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2024-04-25 15:47:10, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002880 3291 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens v-raf-1 murine leukemia viral oncogene homolog 1
(RAF1), mRNA.
ACCESSION NM_002880
VERSION NM_002880.3 GI:189458830
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3291)
AUTHORS Weisbart,R.H., Chan,G., Li,E., Farmani,N., Heinze,E., Rubell,A.,
Nishimura,R.N. and Colburn,K.
TITLE BRAF splice variants in rheumatoid arthritis synovial fibroblasts
activate MAPK through CRAF
JOURNAL Mol. Immunol. 55 (3-4), 247-252 (2013)
PUBMED 23517740
REMARK GeneRIF: Aberrant BRAF splice variants with deletions in both
kinase and RAS-binding domains in rheumatoid arthritis patients
demonstrate that these BRAF splice variants constitutively activate
MAPK through CRAF
REFERENCE 2 (bases 1 to 3291)
AUTHORS Leicht,D.T., Balan,V., Zhu,J., Kaplun,A., Bronisz,A., Rana,A. and
Tzivion,G.
TITLE MEK-1 activates C-Raf through a Ras-independent mechanism
JOURNAL Biochim. Biophys. Acta 1833 (5), 976-986 (2013)
PUBMED 23360980
REMARK GeneRIF: The ability of MEK to activate C-Raf was only partially
dependent on MEK kinase activity but required MEK binding to C-Raf,
suggesting that the binding results in a conformational change that
increases C-Raf susceptibility to phosphorylation
REFERENCE 3 (bases 1 to 3291)
AUTHORS Freeman,A.K., Ritt,D.A. and Morrison,D.K.
TITLE Effects of Raf dimerization and its inhibition on normal and
disease-associated Raf signaling
JOURNAL Mol. Cell 49 (4), 751-758 (2013)
PUBMED 23352452
REMARK GeneRIF: Ras pathway activation via EGF treatment induced strong
binding between B-Raf and C-Raf and a low level of binding between
B-Raf and A-Raf.
REFERENCE 4 (bases 1 to 3291)
AUTHORS Klingauf,M., Beck,M., Berge,U., Turgay,Y., Heinzer,S., Horvath,P.
and Kroschewski,R.
TITLE The tumour suppressor DiRas3 interacts with C-RAF and downregulates
MEK activity to restrict cell migration
JOURNAL Biol. Cell 105 (2), 91-107 (2013)
PUBMED 23157514
REMARK GeneRIF: DiRas3 interacts with C-RAF and downregulates MEK1
activity to restrict cell migration.
REFERENCE 5 (bases 1 to 3291)
AUTHORS Sypniewski,D., Bednarek,I., Galka,S., Loch,T., Blaszczyk,D. and
Soltysik,D.
TITLE Cytotoxicity of etoposide in cancer cell lines in vitro after BCL-2
and C-RAF gene silencing with antisense oligonucleotides
JOURNAL Acta Pol Pharm 70 (1), 87-97 (2013)
PUBMED 23610963
REMARK GeneRIF: Antisense oligonucleotides targeting BCL-2 and C-RAF
transcripts in tumor cell lines increases sensitivity to cytotoxic
effect of etoposide.
REFERENCE 6 (bases 1 to 3291)
AUTHORS Maslinski,W., Remillard,B., Tsudo,M. and Strom,T.B.
TITLE Interleukin-2 (IL-2) induces tyrosine kinase-dependent
translocation of active raf-1 from the IL-2 receptor into the
cytosol
JOURNAL J. Biol. Chem. 267 (22), 15281-15284 (1992)
PUBMED 1639773
REFERENCE 7 (bases 1 to 3291)
AUTHORS Tory,K., Latif,F., Modi,W., Schmidt,L., Wei,M.H., Li,H., Cobler,P.,
Orcutt,M.L., Delisio,J., Geil,L. et al.
TITLE A genetic linkage map of 96 loci on the short arm of human
chromosome 3
JOURNAL Genomics 13 (2), 275-286 (1992)
PUBMED 1612588
REFERENCE 8 (bases 1 to 3291)
AUTHORS Galland,F., Stefanova,M., Lafage,M. and Birnbaum,D.
