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2024-04-25 00:08:09, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003028 6021 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens Src homology 2 domain containing adaptor protein B
(SHB), mRNA.
ACCESSION NM_003028
VERSION NM_003028.2 GI:106879209
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6021)
AUTHORS Stein,J.L., Hua,X., Lee,S., Ho,A.J., Leow,A.D., Toga,A.W.,
Saykin,A.J., Shen,L., Foroud,T., Pankratz,N., Huentelman,M.J.,
Craig,D.W., Gerber,J.D., Allen,A.N., Corneveaux,J.J.,
Dechairo,B.M., Potkin,S.G., Weiner,M.W. and Thompson,P.
CONSRTM Alzheimer's Disease Neuroimaging Initiative
TITLE Voxelwise genome-wide association study (vGWAS)
JOURNAL Neuroimage 53 (3), 1160-1174 (2010)
PUBMED 20171287
REFERENCE 2 (bases 1 to 6021)
AUTHORS Kriz,V., Agren,N., Lindholm,C.K., Lenell,S., Saldeen,J., Mares,J.
and Welsh,M.
TITLE The SHB adapter protein is required for normal maturation of
mesoderm during in vitro differentiation of embryonic stem cells
JOURNAL J. Biol. Chem. 281 (45), 34484-34491 (2006)
PUBMED 16971391
REFERENCE 3 (bases 1 to 6021)
AUTHORS Saldeen,J., Kriz,V., Agren,N. and Welsh,M.
TITLE SHB and angiogenic factors promote ES cell differentiation to
insulin-producing cells
JOURNAL Biochem. Biophys. Res. Commun. 344 (2), 517-524 (2006)
PUBMED 16630561
REMARK GeneRIF: It is concluded that SHB and angiogenic factors promote
the development of cells expressing PDX-1 and insulin in EBs and
that such cells can be separated by FACS.
REFERENCE 4 (bases 1 to 6021)
AUTHORS Zhang,Y., Zhu,W., Wang,Y.G., Liu,X.J., Jiao,L., Liu,X., Zhang,Z.H.,
Lu,C.L. and He,C.
TITLE Interaction of SH2-Bbeta with RET is involved in signaling of
GDNF-induced neurite outgrowth
JOURNAL J. Cell. Sci. 119 (PT 8), 1666-1676 (2006)
PUBMED 16569669
REMARK GeneRIF: Taken together, our results suggest that SH2-Bbeta is a
new signaling molecule involved in GDNF-induced neurite outgrowth.
REFERENCE 5 (bases 1 to 6021)
AUTHORS Zhang,Y., Wolf-Yadlin,A., Ross,P.L., Pappin,D.J., Rush,J.,
Lauffenburger,D.A. and White,F.M.
TITLE Time-resolved mass spectrometry of tyrosine phosphorylation sites
in the epidermal growth factor receptor signaling network reveals
dynamic modules
JOURNAL Mol. Cell Proteomics 4 (9), 1240-1250 (2005)
PUBMED 15951569
REFERENCE 6 (bases 1 to 6021)
AUTHORS Welsh,M., Songyang,Z., Frantz,J.D., Trub,T., Reedquist,K.A.,
Karlsson,T., Miyazaki,M., Cantley,L.C., Band,H. and Shoelson,S.E.
TITLE Stimulation through the T cell receptor leads to interactions
between SHB and several signaling proteins
JOURNAL Oncogene 16 (7), 891-901 (1998)
PUBMED 9484780
REFERENCE 7 (bases 1 to 6021)
AUTHORS Karlsson,T. and Welsh,M.
TITLE Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain
protein Shb
JOURNAL Oncogene 13 (5), 955-961 (1996)
PUBMED 8806685
REFERENCE 8 (bases 1 to 6021)
AUTHORS Karlsson,T., Songyang,Z., Landgren,E., Lavergne,C., Di Fiore,P.P.,
Anafi,M., Pawson,T., Cantley,L.C., Claesson-Welsh,L. and Welsh,M.
