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2024-04-24 07:52:07, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003010 3752 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens mitogen-activated protein kinase kinase 4 (MAP2K4),
mRNA.
ACCESSION NM_003010
VERSION NM_003010.2 GI:24497520
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3752)
AUTHORS Lai,L., Song,Y., Liu,Y., Chen,Q., Han,Q., Chen,W., Pan,T.,
Zhang,Y., Cao,X. and Wang,Q.
TITLE MicroRNA-92a negatively regulates Toll-like receptor
(TLR)-triggered inflammatory response in macrophages by targeting
MKK4 kinase
JOURNAL J. Biol. Chem. 288 (11), 7956-7967 (2013)
PUBMED 23355465
REMARK GeneRIF: MicroRNA-92a negatively regulates Toll-like receptor
(TLR)-triggered inflammatory response in macrophages by targeting
MKK4 kinase
REFERENCE 2 (bases 1 to 3752)
AUTHORS Shao,N., Wang,Y., Lu,K., Jiang,W.Y., Li,Q., Wang,N., Feng,N.H. and
Hua,L.X.
TITLE Role of the functional MKK4 promoter variant (-1304T>G) in a
decreased risk of prostate cancer: case-control study and
meta-analysis
JOURNAL J. Cancer Res. Clin. Oncol. 138 (9), 1531-1539 (2012)
PUBMED 22526163
REMARK GeneRIF: Results suggest that the functional -1304G variant in the
MKK4 promoter decreases the risk of PCa by increasing the promoter
activity.
REFERENCE 3 (bases 1 to 3752)
AUTHORS Matsumoto,T., Kinoshita,T., Kirii,Y., Tada,T. and Yamano,A.
TITLE Crystal and solution structures disclose a putative transient state
of mitogen-activated protein kinase kinase 4
JOURNAL Biochem. Biophys. Res. Commun. 425 (2), 195-200 (2012)
PUBMED 22828509
REMARK GeneRIF: Crystal structures combined with small-angle X-ray
scattering experiments revealed that the apo form of
non-phosphorylated MAP2K4 (npMAP2K4) exists in a transient state
which has a longer conformation compared with the typical kinase
folding.
REFERENCE 4 (bases 1 to 3752)
AUTHORS Hawkes,W.C. and Alkan,Z.
TITLE Delayed cell cycle progression in selenoprotein W-depleted cells is
regulated by a mitogen-activated protein kinase kinase 4-p38/c-Jun
NH2-terminal kinase-p53 pathway
JOURNAL J. Biol. Chem. 287 (33), 27371-27379 (2012)
PUBMED 22730327
REMARK GeneRIF: SEPW1 silencing increases MKK4, which activates p38gamma,
p38delta, and JNK2 to phosphorylate p53 on Ser-33 and cause a
transient G(1) arrest.
REFERENCE 5 (bases 1 to 3752)
AUTHORS Hart,A.B., Engelhardt,B.E., Wardle,M.C., Sokoloff,G., Stephens,M.,
de Wit,H. and Palmer,A.A.
TITLE Genome-wide association study of d-amphetamine response in healthy
volunteers identifies putative associations, including cadherin 13
(CDH13)
JOURNAL PLoS ONE 7 (8), E42646 (2012)
PUBMED 22952603
REFERENCE 6 (bases 1 to 3752)
AUTHORS Gale,N.W., Holland,S.J., Valenzuela,D.M., Flenniken,A., Pan,L.,
Ryan,T.E., Henkemeyer,M., Strebhardt,K., Hirai,H., Wilkinson,D.G.,
Pawson,T., Davis,S. and Yancopoulos,G.D.
TITLE Eph receptors and ligands comprise two major specificity subclasses
and are reciprocally compartmentalized during embryogenesis
JOURNAL Neuron 17 (1), 9-19 (1996)
PUBMED 8755474
REFERENCE 7 (bases 1 to 3752)
AUTHORS Salmeron,A., Ahmad,T.B., Carlile,G.W., Pappin,D., Narsimhan,R.P.
and Ley,S.C.