TITLE Localization of the 5' end of the MCF2 oncogene to human chromosome
15q15----q23
JOURNAL Cytogenet. Cell Genet. 60 (2), 114-116 (1992)
PUBMED 1611909
REFERENCE 9 (bases 1 to 3291)
AUTHORS Li,P., Wood,K., Mamon,H., Haser,W. and Roberts,T.
TITLE Raf-1: a kinase currently without a cause but not lacking in
effects
JOURNAL Cell 64 (3), 479-482 (1991)
PUBMED 1846778
REMARK Review article
REFERENCE 10 (bases 1 to 3291)
AUTHORS Morrison,D.K., Kaplan,D.R., Escobedo,J.A., Rapp,U.R., Roberts,T.M.
and Williams,L.T.
TITLE Direct activation of the serine/threonine kinase activity of Raf-1
through tyrosine phosphorylation by the PDGF beta-receptor
JOURNAL Cell 58 (4), 649-657 (1989)
PUBMED 2475255
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC342671.1, BC018119.2 and
BU683389.1.
This sequence is a reference standard in the RefSeqGene project.
On Jun 6, 2008 this sequence version replaced gi:52486392.
Summary: This gene is the cellular homolog of viral raf gene
(v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K),
which functions downstream of the Ras family of membrane associated
GTPases to which it binds directly. Once activated, the cellular
RAF1 protein can phosphorylate to activate the dual specificity
protein kinases MEK1 and MEK2, which in turn phosphorylate to
activate the serine/threonine specific protein kinases, ERK1 and
ERK2. Activated ERKs are pleiotropic effectors of cell physiology
and play an important role in the control of gene expression
involved in the cell division cycle, apoptosis, cell
differentiation and cell migration. Mutations in this gene are
associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided
by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC018119.2, X03484.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-596 DC342671.1 1-596
597-3268 BC018119.2 511-3182
3269-3291 BU683389.1 1-23 c
FEATURES Location/Qualifiers
source 1..3291
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p25"
gene 1..3291
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/note="v-raf-1 murine leukemia viral oncogene homolog 1"
/db_xref="GeneID:5894"
/db_xref="HGNC:9829"
/db_xref="HPRD:01265"
/db_xref="MIM:164760"
exon 1..389
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/inference="alignment:Splign:1.39.8"
variation 135
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="c"
/replace="g"
/db_xref="dbSNP:61761285"
exon 390..622
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/inference="alignment:Splign:1.39.8"
misc_feature 404..406
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/note="upstream in-frame stop codon"
CDS 416..2362
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/EC_number="2.7.11.1"
/note="raf proto-oncogene serine/threonine protein kinase;
Oncogene RAF1; proto-oncogene c-RAF"
/codon_start=1
/product="RAF proto-oncogene serine/threonine-protein
kinase"
/protein_id="NP_002871.1"
/db_xref="GI:4506401"
/db_xref="CCDS:CCDS2612.1"
/db_xref="GeneID:5894"
/db_xref="HGNC:9829"
/db_xref="HPRD:01265"
/db_xref="MIM:164760"
/translation="
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
"
misc_feature 500..502
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01496"
misc_feature 542..544
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by PKA and MAPK1; propagated from
UniProtKB/Swiss-Prot (P04049.1); phosphorylation site"
misc_feature 542..544
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03382"
misc_feature 584..808
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/note="Ubiquitin domain of Raf serine/threonine kinases;
Region: Raf_RBD; cd01816"
/db_xref="CDD:176411"
misc_feature order(590..592,605..607,611..622,626..628,665..667,
677..685)
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/note="RafRBD - Ras interaction site [polypeptide
binding]; other site"
/db_xref="CDD:176411"
misc_feature 830..967
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/note="Protein kinase C conserved region 1 (C1) .
