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2024-04-20 03:39:28, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003011 2936 bp mRNA linear PRI 16-JUN-2013
DEFINITION Homo sapiens SET nuclear oncogene (SET), transcript variant 2,
mRNA.
ACCESSION NM_003011
VERSION NM_003011.3 GI:170763497
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2936)
AUTHORS Avet,C., Garrel,G., Denoyelle,C., Laverriere,J.N., Counis,R.,
Cohen-Tannoudji,J. and Simon,V.
TITLE SET protein interacts with intracellular domains of the
gonadotropin-releasing hormone receptor and differentially
regulates receptor signaling to cAMP and calcium in gonadotrope
cells
JOURNAL J. Biol. Chem. 288 (4), 2641-2654 (2013)
PUBMED 23233674
REMARK GeneRIF: SET protein interacts with intracellular domains of the
gonadotropin-releasing hormone receptor and differentially
regulates receptor signaling to cAMP and calcium in gonadotrope
cells
REFERENCE 2 (bases 1 to 2936)
AUTHORS Lam,B.D., Anthony,E.C. and Hordijk,P.L.
TITLE Cytoplasmic targeting of the proto-oncogene SET promotes cell
spreading and migration
JOURNAL FEBS Lett. 587 (2), 111-119 (2013)
PUBMED 23195690
REMARK GeneRIF: A SET mutant, lacking a nuclear localization signal,
SET(DeltaNLS), promotes cell spreading and motility. This was
accompanied by an increase in the number and frequency of membrane
ruffles.
REFERENCE 3 (bases 1 to 2936)
AUTHORS Almeida,L.O., Goto,R.N., Pestana,C.R., Uyemura,S.A., Gutkind,S.,
Curti,C. and Leopoldino,A.M.
TITLE SET overexpression decreases cell detoxification efficiency: ALDH2
and GSTP1 are downregulated, DDR is impaired and DNA damage
accumulates
JOURNAL FEBS J. 279 (24), 4615-4628 (2012)
PUBMED 23106910
REMARK GeneRIF: SET downregulated repair genes ATM, BRCA1 and CHEK2 and
upregulated TP53
REFERENCE 4 (bases 1 to 2936)
AUTHORS Kim,J.Y., Kim,K.B., Son,H.J., Chae,Y.C., Oh,S.T., Kim,D.W.,
Pak,J.H. and Seo,S.B.
TITLE H3K27 methylation and H3S28 phosphorylation-dependent
transcriptional regulation by INHAT subunit SET/TAF-Ibeta
JOURNAL FEBS Lett. 586 (19), 3159-3165 (2012)
PUBMED 22796192
REMARK GeneRIF: SET/TAF-Ibeta is sequentially recruited to the target gene
promoter ATF3 after the PRC2 complex via H3K27me recognition and
may offer additive effects in the repression of the target gene.
REFERENCE 5 (bases 1 to 2936)
AUTHORS Irie,A., Harada,K., Araki,N. and Nishimura,Y.
TITLE Phosphorylation of SET protein at Ser171 by protein kinase D2
diminishes its inhibitory effect on protein phosphatase 2A
JOURNAL PLoS ONE 7 (12), E51242 (2012)
PUBMED 23251465
REMARK GeneRIF: Recombinant SET with phosphorylation-mimic Ser171 to Glu
substitution reduced its inhibitory effects on PP2A phosphatase
activity compared with Ser171 to Ala substituted or wild-type SET
REFERENCE 6 (bases 1 to 2936)
AUTHORS Nagata,K., Kawase,H., Handa,H., Yano,K., Yamasaki,M., Ishimi,Y.,
Okuda,A., Kikuchi,A. and Matsumoto,K.
TITLE Replication factor encoded by a putative oncogene, set, associated
with myeloid leukemogenesis
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (10), 4279-4283 (1995)
PUBMED 7753797
REFERENCE 7 (bases 1 to 2936)
AUTHORS Adachi,Y., Pavlakis,G.N. and Copeland,T.D.
TITLE Identification of in vivo phosphorylation sites of SET, a nuclear
phosphoprotein encoded by the translocation breakpoint in acute
undifferentiated leukemia
JOURNAL FEBS Lett. 340 (3), 231-235 (1994)
PUBMED 8131851
REFERENCE 8 (bases 1 to 2936)
AUTHORS Vaesen,M., Barnikol-Watanabe,S., Gotz,H., Awni,L.A., Cole,T.,
Zimmermann,B., Kratzin,H.D. and Hilschmann,N.