TITLE Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel
MAP kinase kinase kinase
JOURNAL EMBO J. 15 (4), 817-826 (1996)
PUBMED 8631303
REFERENCE 8 (bases 1 to 3752)
AUTHORS Lin,A., Minden,A., Martinetto,H., Claret,F.X., Lange-Carter,C.,
Mercurio,F., Johnson,G.L. and Karin,M.
TITLE Identification of a dual specificity kinase that activates the Jun
kinases and p38-Mpk2
JOURNAL Science 268 (5208), 286-290 (1995)
PUBMED 7716521
REFERENCE 9 (bases 1 to 3752)
AUTHORS Derijard,B., Raingeaud,J., Barrett,T., Wu,I.H., Han,J.,
Ulevitch,R.J. and Davis,R.J.
TITLE Independent human MAP-kinase signal transduction pathways defined
by MEK and MKK isoforms
JOURNAL Science 267 (5198), 682-685 (1995)
PUBMED 7839144
REMARK Erratum:[Science 1995 Jul 7;269(5220):17]
REFERENCE 10 (bases 1 to 3752)
AUTHORS Yan,M., Dai,T., Deak,J.C., Kyriakis,J.M., Zon,L.I., Woodgett,J.R.
and Templeton,D.J.
TITLE Activation of stress-activated protein kinase by MEKK1
phosphorylation of its activator SEK1
JOURNAL Nature 372 (6508), 798-800 (1994)
PUBMED 7997270
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from L36870.1, AA293365.1 and
BC036032.1.
On Nov 3, 2002 this sequence version replaced gi:4506888.
Summary: This gene encodes a dual specificity protein kinase that
belongs to the Ser/Thr protein kinase family. This kinase is a
direct activator of MAP kinases in response to various
environmental stresses or mitogenic stimuli. It has been shown to
activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2
or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by
MAP3K1/MEKK. The knockout studies in mice suggested the roles of
this kinase in mediating survival signal in T cell development, as
well as in the organogenesis of liver. [provided by RefSeq, Jul
2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC036032.1, BC060764.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025082, ERS025083 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
FEATURES Location/Qualifiers
source 1..3752
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17p12"
gene 1..3752
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/note="mitogen-activated protein kinase kinase 4"
/db_xref="GeneID:6416"
/db_xref="HGNC:6844"
/db_xref="HPRD:03213"
/db_xref="MIM:601335"
exon 1..184
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/inference="alignment:Splign:1.39.8"
variation 3
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace=""
/replace="c"
/db_xref="dbSNP:370540710"
variation 41
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371308400"
variation 61
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:62060968"
CDS 70..1269
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/EC_number="2.7.12.2"
/note="MAP kinase kinase 4; c-Jun N-terminal kinase kinase
1; JNK activating kinase 1; SAPK/ERK kinase 1; MAPK/ERK
kinase 4; JNK-activated kinase 1; MEK 4; MAPKK 4;
JNK-activating kinase 1; SAPK kinase 1; stress-activated
protein kinase kinase 1"
/codon_start=1
/product="dual specificity mitogen-activated protein
kinase kinase 4"
/protein_id="NP_003001.1"
/db_xref="GI:4506889"
/db_xref="CCDS:CCDS11162.1"
/db_xref="GeneID:6416"
/db_xref="HGNC:6844"
/db_xref="HPRD:03213"
/db_xref="MIM:601335"
/translation="
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
"
misc_feature 178..225
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P45985.1);
Region: D domain"
misc_feature 202..207
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/experiment="experimental evidence, no additional details
recorded"
/note="Cleavage, by anthrax lethal factor; propagated from
UniProtKB/Swiss-Prot (P45985.1); cleavage site"
misc_feature 241..246
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/experiment="experimental evidence, no additional details
recorded"
/note="Cleavage, by anthrax lethal factor; propagated from
UniProtKB/Swiss-Prot (P45985.1); cleavage site"
misc_feature 307..309
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01261"
misc_feature 337..339
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P45985.1); phosphorylation site"
misc_feature 358..1224
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/note="Catalytic domain of the dual-specificity Protein
Kinase, MAP kinase kinase 4; Region: PKc_MKK4; cd06616"
/db_xref="CDD:132947"
misc_feature 376..1170
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature order(391..405,409..411,415..417,454..456,460..462,
553..555,601..612,616..621,625..630,754..756,760..771,
775..777,808..810,817..819,856..867,871..873,964..966,
991..993)
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/note="active site"
/db_xref="CDD:132947"
misc_feature order(391..405,409..411,415..417,454..456,460..462,
553..555,601..612,616..621,625..630,760..762,766..771,
775..777,808..810)
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:132947"
misc_feature order(400..405,754..756,760..768,817..819,856..867,
871..873,964..966,991..993)
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:132947"
