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2024-04-20 07:15:49, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002868 5340 bp mRNA linear PRI 16-JUN-2013
DEFINITION Homo sapiens RAB5B, member RAS oncogene family (RAB5B), transcript
variant 1, mRNA.
ACCESSION NM_002868
VERSION NM_002868.3 GI:354725900
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5340)
AUTHORS Tang,X.F., Zhang,Z., Hu,D.Y., Xu,A.E., Zhou,H.S., Sun,L.D., Gao,M.,
Gao,T.W., Gao,X.H., Chen,H.D., Xie,H.F., Tu,C.X., Hao,F., Wu,R.N.,
Zhang,F.R., Liang,L., Pu,X.M., Zhang,J.Z., Han,J.W., Pan,G.P.,
Wu,J.Q., Li,K., Su,M.W., Du,W.D., Zhang,W.J., Liu,J.J., Xiang,L.H.,
Yang,S., Zhou,Y.W. and Zhang,X.J.
TITLE Association analyses identify three susceptibility Loci for
vitiligo in the Chinese Han population
JOURNAL J. Invest. Dermatol. 133 (2), 403-410 (2013)
PUBMED 22951725
REFERENCE 2 (bases 1 to 5340)
AUTHORS Shi,Y., Zhao,H., Shi,Y., Cao,Y., Yang,D., Li,Z., Zhang,B.,
Liang,X., Li,T., Chen,J., Shen,J., Zhao,J., You,L., Gao,X., Zhu,D.,
Zhao,X., Yan,Y., Qin,Y., Li,W., Yan,J., Wang,Q., Zhao,J., Geng,L.,
Ma,J., Zhao,Y., He,G., Zhang,A., Zou,S., Yang,A., Liu,J., Li,W.,
Li,B., Wan,C., Qin,Y., Shi,J., Yang,J., Jiang,H., Xu,J.E., Qi,X.,
Sun,Y., Zhang,Y., Hao,C., Ju,X., Zhao,D., Ren,C.E., Li,X.,
Zhang,W., Zhang,Y., Zhang,J., Wu,D., Zhang,C., He,L. and Chen,Z.J.
TITLE Genome-wide association study identifies eight new risk loci for
polycystic ovary syndrome
JOURNAL Nat. Genet. 44 (9), 1020-1025 (2012)
PUBMED 22885925
REFERENCE 3 (bases 1 to 5340)
AUTHORS Chen,P.I., Kong,C., Su,X. and Stahl,P.D.
TITLE Rab5 isoforms differentially regulate the trafficking and
degradation of epidermal growth factor receptors
JOURNAL J. Biol. Chem. 284 (44), 30328-30338 (2009)
PUBMED 19723633
REMARK GeneRIF: suppression of Rab5A or 5B hampered the degradation of
EGFR
REFERENCE 4 (bases 1 to 5340)
AUTHORS Shin,N., Jeong,H., Kwon,J., Heo,H.Y., Kwon,J.J., Yun,H.J.,
Kim,C.H., Han,B.S., Tong,Y., Shen,J., Hatano,T., Hattori,N.,
Kim,K.S., Chang,S. and Seol,W.
TITLE LRRK2 regulates synaptic vesicle endocytosis
JOURNAL Exp. Cell Res. 314 (10), 2055-2065 (2008)
PUBMED 18445495
REMARK GeneRIF: Results suggest that LRRK2, in conjunction with its
interaction with Rab5b, plays an important role in synaptic
function by modulating the endocytosis of synaptic vesicles.
REFERENCE 5 (bases 1 to 5340)
AUTHORS Hakonarson,H., Qu,H.Q., Bradfield,J.P., Marchand,L., Kim,C.E.,
Glessner,J.T., Grabs,R., Casalunovo,T., Taback,S.P.,
Frackelton,E.C., Eckert,A.W., Annaiah,K., Lawson,M.L., Otieno,F.G.,
Santa,E., Shaner,J.L., Smith,R.M., Onyiah,C.C., Skraban,R.,
Chiavacci,R.M., Robinson,L.J., Stanley,C.A., Kirsch,S.E.,
Devoto,M., Monos,D.S., Grant,S.F. and Polychronakos,C.
