2024-03-29 20:02:07, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003048 5446 bp mRNA linear PRI 11-MAY-2013 DEFINITION Homo sapiens solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 (SLC9A2), mRNA. ACCESSION NM_003048 VERSION NM_003048.3 GI:38569454 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5446) AUTHORS Muthusamy,S., Shukla,S., Amin,M.R., Cheng,M., Orenuga,T., Dudeja,P.K. and Malakooti,J. TITLE PKCdelta-dependent activation of ERK1/2 leads to upregulation of the human NHE2 transcriptional activity in intestinal epithelial cell line C2BBe1 JOURNAL Am. J. Physiol. Gastrointest. Liver Physiol. 302 (3), G317-G325 (2012) PUBMED 22052014 REMARK GeneRIF: Phosphorylation of nPKC-delta results in activation of ERK1/2 kinase and subsequent induction of Egr-1. Subsequently, Egr-1 directly targets NHE2 promoter and promotes NHE2 transcriptional upregulation by interaction with NHE2-PMA response element. REFERENCE 2 (bases 1 to 5446) AUTHORS Son,E.J., Moon,I.S., Kim,S.H., Kim,S.J. and Choi,J.Y. TITLE Interferon-gamma suppresses Na+ -H+ exchanger in cultured human endolymphatic sac epithelial cells JOURNAL J. Cell. Biochem. 107 (5), 965-972 (2009) PUBMED 19479940 REMARK GeneRIF: The functional and molecular expression of NHEs in cultured human endolymphatic sac (ES) epithelial cells was determined and the effect of IFN-gamma on NHE function, was examined. REFERENCE 3 (bases 1 to 5446) AUTHORS Joly,F., Mayeur,C., Messing,B., Lavergne-Slove,A., Cazals-Hatem,D., Noordine,M.L., Cherbuy,C., Duee,P.H. and Thomas,M. TITLE Morphological adaptation with preserved proliferation/transporter content in the colon of patients with short bowel syndrome JOURNAL Am. J. Physiol. Gastrointest. Liver Physiol. 297 (1), G116-G123 (2009) PUBMED 19389806 REMARK GeneRIF: Report morphological adaptation with preserved proliferation/NHE2 content in the colon of patients with short bowel syndrome. REFERENCE 4 (bases 1 to 5446) AUTHORS Musch,M.W., Arvans,D.L., Wu,G.D. and Chang,E.B. TITLE Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3 JOURNAL Am. J. Physiol. Gastrointest. Liver Physiol. 296 (2), G202-G210 (2009) PUBMED 19056765 REMARK GeneRIF: Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3 in intestinal epithelial cells. REFERENCE 5 (bases 1 to 5446) AUTHORS Beltran,A.R., Ramirez,M.A., Carraro-Lacroix,L.R., Hiraki,Y., Reboucas,N.A. and Malnic,G. TITLE NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells JOURNAL Pflugers Arch. 455 (5), 799-810 (2008) PUBMED 17943310 REMARK GeneRIF: T84 human colon cells contain three isoforms of the Na+/H+ exchanger, NHE1, NHE2, and NHE4, but not the Cl-dependent NHE REFERENCE 6 (bases 1 to 5446) AUTHORS Lin,X. and Barber,D.L. TITLE A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (22), 12631-12636 (1996) PUBMED 8901634 REFERENCE 7 (bases 1 to 5446) AUTHORS Dudeja,P.K., Rao,D.D., Syed,I., Joshi,V., Dahdal,R.Y., Gardner,C., Risk,M.C., Schmidt,L., Bavishi,D., Kim,K.E., Harig,J.M., Goldstein,J.L., Layden,T.J. and Ramaswamy,K. TITLE Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA JOURNAL Am. J. Physiol. 271 (3 PT 1), G483-G493 (1996) PUBMED 8843774 REFERENCE 8 (bases 1 to 5446) AUTHORS Ghishan,F.K., Knobel,S.M. and Summar,M. TITLE Molecular cloning, sequencing, chromosomal localization, and tissue distribution of the human Na+/H+ exchanger (SLC9A2) JOURNAL Genomics 30 (1), 25-30 (1995) PUBMED 8595899 REFERENCE 9 (bases 1 to 5446) AUTHORS Collins,J.F., Honda,T., Knobel,S., Bulus,N.M., Conary,J., DuBois,R. and Ghishan,F.K. TITLE Molecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2) JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (9), 3938-3942 (1993) PUBMED 7683411 REFERENCE 10 (bases 1 to 5446) AUTHORS Kulanthaivel,P., Furesz,T.C., Moe,A.J., Smith,C.H., Mahesh,V.B., Leibach,F.H. and Ganapathy,V. TITLE Human placental syncytiotrophoblast expresses two pharmacologically distinguishable types of Na(+)-H+ exchangers, NHE-1 in the maternal-facing (brush border) membrane and NHE-2 in the fetal-facing (basal) membrane JOURNAL Biochem. J. 284 (PT 1), 33-38 (1992) PUBMED 1318024 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC035787.1, AF073299.1, AK129936.1 and AA843986.1. On Dec 1, 2003 this sequence version replaced gi:15529997. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035787.1, BC136377.1 [ECO:0000332] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-199 BC035787.1 1-199 200-2747 AF073299.1 148-2695 2748-4767 BC035787.1 2747-4766 4768-5257 AK129936.1 2019-2508 5258-5387 AA843986.1 61-190 c 5388-5446 AA843986.1 1-59 c FEATURES Location/Qualifiers source 1..5446 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="2" /map="2q11.2" gene 1..5446 /gene="SLC9A2" /gene_synonym="NHE2" /note="solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2" /db_xref="GeneID:6549" /db_xref="HGNC:11072" /db_xref="HPRD:02756" /db_xref="MIM:600530" exon 1..431 /gene="SLC9A2" /gene_synonym="NHE2" /inference="alignment:Splign:1.39.8" variation 23 /gene="SLC9A2" /gene_synonym="NHE2" /replace="g" /replace="t" /db_xref="dbSNP:372115805" variation 64 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:114579143" variation 96 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:375752301" variation 103 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:368856851" variation 135 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="c" /db_xref="dbSNP:190686338" CDS 143..2581 /gene="SLC9A2" /gene_synonym="NHE2" /note="solute carrier family 9 (sodium/hydrogen exchanger), isoform 2; sodium/hydrogen exchanger 2; NHE-2; solute carrier family 9 member 2; Na(+)/H(+) exchanger 2; solute carrier family 9 (sodium/hydrogen exchanger), member 2" /codon_start=1 /product="sodium/hydrogen exchanger 2 precursor" /protein_id="NP_003039.2" /db_xref="GI:15529998" /db_xref="CCDS:CCDS2062.1" /db_xref="GeneID:6549" /db_xref="HGNC:11072" /db_xref="HPRD:02756" /db_xref="MIM:600530" /translation="
MEPLGNWRSLRAPLPPMLLLLLLQVAGPVGALAETLLNAPRAMGTSSSPPSPASVVAPGTTLFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDEIRELLSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRASTSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFSKKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDSLTEGIPPKPPPRLVWRASEPGSRKARFGSEKP
" sig_peptide 143..241 /gene="SLC9A2" /gene_synonym="NHE2" /inference="COORDINATES: ab initio prediction:SignalP:4.0" misc_feature 362..2032 /gene="SLC9A2" /gene_synonym="NHE2" /note="sodium/hydrogen exchanger 3; Region: b_cpa1; TIGR00840" /db_xref="CDD:162063" misc_feature 461..523 /gene="SLC9A2" /gene_synonym="NHE2" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q9UBY0.1); transmembrane region" misc_feature 557..619 /gene="SLC9A2" /gene_synonym="NHE2" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q9UBY0.1); transmembrane region" misc_feature 647..709 /gene="SLC9A2" /gene_synonym="NHE2" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q9UBY0.1); transmembrane region" misc_feature 767..829 /gene="SLC9A2" /gene_synonym="NHE2" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q9UBY0.1); transmembrane region" misc_feature 851..913 /gene="SLC9A2" /gene_synonym="NHE2" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q9UBY0.1); transmembrane region" misc_feature 974..1036 /gene="SLC9A2" /gene_synonym="NHE2" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q9UBY0.1); transmembrane region" misc_feature 1064..1126 /gene="SLC9A2" /gene_synonym="NHE2" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q9UBY0.1); transmembrane region" misc_feature 1223..1285 /gene="SLC9A2" /gene_synonym="NHE2" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q9UBY0.1); transmembrane region" misc_feature 1316..1378 /gene="SLC9A2" /gene_synonym="NHE2" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q9UBY0.1); transmembrane region" misc_feature 1517..1579 /gene="SLC9A2" /gene_synonym="NHE2" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q9UBY0.1); transmembrane region" variation 181 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="t" /db_xref="dbSNP:376555739" variation 189 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:183972576" variation 195 /gene="SLC9A2" /gene_synonym="NHE2" /replace="g" /replace="t" /db_xref="dbSNP:373622533" variation 223 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:199622272" variation 224 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:376898546" variation 258 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="g" /db_xref="dbSNP:201327150" variation 267 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="c" /db_xref="dbSNP:74685539" variation 276 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:141211710" variation 300 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:201535448" variation 322 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:199718995" variation 333 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="t" /db_xref="dbSNP:368226194" variation 373 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:137906470" exon 