misc_feature 805..873
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/note="activation loop (A-loop); other site"
/db_xref="CDD:132947"
misc_feature 838..840
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by MAP3K; propagated from
UniProtKB/Swiss-Prot (P45985.1); phosphorylation site"
misc_feature 838..840
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03213"
misc_feature 850..852
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by MAP3K; propagated from
UniProtKB/Swiss-Prot (P45985.1); phosphorylation site"
misc_feature 850..852
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03213"
misc_feature 1159..1230
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P45985.1);
Region: DVD domain"
variation 115
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:17855590"
exon 185..287
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/inference="alignment:Splign:1.39.8"
variation 194
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:111801039"
variation 216
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:113748639"
variation 227
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372872972"
variation 272
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201981451"
exon 288..462
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/inference="alignment:Splign:1.39.8"
variation 295
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:377490722"
variation 303
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370348659"
variation 408
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374744100"
variation 441
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:148203118"
variation 444
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:55763083"
variation 458
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:77267737"
exon 463..582
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/inference="alignment:Splign:1.39.8"
variation 469
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:375500789"
exon 583..702
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/inference="alignment:Splign:1.39.8"
variation 641
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150905259"
variation 645
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374022234"
exon 703..754
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/inference="alignment:Splign:1.39.8"
exon 755..882
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/inference="alignment:Splign:1.39.8"
variation 859
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:200798818"
variation 861
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138304516"
variation 867
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:76726054"
exon 883..960
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/inference="alignment:Splign:1.39.8"
variation 889
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:56102360"
variation 957
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377585343"
exon 961..1109
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/inference="alignment:Splign:1.39.8"
variation 971
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:144008624"
variation 1017
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:202076088"
variation 1023
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:374357599"
variation 1029
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368291515"
variation 1047
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147290941"
variation 1082
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371746849"
variation 1083
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373999106"
variation 1091
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367710581"
variation 1094
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:191244765"
STS 1098..1290
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/standard_name="RH70575"
/db_xref="UniSTS:74809"
exon 1110..1155
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/inference="alignment:Splign:1.39.8"
variation 1116
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:55794822"
exon 1156..3743
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/inference="alignment:Splign:1.39.8"
STS 1167..2053
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/standard_name="MAP2K4_908"
/db_xref="UniSTS:277468"
variation 1192
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367662793"
variation 1200
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:55924570"
variation 1218
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144754357"
variation 1273
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201971628"
variation 1290
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:189817203"
variation 1319
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368292817"
variation 1320
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:376888511"
variation 1338
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:182465459"
variation 1357