TITLE A novel susceptibility locus for type 1 diabetes on Chr12q13
identified by a genome-wide association study
JOURNAL Diabetes 57 (4), 1143-1146 (2008)
PUBMED 18198356
REFERENCE 6 (bases 1 to 5340)
AUTHORS Callaghan,J., Nixon,S., Bucci,C., Toh,B.H. and Stenmark,H.
TITLE Direct interaction of EEA1 with Rab5b
JOURNAL Eur. J. Biochem. 265 (1), 361-366 (1999)
PUBMED 10491193
REFERENCE 7 (bases 1 to 5340)
AUTHORS Chiariello,M., Bruni,C.B. and Bucci,C.
TITLE The small GTPases Rab5a, Rab5b and Rab5c are differentially
phosphorylated in vitro
JOURNAL FEBS Lett. 453 (1-2), 20-24 (1999)
PUBMED 10403367
REFERENCE 8 (bases 1 to 5340)
AUTHORS Bao,S., Zhu,J. and Garvey,W.T.
TITLE Cloning of Rab GTPases expressed in human skeletal muscle: studies
in insulin-resistant subjects
JOURNAL Horm. Metab. Res. 30 (11), 656-662 (1998)
PUBMED 9918381
REFERENCE 9 (bases 1 to 5340)
AUTHORS Bucci,C., Lutcke,A., Steele-Mortimer,O., Olkkonen,V.M., Dupree,P.,
Chiariello,M., Bruni,C.B., Simons,K. and Zerial,M.
TITLE Co-operative regulation of endocytosis by three Rab5 isoforms
JOURNAL FEBS Lett. 366 (1), 65-71 (1995)
PUBMED 7789520
REFERENCE 10 (bases 1 to 5340)
AUTHORS Wilson,D.B. and Wilson,M.P.
TITLE Identification and subcellular localization of human rab5b, a new
member of the ras-related superfamily of GTPases
JOURNAL J. Clin. Invest. 89 (3), 996-1005 (1992)
PUBMED 1541686
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DA811144.1, DA401343.1, BX537408.1 and AC034102.32.
On Oct 30, 2011 this sequence version replaced gi:33943097.
Transcript Variant: This variant (1) represents the longest
transcript. Variants 1 and 2 encode the same isoform (1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC040143.1, BX537408.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-24 DA811144.1 1-24
25-67 DA401343.1 2-44
68-3363 BX537408.1 2-3297
3364-5340 AC034102.32 164616-166592 c
FEATURES Location/Qualifiers
source 1..5340
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q13"
gene 1..5340
/gene="RAB5B"
/note="RAB5B, member RAS oncogene family"
/db_xref="GeneID:5869"
/db_xref="HGNC:9784"
/db_xref="HPRD:01544"
/db_xref="MIM:179514"
exon 1..129
/gene="RAB5B"
/inference="alignment:Splign:1.39.8"
variation 107
/gene="RAB5B"
/replace="c"
/replace="g"
/db_xref="dbSNP:75639074"
exon 130..384
/gene="RAB5B"
/inference="alignment:Splign:1.39.8"
variation 140
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:191222040"
variation 166
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:370178643"
variation 194
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:199632895"
variation 197
/gene="RAB5B"
/replace="c"
/replace="g"
/db_xref="dbSNP:202056188"
CDS 222..869
/gene="RAB5B"
/note="isoform 1 is encoded by transcript variant 1;
ras-related protein Rab-5B"
/codon_start=1
/product="ras-related protein Rab-5B isoform 1"
/protein_id="NP_002859.1"
/db_xref="GI:4506371"
/db_xref="CCDS:CCDS8900.1"
/db_xref="GeneID:5869"
/db_xref="HGNC:9784"
/db_xref="HPRD:01544"
/db_xref="MIM:179514"
/translation="
MTSRSTARPNGQPQASKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQSVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQETFARAKTWVKELQRQASPSIVIALAGNKADLANKRMVEYEEAQAYADDNSLLFMETSAKTAMNVNDLFLAIAKKLPKSEPQNLGGAAGRSRGVDLHEQSQQNKSQCCSN
"
misc_feature 279..815
