HGNC:11097"
/db_xref="HPRD:02055"
/db_xref="MIM:300012"
/translation="
MEQDTAAVAATVAAADATATIVVIEDEQPGPSTSQEEGAAAAATEATAATEKGEKKKEKNVSSFQLKLAAKAPKSEKEMDPEYEEKMKADRAKRFEFLLKQTELFAHFIQPSAQKSPTSPLNMKLGRPRIKKDEKQSLISAGDYRHRRTEQEEDEELLSESRKTSNVCIRFEVSPSYVKGGPLRDYQIRGLNWLISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRVICFVGDKDARAAFIRDEMMPGEWDVCVTSYEMVIKEKSVFKKFHWRYLVIDEAHRIKNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCLGDQKLVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWYTKILMKDIDVLNSSGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDEHIVSNSGKMVVLDKLLAKLKEQGSRVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEEREDKFLEVEFLGQREAIEAFNAPNSSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNTVEERIVERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEMLQMIRHGATHVFASKESELTDEDITTILERGEKKTAEMNERLQKMGESSLRNFRMDIEQSLYKFEGEDYREKQKLGMVEWIEPPKRERKANYAVDAYFREALRVSEPKIPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYKVPRNPDIPNPALAQREEQKKIDGAEPLTPEETEEKEKLLTQGFTNWTKRDFNQFIKANEKYGRDDIDNIAREVEGKSPEEVMEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDAKIARYKAPFHQLRIQYGTSKGKNYTEEEDRFLICMLHKMGFDRENVYEELRQCVRNAPQFRFDWFIKSRTAMEFQRRCNTLISLIEKENMEIEERERAEKKKRATKTPMVKFSAFS
"
misc_feature <324..443
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/note="DNA-binding domain; Region: DBINO; pfam13892"
/db_xref="CDD:206063"
misc_feature 447..449
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 459..461
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P28370.2); phosphorylation site"
misc_feature 468..470
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P28370.2); phosphorylation site"
misc_feature 669..1511
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/note="SNF2 family N-terminal domain; Region: SNF2_N;
pfam00176"
/db_xref="CDD:201060"
misc_feature 720..1139
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/note="DEAD-like helicases superfamily. A diverse family
of proteins involved in ATP-dependent RNA or DNA
unwinding. This domain contains the ATP-binding region;
Region: DEXDc; cd00046"
/db_xref="CDD:28927"
misc_feature 744..758
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:28927"
misc_feature 1044..1055
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P28370.2);
Region: DEAH box"
misc_feature 1044..1055
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/note="putative Mg++ binding site [ion binding]; other
site"
/db_xref="CDD:28927"
misc_feature 1542..1973
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/note="Helicase superfamily c-terminal domain; associated
with DEXDc-, DEAD-, and DEAH-box proteins, yeast
initiation factor 4A, Ski2p, and Hepatitis C virus NS3
helicases; this domain is found in a wide variety of
helicases and helicase related proteins; may...; Region:
HELICc; cd00079"
/db_xref="CDD:28960"
misc_feature order(1641..1652,1710..1715,1833..1841)
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/note="nucleotide binding region [chemical binding]; other
site"
/db_xref="CDD:28960"
misc_feature order(1857..1859,1920..1922,1932..1934,1941..1943)
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/note="ATP-binding site [chemical binding]; other site"
/db_xref="CDD:28960"
misc_feature 2385..2627
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/note="HAND; Region: HAND; pfam09110"
/db_xref="CDD:204139"
misc_feature 2682..2807
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/note="SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding
domains; Region: SANT; smart00717"
/db_xref="CDD:197842"
misc_feature 2688..2807
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
Tandem copies of the domain bind telomeric DNA tandem
repeatsas part of the capping complex. Binding is sequence
dependent for repeats which contain the G/C rich motif
[C2-3 A (CA)1-6]. The domain is...; Region: SANT; cd00167"
/db_xref="CDD:29107"
misc_feature order(2691..2693,2781..2786,2790..2795,2799..2807)
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:29107"
misc_feature 2850..3179
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/note="SLIDE; Region: SLIDE; pfam09111"