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:139724158"
variation 1372
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:185329765"
variation 1470
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:190190304"
variation 1670
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1049438"
variation 1718
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146597820"
variation 1719
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:183470579"
variation 1823
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:188410287"
variation 1871
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:193245128"
variation 1917
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141440676"
variation 1974
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:1049439"
variation 1985
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:28921113"
variation 1994..1995
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace=""
/replace="g"
/db_xref="dbSNP:28921114"
variation 2005
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:184089088"
variation 2035
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11555725"
variation 2066
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:59832266"
variation 2074
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:186704791"
variation 2089
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:201362372"
variation 2125
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:191563418"
variation 2223
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:183860741"
variation 2368
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:188576778"
variation 2391
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:192717367"
variation 2440
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace=""
/replace="t"
/db_xref="dbSNP:35163626"
variation 2455
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373075028"
variation 2484
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1049441"
variation 2495
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1049442"
variation 2531
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:377467531"
variation 2550
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1049443"
variation 2597
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:4792219"
variation 2607
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140706208"
variation 2701
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150125305"
variation 2710
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:185127839"
variation 2728
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:138715568"
variation 2781
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:190166554"
variation 2834
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:182288643"
variation 2866
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:35027510"
variation 2945
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142822302"
variation 3040
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:189374285"
variation 3051
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:180737708"
variation 3067
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:1049444"
variation 3068
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:1049445"
variation 3224
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:1803981"
variation 3226
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:374613560"
variation 3315
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:185090127"
variation 3406
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377631607"
variation 3451
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:146989618"
STS 3496..3690
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/standard_name="A003B48"
/db_xref="UniSTS:36273"
STS 3540..3713
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/standard_name="RH12704"
/db_xref="UniSTS:43438"
variation 3583
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:28921115"
variation 3583
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199658174"
variation 3660
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:28921116"
polyA_signal 3720..3725
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
polyA_site 3743
/gene="MAP2K4"
/gene_synonym="JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4;
SAPKK-1; SAPKK1; SEK1; SERK1"
/experiment="experimental evidence, no additional details
recorded"
ORIGIN