TITLE Molecular interactions of the Src homology 2 domain protein Shb
with phosphotyrosine residues, tyrosine kinase receptors and Src
homology 3 domain proteins
JOURNAL Oncogene 10 (8), 1475-1483 (1995)
PUBMED 7537362
REFERENCE 9 (bases 1 to 6021)
AUTHORS Yulug,I.G., Hillermann,R. and Fisher,E.M.
TITLE The SHB adaptor protein maps to human chromosome 9
JOURNAL Genomics 24 (3), 615-617 (1994)
PUBMED 7713524
REFERENCE 10 (bases 1 to 6021)
AUTHORS Welsh,M., Mares,J., Karlsson,T., Lavergne,C., Breant,B. and
Claesson-Welsh,L.
TITLE Shb is a ubiquitously expressed Src homology 2 protein
JOURNAL Oncogene 9 (1), 19-27 (1994)
PUBMED 8302579
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL161448.16, AL583849.10 and AL138752.5.
On Jun 3, 2006 this sequence version replaced gi:4506934.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: X75342.1, BC136581.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1285 AL161448.16 78568-79852 c
1286-1406 AL161448.16 26650-26770 c
1407-1622 AL583849.10 31434-31649 c
1623-1794 AL583849.10 12695-12866 c
1795-1914 AL583849.10 5447-5566 c
1915-6021 AL138752.5 25185-29291
FEATURES Location/Qualifiers
source 1..6021
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9p13.2"
gene 1..6021
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/note="Src homology 2 domain containing adaptor protein B"
/db_xref="GeneID:6461"
/db_xref="HGNC:10838"
/db_xref="MIM:600314"
exon 1..1285
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/inference="alignment:Splign:1.39.8"
misc_feature 311..313
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/note="upstream in-frame stop codon"
CDS 569..2098
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/note="SHB adaptor protein (a Src homology 2 protein); SHB
(Src homology 2 domain containing) adaptor protein B"
/codon_start=1
/product="SH2 domain-containing adapter protein B"
/protein_id="NP_003019.2"
/db_xref="GI:106879210"
/db_xref="CCDS:CCDS43806.1"
/db_xref="GeneID:6461"
/db_xref="HGNC:10838"
/db_xref="MIM:600314"
/translation="
MAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGSPHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSDPFDAKNDLKSKAGKGESAGYMEPYEAQRIMTEFQRQESVRSQHKGIQLYDTPYEPEGQSVDSDSESTVSPRLRESKLPQDDDRPADEYDQPWEWNRVTIPALAAQFNGNEKRQSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPAVPLEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEKYVLGQNSPPFDSVPEVIHYYTTRKLPIKGAEHLSLLYPVAVRTL
"
misc_feature 569..1798
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q15464.2);
Region: Mediates interaction with LAT, PTK2/FAK1, JAK1 and
JAK3"
misc_feature 1304..1306
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[5]
misc_feature 1517..1519
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q15464.2); phosphorylation site"
misc_feature 1730..1732
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q15464.2); phosphorylation site"
misc_feature 1790..2080
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/note="Src homology 2 domain found in SH2
domain-containing adapter protein B (SHB); Region:
SH2_SHB; cd10389"
/db_xref="CDD:198252"