TITLE Purification and characterization of two putative HLA class II
associated proteins: PHAPI and PHAPII
JOURNAL Biol. Chem. Hoppe-Seyler 375 (2), 113-126 (1994)
PUBMED 8192856
REFERENCE 9 (bases 1 to 2936)
AUTHORS Adachi,Y., Pavlakis,G.N. and Copeland,T.D.
TITLE Identification and characterization of SET, a nuclear
phosphoprotein encoded by the translocation break point in acute
undifferentiated leukemia
JOURNAL J. Biol. Chem. 269 (3), 2258-2262 (1994)
PUBMED 8294483
REFERENCE 10 (bases 1 to 2936)
AUTHORS von Lindern,M., van Baal,S., Wiegant,J., Raap,A., Hagemeijer,A. and
Grosveld,G.
TITLE Can, a putative oncogene associated with myeloid leukemogenesis,
may be activated by fusion of its 3' half to different genes:
characterization of the set gene
JOURNAL Mol. Cell. Biol. 12 (8), 3346-3355 (1992)
PUBMED 1630450
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CA392072.1, AK223556.1,
BP343325.1, CN408133.1 and BQ774097.1.
On Mar 25, 2008 this sequence version replaced gi:142361523.
Summary: The protein encoded by this gene inhibits acetylation of
nucleosomes, especially histone H4, by histone acetylases (HAT).
This inhibition is most likely accomplished by masking histone
lysines from being acetylated, and the consequence is to silence
HAT-dependent transcription. The encoded protein is part of a
complex localized to the endoplasmic reticulum but is found in the
nucleus and inhibits apoptosis following attack by cytotoxic T
lymphocytes. This protein can also enhance DNA replication of the
adenovirus genome. Several transcript variants encoding different
isoforms have been found for this gene. [provided by RefSeq, Oct
2011].
Transcript Variant: This variant (2) differs in the 5' UTR and
coding sequence compared to variant 1. The resulting isoform (2)
has a shorter and distinct N-terminus compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: M93651.1, BC014567.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-27 CA392072.1 1-27
28-1277 AK223556.1 1-1250
1278-1721 BP343325.1 135-578
1722-2428 CN408133.1 50-756
2429-2936 BQ774097.1 1-508 c
FEATURES Location/Qualifiers
source 1..2936
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q34"
gene 1..2936
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/note="SET nuclear oncogene"
/db_xref="GeneID:6418"
/db_xref="HGNC:10760"
/db_xref="MIM:600960"
exon 1..426
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
misc_feature 273..275
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/note="upstream in-frame stop codon"
variation 309
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:11542564"
CDS 354..1187
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/note="isoform 2 is encoded by transcript variant 2; SET
translocation (myeloid leukemia-associated); protein
phosphatase type 2A inhibitor; Template-Activating
Factor-I, chromatin remodelling factor; inhibitor of
granzyme A-activated DNase; HLA-DR-associated protein II;
inhibitor-2 of protein phosphatase-2A; phosphatase 2A
inhibitor I2PP2A"
/codon_start=1
/product="protein SET isoform 2"
/protein_id="NP_003002.2"
/db_xref="GI:170763498"
/db_xref="CCDS:CCDS6907.1"
/db_xref="GeneID:6418"
/db_xref="HGNC:10760"
/db_xref="MIM:600960"
/translation="
MSAPAAKVSKKELNSNHDGADETSEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEGEEDDDDDEEEEGLEDIDEEGDEDEGEEDEDDDEGEEGEEDEGEDD
"
misc_feature 438..1025
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/note="Nucleosome assembly protein (NAP); Region: NAP;
pfam00956"
/db_xref="CDD:216213"
misc_feature 486..1016
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/note="(NAP-L) nucleosome assembly protein -L;
Provisional; Region: PTZ00007; cl08298"
/db_xref="CDD:244897"
variation 364
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="c"
/db_xref="dbSNP:1141138"
variation 390
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:11542565"
exon 427..484
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
exon 485..627
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
variation 551
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:372830096"
variation 578
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:148209973"
exon 628..731
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
variation 653
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:62641744"
variation 669
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:141752935"
exon 732..845
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
variation 746
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:146235252"
variation 750
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:374932364"