ggccgtgcgagaggccgagcttgctgcattgcagccgccgcggcgccgctcggctcttcactcccaacaatggcggctccgagcccgagcggcggcggcggctccgggggcggcagcggcagcggcacccccggccccgtagggtccccggcgccaggccacccggccgtcagcagcatgcagggtaaacgcaaagcactgaagttgaattttgcaaatccacctttcaaatctacagcaaggtttactctgaatcccaatcctacaggagttcaaaacccacacatagagagactgagaacacacagcattgagtcatcaggaaaactgaagatctcccctgaacaacactgggatttcactgcagaggacttgaaagaccttggagaaattggacgaggagcttatggttctgtcaacaaaatggtccacaaaccaagtgggcaaataatggcagttaaaagaattcggtcaacagtggatgaaaaagaacaaaaacaacttcttatggatttggatgtagtaatgcggagtagtgattgcccatacattgttcagttttatggtgcactcttcagagagggtgactgttggatctgtatggaactcatgtctacctcgtttgataagttttacaaatatgtatatagtgtattagatgatgttattccagaagaaattttaggcaaaatcactttagcaactgtgaaagcactaaaccacttaaaagaaaacttgaaaattattcacagagatatcaaaccttccaatattcttctggacagaagtggaaatattaagctctgtgacttcggcatcagtggacagcttgtggactctattgccaagacaagagatgctggctgtaggccatacatggcacctgaaagaatagacccaagcgcatcacgacaaggatatgatgtccgctctgatgtctggagtttggggatcacattgtatgagttggccacaggccgatttccttatccaaagtggaatagtgtatttgatcaactaacacaagtcgtgaaaggagatcctccgcagctgagtaattctgaggaaagggaattctccccgagtttcatcaactttgtcaacttgtgccttacgaaggatgaatccaaaaggccaaagtataaagagcttctgaaacatccctttattttgatgtatgaagaacgtgccgttgaggtcgcatgctatgtttgtaaaatcctggatcaaatgccagctactcccagctctcccatgtatgtcgattgatatcgctgctacatcagactctagaaaaaagggctgagaggaagcaagacgtaaagaattttcatcccgtatcacagtgtttttattgctcgcccagacaccatgtgcaataagattggtgttcgtttccatcatgtctgtatactcctgtcacctagaacgtgcatccttgtaatacctgattgatcacacagtgttagtgctggtcagagagacctcatcctgctcttttgtgatgaacatattcatgaaatgtggaagtcagtacgatcaagttgttgactgtgattagatcacatcttaaattcatttctagactcaaaacctggagatgcagctactggaatggtgttttgtcagacttccaaatcctggaaggacacagtgatgaatgtactatgtctgaacatagaaactcgggcttgagtgagaagagcttgcacagccaacgagacacattgccttctggagctgggagacaaaggaggaatttactttcttcaccaagtgcaatagattactgatgtgatattctgttgctttacagttacagttgatgtttggggatcgatgtgctcagccaaatttcctgtttgaaatatcatgttaaattagaatgaatttatctttaccaaaaaccatgttgcgttcaaagaggtgaacattaaaatatagagacaggacagaatgtgttcttttctcctttaccagtcctatttttcaatgggaagactcaggagtctgccacttgtcaaagaaggtgctgatcctaagaatttttcattctcagaattcggtgtgctgccaacttgatgttccacctgccacaaaccaccaggactgaaagaagaaaacagtacagaaggcaaagtttacagatgtttttaattctagtattttatctggaacaacttgtagcagctatatatttccccttggtcccaagcctgatactttagccatcataactcactaacagggagaagtagctagtagcaatgtgccttgattgattagataaagatttctagtaggcagcaaaagaccaaatctcagttgtttgcttcttgccatcactggtccaggtcttcagtttccgaatctctttcccttcccctgtggtctattgtcgctatgtgacttgcgcttaatccaatattttgccttttttctatatcaaaaaacctttacagttagcagggatgttccttaccaaggatttttagccccaaatctctcatattcgctagtgtttaaaaggctaagaatagtggggcccagccgatgtggtaggtgataaagaggcatcttttctagagacacattggaccagatgaggatccgaaacggcagcctttacgttcatcacctgctagaacctctcgtagtccatcaccatttcttggcattggaattctactggaaaaaaatacaaaaagcaaaacaaaaccctcagcactgttacaagaggccatttaagtatcttgtgcttcttcacttacccattagccaggttctcattaggttttgcttgggcctccctggcactgaaccttaggctttgtatgacagtgaagcagcactgtgagtggttcaagcacactggaatataaaacagtcatggcctgagatgcaggtgatgccattacagaaccaaatcgtggcacgtattgctgtgtctcctctcagagtgacagtcataaatactgtcaaacaataaagggagaatggtgctgtttaaagtcacatccctgtaaattgcagaattcaaaagtgattatctctttgatctacttgcctcatttccctatcttctcccccacggtatcctaaactttagacttcccactgttctgaaaggagacattgctctatgtctgccttcgaccacagcaagccatcatcctccattgctcccggggactcaagaggaatctgtttctctgctgtcaacttcccatctggctcagcatagggtcactttgccattatgcaaatggagataaaagcaattctgactgtccaggagctaatctgaccgttctattgtgtggatgaccacataagaaggcaattttagtgtattaatcatagattattataaactataaacttaagggcaaggagtttattacaatgtatctttattaaaacaaaagggtgtatagtgttcacaaactgtgaaaatagtgtaagaactgtacattgtgagctctggttatttttctcttgtaccatagaaaaatgtataaaaattatcaaaaagctaatgtgcagggatattgccttatttgtctgtaaaaaatggagctcagtaacataactgcttcttggagctttggaatattttatcctgtattcttgtttgaattcctcctctatttaagatatatacatggaatcgaagtgtttatgtaatagttctatccttttgcctgcaggtcagttgtaataaatctaggatgtgatgatgaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6416 -> Molecular function: GO:0004672 [protein kinase activity] evidence: TAS
GeneID:6416 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA
GeneID:6416 -> Molecular function: GO:0004713 [protein tyrosine kinase activity] evidence: IEA
GeneID:6416 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6416 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:6416 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
GeneID:6416 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:6416 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
GeneID:6416 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:6416 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:6416 -> Biological process: GO:0007254 [JNK cascade] evidence: TAS
GeneID:6416 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS
GeneID:6416 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
GeneID:6416 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
GeneID:6416 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS
GeneID:6416 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS
GeneID:6416 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS
GeneID:6416 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:6416 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
GeneID:6416 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS
GeneID:6416 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS
GeneID:6416 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:6416 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS
GeneID:6416 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP
GeneID:6416 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:6416 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_003001 -> EC 2.7.12.2
by
@meso_cacase at
DBCLS
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