Cysteine-rich zinc binding domain. Some members of this
domain family bind phorbol esters and diacylglycerol, some
are reported to bind RasGTP. May occur in tandem
arrangement. Diacylglycerol (DAG) is a second...; Region:
C1; cd00029"
/db_xref="CDD:28911"
misc_feature order(830..832,869..871,878..880,908..910,917..919,
932..934,941..943,965..967)
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/note="zinc binding sites [ion binding]; other site"
/db_xref="CDD:28911"
misc_feature order(851..853,860..865,890..892,893..898)
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/note="putative DAG/PE binding site; other site"
/db_xref="CDD:28911"
misc_feature order(860..862,866..868)
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/note="putative RAS interaction site [polypeptide
binding]; other site"
/db_xref="CDD:28911"
misc_feature 1112..1114
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by PKA; propagated from
UniProtKB/Swiss-Prot (P04049.1); phosphorylation site"
misc_feature 1112..1114
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03382"
misc_feature 1169..1171
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P04049.1); phosphorylation site"
misc_feature 1169..1171
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1190..1192
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by PKA, PKC and PKB/AKT1; propagated
from UniProtKB/Swiss-Prot (P04049.1); phosphorylation
site"
misc_feature 1190..1192
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01261"
misc_feature 1190..1192
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03382"
misc_feature 1190..1192
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1217..1219
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (P04049.1); phosphorylation site"
misc_feature 1217..1219
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01265"
misc_feature 1220..1222
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by PKA; propagated from
UniProtKB/Swiss-Prot (P04049.1); phosphorylation site"
misc_feature 1220..1222
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1280..1282
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by MAPK1; propagated from
UniProtKB/Swiss-Prot (P04049.1); phosphorylation site"
misc_feature 1280..1282
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01496"
misc_feature 1295..1297
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1301..1303
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01496"
misc_feature 1316..1318
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by MAPK1; propagated from
UniProtKB/Swiss-Prot (P04049.1); phosphorylation site"
misc_feature 1316..1318
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01496"
misc_feature 1406..1462
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04049.1);
Region: Interaction with PEBP1/RKIP"
misc_feature 1427..1429
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by PAK1, PAK2, PAK3 and PAK7/PAK5;
propagated from UniProtKB/Swiss-Prot (P04049.1);
phosphorylation site"
misc_feature 1427..1429
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:02142"
misc_feature 1427..1429
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03995"
misc_feature 1427..1429
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01819"
misc_feature 1427..1429
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03188"
misc_feature 1430..1432
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by PAK1, PAK2 and PAK3; propagated
from UniProtKB/Swiss-Prot (P04049.1); phosphorylation
site"
misc_feature 1430..1432
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1430..1432
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01819"
misc_feature 1433..1435
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:00305"
misc_feature 1433..1435
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by SRC; propagated from
UniProtKB/Swiss-Prot (P04049.1); phosphorylation site"
misc_feature 1433..1435
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:00993"
misc_feature 1433..1435
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01819"
misc_feature 1436..1438
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by SRC; propagated from
UniProtKB/Swiss-Prot (P04049.1); phosphorylation site"
misc_feature 1436..1438
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:00993"
misc_feature 1436..1438
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01819"
misc_feature 1475..2230
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/note="Protein kinase domain; Region: Pkinase; pfam00069"
/db_xref="CDD:200973"
misc_feature 1478..2236
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/note="Protein Kinases, catalytic domain; Region:
PKc_like; cl09925"
/db_xref="CDD:214163"