432..895 /gene="SLC9A2" /gene_synonym="NHE2" /inference="alignment:Splign:1.39.8" variation 451 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:199869459" variation 478 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:61740600" variation 502 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:368634669" variation 532 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:147336616" variation 589 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:143241362" variation 590 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:372934406" variation 601 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:200268302" variation 602 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:201828131" variation 628 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="g" /db_xref="dbSNP:201412062" variation 690 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:140049116" variation 725 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:61743555" variation 733 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="c" /replace="t" /db_xref="dbSNP:139722927" variation 742 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:199725113" variation 766 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:147714670" variation 826 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:369331319" variation 833 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:373112278" variation 851 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:376604164" exon 896..1146 /gene="SLC9A2" /gene_synonym="NHE2" /inference="alignment:Splign:1.39.8" variation 918 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:146727651" variation 947 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:115807121" variation 1003 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:112646996" variation 1012 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="c" /db_xref="dbSNP:373377407" variation 1026 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:377535586" variation 1069 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="c" /db_xref="dbSNP:148004830" variation 1113 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:370904789" exon 1147..1364 /gene="SLC9A2" /gene_synonym="NHE2" /inference="alignment:Splign:1.39.8" variation 1181 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:368738669" variation 1211 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="t" /db_xref="dbSNP:13021567" variation 1222 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:371266585" variation 1238 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="c" /db_xref="dbSNP:12996049" variation 1286 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:201007398" variation 1292 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:374484897" variation 1303 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:373845750" variation 1309 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:138052501" variation 1321 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:368048763" variation 1322 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:200472482" variation 1326 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:199631560" variation 1327 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:148935269" variation 1356 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:372115727" variation 1359 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:375433711" exon 1365..1567 /gene="SLC9A2" /gene_synonym="NHE2" /inference="alignment:Splign:1.39.8" variation 1378 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="g" /db_xref="dbSNP:372641100" variation 1411 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:145744861" variation 1473 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:377206233" variation 1509 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:200846141" variation 1517 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="t" /db_xref="dbSNP:368185370" variation 1528 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:201428753" variation 1561 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:149530548" exon 1568..1657 /gene="SLC9A2" /gene_synonym="NHE2" /inference="alignment:Splign:1.39.8" variation 1617 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:191805679" exon 1658..1728 /gene="SLC9A2" /gene_synonym="NHE2" /inference="alignment:Splign:1.39.8" variation 1667 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:41280603" variation 1714 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:199687608" exon 