variation 755
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:375022413"
variation 782
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:369280257"
exon 846..1016
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
variation 859
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:139428399"
variation 862
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="g"
/db_xref="dbSNP:142648600"
variation 871
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:150832256"
variation 920
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:200600519"
variation 944
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:139252094"
variation 959
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:376525055"
variation 962
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:75427242"
variation 963
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="g"
/replace="t"
/db_xref="dbSNP:4836619"
exon 1017..1163
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
variation 1037
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:142411393"
variation 1046
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:150020269"
variation 1055
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:145251942"
variation 1058
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:368663030"
variation 1133
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:372294597"
variation 1140
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace=""
/replace="g"
/db_xref="dbSNP:71497404"
exon 1164..2919
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
variation 1172
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:201761796"
variation 1189
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:201084109"
variation 1214
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:374784143"
variation 1234
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:371016083"
variation 1258
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace=""
/replace="t"
/db_xref="dbSNP:35778650"
variation 1278
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:77610267"
variation 1281..1282
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace=""
/replace="c"
/db_xref="dbSNP:201363886"
variation 1290
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="g"
/replace="t"
/db_xref="dbSNP:10988092"
variation 1369
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:10988093"
variation 1499
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:1061240"
variation 1516
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="g"
/db_xref="dbSNP:78124756"
variation 1548
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:10988094"
variation 1590
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:10988095"
variation 1592
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:10988096"
variation 1673
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:10988097"
variation 1680
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:139027346"
variation 1701
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:143324900"
variation 1734
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:60115664"
variation 1793
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:191018343"
variation 1850
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:369703905"
variation 1916
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:373337066"
variation 1948
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:184069752"
variation 2251
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:189098066"
variation 2306
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:377534760"
STS 2313..2652
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/standard_name="WI-7839"
/db_xref="UniSTS:5472"
variation 2317..2318
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace=""
/replace="ct"
/db_xref="dbSNP:201161315"
variation 2441
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:375728256"
variation 2452..2453
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace=""
/replace="g"
/db_xref="dbSNP:34355767"
variation 2483
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="c"
/db_xref="dbSNP:1141306"
variation 2510
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="g"
/replace="t"
/db_xref="dbSNP:192423121"
STS 2522..2615
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/standard_name="RH69637"
/db_xref="UniSTS:84497"
variation 2801
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:11542566"
variation 2811
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:183084664"
ORIGIN