misc_feature order(1817..1819,1871..1873,1934..1936,1940..1942)
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/note="phosphotyrosine binding pocket [polypeptide
binding]; other site"
/db_xref="CDD:198252"
misc_feature order(1937..1939,2021..2023)
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/note="hydrophobic binding pocket [polypeptide binding];
other site"
/db_xref="CDD:198252"
variation 679
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/replace="c"
/replace="t"
/db_xref="dbSNP:3750444"
variation 839
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/replace="c"
/replace="g"
/db_xref="dbSNP:1065372"
variation 845
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/replace="c"
/replace="g"
/db_xref="dbSNP:1065373"
variation 966
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/replace="c"
/replace="t"
/db_xref="dbSNP:1061289"
variation 1009
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/replace="c"
/replace="g"
/db_xref="dbSNP:1065374"
exon 1286..1406
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/inference="alignment:Splign:1.39.8"
exon 1407..1622
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/inference="alignment:Splign:1.39.8"
variation 1498
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/replace="a"
/replace="g"
/db_xref="dbSNP:1138374"
variation 1608
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/replace="g"
/replace="t"
/db_xref="dbSNP:1142954"
exon 1623..1794
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/inference="alignment:Splign:1.39.8"
exon 1795..1914
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/inference="alignment:Splign:1.39.8"
exon 1915..6021
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/inference="alignment:Splign:1.39.8"
STS 1951..2489
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/standard_name="SHB_8624"
/db_xref="UniSTS:467884"
STS 2103..2268
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/standard_name="STS-X75342"
/db_xref="UniSTS:8806"
STS 2109..2292
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/standard_name="GDB:594944"
/db_xref="UniSTS:158012"
variation 2173
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/replace="a"
/replace="g"
/db_xref="dbSNP:2281784"
STS 2184..2295
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/standard_name="WI-19223"
/db_xref="UniSTS:38867"
variation 2220
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/replace="c"
/replace="t"
/db_xref="dbSNP:17847958"
polyA_site 2771
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
polyA_signal 2784..2785
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
variation 3807
/gene="SHB"
/gene_synonym="bA3J10.2; RP11-3J10.8"
/replace="c"
/replace="t"
/db_xref="dbSNP:706148"
ORIGIN