/gene="RAB5B"
/note="Ras-like protein; Provisional; Region: PTZ00369"
/db_xref="CDD:240385"
misc_feature 279..767
/gene="RAB5B"
/note="Rab-related GTPase family includes Rab5 and Rab22;
regulates early endosome fusion; Region: Rab5_related;
cd01860"
/db_xref="CDD:206653"
misc_feature 279..287
/gene="RAB5B"
/note="Rab subfamily motif 1 (RabSF1); other site"
/db_xref="CDD:206653"
misc_feature 300..323
/gene="RAB5B"
/note="G1 box; other site"
/db_xref="CDD:206653"
misc_feature order(306..326,354..359,372..377,453..455,618..623,
627..629,708..716)
/gene="RAB5B"
/note="GTP/Mg2+ binding site [chemical binding]; other
site"
/db_xref="CDD:206653"
misc_feature order(324..359,369..374)
/gene="RAB5B"
/note="Rab subfamily motif 2 (RabSF2); other site"
/db_xref="CDD:206653"
misc_feature order(354..356,369..395)
/gene="RAB5B"
/note="Switch I region; other site"
/db_xref="CDD:206653"
misc_feature 366..392
/gene="RAB5B"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P61020.1);
Region: Effector region (Potential)"
misc_feature order(369..371,381..404,423..425,429..431)
/gene="RAB5B"
/note="putative GEF interaction site [polypeptide
binding]; other site"
/db_xref="CDD:206653"
misc_feature 375..377
/gene="RAB5B"
/note="G2 box; other site"
/db_xref="CDD:206653"
misc_feature order(378..383,387..389,441..446,465..467,471..473,
477..485)
/gene="RAB5B"
/note="putative GDI interaction site [polypeptide
binding]; other site"
/db_xref="CDD:206653"
misc_feature 378..392
/gene="RAB5B"
/note="Rab family motif 1 (RabF1); other site"
/db_xref="CDD:206653"
misc_feature order(384..392,396..398,462..464,483..488)
/gene="RAB5B"
/note="effector interaction site; other site"
/db_xref="CDD:206653"
misc_feature 429..443
/gene="RAB5B"
/note="Rab family motif 2 (RabF2); other site"
/db_xref="CDD:206653"
misc_feature 444..455
/gene="RAB5B"
/note="G3 box; other site"
/db_xref="CDD:206653"
misc_feature order(453..455,459..491)
/gene="RAB5B"
/note="Switch II region; other site"
/db_xref="CDD:206653"
misc_feature 462..479
/gene="RAB5B"
/note="Rab family motif 3 (RabF3); other site"
/db_xref="CDD:206653"
misc_feature 486..491
/gene="RAB5B"
/note="Rab family motif 4 (RabF4); other site"
/db_xref="CDD:206653"
misc_feature 513..530
/gene="RAB5B"
/note="Rab family motif 5 (RabF5); other site"
/db_xref="CDD:206653"
misc_feature 588..590
/gene="RAB5B"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[7]
/db_xref="HPRD:00302"
misc_feature 594..611
/gene="RAB5B"
/note="Rab subfamily motif 3 (RabSF3); other site"
/db_xref="CDD:206653"
misc_feature 618..629
/gene="RAB5B"
/note="G4 box; other site"
/db_xref="CDD:206653"
misc_feature 708..716
/gene="RAB5B"
/note="G5 box; other site"
/db_xref="CDD:206653"
misc_feature 756..764
/gene="RAB5B"
/note="Rab subfamily motif 4 (RabSF4); other site"
/db_xref="CDD:206653"
variation 250
/gene="RAB5B"
/replace="a"
/replace="t"
/db_xref="dbSNP:151173738"
variation 299
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:200823103"
exon 385..536
/gene="RAB5B"
/inference="alignment:Splign:1.39.8"
variation 404
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:140257679"
variation 420
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:145456965"
variation 439
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:200178158"
variation 510