gtaggaggaggtggaggaggaggcggctcgggagagcgagcagcgagctggctggatcgccgagcgcgagtgagggagccgagccgcccgccgccgccgcctccgcctcccctccgcgaacaggagcccgggccggggcccggcacgccgccccagcccgtccctcggcgtcaggccgcgagggtagcgcgcgcgagcgagcgagggggagggagagcgagcgagcgccgggaggaggcggccggaccgagcgggcgcccgcgcgtgtggcgtgaggggaagccgcttgcccgcccccttcgccttcccttctctccccctccccgctccccccccgaccgcggagcagcaccatgtcggcgccggcggccaaagtcagtaaaaaggagctcaactccaaccacgacggggccgacgagacctcagaaaaagaacagcaagaagcgattgaacacattgatgaagtacaaaatgaaatagacagacttaatgaacaagccagtgaggagattttgaaagtagaacagaaatataacaaactccgccaaccattttttcagaagaggtcagaattgatcgccaaaatcccaaatttttgggtaacaacatttgtcaaccatccacaagtgtctgcactgcttggggaggaagatgaagaggcactgcattatttgaccagagttgaagtgacagaatttgaagatattaaatcaggttacagaatagatttttattttgatgaaaatccttactttgaaaataaagttctctccaaagaatttcatctgaatgagagtggtgatccatcttcgaagtccaccgaaatcaaatggaaatctggaaaggatttgacgaaacgttcgagtcaaacgcagaataaagccagcaggaagaggcagcatgaggaaccagagagcttctttacctggtttactgaccattctgatgcaggtgctgatgagttaggagaggtcatcaaagatgatatttggccaaacccattacagtactacttggttcccgatatggatgatgaagaaggagaaggagaagaagatgatgatgatgatgaagaggaggaaggattagaagatattgacgaagaaggggatgaggatgaaggtgaagaagatgaagatgatgatgaaggggaggaaggagaggaggatgaaggagaagatgactaaatagaacactgatggattccaaccttcctttttttaaattttctccagtccctgggagcaagttgcagtcttttttttttttttttttttttttccctcttgtgctcagtcgccctgttcttgaggtctcttttctctactccatggttctcaatttatttggggggaaataccttgagcagaatacaatgggaaaagagtctctacccctttctgttcgaagttcatttttatcccttcctgtctgaacaaaaactgtatggaatcaacaccaccgagctctgtgggaaaaaagaaaaacctgctcccttcgctctgctggaagctggagggtgctaggcccctgtgtagtagtgcatagaattctagcttttttcctcctttctctgtatattgggctcagagagtacactgtgtctctatgtgaatatggacagttagcatttaccaacatgtatctgtctactttctcttgtttaaaaaaagaaaaaaaaacttaaaaaaatggggttatagaaggtcagcaaagggtgggtttgagatgtttgggtgggttaagtgggcattttgacaacatggcttctcctttggcatgtttaattgtgatatttgacagacatccttgcagtttaagatgacacttttaaaataaattctctcctaatgatgacttgagccctgccactcaatgggagaatcagcagaacctgtaggatcttatttggaattgacattctctattgtaattttgttcctgtttatttttaaattttctttttgtttcactggaaaggaaagatgatgctcagttttaaacgttaaaagtgtacaagttgctttgttacaataaaactaaatgtgtacacaaaggatttgatgcttttctctcagcataggtatgcttactatgaccttccaagtttgacttgtataacatcactgtcaaactttgtcaccctaacttcgtattttttgatacgcactttgcaggatgacctcagggctatgtggattgagtaatgggatttgaatcaatgtattaatatctccatagctgggaaacgtgggttcaatttgccattggtttctgaaagtattcacatcatttgggataccagatagctcaatactctctgagtacattgtgcccttgatttttatctccaagtggcagtttttaaaattggccttttacctggatataaattaattgtgcctgccaccaccatccaacagacctggtgctctaatgccaagttatacacgggacagttgctggcatgtcttcattggctatataaaatgtggccaagaagataggctctcagtaagaagtctgatggtgagcagtaactgtccctgctttctggtataaagctctcaaatgtgaccatgtgaatctgggtgggataatggactcagctctgtctgctcaatgccattgtgcagagaagcaccctaatgcataagctttttaatgctgtaaaatatagtcgctgaaattaaatgccactttttcagaggtgaattaatggacagtctggtgaacttcaaaagctttttgatgtataaaacttgataaatggaactattccatcaataggcaaaagtgtaacaacctatctagatggatagtatgtaatttctgcacaggtctctgtttagtaaatacatcactgtataccgatcaggaatcttgctccaataaaggaacataaagattttttttggaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6418 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:6418 -> Molecular function: GO:0004864 [protein phosphatase inhibitor activity] evidence: TAS
GeneID:6418 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6418 -> Molecular function: GO:0008601 [protein phosphatase type 2A regulator activity] evidence: TAS
GeneID:6418 -> Molecular function: GO:0042393 [histone binding] evidence: TAS
GeneID:6418 -> Biological process: GO:0006260 [DNA replication] evidence: TAS
GeneID:6418 -> Biological process: GO:0006334 [nucleosome assembly] evidence: IEA
GeneID:6418 -> Biological process: GO:0006337 [nucleosome disassembly] evidence: TAS
GeneID:6418 -> Biological process: GO:0006913 [nucleocytoplasmic transport] evidence: NAS
GeneID:6418 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:6418 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:6418 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:6418 -> Biological process: GO:0035067 [negative regulation of histone acetylation] evidence: TAS
GeneID:6418 -> Biological process: GO:0043524 [negative regulation of neuron apoptotic process] evidence: IGI
GeneID:6418 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
GeneID:6418 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:6418 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:6418 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:6418 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IDA
GeneID:6418 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
GeneID:6418 -> Cellular component: GO:0043234 [protein complex] evidence: IDA
GeneID:6418 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IDA
by
@meso_cacase at
DBCLS
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