Home |
Help |
Advanced search
2024-04-19 23:20:16, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002944 7368 bp mRNA linear PRI 16-JUN-2013
DEFINITION Homo sapiens c-ros oncogene 1 , receptor tyrosine kinase (ROS1),
mRNA.
ACCESSION NM_002944
VERSION NM_002944.2 GI:19924164
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7368)
AUTHORS Lee,J., Lee,S.E., Kang,S.Y., Do,I.G., Lee,S., Ha,S.Y., Cho,J.,
Kang,W.K., Jang,J., Ou,S.H. and Kim,K.M.
TITLE Identification of ROS1 rearrangement in gastric adenocarcinoma
JOURNAL Cancer 119 (9), 1627-1635 (2013)
PUBMED 23400546
REMARK GeneRIF: SLC34A2-ROS1 rearrangement was identified in GC, and the
results provide a rationale for investigating the clinical efficacy
of ROS1 inhibitors in this unique molecular subset of GC
REFERENCE 2 (bases 1 to 7368)
AUTHORS Cilloni,D., Carturan,S., Bracco,E., Campia,V., Rosso,V., Torti,D.,
Calabrese,C., Gaidano,V., Niparuck,P., Favole,A., Signorino,E.,
Iacobucci,I., Morano,A., De Luca,L., Musto,P., Frassoni,F. and
Saglio,G.
TITLE Aberrant activation of ROS1 represents a new molecular defect in
chronic myelomonocytic leukemia
JOURNAL Leuk. Res. 37 (5), 520-530 (2013)
PUBMED 23415111
REMARK GeneRIF: Aberrant activation of ROS1 represents a new molecular
defect in chronic myelomonocytic leukemia.
REFERENCE 3 (bases 1 to 7368)
AUTHORS Yoshida,A., Kohno,T., Tsuta,K., Wakai,S., Arai,Y., Shimada,Y.,
Asamura,H., Furuta,K., Shibata,T. and Tsuda,H.
TITLE ROS1-rearranged lung cancer: a clinicopathologic and molecular
study of 15 surgical cases
JOURNAL Am. J. Surg. Pathol. 37 (4), 554-562 (2013)
PUBMED 23426121
REMARK GeneRIF: All ROS1 fusion-positive lung tumors lacked alteration of
EGFR, KRAS, HER2, ALK, and RET genes.
REFERENCE 4 (bases 1 to 7368)
AUTHORS Oxnard,G.R., Binder,A. and Janne,P.A.
TITLE New targetable oncogenes in non-small-cell lung cancer
JOURNAL J. Clin. Oncol. 31 (8), 1097-1104 (2013)
PUBMED 23401445
REMARK GeneRIF: ROS1 gene was first identified as an oncogene in NSCLC
through a phosphoproteomic screen, leveraging the fact that
oncogenic kinases should be highly phosphorylated proteins.
Review article
REFERENCE 5 (bases 1 to 7368)
AUTHORS Avery,C.L., Sitlani,C.M., Arking,D.E., Arnett,D.K., Bis,J.C.,
Boerwinkle,E., Buckley,B.M., Ida Chen,Y.D., de Craen,A.J.,
Eijgelsheim,M., Enquobahrie,D., Evans,D.S., Ford,I., Garcia,M.E.,
Gudnason,V., Harris,T.B., Heckbert,S.R., Hochner,H., Hofman,A.,
Hsueh,W.C., Isaacs,A., Jukema,J.W., Knekt,P., Kors,J.A.,
Krijthe,B.P., Kristiansson,K., Laaksonen,M., Liu,Y., Li,X.,
Macfarlane,P.W., Newton-Cheh,C., Nieminen,M.S., Oostra,B.A.,
Peloso,G.M., Porthan,K., Rice,K., Rivadeneira,F.F., Rotter,J.I.,
Salomaa,V., Sattar,N., Siscovick,D.S., Slagboom,P.E., Smith,A.V.,
Sotoodehnia,N., Stott,D.J., Stricker,B.H., Sturmer,T., Trompet,S.,
Uitterlinden,A.G., van Duijn,C., Westendorp,R.G., Witteman,J.C.,
Whitsel,E.A. and Psaty,B.M.