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:146500812"
variation 512
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:141101772"
exon 537..659
/gene="RAB5B"
/inference="alignment:Splign:1.39.8"
variation 560
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:201304194"
variation 600
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:140556276"
exon 660..753
/gene="RAB5B"
/inference="alignment:Splign:1.39.8"
variation 664
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:375947629"
variation 669
/gene="RAB5B"
/replace="c"
/replace="g"
/db_xref="dbSNP:201470751"
variation 710
/gene="RAB5B"
/replace="a"
/replace="c"
/db_xref="dbSNP:2292240"
variation 728
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:199813423"
variation 729
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:371700996"
variation 731
/gene="RAB5B"
/replace="c"
/replace="g"
/db_xref="dbSNP:144915792"
exon 754..5340
/gene="RAB5B"
/inference="alignment:Splign:1.39.8"
variation 758
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:80286187"
variation 798
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:375538585"
variation 807
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:373383204"
variation 810
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:377046623"
variation 811
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:201485586"
variation 812
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:370187474"
variation 820
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:373831332"
variation 880
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:377488300"
variation 881
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:185392988"
variation 882
/gene="RAB5B"
/replace="a"
/replace="c"
/db_xref="dbSNP:189968231"
variation 891
/gene="RAB5B"
/replace="a"
/replace="c"
/db_xref="dbSNP:200616190"
variation 909
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:367803941"
variation 925
/gene="RAB5B"
/replace="g"
/replace="t"
/db_xref="dbSNP:1050198"
variation 949
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:11550558"
variation 1130
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:140669038"
variation 1160
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:12307159"
variation 1167
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:11611579"
variation 1168
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:374752542"
variation 1183
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:145665894"
variation 1217
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:3741500"
variation 1234
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:79669954"
variation 1297
/gene="RAB5B"
/replace="a"
/replace="t"
/db_xref="dbSNP:1050200"
variation 1447
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:185729836"
variation 1458
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:188482287"
variation 1503
/gene="RAB5B"
/replace="c"
/replace="g"
/db_xref="dbSNP:368421639"
variation 1526
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:1050201"
variation 1539
/gene="RAB5B"
/replace="g"
/replace="t"
/db_xref="dbSNP:1050202"
variation 1540
/gene="RAB5B"
/replace="g"
/replace="t"
/db_xref="dbSNP:1050203"
variation 1592..1593
/gene="RAB5B"
/replace=""
/replace="ct"
/db_xref="dbSNP:113186187"