misc_feature order(1478..1492,1502..1504,1532..1534,1538..1540,
1631..1633,1676..1687,1697..1699,1703..1705,1817..1819,
1823..1825,1829..1834,1838..1840,1871..1873,1880..1882,
1943..1945)
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(1478..1492,1502..1504,1532..1534,1538..1540,
1631..1633,1676..1687,1697..1699,1817..1819,1823..1825,
1829..1834,1838..1840,1871..1873)
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature order(1490..1492,1697..1699,1703..1705,1817..1819,
1823..1825,1829..1831,1880..1882,1943..1945)
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature 1826..1828
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P04049.1); phosphorylation site"
misc_feature order(1868..1882,1895..1900,1943..1945)
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
misc_feature 1886..1888
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (P04049.1); phosphorylation site"
misc_feature 1886..1888
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1895..1897
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P04049.1); phosphorylation site"
misc_feature 1895..1897
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1904..1906
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by PKC; propagated from
UniProtKB/Swiss-Prot (P04049.1); phosphorylation site"
misc_feature 1910..1912
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by PKC; propagated from
UniProtKB/Swiss-Prot (P04049.1); phosphorylation site"
misc_feature 1910..1912
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01498"
misc_feature 2102..2104
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Symmetric dimethylarginine, by PRMT5; propagated
from UniProtKB/Swiss-Prot (P04049.1); methylation site"
misc_feature 2276..2278
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P04049.1); phosphorylation site"
misc_feature 2276..2278
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01265"
misc_feature 2276..2278
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03382"
misc_feature 2276..2278
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:04115"
misc_feature 2339..2341
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by MAPK1; propagated from
UniProtKB/Swiss-Prot (P04049.1); phosphorylation site"
misc_feature 2339..2341
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01496"
variation 540
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11549992"
exon 623..735
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/inference="alignment:Splign:1.39.8"
exon 736..838
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/inference="alignment:Splign:1.39.8"
exon 839..996
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/inference="alignment:Splign:1.39.8"
exon 997..1095
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/inference="alignment:Splign:1.39.8"
exon 1096..1249
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/inference="alignment:Splign:1.39.8"
variation 1190
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:3730271"
variation 1222
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="c"
/replace="g"
/db_xref="dbSNP:1063664"
exon 1250..1277
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/inference="alignment:Splign:1.39.8"
exon 1278..1405
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/inference="alignment:Splign:1.39.8"
variation 1324
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="a"
/replace="c"
/db_xref="dbSNP:5746219"
variation 1338
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:5746220"
exon 1406..1523
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/inference="alignment:Splign:1.39.8"
exon 1524..1608
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/inference="alignment:Splign:1.39.8"
exon 1609..1785
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/inference="alignment:Splign:1.39.8"
variation 1612
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11549993"
variation 1640
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3730273"
variation 1688
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="c"
/replace="g"
/db_xref="dbSNP:3729929"
exon 1786..1832
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/inference="alignment:Splign:1.39.8"
exon 1833..1951
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/inference="alignment:Splign:1.39.8"
exon 1952..2083
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/inference="alignment:Splign:1.39.8"
variation 2044
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:5746244"
exon 2084..2218
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/inference="alignment:Splign:1.39.8"
variation 2170
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3730296"
exon 2219..3275
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/inference="alignment:Splign:1.39.8"