TITLE Drug-gene interactions and the search for missing heritability: a
cross-sectional pharmacogenomics study of the QT interval
JOURNAL Pharmacogenomics J. (2013) In press
PUBMED 23459443
REMARK Publication Status: Available-Online prior to print
REFERENCE 6 (bases 1 to 7368)
AUTHORS Galland,F., Stefanova,M., Lafage,M. and Birnbaum,D.
TITLE Localization of the 5' end of the MCF2 oncogene to human chromosome
15q15----q23
JOURNAL Cytogenet. Cell Genet. 60 (2), 114-116 (1992)
PUBMED 1611909
REFERENCE 7 (bases 1 to 7368)
AUTHORS Birchmeier,C., O'Neill,K., Riggs,M. and Wigler,M.
TITLE Characterization of ROS1 cDNA from a human glioblastoma cell line
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (12), 4799-4803 (1990)
PUBMED 2352949
REFERENCE 8 (bases 1 to 7368)
AUTHORS Sharma,S., Birchmeier,C., Nikawa,J., O'Neill,K., Rodgers,L. and
Wigler,M.
TITLE Characterization of the ros1-gene products expressed in human
glioblastoma cell lines
JOURNAL Oncogene Res. 5 (2), 91-100 (1989)
PUBMED 2691958
REFERENCE 9 (bases 1 to 7368)
AUTHORS Birchmeier,C., Sharma,S. and Wigler,M.
TITLE Expression and rearrangement of the ROS1 gene in human glioblastoma
cells
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 84 (24), 9270-9274 (1987)
PUBMED 2827175
REFERENCE 10 (bases 1 to 7368)
AUTHORS Matsushime,H., Wang,L.H. and Shibuya,M.
TITLE Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma
virus encodes for a transmembrane receptorlike molecule
JOURNAL Mol. Cell. Biol. 6 (8), 3000-3004 (1986)
PUBMED 3023956
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from M34353.1.
On Apr 4, 2002 this sequence version replaced gi:4506578.
Summary: This proto-oncogene, highly-expressed in a variety of
tumor cell lines, belongs to the sevenless subfamily of tyrosine
kinase insulin receptor genes. The protein encoded by this gene is
a type I integral membrane protein with tyrosine kinase activity.
The protein may function as a growth or differentiation factor
receptor. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: M34353.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025082, ERS025084 [ECO:0000350]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..7368
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6q22"
gene 1..7368
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="c-ros oncogene 1 , receptor tyrosine kinase"
/db_xref="GeneID:6098"
/db_xref="HGNC:10261"
/db_xref="HPRD:01295"
/db_xref="MIM:165020"
exon 1..322
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
misc_feature 176..178
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="upstream in-frame stop codon"
CDS 200..7243
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/EC_number="2.7.10.1"
/note="v-ros avian UR2 sarcoma virus oncogene homolog 1;
transmembrane tyrosine-specific protein kinase;
proto-oncogene tyrosine-protein kinase ROS; proto-oncogene
c-Ros-1; v-ros UR2 sarcoma virus oncogene homolog 1; c-Ros
receptor tyrosine kinase; receptor tyrosine kinase c-ros
oncogene 1"
/codon_start=1
/product="proto-oncogene tyrosine-protein kinase ROS
precursor"
/protein_id="NP_002935.2"
/db_xref="GI:19924165"
/db_xref="CCDS:CCDS5116.1"
/db_xref="GeneID:6098"
/db_xref="HGNC:10261"
/db_xref="HPRD:01295"
/db_xref="MIM:165020"
/translation="
MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQGCHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWKSANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYSPPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYNGYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMSTFLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEFGFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFELGPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPWSEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYSDTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDLSDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWINGFRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEGNASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTPYTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLTKFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYADVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAEGDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKVKYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQQNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAMLAGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFPDKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNSSDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEAVQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTLLVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPLNVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDGSD
"
sig_peptide 200..307
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
mat_peptide 308..7240
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/product="proto-oncogene tyrosine-protein kinase ROS"
misc_feature 503..754
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(677..679,722..724)
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(734..739,743..748)
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 788..1018
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(962..964,1007..1009)
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature 1010..1015
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 1871..2203
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(1871..1873,2120..2122,2165..2167)
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(2168..2173,2177..2182)
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 3320..3640
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(3320..3322,3557..3559,3602..3604)
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(3605..3610,3614..3619)
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 5174..5443
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(5174..5176,5360..5362,5405..5407)
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(5408..5413,5417..5422)
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 5456..5725
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(5456..5458,5708..5710)
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(5711..5716,5720..5725)
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 5753..5758
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/experiment="experimental evidence, no additional details
recorded"
/note="Breakpoint for translocation to form SLC34A2-ROS1
and CD74-ROS1 fusion proteins; propagated from
UniProtKB/Swiss-Prot (P08922.3); other site"
misc_feature 5777..5845
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P08922.3);
transmembrane region"
misc_feature 5837..5842
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/experiment="experimental evidence, no additional details
recorded"
/note="Breakpoint for translocation to form GOPC-ROS1
fusion protein; propagated from UniProtKB/Swiss-Prot
(P08922.3); other site"
misc_feature 6032..6844
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Protein tyrosine kinase; Region: Pkinase_Tyr;
pfam07714"
/db_xref="CDD:203736"
misc_feature 6044..6850
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="Catalytic domain of the Protein Tyrosine Kinase,
C-ros; Region: PTKc_c-ros; cd05044"
/db_xref="CDD:173630"
misc_feature order(6050..6064,6074..6076,6131..6133,6137..6139,
6275..6286,6293..6298,6434..6436,6446..6451,6455..6457,
6503..6505,6557..6571,6596..6598,6698..6700)
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="active site"
/db_xref="CDD:173630"
misc_feature order(6050..6055,6059..6064,6074..6076,6131..6133,
6137..6139,6275..6286,6293..6298,6446..6451,6455..6457,
6503..6505)
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173630"
misc_feature order(6434..6436,6446..6448,6557..6571,6596..6598,
6698..6700)
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173630"
misc_feature 6500..6577
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173630"
exon 323..367
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 368..427
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 428..488
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 489..637
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
variation 502
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/replace="a"
/replace="t"
/db_xref="dbSNP:2243378"
variation 632
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/replace="a"
/replace="c"
/db_xref="dbSNP:1998206"
exon 638..776
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
variation 699
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/replace="a"
/replace="g"
/db_xref="dbSNP:2243380"
exon 777..978
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 979..1055