variation 1619
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:148119300"
variation 1671
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:78564985"
variation 1682
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:79132668"
variation 1697
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:1050205"
variation 1699
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:1050206"
variation 1702
/gene="RAB5B"
/replace="g"
/replace="t"
/db_xref="dbSNP:79333113"
variation 1772
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:1050209"
variation 1888
/gene="RAB5B"
/replace="g"
/replace="t"
/db_xref="dbSNP:77597377"
variation 1908
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:180938710"
variation 2036
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:370209440"
variation 2140
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:141821738"
variation 2281
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:150189189"
variation 2326
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:138736571"
STS 2385..2488
/gene="RAB5B"
/standard_name="RH44840"
/db_xref="UniSTS:89878"
variation 2484
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:7350566"
variation 2485
/gene="RAB5B"
/replace="g"
/replace="t"
/db_xref="dbSNP:185902941"
variation 2549
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:143728615"
variation 2618
/gene="RAB5B"
/replace=""
/replace="t"
/db_xref="dbSNP:34151959"
STS 2693..2866
/gene="RAB5B"
/standard_name="RH98226"
/db_xref="UniSTS:92502"
variation 2721
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:192424702"
variation 2997
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:373881222"
variation 3042..3043
/gene="RAB5B"
/replace=""
/replace="c"
/db_xref="dbSNP:371574885"
variation 3046
/gene="RAB5B"
/replace="c"
/replace="g"
/db_xref="dbSNP:147229892"
variation 3081
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:1050231"
variation 3087
/gene="RAB5B"
/replace="c"
/replace="g"
/db_xref="dbSNP:9323"
variation 3091
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:183872315"
variation 3180
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:187146028"
variation 3205
/gene="RAB5B"
/replace="g"
/replace="t"
/db_xref="dbSNP:11673"
variation 3237
/gene="RAB5B"
/replace="a"
/replace="c"
/db_xref="dbSNP:11550559"
variation 3441
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:191623441"
variation 3464
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:182724443"
variation 3590
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:112828948"
variation 3614
/gene="RAB5B"
/replace="a"
/replace="c"
/db_xref="dbSNP:187091639"
variation 3664
/gene="RAB5B"
/replace="c"
/replace="g"
/db_xref="dbSNP:191538953"
variation 3762
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:34962186"
variation 3766
/gene="RAB5B"
/replace="a"
/replace="t"
/db_xref="dbSNP:77935289"
variation 3768
/gene="RAB5B"
/replace="a"
/replace="t"
/db_xref="dbSNP:61937250"
variation 3792
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:140466173"
STS 3851..3939
/gene="RAB5B"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 3883
/gene="RAB5B"
/replace="g"
/replace="t"
/db_xref="dbSNP:142807841"
variation 3888
/gene="RAB5B"
/replace="c"
/replace="g"
/db_xref="dbSNP:147371885"