gcgccgccgggacgggcacgggcgcgcgggctccggcgggcgccggctgccttcctccgtcgctcgctgtctctcccggccgcattctcctccgctgcggggccgagctctccccagcgctcgcaggaaggaagaagggagccgaggacgccgagaagttcccgcggcagccgcggatcccggccaaggcggaggctgcggctccgacggggcaggagcgcgatccacggcgaggggcgtacggccaaagggtccgcggcgtggagcgctcggaccttccgctctcccccgggcgtgggccgggaccccatgagacgcgcccacgaggggcgcgagattcctagcttgggcggcgctaggcggagggaggtgttgcagccgccggagccagagagctgccggcaggaggcggcggcggcaagaacttgaacttggcgtcgggagcgggcgccccggacgccccccgccggggccggggcgccgagggacctgcgccgcagcgctgccccccgaatggccgcggcggcggaccgggctcccgcgccgcggccctaggcggcctctcgccatggccaagtggctaaacaagtacttcagcttgggcaacagcaagaccaagagccccccgcagccgccgcggccagactaccgcgagcagcggcgccgaggcgagcggccttcgcagcccccccaggccgtgccgcaggcctcctccgccgcctcggcgtcctgcggtccggccaccgcctcctgcttctcagcctcttcgggctcgctgcccgacgacagcggcagcaccagcgacctcatccgcgcctaccgcgcgcagaaggagcgagacttcgaggacccctacaacgggcctggctcgtcgctgcgcaaactgcgcgccatgtgccgcctggactactgcggcggcagcggggagccaggcggggtccagcgcgccttctcggcctcgtccgcgtcgggcgccgcgggctgttgctgcgcctcctcgggcgcgggggccgccgcgtcctcgtcctcgtcctccggctctccgcatctctaccgcagcagcagcgagcggcggcccgccacgccggccgaggtgcgctacatctcccccaagcaccgcctcatcaaagtggagagcgccgcgggcggtggggccggggaccccctggggggcgcctgcgcgggcggccgcacctggagcccgacggcctgcggaggcaagaaactgctcaacaagtgcgccgcctcagccgcggaggagagcggggccggcaagaaggacaaggtgaccatagccgatgactactcagatccctttgatgccaagaatgatctcaagagcaaagcaggaaagggggagagtgctggctacatggagccctatgaggcacagaggatcatgacagaatttcagaggcaggaaagtgtccggtcccagcataaaggtatccagttatatgacaccccttacgaacctgaaggccaaagtgttgactcagactcggagagcacagtcagcccccgactgcgggagagcaagctgccccaggatgacgacaggcccgccgatgagtacgaccagccttgggagtggaaccgggtcaccatcccagccctggcagcacagtttaatggcaacgagaagcggcagtcatccccctcaccttcgcgggaccggcggcgccagcttcgtgcccctggagggggctttaagcctatcaaacatgggagccctgagttctgcgggatcctaggagaaagggtggatcctgccgtccccctggagaagcaaatatggtatcacggagccatcagcagaggagacgccgagaacctgctgcgactctgcaaggagtgtagctaccttgtccggaacagccagaccagcaagcatgactactccctctccctgaggagcaaccagggttttatgcacatgaaactggccaaaaccaaagagaaatacgttctgggtcagaacagccctccgttcgacagtgtcccggaagtcatccactactacaccaccagaaagctacccatcaaaggggctgagcacttgtccctcctctatcccgtggctgtgaggaccctgtgagcggaccagacctgccctgctctgtgacagagcctgagacttggaggtgccagaggccccccaccaaccagcccagccactgttgctggctgtgtcgtttgtgttgtgtgtatggtactagcacaccactgcatgtctctagaatgctgttgccacttacgggggctggagaaggcctggataaagacagaagggcggcaacacaccaccccagcccccacccccaccctctccttgagtttctgtgaattaaaatatttgcaaatccaaagagatgccttccaggatgaacaaaggcagaccagctccgaggggcggggtagggtggggcgggagctccctggctgacatctctttgttctccagctgtctcaaattcacacctctgtacagggcaaagttttcccacaggagcccccctactgatgctgggagccaaatgctggtgctttgagagtcccggaggccccggggttcccgccccgctggtgtgtatatgtgtgtctgtgtgagtgtgtgtgtgagtacagatgtgagaaggtggtcacacacagatgggtaagcccactgatctacttgtagtcactcagtgtaatcattaggctatcttcaaggaatcattgtgcagtcaaaaagaggattcaattatttatgaatagggtgtgtaaataaaatagtcatttaatatatagccttatccttttttgatatactgcagagggtctctgagggggcagttctggtttcactcccagagcaaggcgtgtctcctctgggcttgctgctgtggcaggccccagggaggggagggaggccgaggcctcagctccagccctcagcagctctggacacaagagccgtctgctctgacaactgggctgaggcagtcggtagcactctgggagtcaacccagagctcagagttcaggcttcagcagtggacatagtcaggagcctccagtgttgaccaaaaaaccagtctttccctcctgcagtgggacgtctgtgttgacacccccccaacccctggacacagcacccagctggctacaaagggctctctccccactatctgttagcaccacctgggaggtatttggcatgtagggaaagggagacagagaaggaacgtcatttgcccaaagccacacagctcaccagcagcagagcggttctgcagccaatgctctttcgttggttctgcatggccttgctgtcaccctgcccatggaggagggagaatcctgacctcccagggacatagagccctcagtggtccacactgcttccacacacaagaacacctacacacacacacacacacacacacacagccctcagtggtccacactgcttccacacacaagaacacctacacacacacacacacacacacacagccctcagtggtccacactgcttccacacacaagaacacctacacacgcacacgcacacgcgacctctctcttgcttgccatagcagggtcctcccacacaggccaggcagccccgatgaggctaagagtttctcagctctcctgctttttccacccacccagtagcatgaagatgtggctgccctctcctgaatgagatacaagggttccagagccttcgccaggcaccagctggtctgaatgaactagaagtttgacgactgtcatccctggcccacctgggcagagcacaaggggccgagtttgaatgtcatcagcaggttcagacatcagcgctgctcatgtctttagagactgtttggaggtggttccagctcactgttcacatgcagagacacaggcccggagaaggaggactcgccaaggccacgtgtcgagctgggactgagccctgcccctttaggtagctgcgtggacttcagcggtttgtgcaaagccctgcccttggtgacccgcctttagtgaccagtctgcctcttgggtcttcctcccaggccttgtctggcacgtccacgtggcccagccctcatagagaccacgctggctgtggcctgggtttaatctcttaaagaagccaatcctttccttgcctgtttggcatttcctaaaacatccctcaatgagggaggaaggcagggacaccctggaacgattcgtgctttcctttgggggagtgggaaggtaggtgggaaatgacaagatgagtgaggagttggcacttggccaaacagaggagcctggaccccaaggcttattctcagaggaggcccaagagaggctgaggaagagggggaacaaccctccggcgggggaggagggtgagacctcacactggcaagttcaggtccagccacttcctgaggctgctgggtggggccgcacctcacggtccttccctgtagaccatcttcccgggcacattgctcctcagaaaaggctctgggagggtctcagtggaagctggcagctgtgccctctggccctgacttggcctcttagggtattcctgggaccctccctctgtccctggccttcgtcttcctgaagtttccctgggaggcccaacctcctgcccctctcagggacagaggccagcagaggagccagcttacaggatgggagctgctgaaaagaatttttttcccttaattttatgaacctctccctcttcttcctctaattgtgaccgtttcctgtgtcagcctgtattcatgttttcttggacatctaacaattgaaacagcttttccctttcagaaacactcacattcaggttactggctttggtttggtttttgttttgggtttgttttttttttttttcatctgctgccaattaattggggaaaaaattgagctggatttctttgagagaaaagaaaagctcctgccacacaacgtcgcgccctcggcattttgtctgagaacctccagcactagcggctgtttctgtgtctcccttctttgctggctttattattgaccataatgcctgcccacttgagcaactctgtccttgagcgctgaggagtcaagggcccttctggcagccccccaaacaggatggcgcccacagaaagaaaggaggctttgtaggggaagagggccccaccgcctgccagtcccgtcctgaagtcagaagaatggcccaggctgacaccctctcctggagagaggctcacagcgtagctgttcccaggaaaggggtgcaaagactccgaggcttcaggaggcaggccctgtcctcacagggcggctgtgggccggggcccctctgtggcctgagagtgagcaggagggaaacctgaagcagctacccgcaaggcgtccggtcaacagggtggagctgcaggctccctctgcccattcccagaaccagcggccccctttgtaagatgctgaacacgaagttccggtagctccccagacgctgtctcagaagtggtgatatcattgaccaagggcctggcaaggaccggcagccagggtccccatttgctcttgcagccctagggactgtgcaggtagaagccctgccagcagagcaggctggcgtttggtgttggcccacagacacccgtgaagggtcatggccgaatcaggcagctgtccagccaactgtctctccacccttccagaattggtgatcagcgaagaccaaattcggcaagccatccagagggagtgcagggcgcacagtcttagatgtgggcgcacctcccagaaccccacggggacttgttcacaggcgcgcttgcaggagggcaagccccttggtcctggaacacaggtgccccttggcctttccacctccctccttggggctgtttgcatccctgccaggagccttaaaccagccacctactgctgaagtctcttgtaacattccaaatctatgtgacacactgtataatgatgaatatttaatgtgaagctcttaatatactacaagtgtcttgttta
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6461 -> Molecular function: GO:0005070 [SH3/SH2 adaptor activity] evidence: TAS
GeneID:6461 -> Biological process: GO:0001525 [angiogenesis] evidence: IEA
GeneID:6461 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:6461 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:6461 -> Biological process: GO:0030154 [cell differentiation] evidence: IEA
GeneID:6461 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
GeneID:6461 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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