variation 2356
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:3730297"
variation 2445
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2229757"
variation 2462
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3730298"
variation 2480
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3730299"
variation 2522
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:5746246"
variation 2628
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:1051208"
variation 2710
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:5746247"
variation 2717
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:5746248"
variation 2755
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="a"
/replace="c"
/db_xref="dbSNP:5746249"
variation 2814
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:5746250"
STS 2828..3170
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/standard_name="D3S4000"
/db_xref="UniSTS:8196"
variation 2857
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:12808"
variation 2936
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:1063610"
variation 2994
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:1051674"
STS 3009..3164
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/standard_name="G15882"
/db_xref="UniSTS:44344"
STS 3036..3159
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/standard_name="GDB:217154"
/db_xref="UniSTS:156230"
variation 3087
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:1051816"
variation 3089
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:3192209"
STS 3114..3225
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/standard_name="A009W45"
/db_xref="UniSTS:64891"
STS 3114..3225
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/standard_name="G32929"
/db_xref="UniSTS:117507"
variation 3127
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:5746251"
variation 3167
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:3192264"
polyA_signal 3249..3254
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
polyA_signal 3254..3259
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
polyA_site 3275
/gene="RAF1"
/gene_synonym="c-Raf; CRAF; NS5; Raf-1"
ORIGIN
agaatcggagagccggtggcgtcgcaggtcgggaggacgagcaccgagtcgagggctcgctcgtctgggccgcccgagagtcttaatcgcgggcgcttgggccgccatcttagatggcgggagtaagaggaaaacgattgtgaggcgggaacggctttctgctgccttttttgggccccgaaaagggtcagctggccgggctttggggcgcgtgccctgaggcgcggagcgcgtttgctacgatgcgggggctgctcggggctccgtcccctgggctggggacgcgccgaatgtgaccgcctcccgctccctcacccgccgcggggaggaggagcgggcgagaagctgccgccgaacgacaggacgttggggcggcctggctccctcaggtttaagaattgtttaagctgcatcaatggagcacatacagggagcttggaagacgatcagcaatggttttggattcaaagatgccgtgtttgatggctccagctgcatctctcctacaatagttcagcagtttggctatcagcgccgggcatcagatgatggcaaactcacagatccttctaagacaagcaacactatccgtgttttcttgccgaacaagcaaagaacagtggtcaatgtgcgaaatggaatgagcttgcatgactgccttatgaaagcactcaaggtgaggggcctgcaaccagagtgctgtgcagtgttcagacttctccacgaacacaaaggtaaaaaagcacgcttagattggaatactgatgctgcgtctttgattggagaagaacttcaagtagatttcctggatcatgttcccctcacaacacacaactttgctcggaagacgttcctgaagcttgccttctgtgacatctgtcagaaattcctgctcaatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagtacctactatgtgtgtggactggagtaacatcagacaactcttattgtttccaaattccactattggtgatagtggagtcccagcactaccttctttgactatgcgtcgtatgcgagagtctgtttccaggatgcctgttagttctcagcacagatattctacacctcacgccttcacctttaacacctccagtccctcatctgaaggttccctctcccagaggcagaggtcgacatccacacctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgaggatgcaattcgaagtcacagcgaatcagcctcaccttcagccctgtccagtagccccaacaatctgagcccaacaggctggtcacagccgaaaacccccgtgccagcacaaagagagcgggcaccagtatctgggacccaggagaaaaacaaaattaggcctcgtggacagagagattcaagctattattgggaaatagaagccagtgaagtgatgctgtccactcggattgggtcaggctcttttggaactgtttataagggtaaatggcacggagatgttgcagtaaagatcctaaaggttgtcgacccaaccccagagcaattccaggccttcaggaatgaggtggctgttctgcgcaaaacacggcatgtgaacattctgcttttcatggggtacatgacaaaggacaacctggcaattgtgacccagtggtgcgagggcagcagcctctacaaacacctgcatgtccaggagaccaagtttcagatgttccagctaattgacattgcccggcagacggctcagggaatggactatttgcatgcaaagaacatcatccatagagacatgaaatccaacaatatatttctccatgaaggcttaacagtgaaaattggagattttggtttggcaacagtaaagtcacgctggagtggttctcagcaggttgaacaacctactggctctgtcctctggatggccccagaggtgatccgaatgcaggataacaacccattcagtttccagtcggatgtctactcctatggcatcgtattgtatgaactgatgacgggggagcttccttattctcacatcaacaaccgagatcagatcatcttcatggtgggccgaggatatgcctccccagatcttagtaagctatataagaactgccccaaagcaatgaagaggctggtagctgactgtgtgaagaaagtaaaggaagagaggcctctttttccccagatcctgtcttccattgagctgctccaacactctctaccgaagatcaaccggagcgcttccgagccatccttgcatcgggcagcccacactgaggatatcaatgcttgcacgctgaccacgtccccgaggctgcctgtcttctagttgactttgcacctgtcttcaggctgccaggggaggaggagaagccagcaggcaccacttttctgctccctttctccagaggcagaacacatgttttcagagaagctgctgctaaggaccttctagactgctcacagggccttaacttcatgttgccttcttttctatccctttgggccctgggagaaggaagccatttgcagtgctggtgtgtcctgctccctccccacattccccatgctcaaggcccagccttctgtagatgcgcaagtggatgttgatggtagtacaaaaagcaggggcccagccccagctgttggctacatgagtatttagaggaagtaaggtagcaggcagtccagccctgatgtggagacacatgggattttggaaatcagcttctggaggaatgcatgtcacaggcgggactttcttcagagagtggtgcagcgccagacattttgcacataaggcaccaaacagcccaggactgccgagactctggccgcccgaaggagcctgctttggtactatggaacttttcttaggggacacgtcctcctttcacagcttctaaggtgtccagtgcattgggatggttttccaggcaaggcactcggccaatccgcatctcagccctctcagggagcagtcttccatcatgctgaattttgtcttccaggagctgcccctatggggcggggccgcagggccagccttgtttctctaacaaacaaacaaacaaacagccttgtttctctagtcacatcatgtgtatacaaggaagccaggaatacaggttttcttgatgatttgggttttaattttgtttttattgcacctgacaaaatacagttatctgatggtccctcaattatgttattttaataaaataaattaaatttaggtgtaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5894 -> Molecular function: GO:0004672 [protein kinase activity] evidence: TAS
GeneID:5894 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:5894 -> Molecular function: GO:0004709 [MAP kinase kinase kinase activity] evidence: IEA
GeneID:5894 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5894 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:5894 -> Molecular function: GO:0017016 [Ras GTPase binding] evidence: IEA
GeneID:5894 -> Molecular function: GO:0031434 [mitogen-activated protein kinase kinase binding] evidence: IEA
GeneID:5894 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
GeneID:5894 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:5894 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA
GeneID:5894 -> Biological process: GO:0000165 [MAPK cascade] evidence: TAS
GeneID:5894 -> Biological process: GO:0000186 [activation of MAPKK activity] evidence: TAS
GeneID:5894 -> Biological process: GO:0001666 [response to hypoxia] evidence: IEA
GeneID:5894 -> Biological process: GO:0006468 [protein phosphorylation] evidence: TAS
GeneID:5894 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:5894 -> Biological process: GO:0007010 [cytoskeleton organization] evidence: IEA
GeneID:5894 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:5894 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
GeneID:5894 -> Biological process: GO:0007190 [activation of adenylate cyclase activity] evidence: NAS
GeneID:5894 -> Biological process: GO:0007264 [small GTPase mediated signal transduction] evidence: TAS
GeneID:5894 -> Biological process: GO:0007265 [Ras protein signal transduction] evidence: TAS
GeneID:5894 -> Biological process: GO:0007268 [synaptic transmission] evidence: TAS
GeneID:5894 -> Biological process: GO:0007411 [axon guidance] evidence: TAS
GeneID:5894 -> Biological process: GO:0007507 [heart development] evidence: IEA
GeneID:5894 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:5894 -> Biological process: GO:0008283 [cell proliferation] evidence: TAS
GeneID:5894 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IDA
GeneID:5894 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: TAS
GeneID:5894 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS
GeneID:5894 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
GeneID:5894 -> Biological process: GO:0031333 [negative regulation of protein complex assembly] evidence: IDA
GeneID:5894 -> Biological process: GO:0033138 [positive regulation of peptidyl-serine phosphorylation] evidence: IDA
GeneID:5894 -> Biological process: GO:0034220 [ion transmembrane transport] evidence: TAS
GeneID:5894 -> Biological process: GO:0035023 [regulation of Rho protein signal transduction] evidence: TAS
GeneID:5894 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
GeneID:5894 -> Biological process: GO:0042060 [wound healing] evidence: TAS
GeneID:5894 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:5894 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA
GeneID:5894 -> Biological process: GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: TAS
GeneID:5894 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:5894 -> Biological process: GO:0045595 [regulation of cell differentiation] evidence: TAS
GeneID:5894 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:5894 -> Biological process: GO:0055085 [transmembrane transport] evidence: TAS
GeneID:5894 -> Biological process: GO:2000145 [regulation of cell motility] evidence: TAS
GeneID:5894 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:5894 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS
GeneID:5894 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: TAS
GeneID:5894 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5894 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:5894 -> Cellular component: GO:0031143 [pseudopodium] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_002871 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.