variation 3927
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:144937485"
variation 4034
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:35105856"
variation 4166
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:705700"
variation 4230
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:150930056"
variation 4296
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:139483301"
variation 4337
/gene="RAB5B"
/replace="c"
/replace="g"
/db_xref="dbSNP:143859506"
variation 4356
/gene="RAB5B"
/replace="c"
/replace="g"
/db_xref="dbSNP:146878814"
variation 4387..4390
/gene="RAB5B"
/replace=""
/replace="tagt"
/db_xref="dbSNP:77509148"
variation 4398
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:182310393"
variation 4438
/gene="RAB5B"
/replace="c"
/replace="g"
/db_xref="dbSNP:58717357"
variation 4495
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:11171718"
variation 4598..4599
/gene="RAB5B"
/replace=""
/replace="ct"
/db_xref="dbSNP:139044776"
variation 4615
/gene="RAB5B"
/replace="a"
/replace="t"
/db_xref="dbSNP:191633678"
variation 4628
/gene="RAB5B"
/replace="a"
/replace="c"
/db_xref="dbSNP:187526536"
variation 4629..4630
/gene="RAB5B"
/replace=""
/replace="at"
/db_xref="dbSNP:34061457"
variation 4630..4631
/gene="RAB5B"
/replace=""
/replace="atatatatatatatatatat"
/db_xref="dbSNP:72297536"
variation 4641..4660
/gene="RAB5B"
/replace="catatatatatatatatata"
/replace="tatatatatttttttttttt"
/db_xref="dbSNP:71457813"
variation 4641
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:705701"
variation 4642..4643
/gene="RAB5B"
/replace=""
/replace="at"
/db_xref="dbSNP:375903673"
variation 4658
/gene="RAB5B"
/replace="a"
/replace="t"
/db_xref="dbSNP:374518488"
variation 4660
/gene="RAB5B"
/replace=""
/replace="a"
/db_xref="dbSNP:201079136"
variation 4660
/gene="RAB5B"
/replace="a"
/replace="t"
/db_xref="dbSNP:4759233"
variation 4661..4662
/gene="RAB5B"
/replace=""
/replace="a"
/replace="atatatatatatatattttt"
/replace="atattttt"
/db_xref="dbSNP:376451058"
variation 4662..4663
/gene="RAB5B"
/replace=""
/replace="atatatatatatatattttt"
/replace="attttt"
/db_xref="dbSNP:63191860"
variation 4662
/gene="RAB5B"
/replace="a"
/replace="t"
/db_xref="dbSNP:60028217"
variation 4670..4671
/gene="RAB5B"
/replace=""
/replace="ttttttt"
/db_xref="dbSNP:56291639"
variation 4850
/gene="RAB5B"
/replace="g"
/replace="t"
/db_xref="dbSNP:11612906"
variation 4912
/gene="RAB5B"
/replace="c"
/replace="g"
/db_xref="dbSNP:185511541"
variation 5060
/gene="RAB5B"
/replace="g"
/replace="t"
/db_xref="dbSNP:78877196"
STS 5176..5278
/gene="RAB5B"
/standard_name="D11S2921"
/db_xref="UniSTS:152074"
variation 5196
/gene="RAB5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:190463944"
variation 5237
/gene="RAB5B"
/replace="c"
/replace="g"
/db_xref="dbSNP:772920"
variation 5278
/gene="RAB5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:115698836"
variation 5303..5304
/gene="RAB5B"
/replace=""
/replace="t"
/db_xref="dbSNP:375369217"
variation 5304
/gene="RAB5B"
/replace=""
/replace="t"
/db_xref="dbSNP:143552015"
ORIGIN