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 1056..1178
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 1179..1363
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 1364..1461
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 1462..1958
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 1959..2213
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
variation 2157
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/replace="c"
/replace="t"
/db_xref="dbSNP:34203286"
exon 2214..2324
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
variation 2241
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/replace="g"
/replace="t"
/db_xref="dbSNP:200174940"
exon 2325..2503
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 2504..2695
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
variation 2568
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/replace="a"
/replace="g"
/db_xref="dbSNP:34582164"
exon 2696..2796
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 2797..3011
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 3012..3172
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
variation 3076
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/replace="a"
/replace="g"
/db_xref="dbSNP:2229078"
exon 3173..3317
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 3318..3580
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
variation 3525
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/replace="c"
/replace="t"
/db_xref="dbSNP:2229079"
exon 3581..3644
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 3645..3847
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
variation 3730
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/replace="a"
/replace="g"
/db_xref="dbSNP:35613256"
exon 3848..4053
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 4054..4340
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 4341..4520
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 4521..4723
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
variation 4715
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/replace="a"
/replace="g"
/db_xref="dbSNP:35841892"
exon 4724..4868
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 4869..5101
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
variation 4982
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/replace="c"
/replace="t"
/db_xref="dbSNP:3752564"
exon 5102..5278
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 5279..5447
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 5448..5565
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 5566..5756
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 5757..5840
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 5841..5976
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 5977..6139
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 6140..6204
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 6205..6334
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
variation 6315
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/replace="a"
/replace="g"
/db_xref="dbSNP:3752566"
exon 6335..6432
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 6433..6633
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
variation 6446
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/replace="a"
/replace="c"
/db_xref="dbSNP:552183"
exon 6634..6768
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
exon 6769..6932
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
variation 6836
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:529038"
variation 6881
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/replace="a"
/replace="c"
/db_xref="dbSNP:529156"
variation 6885
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/replace="c"
/replace="g"
/db_xref="dbSNP:619203"
exon 6933..7368
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/inference="alignment:Splign:1.39.8"
variation 7182
/gene="ROS1"
/gene_synonym="c-ros-1; MCF3; ROS"
/replace="a"
/replace="g"
/db_xref="dbSNP:35932630"
ORIGIN