1729..1890 /gene="SLC9A2" /gene_synonym="NHE2" /inference="alignment:Splign:1.39.8" variation 1747 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:200485887" variation 1757 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:371605244" variation 1803 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:374840608" variation 1849 /gene="SLC9A2" /gene_synonym="NHE2" /replace="g" /replace="t" /db_xref="dbSNP:143332304" variation 1855 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="g" /db_xref="dbSNP:374852380" variation 1867 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:368150467" variation 1876 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:17776702" variation 1883 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:372340067" exon 1891..1987 /gene="SLC9A2" /gene_synonym="NHE2" /inference="alignment:Splign:1.39.8" variation 1899 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:143663218" variation 1913 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="c" /db_xref="dbSNP:372771066" variation 1924 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:374054836" variation 1935 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:146306086" variation 1969 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="g" /db_xref="dbSNP:146755145" variation 1984 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:114491816" exon 1988..2119 /gene="SLC9A2" /gene_synonym="NHE2" /inference="alignment:Splign:1.39.8" variation 1999 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:371958493" variation 2020 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:202139053" variation 2061 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:144961744" variation 2075 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:201034436" variation 2109 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:115244050" exon 2120..2210 /gene="SLC9A2" /gene_synonym="NHE2" /inference="alignment:Splign:1.39.8" variation 2125 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:148165091" variation 2132 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="t" /db_xref="dbSNP:201372565" variation 2172 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:376425428" variation 2176 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:369057289" exon 2211..5442 /gene="SLC9A2" /gene_synonym="NHE2" /inference="alignment:Splign:1.39.8" variation 2241 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:199943468" variation 2277 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:111701551" variation 2322 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:375217344" variation 2385 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="c" /db_xref="dbSNP:150662206" variation 2390 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:202141524" variation 2402 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:147224345" variation 2453 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:56156264" variation 2463 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:368881882" variation 2550 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:144197023" variation 2557 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="c" /db_xref="dbSNP:112482803" variation 2570 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="g" /db_xref="dbSNP:144642954" variation 2628 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:145995419" variation 2631 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:55898548" variation 2775 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:7585959" variation 2811 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:17027769" variation 3034 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:114811113" variation 3065 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:112685831" variation 3067 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:181320416" variation 3086 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:115630065" variation 3121 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:141820817" variation 3243 /gene="SLC9A2" /gene_synonym="NHE2" /replace="g" /replace="t" /db_xref="dbSNP:146277126" variation 3262 /gene="SLC9A2" /gene_synonym="NHE2" /replace="g" /replace="t" /db_xref="dbSNP:185260366" variation 3295 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:77699823" variation 3378 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:17027770" variation 3403 /gene="SLC9A2" /gene_synonym="NHE2" /replace="g" /replace="t" /db_xref="dbSNP:189168907" variation 