aatcgagctattggctggagccccgccccagggcgaggaggagaaggaggggcaggagggtttggttgagctgcagctgtttgtctgttcgacacaggcttggggccgacgggggagacggagccccaggagtgttgaagcctggaaatcccctccccttccccctcccccctttacagtatccccctccctccaccctttcccattctgataatctggccatgactagcagaagcacagctaggcccaatgggcaaccccaggccagcaaaatttgccagttcaaattggtcctgctgggagaatctgcagtgggaaagtcaagcctggtattacgttttgtcaaagggcagttccatgagtaccaggagagcaccattggagcggccttcctcacccagtccgtttgtctagatgacacaacagtgaagtttgagatctgggacacagctgggcaggagcgatatcacagcttagcccccatgtactacaggggtgcccaagctgcaatcgtggtttacgacattactaatcaggaaacctttgcccgagcaaagacatgggtgaaggaactacagcgacaggccagtcctagcatcgttattgccctggcagggaacaaagctgacctggccaacaaacgtatggtggagtatgaagaggcccaggcatatgcagatgacaacagcttattgttcatggagacttcagccaagacagctatgaacgtgaatgatctcttcctggcaatagctaagaagttgccaaagagtgaaccccagaatctgggaggtgcagcaggccgaagccggggtgtggatctccatgaacagtcccagcagaacaagagccagtgttgtagcaactgagggggtggctagcagcaaacaagtatggagctagcacaagagctaagaaataacctccatccctacccctcagcacacaacccctacggtaacagcacactgagccctggctcccaagggctgcctcctgacagctccgtcatggcactttttaacgcttcagcaacaaacaccaggcagctgttgccactggcctcctaccccctactctggggcttgggggtcaactccccccaggacttaccttccaaaacaaactttcttcactttgtattataggtacaagacagcgacttacgtatcttttctcctcctccctagtgttcctccccattttttcagaaaacacttctgactcctgtcccttccccttctgcttttggtcagtccctgttcttgagcctcttttctcctctccccaggatgcagaaagtggtgaacccaggaactgaggaaggaggtttccagttcatttacattaagggccctgggggagaataaagctcagagcaggagggagtaaggaaacatttcctttttgtttttatttggttggagtttctcatatttgaaaacattgcggtatccatgatttggccttgtggagggtgttcctaggtagaggtgagaatggggaggcaagatctcaggcaccaggcaggaggtgccttgtaagctaactgggcggaggtggaggtgcagtgtcaactgtggctctgtaactcttcaaaggcccagtttcccctcacgcagcctcttaggtagcgtttcccctaatcgtgggggttggaccccagagtcttccaaagaattttcactggttgcctgcatctttggctctgctgtgatctgattggaggagggacagtttctggtacccatcctctgatttatacatatgcattttttcccctctggcctttagatggcctcagccccagccaccatatacccctgcagtttgcactttaattgatggtagttcagttggggtacttgttttatggaagttttgattgatttacttgccctcccaccttctttttaattcaatgaaatctgaggttaatgcgaggttcgaggagaggttatagataaaactaccagtggcagctactcaagtcctatctccactgttagcttcctccaactctaattattaacctatattcttgccaagctaactattgactataggtttgcctttcctggagaattaattgagcaattgaggagtgtctcaggatagcacaggccaaggtaggggagtaaaaaggaggtcaggcaaaagggaggagttttctgtcctttcccaggtttcacactcaatttgatatccattaccatgtcttttctacttccttgtaaataggtatgatctttattcccactgtacagtctgttctatcctctgcctcccatcaggccctgtttctttgttcctttgttaatatcttgaatttagtccctccatccttaatccccccatccctccccatcatgcaaccagtggtttaatccatgtaccaataggggctagtaccacagaggcctcctgtggtgccctcgtatcataccacctgttcctgtggagagggaatgaccggcactgaaggtaccttacaactggctcatattatcagaggaccttggtcctttctaaatctctagtctctcttcatatccttcatcaggtgttttaagatgtctctgagaagccatcaaggcaaaagagaactttaagttccttgttccagcccggagttttgggaaagaaagaaaggaaaggtcacagtgacctaggattggaaccttcctgcccttttggcttgcagactgccttctatcccagaacagctgagaaatctatgaagctgagattctgaaggacccagcttaggttcttccacttaggcctcaattcccttccttttccaggggcagccttagttcccatggccctgaaacacacacatttcccccttcctttcccagaagccactggccccccatagcacccagtgcatcctttttacaagtggaagaactaggatggctttccaaagtcttctagaaatgaagttctttctctgtgcagctttcccccttggagcaggagtgaagatgtttcattatcttgggcctgggaaaccacttccccaggcttctccctccccccacccccataggaacaggatttggccttagcttctgggcctatcggctgccttccctctacttcctaccacctcttctgccttcctttgagctctgttgggcttggggatcttagttttcttttgtttatttcccagctcatttttttcttctggtcagtttttttaagggggggtgttgtggttttttgtttttgttttgcttctgagaaagcatttgcctttcttcctctcccaacataacaatcgtggtaacagaatgcgactgctgatttaccgatgtatttaatgtaagtaaaaaaaggaaaaaaagaaaagggcattggagtgttgcttttttttattttattgttattattattattatttttgctatttgtcaggtactaggaatttggaagaaaggatacccagtaatgttctactgaatcagaaacacacctttccctgcatcttgatacatctttattccctttaatcttttcttaaacatctagtttagaaaatagcccttctattgctatttaatcacccctcttctaaggccactagattgttcatcaaatcaaaccctattatatctttttaggccctcttaacagaatgtatatgtgtagggtatggtctgtggatctttgggcccactgatcagattagagagaggggtgctatttgaagtagtatacaaaaatgtatgtgcatatttctttttttttttttaattgagacggagtctctgtcgctagcctggagtacagtggcacgatcttggctcacagcaatctccgcctcctgagttcaagtgattctcctgcctcagcctcctgagtagctaggattacaggcacgcaccaacacacccagctaatttttgtatttttagtagagacggggtttcaccatgttggtcaggctggtcttgaactcctgacctcgtgatccacccaccttggcctcccaaagtgctgggattacgggcgtgagccactgcgcccggccgtatgtgcatatttctaggatccatttctatatgtttctcaaaggggtccatgacccaaaggttgaaaaacatcactgagttagttttcttgtagcttccacctcaacgggaaaatttcctctggatctgctcttgactcctagtgtacttcaaacccttcagtccaccacagtctaaaggtcgagggaagggaaatgaaataggattatgtgtggttgcagtaggctttaaattccaaagaatctgaaggtggataggaaagaggactggtgccagacaaatctgacattctaggcctgtctctgtcaacttaaccagctgtggccttgatcaagttagttagtgccttccgcctcgtttcttcatctgtaaagtaaaagctgaagattaaggtcaattatgtaaagtatgtgtgtcacacaaaagtagatgacactattaggaaggaggcttttagatagtccctaactgacttctctgtatcttcctttggctgagacttttttttttttaggttgaagctcgctttctctctctctccctctttctccctctctctctctctctcactctctctctctccatatatatatacatatatatatatatatatattttttttttaacaactggtaggataggttgggcattagccttcttcagtgatttgattgtatacagattgaaatcctttccatttccaaacacttaagagccaaagccaacttgccaacttttcactgtcggttcccttaccttatatctcttggtaataccccccacccccgttccctgattcctggtaaaagctctagttggagagccgaaaggaaaggaaatgatctttcaaaattaaaggtgaacaccttcacttaaactgattaaaattgcagctccaccgtccggcctctagagggcagtgtatggatacatttgtccagattgggggactaggtttgataaattttgtcctgcatcaaatgacaaaagggtaataggaaatgtattatatttatgccccttactttgagataagagactacaaccttcatacttcggggtgttaagctgccattgctcttgttaaggggcagtttgttttttaagagatggggtcttgctctgttgtccaggctggagtgcagtgccgcgatcttggctcagtgcaacctcgaactcctgggcttaagcgatcctcccgcctcagcctcccgagtactgggactacaggcgtgtgccaccaaggggcgattattattttttttttctacgcaaaataaaagacggctattca
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5869 -> Molecular function: GO:0003924 [GTPase activity] evidence: TAS
GeneID:5869 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5869 -> Molecular function: GO:0005525 [GTP binding] evidence: IEA
GeneID:5869 -> Molecular function: GO:0019003 [GDP binding] evidence: IDA
GeneID:5869 -> Molecular function: GO:0030742 [GTP-dependent protein binding] evidence: IDA
GeneID:5869 -> Biological process: GO:0006184 [GTP catabolic process] evidence: TAS
GeneID:5869 -> Biological process: GO:0007032 [endosome organization] evidence: IEA
GeneID:5869 -> Biological process: GO:0007264 [small GTPase mediated signal transduction] evidence: IEA
GeneID:5869 -> Biological process: GO:0015031 [protein transport] evidence: IEA
GeneID:5869 -> Biological process: GO:0030100 [regulation of endocytosis] evidence: IEA
GeneID:5869 -> Cellular component: GO:0005622 [intracellular] evidence: IDA
GeneID:5869 -> Cellular component: GO:0005768 [endosome] evidence: IDA
GeneID:5869 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
GeneID:5869 -> Cellular component: GO:0016020 [membrane] evidence: TAS
GeneID:5869 -> Cellular component: GO:0030139 [endocytic vesicle] evidence: IEA
GeneID:5869 -> Cellular component: GO:0031901 [early endosome membrane] evidence: IEA
GeneID:5869 -> Cellular component: GO:0042470 [melanosome] evidence: IEA
by
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