caagctttcaagcattcaaaggtctaaatgaaaaaggctaagtattatttcaaaaggcaagtatatcctaatatagcaaaacaaacaaagcaaaatccatcagctactcctccaattgaagtgatgaagcccaaataattcatatagcaaaatggagaaaattagaccggccatctaaaaatctgccattggtgaagtgatgaagaacatttactgtcttattccgaagcttgtcaattttgcaactcttggctgcctatggatttctgtggtgcagtgtacagttttaaatagctgcctaaagtcgtgtgtaactaatctgggccagcagcttgaccttggcacaccacataatctgagtgaaccgtgtatccaaggatgtcacttttggaactctgtagatcagaaaaactgtgctttaaagtgtcgggagtcgtgtgaggttggctgtagcagcgcggaaggtgcatatgaagaggaagtactggaaaatgcagacctaccaactgctccctttgcttcttccattggaagccacaatatgacattacgatggaaatctgcaaacttctctggagtaaaatacatcattcagtggaaatatgcacaacttctgggaagctggacttatactaagactgtgtccagaccgtcctatgtggtcaagcccctgcaccccttcactgagtacattttccgagtggtttggatcttcacagcgcagctgcagctctactcccctccaagtcccagttacaggactcatcctcatggagttcctgaaactgcacctttgattaggaatattgagagctcaagtcccgacactgtggaagtcagctgggatccacctcaattcccaggtggacctattttgggttataacttaaggctgatcagcaaaaatcaaaaattagatgcagggacacagagaaccagtttccagttttactccactttaccaaatactatctacaggttttctattgcagcagtaaatgaagttggtgagggtccagaagcagaatctagtattaccacttcatcttcagcagttcaacaagaggaacagtggctctttttatccagaaaaacttctctaagaaagagatctttaaaacatttagtagatgaagcacattgccttcggttggatgctatataccataatattacaggaatatctgttgatgtccaccagcaaattgtttatttctctgaaggaactctcatatgggcgaagaaggctgccaacatgtctgatgtatctgacctgagaattttttacagaggttcaggattaatttcttctatctccatagattggctttatcaaagaatgtatttcatcatggatgaactggtatgtgtctgtgatttagagaactgctcaaacatcgaggaaattactccaccctctattagtgcacctcaaaaaattgtggctgattcatacaatgggtatgtcttttacctcctgagagatggcatttatagagcagaccttcctgtaccatctggccggtgtgcagaagctgtgcgtattgtggagagttgcacgttaaaggactttgcaatcaagccacaagccaagcgaatcatttacttcaatgacactgcccaagtcttcatgtcaacatttctggatggctctgcttcccatctcatcctacctcgcatcccctttgctgatgtgaaaagttttgcttgtgaaaacaatgactttcttgtcacagatggcaaggtcattttccaacaggatgctttgtcttttaatgaattcatcgtgggatgtgacctgagtcacatagaagaatttgggtttggtaacttggtcatctttggctcatcctcccagctgcaccctctgccaggccgcccgcaggagctttcggtgctgtttggctctcaccaggctcttgttcaatggaagcctcctgcccttgccataggagccaatgtcatcctgatcagtgatattattgaactctttgaattaggcccttctgcctggcagaactggacctatgaggtgaaagtatccacccaagaccctcctgaagtcactcatattttcttgaacataagtggaaccatgctgaatgtacctgagctgcagagtgctatgaaatacaaggtttctgtgagagcaagttctccaaagaggccaggcccctggtcagagccctcagtgggtactaccctggtgccagctagtgaaccaccatttatcatggctgtgaaagaagatgggctttggagtaaaccattaaatagctttggcccaggagagttcttatcctctgatataggaaatgtgtcagacatggattggtataacaacagcctctactacagtgacacgaaaggcgacgtttttgtgtggctgctgaatgggacggatatctcagagaattatcacctacccagcattgcaggagcaggggctttagcttttgagtggctgggtcactttctctactgggctggaaagacatatgtgatacaaaggcagtctgtgttgacgggacacacagacattgttacccacgtgaagctattggtgaatgacatggtggtggattcagttggtggatatctctactggaccacactctattcagtggaaagcaccagactaaatggggaaagttcccttgtactacagacacagccttggttttctgggaaaaaggtaattgctctaactttagacctcagtgatgggctcctgtattggttggttcaagacagtcaatgtattcacctgtacacagctgttcttcggggacagagcactggggataccaccatcacagaatttgcagcctggagtacttctgaaatttcccagaatgcactgatgtactatagtggtcggctgttctggatcaatggctttaggattatcacaactcaagaaataggtcagaaaaccagtgtctctgttttggaaccagccagatttaatcagttcacaattattcagacatcccttaagcccctgccagggaacttttcctttacccctaaggttattccagattctgttcaagagtcttcatttaggattgaaggaaatgcttcaagttttcaaatcctgtggaatggtccccctgcggtagactggggtgtagttttctacagtgtagaatttagtgctcattctaagttcttggctagtgaacaacactctttacctgtatttactgtggaaggactggaaccttatgccttatttaatctttctgtcactccttatacctactggggaaagggccccaaaacatctctgtcacttcgagcacctgaaacagttccatcagcaccagagaaccccagaatatttatattaccaagtggaaaatgctgcaacaagaatgaagttgtggtggaatttaggtggaacaaacctaagcatgaaaatggggtgttaacaaaatttgaaattttctacaatatatccaatcaaagtattacaaacaaaacatgtgaagactggattgctgtcaatgtcactccctcagtgatgtcttttcaacttgaaggcatgagtcccagatgctttattgccttccaggttagggcctttacatctaaggggccaggaccatatgctgacgttgtaaagtctacaacatcagaaatcaacccatttcctcacctcataactcttcttggtaacaagatagtttttttagatatggatcaaaatcaagttgtgtggacgttttcagcagaaagagttatcagtgccgtttgctacacagctgataatgagatgggatattatgctgaaggggactcactctttcttctgcacttgcacaatcgctctagctctgagcttttccaagattcactggtttttgatatcacagttattacaattgactggatttcaaggcacctctactttgcactgaaagaatcacaaaatggaatgcaagtatttgatgttgatcttgaacacaaggtgaaatatcccagagaggtgaagattcacaataggaattcaacaataatttctttttctgtatatcctcttttaagtcgcttgtattggacagaagtttccaattttggctaccagatgttctactacagtattatcagtcacaccttgcaccgaattctgcaacccacagctacaaaccaacaaaacaaaaggaatcaatgttcttgtaatgtgactgaatttgagttaagtggagcaatggctattgatacctctaacctagagaaaccattgatatactttgccaaagcacaagagatctgggcaatggatctggaaggctgtcagtgttggagagttatcacagtacctgctatgctcgcaggaaaaacccttgttagcttaactgtggatggagatcttatatactggatcatcacagcaaaggacagcacacagatttatcaggcaaagaaaggaaatggggccatcgtttcccaggtgaaggccctaaggagtaggcatatcttggcttacagttcagttatgcagccttttccagataaagcgtttctgtctctagcttcagacactgtggaaccaactatacttaatgccactaacactagcctcacaatcagattacctctggccaagacaaacctcacatggtatggcatcaccagccctactccaacatacctggtttattatgcagaagttaatgacaggaaaaacagctctgacttgaaatatagaattctggaatttcaggacagtatagctcttattgaagatttacaaccattttcaacatacatgatacagatagctgtaaaaaattattattcagatcctttggaacatttaccaccaggaaaagagatttggggaaaaactaaaaatggagtaccagaggcagtgcagctcattaatacaactgtgcggtcagacaccagcctcattatatcttggagagaatctcacaagccaaatggacctaaagaatcagtccgttatcagttggcaatctcacacctggccctaattcctgaaactcctctaagacaaagtgaatttccaaatggaaggctcactctccttgttactagactgtctggtggaaatatttatgtgttaaaggttcttgcctgccactctgaggaaatgtggtgtacagagagtcatcctgtcactgtggaaatgtttaacacaccagagaaaccttattccttggttccagagaacactagtttgcaatttaattggaaggctccattgaatgttaacctcatcagattttgggttgagctacagaagtggaaatacaatgagttttaccatgttaaaacttcatgcagccaaggtcctgcttatgtctgtaatatcacaaatctacaaccttatacttcatataatgtcagagtagtggtggtttataagacgggagaaaatagcacctcacttccagaaagctttaagacaaaagctggagtcccaaataaaccaggcattcccaaattactagaagggagtaaaaattcaatacagtgggagaaagctgaagataatggatgtagaattacatactatatccttgagataagaaagagcacttcaaataatttacagaaccagaatttaaggtggaagatgacatttaatggatcctgcagtagtgtttgcacatggaagtccaaaaacctgaaaggaatatttcagttcagagtagtagctgcaaataatctagggtttggtgaatatagtggaatcagtgagaatattatattagttggagatgatttttggataccagaaacaagtttcatacttactattatagttggaatatttctggttgttacaatcccactgacctttgtctggcatagaagattaaagaatcaaaaaagtgccaaggaaggggtgacagtgcttataaacgaagacaaagagttggctgagctgcgaggtctggcagccggagtaggcctggctaatgcctgctatgcaatacatactcttccaacccaagaggagattgaaaatcttcctgccttccctcgggaaaaactgactctgcgtctcttgctgggaagtggagcctttggagaagtgtatgaaggaacagcagtggacatcttaggagttggaagtggagaaatcaaagtagcagtgaagactttgaagaagggttccacagaccaggagaagattgaattcctgaaggaggcacatctgatgagcaaatttaatcatcccaacattctgaagcagcttggagtttgtctgctgaatgaaccccaatacattatcctggaactgatggagggaggagaccttcttacttatttgcgtaaagcccggatggcaacgttttatggtcctttactcaccttggttgaccttgtagacctgtgtgtagatatttcaaaaggctgtgtctacttggaacggatgcatttcattcacagggatctggcagctagaaattgccttgtttccgtgaaagactataccagtccacggatagtgaagattggagactttggactcgccagagacatctataaaaatgattactatagaaagagaggggaaggcctgctcccagttcggtggatggctccagaaagtttgatggatggaatcttcactactcaatctgatgtatggtcttttggaattctgatttgggagattttaactcttggtcatcagccttatccagctcattccaaccttgatgtgttaaactatgtgcaaacaggagggagactggagccaccaagaaattgtcctgatgatctgtggaatttaatgacccagtgctgggctcaagaacccgaccaaagacctacttttcatagaattcaggaccaacttcagttattcagaaattttttcttaaatagcatttataagtccagagatgaagcaaacaacagtggagtcataaatgaaagctttgaaggtgaagatggcgatgtgatttgtttgaattcagatgacattatgccagttgctttaatggaaacgaagaaccgagaagggttaaactatatggtacttgctacagaatgtggccaaggtgaagaaaagtctgagggtcctctaggctcccaggaatctgaatcttgtggtctgaggaaagaagagaaggaaccacatgcagacaaagatttctgccaagaaaaacaagtggcttactgcccttctggcaagcctgaaggcctgaactatgcctgtctcactcacagtggatatggagatgggtctgattaatagcgttgtttgggaaatagagagttgagataaacactctcattcagtagttactgaaagaaaactctgctagaatgataaatgtcatggtggtctataactccaaataaacaatgcaacgttcc
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6098 -> Molecular function: GO:0004713 [protein tyrosine kinase activity] evidence: IDA
GeneID:6098 -> Molecular function: GO:0004714 [transmembrane receptor protein tyrosine kinase activity] evidence: IEA
GeneID:6098 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:6098 -> Molecular function: GO:0019903 [protein phosphatase binding] evidence: IPI
GeneID:6098 -> Biological process: GO:0002066 [columnar/cuboidal epithelial cell development] evidence: ISS
GeneID:6098 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:6098 -> Biological process: GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] evidence: IEA
GeneID:6098 -> Biological process: GO:0007283 [spermatogenesis] evidence: ISS
GeneID:6098 -> Biological process: GO:0008283 [cell proliferation] evidence: ISS
GeneID:6098 -> Biological process: GO:0010629 [negative regulation of gene expression] evidence: IEA
GeneID:6098 -> Biological process: GO:0010966 [regulation of phosphate transport] evidence: IEA
GeneID:6098 -> Biological process: GO:0016049 [cell growth] evidence: IDA
GeneID:6098 -> Biological process: GO:0030154 [cell differentiation] evidence: ISS
GeneID:6098 -> Biological process: GO:0032006 [regulation of TOR signaling cascade] evidence: IDA
GeneID:6098 -> Biological process: GO:0070372 [regulation of ERK1 and ERK2 cascade] evidence: ISS
GeneID:6098 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
GeneID:6098 -> Cellular component: GO:0016020 [membrane] evidence: TAS
GeneID:6098 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_002935 -> EC 2.7.10.1
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.