/db_xref="CDD:204140"
misc_feature 2973..2975
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (P28370.2); phosphorylation site"
exon 288..374
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 375..541
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 542..642
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 643..743
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 744..923
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 924..1079
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 1080..1211
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 1212..1280
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 1281..1390
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 1391..1617
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 1618..1739
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 1740..1775
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 1776..1928
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 1929..2061
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 2062..2210
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
variation 2080
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1134838"
exon 2211..2330
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 2331..2441
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
STS 2363..2499
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/standard_name="MARC_12207-12208:1004716010:1"
/db_xref="UniSTS:267364"
exon 2442..2555
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 2556..2678
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
variation 2623
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/replace="c"
/replace="g"
/db_xref="dbSNP:34182579"
exon 2679..2811
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 2812..2930
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 2931..3143
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 3144..3285
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
exon 3286..4086
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/inference="alignment:Splign:1.39.8"
variation 3883
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:15261"
polyA_signal 4059..4064
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
polyA_site 4086
/gene="SMARCA1"
/gene_synonym="ISWI; NURF140; SNF2L; SNF2L1; SNF2LB;
SNF2LT; SWI; SWI2"
ORIGIN
gcggagtgattccccacccctgctccatctagctctttccagtgcagccactgccgccgcccaggagccctcgtcccctgccttgtccccctactcgttcccgctcccacggcatggagcaggacactgccgcagtggcagccaccgtggcagccgcggatgcgaccgccactatcgtggtcatagaggacgagcagcccgggccgtccacctctcaggaggagggagcggccgccgcggccaccgaagccaccgcggccacggagaagggcgagaagaagaaggagaaaaacgtttcttcatttcaactcaaacttgctgctaaagcgcctaaatctgaaaaggaaatggacccagaatatgaagagaaaatgaaagccgaccgagcaaagagatttgaatttttactgaagcagacagaactttttgcacatttcattcagccttcagcacagaaatctccaacatctccactgaacatgaaattgggacgtccccgaataaagaaagatgaaaagcagagcttaatttctgctggagactaccgccataggcgcacagagcaagaagaagatgaagagctactgtctgagagtcggaaaacatctaatgtgtgtattagatttgaggtgtcaccttcatatgtgaaaggggggccactgagagattatcagattcgaggactgaattggttgatctctttatatgaaaatggagtcaatggcattttggctgatgaaatgggccttgggaaaactttacaaacaattgctttgcttggttacctgaaacactaccgaaatattcctggacctcacatggttttagttccaaagtctactttacacaactggatgaatgaatttaaacgatgggtcccatctctccgtgtcatttgttttgtcggagacaaggatgccagagctgcttttattcgtgatgaaatgatgccaggagagtgggatgtttgcgttacttcttatgagatggtaattaaagaaaaatctgtattcaaaaagtttcactggcgatacctggtcattgatgaagctcacagaataaagaatgaaaaatctaagctttcagagattgttcgtgagttcaagtcgactaaccgcttgctcctaactggaacacctttgcagaataacctgcatgaactgtgggccttactcaactttttattgcctgatgtctttaattctgcagatgactttgattcttggtttgacactaaaaattgtcttggtgatcaaaaactcgtggaaagacttcatgcagttttaaaaccatttttgttacgccgtataaaaactgatgtagagaagagtctgccacctaaaaaggaaataaagatttacttggggctgagtaagatgcaacgagaatggtatacaaaaatcctgatgaaagatattgatgttttaaactcttctggcaagatggacaagatgcgactcttaaacattctgatgcagcttcgaaagtgttgtaatcatccatatctgtttgatggtgctgaacctggtccaccttataccactgatgagcatattgtcagcaacagtggtaaaatggtagttctggataaactattggccaaactcaaagaacagggttcaagggttctcattttcagccagatgactcgcttgctggatattttggaagattattgcatgtggcgtggttatgagtattgtcgactggatggacaaaccccgcatgaagaaagagaggataaattcctagaagtggaatttctgggtcaaagggaagcaatagaggcttttaatgctcctaatagtagcaaattcatctttatgctaagtaccagggctggaggtctcggaattaacctggcaagtgctgatgtggttatactatatgattcagactggaacccacaggttgatctacaagctatggatcgagcacatcgtattggtcagaagaaaccagtacgtgtattccgtctcatcactgacaacactgttgaagagaggattgtagaaagagctgagataaaactgagactcgattcaattgttatacaacaaggaagactcattgaccaacagtctaacaagctggcaaaagaggaaatgttacaaatgatacggcatggagccacccatgtttttgcttctaaagagagtgagttgacagatgaagacattacaactattctggaaagaggggaaaagaagactgcagagatgaatgaacgcctgcaaaaaatgggagagtcttctctaagaaattttagaatggacattgaacaaagtttatacaaatttgagggagaagattatagagaaaaacagaagcttggcatggtggaatggattgaacctcctaaacgagaacgcaaagcaaactacgcagtggatgcctactttagagaggctttgcgtgtcagcgagccaaagattccaaaggctccacggcctccaaaacagccaaatgttcaggattttcaatttttcccaccacgcttatttgagctcctggaaaaggaaattctttattatcggaagacaataggctataaggttccaaggaatcctgatatcccaaatccagctctggctcaaagagaagagcaaaaaaagattgatggagctgaacctcttacaccagaagagactgaagaaaaggaaaaacttctcacacaaggtttcacaaactggactaaacgagattttaaccagtttattaaagctaatgagaaatatggaagagatgacattgataacatagctcgagaggtagagggcaaatcccctgaggaggtcatggagtattcagctgtattttgggaacgttgcaatgaattacaggacattgagaaaattatggctcaaattgaacgtggagaagcaagaattcaacgaaggatcagtatcaagaaagccctggatgccaaaattgcaagatacaaggctccatttcatcagttgcgcattcagtatggaaccagcaaaggaaagaactatactgaggaagaagatagattcttgatttgtatgttacacaaaatgggctttgatagagaaaatgtatatgaagaattaagacagtgtgtacgaaatgctccccagtttagatttgactggtttatcaagtctaggactgccatggaattccagagacgctgtaacactctgatttcattgattgagaaagaaaatatggaaattgaggaaagagagagagcagaaaagaagaaacgggcaactaaaactccaatggtaaaattttcagcattttcctaacttttagatttaacattgttgggccatttaaaatgtgcatattggagcagaacattaaatctgtttccattttagtcacagaaaagaaaagcagagtcagctactgagagctctggaaagaaggatgtcaagaaggtgaaatcctaaagcctagaaataaagttttaaatgggaaactgctattttcttgttcccatcttcaaatgctaattgccagttccagtgtattcatggtactctaagaaaaatctctttggttttgatttcttgcatattttatatattttacaatgctttctacctgaaatgtgtagctttatattttatggcattctagtatttttgtgtactgtattttgtgcatttcatgtcttcatcaaaatcctctcagtccttgttcttttgaagcttgtgctgaggttttagcttttctatgttttatatgccgctgctttgaaagagaacctagattctatagttgtattattgttgtttcatactttaaatttatatggctgtggaaaaacgaattaaaatgttttgaggagaaagactttttcacttctttgttgctttcttttctattgagtctgggcttgtttgtgttactgcatactgtgattagcataataattgtttctttgaggtcatctaaatatttttttcctaaaggaataaagggtgaggaaagaaaaatattaaaaaagctaatatttgatactgtgcttgctgtcagtatgcattacatttaaattattctctattcaagtgggaaaatataataaagaaatgtctataagaaatttaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6594 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:6594 -> Molecular function: GO:0004386 [helicase activity] evidence: IEA
GeneID:6594 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6594 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:6594 -> Molecular function: GO:0008094 [DNA-dependent ATPase activity] evidence: IDA
GeneID:6594 -> Molecular function: GO:0031491 [nucleosome binding] evidence: IEA
GeneID:6594 -> Molecular function: GO:0036310 [annealing helicase activity] evidence: IDA
GeneID:6594 -> Molecular function: GO:0070615 [nucleosome-dependent ATPase activity] evidence: IDA
GeneID:6594 -> Biological process: GO:0000733 [DNA strand renaturation] evidence: IDA
GeneID:6594 -> Biological process: GO:0006338 [chromatin remodeling] evidence: IDA
GeneID:6594 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IMP
GeneID:6594 -> Biological process: GO:0007420 [brain development] evidence: IMP
GeneID:6594 -> Biological process: GO:0030182 [neuron differentiation] evidence: ISS
GeneID:6594 -> Biological process: GO:0043044 [ATP-dependent chromatin remodeling] evidence: IDA
GeneID:6594 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IMP
GeneID:6594 -> Biological process: GO:2000177 [regulation of neural precursor cell proliferation] evidence: IEA
GeneID:6594 -> Cellular component: GO:0000790 [nuclear chromatin] evidence: IEA
GeneID:6594 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:6594 -> Cellular component: GO:0016589 [NURF complex] evidence: IDA
GeneID:6594 -> Cellular component: GO:0090537 [CERF complex] evidence: IDA
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