3406 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:113157216" variation 3420 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="t" /db_xref="dbSNP:139050588" variation 3423 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:142512244" variation 3574 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:73944403" variation 3580 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:181873345" variation 3593 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:13398092" variation 3860 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:186316096" variation 3891..3892 /gene="SLC9A2" /gene_synonym="NHE2" /replace="" /replace="t" /db_xref="dbSNP:201886501" variation 3901 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:191115983" variation 3914 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:180676758" variation 4385 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:185991062" variation 4542..4543 /gene="SLC9A2" /gene_synonym="NHE2" /replace="" /replace="aa" /db_xref="dbSNP:143157377" variation 4543 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:202037069" variation 4562 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="c" /db_xref="dbSNP:368630188" variation 4578 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:191382383" variation 4586 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:183215873" variation 4617 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:150942924" variation 4704 /gene="SLC9A2" /gene_synonym="NHE2" /replace="" /replace="t" /db_xref="dbSNP:72229461" variation 4722..4725 /gene="SLC9A2" /gene_synonym="NHE2" /replace="" /replace="tgac" /db_xref="dbSNP:144629891" variation 4848 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:185782261" variation 4874 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="g" /db_xref="dbSNP:17776875" variation 4950 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="g" /db_xref="dbSNP:190638642" variation 5027 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="t" /db_xref="dbSNP:77140684" variation 5028 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="t" /db_xref="dbSNP:75150031" variation 5029 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:139508966" variation 5109 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:11123946" variation 5265 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:182940775" variation 5275 /gene="SLC9A2" /gene_synonym="NHE2" /replace="g" /replace="t" /db_xref="dbSNP:7605990" variation 5287 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:187645450" variation 5308 /gene="SLC9A2" /gene_synonym="NHE2" /replace="g" /replace="t" /db_xref="dbSNP:375310416" variation 5338 /gene="SLC9A2" /gene_synonym="NHE2" /replace="a" /replace="g" /db_xref="dbSNP:149701404" variation 5359 /gene="SLC9A2" /gene_synonym="NHE2" /replace="c" /replace="t" /db_xref="dbSNP:147923726" ORIGIN
ccggtgccgcagcagcggcgggtggctgtcgctgccctgccctgcacggggcagggcggagcgggctgagcagcccgggcgcgatgcgttgagcgctcggagggccaaccgccggtccccttggcggcaaccggcggcacccatggaaccactgggcaactggaggagcctgcgggcgccactgcctccgatgctgttgctgctgctcctgcaggtggcggggcccgtgggcgccctggcggagaccttgctgaacgcgccgagggccatgggcaccagttccagcccgcctagccctgcgagcgtggtggctcccggaacgacgctgttcgaggagagccggctgcctgtgtttacgctggattacccccacgtgcagatccccttcgagatcaccctttggatcctgctggcctccctggccaagattggcttccatctgtatcacaagttgcccacaatagtgcctgagagctgccttcttataatggttggacttctactaggtgggattatttttggtgttgatgagaagtctccccctgcaatgaagactgatgtatttttcttgtacctcctcccacccatcgtgctggatgccggctatttcatgcccactcgcccattctttgagaacattggcacgattttctggtatgctgtggtagggacactttggaattccattggcattggggtgtctttgtttggtatctgccagatcgaagcattcggcctcagcgacatcactttgctccagaacctgctctttggcagcttaatctcagctgtcgatcctgtggctgtgcttgctgtctttgagaacattcacgtcaatgagcagctctacatcctggtctttggagagtccctgctgaatgatgcagtaacagtggtcctgtacaacttgttcaagtcgttttgccagatgaaaaccattgagaccattgatgtgtttgcaggaatcgccaacttctttgttgtgggaatcggtggggtgctgattggcatcttcttgggctttatagcggcatttactactcgattcacccataatatccgagtgatcgagccactgtttgttttcctgtacagttatttgtcctacatcacagctgaaatgtttcacctctcaggcatcatggcaatcactgcttgtgcaatgactatgaataagtacgtagaagaaaatgtatctcagaaatcctacacgaccatcaagtacttcatgaagatgctgagcagtgtcagcgaaaccttgatcttcatcttcatgggtgtgtctaccgtgggcaagaaccacgagtggaactgggccttcgtctgcttcaccctggccttctgcctcatgtggcgagccctgggtgtttttgtcctgactcaggtcattaataggttccggaccattcccctgacctttaaggaccagttcatcattgcctatggaggacttcgaggtgccatctgttttgcgttagtgtttctccttcctgctgctgtgtttcctcggaaaaaattgtttattacggctgccattgttgtcatattctttactgtcttcattctgggaataactattcgaccactggtggagtttcttgatgtcaagaggtccaataagaaacaacaagctgtcagtgaagaaatctattgtcggttgtttgatcatgtgaagactggaattgaagatgtttgtggacattggggtcacaacttttggagagacaagtttaagaagtttgatgataaatatctgcggaagcttttgattcgggaaaaccaaccaaagtcaagtattgtatctttatataaaaagcttgaaataaaacatgccattgagatggcagagactgggatgataagtactgtccctacatttgcatctctaaatgattgtcgtgaagaaaaaataaggaaggtcacgtccagtgaaactgatgaaattcgagaactcttatcaagaaatctctatcaaatccgtcagcgaactttatcctacaacagacacagtctgacagccgacacaagtgagagacaagccaaggagattctgattcgccggcgacacagtttgcgagaaagcattaggaaggacagcagcttgaatcgagaacacagggcttccacttcaacctcccgatatttatccttacctaaaaatacgaagcttccagaaaagctacaaaagaggaggactatttctattgcagatggcaatagcagcgactcagacgcagatgccgggaccaccgtgctcaatttgcagcccagagccaggcgcttcttgccagaacagttctccaagaaatccccccagtcctataaaatggaatggaagaatgaggtagatgttgattctggccgagatatgcccagcacccccccaacaccccacagcagagaaaagggcacccagacgtcaggcttactacagcagccccttctctctaaagaccagtctggctcagagagggaagacagtttgactgaaggcatcccgcccaagccgccaccacggctggtctggagggcatcggaacctggaagccggaaagcccgatttgggagtgagaagccttaagagaagcagcgaaagcagatctgagtgtctgacccaggacagctgtggtttgtcactctgaaacctgatgcaacagtggaatccatgtaaaactctctgtgcatctaaatacttctggagggcgacagattcatgccacggataaatgaggcaaatccgaagaaaaggaaaatcgaataaaaaatagtcccacaaaataccttttgtgactaatgggtagcaatcgtattatttgctggcctgaagagaaaaaatggtaatgtgtgcctttattgaacttgaatgacagaacttgaaatttttaacacatccttcttggtgaagattttaatatattacttatatgcttcaaattttatttatgaaaaaatatgtatatctgtaatcagttgttaagtgaatggcactaaaagtatcgagaacagctttctttcccaggggtgaaggatggcgctcgggggtgactcctaagctcagcgtggaagcttttccctgtcctgacccgatggagcagccggtaagtgaagagcacagctggaagcagagacaccttatgactcaaactgggcaaacaatcggaacgtcatgcagaaggaatggcctgactcctgcagtgcagattggaggccccagaactcctatgaactactgagagtctactggtttttaacttgttcctctgtctactgtgtgtttgggggtgacatctaaattccatttcttcttcttgtttaaatggtgcagagagaaaggttgcccagacatccaccagcttactgtgttgacagatttgggagcagcttttgatgaagttccacccatgagggtccatgtggcaagtagggccacagggcagcacctggttacaacttgctggtgggttttatgttgtgcaatactaggaggaggaggcaggtgatctatgctgatctatgatcacctgcttcagtagaatttttctgtagagtgttgtttgaattttgagcctccaggttagaggctccaagcagacaaagaagaaagtttgtagacacaatattctaacattgcacaagttgatgagatatcaagttttgaatattattcaggaagcactttggagaatgtgggagtcctactgttttgcactagtctgtaatttgttacctctccccattcgataatatagtaactcagaattttcatataaaattgaattctactcattagagtactttttaaaagtacagcagaaagaaaagaagtggaacataagcattcaagattaatatttgattctctatctcttaactgtagattttattggcctgttttttttttctaaataattctttaaaacttgactggaacatgcctctgcatttctgagtgtagaaattaaatgaagccactcacagtcctttgatttcccactgaagataccccaaaggatgcaagtgcctacagtattatcaggaggagaacatgaaaatattaagacaaaaatcctcagcagttgttctccaccccttctccacctccaccagcaaggagaagtcaatctacacttttttctcatgttctaaagtcttagaatactgctggattgttgagcatgagacagagcaaaggttagatacacaaggtacaagttcataggagcacaattccttgattcagggaaagtagcacagaatgcaatttgaaaactacaggcttaggactctgtgccaaaaatctctattttaaatgaaaatatttatataaaaatacatttattctgcttaacacaaattaaaactgacataaaattttatgataataacatgattcaagaaatgtgatgtagatttttgagaatgccaaaaatcaggtttcagaaaagctacagtatgaaatctgaaaagcaacagaaattgaaagtgaccttaaagaataaatttcctaatttttcccagtttcctatgtttataactattataaagagtttaactttctggaactgaaggagaaaacatgaaaatgtttatattgcttcttgttaagcaggtagaccaaattccgctttcagtaattcatccatacagaatttggatgactatgtataaaggaaaacttaaatcttaattattatcagtttaaattttttttgtttgttgaatgacaaaggcaataaaaataaatttgactttagctttttttctatactttcctctttttgtaattcttaaattctagtcactagtcattatgagagtattgactaaatattttcacaatctaaatattgtcacaatctaaatttctgtagtacagagagccgtagccctttgtaaaggctttcgttcgtccaaacaacacttgatccaaccaaagttccaatgtgactgtggatctttgataggtctttggtgttggttgtaacaaaatttgatttgaactacctataaatgaaaagtcggggtttattactttatatgtaatgctgagaggagactgttgggaacagttatgtcaatgagcaaactagaaattggcttcaaagtctgatacttttaaaagcatgtgttttgtgtatatgctcacaaaatgtctgtgaagagatttctttcagcttttgctcagctttatggtggggtgtactgttttatctgggcggtgagggtattgatttacataaaaactgtagacaaacacagtacgagtctcagcacgttttgcatttattgtactgcccaaattgtttttatgttaaaagtcacgtttcataatctgcaatatttttgtcaaagtgcacactgtactttcttcttaaaaacgtgattaaagagatcactttgtccggatgaagcagctgttggcattatccgctgaggcttgaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:6549 -> Molecular function: GO:0015385 [sodium:hydrogen antiporter activity] evidence: IEA GeneID:6549 -> Biological process: GO:0006811 [ion transport] evidence: TAS GeneID:6549 -> Biological process: GO:0006885 [regulation of pH] evidence: IEA GeneID:6549 -> Biological process: GO:0008104 [protein localization] evidence: IEA GeneID:6549 -> Biological process: GO:0055085 [transmembrane transport] evidence: TAS GeneID:6549 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS GeneID:6549 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
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