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2024-04-27 04:18:35, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002816 1814 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens proteasome (prosome, macropain) 26S subunit,
non-ATPase, 12 (PSMD12), transcript variant 1, mRNA.
ACCESSION NM_002816 XM_942494 XM_946044 XM_946047 XM_946049 XM_946052
XM_946055 XM_946058
VERSION NM_002816.3 GI:109702908
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1814)
AUTHORS Gandhi,T.K., Zhong,J., Mathivanan,S., Karthick,L., Chandrika,K.N.,
Mohan,S.S., Sharma,S., Pinkert,S., Nagaraju,S., Periaswamy,B.,
Mishra,G., Nandakumar,K., Shen,B., Deshpande,N., Nayak,R.,
Sarker,M., Boeke,J.D., Parmigiani,G., Schultz,J., Bader,J.S. and
Pandey,A.
TITLE Analysis of the human protein interactome and comparison with
yeast, worm and fly interaction datasets
JOURNAL Nat. Genet. 38 (3), 285-293 (2006)
PUBMED 16501559
REFERENCE 2 (bases 1 to 1814)
AUTHORS Listovsky,T., Oren,Y.S., Yudkovsky,Y., Mahbubani,H.M., Weiss,A.M.,
Lebendiker,M. and Brandeis,M.
TITLE Mammalian Cdh1/Fzr mediates its own degradation
JOURNAL EMBO J. 23 (7), 1619-1626 (2004)
PUBMED 15029244
REFERENCE 3 (bases 1 to 1814)
AUTHORS Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
Superti-Furga,G.
TITLE A physical and functional map of the human TNF-alpha/NF-kappa B
signal transduction pathway
JOURNAL Nat. Cell Biol. 6 (2), 97-105 (2004)
PUBMED 14743216
REMARK Erratum:[Nat Cell Biol. 2004 May;6(5):465]
REFERENCE 4 (bases 1 to 1814)
AUTHORS Conticello,S.G., Harris,R.S. and Neuberger,M.S.
TITLE The Vif protein of HIV triggers degradation of the human
antiretroviral DNA deaminase APOBEC3G
JOURNAL Curr. Biol. 13 (22), 2009-2013 (2003)
PUBMED 14614829
REFERENCE 5 (bases 1 to 1814)
AUTHORS Yu,X., Yu,Y., Liu,B., Luo,K., Kong,W., Mao,P. and Yu,X.F.
TITLE Induction of APOBEC3G ubiquitination and degradation by an HIV-1
Vif-Cul5-SCF complex
JOURNAL Science 302 (5647), 1056-1060 (2003)
PUBMED 14564014
REFERENCE 6 (bases 1 to 1814)
AUTHORS Madani,N. and Kabat,D.
TITLE An endogenous inhibitor of human immunodeficiency virus in human
lymphocytes is overcome by the viral Vif protein
JOURNAL J. Virol. 72 (12), 10251-10255 (1998)
PUBMED 9811770
REFERENCE 7 (bases 1 to 1814)
AUTHORS Saito,A., Watanabe,T.K., Shimada,Y., Fujiwara,T., Slaughter,C.A.,
DeMartino,G.N., Tanahashi,N. and Tanaka,K.
TITLE cDNA cloning and functional analysis of p44.5 and p55, two
regulatory subunits of the 26S proteasome
JOURNAL Gene 203 (2), 241-250 (1997)
PUBMED 9426256
REFERENCE 8 (bases 1 to 1814)
AUTHORS Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
TITLE HIV-1 tat inhibits the 20 S proteasome and its 11 S
regulator-mediated activation
JOURNAL J. Biol. Chem. 272 (13), 8145-8148 (1997)
PUBMED 9079628
REFERENCE 9 (bases 1 to 1814)
AUTHORS Coux,O., Tanaka,K. and Goldberg,A.L.
TITLE Structure and functions of the 20S and 26S proteasomes
JOURNAL Annu. Rev. Biochem. 65, 801-847 (1996)
PUBMED 8811196
REMARK Review article
REFERENCE 10 (bases 1 to 1814)
AUTHORS Kanayama,H.O., Tamura,T., Ugai,S., Kagawa,S., Tanahashi,N.,
Yoshimura,T., Tanaka,K. and Ichihara,A.
TITLE Demonstration that a human 26S proteolytic complex consists of a
proteasome and multiple associated protein components and
hydrolyzes ATP and ubiquitin-ligated proteins by closely linked
mechanisms
JOURNAL Eur. J. Biochem. 206 (2), 567-578 (1992)
PUBMED 1317798
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK091198.1 and BC019062.2.
On Jun 28, 2006 this sequence version replaced gi:28872726.
Summary: The 26S proteasome is a multicatalytic proteinase complex
with a highly ordered structure composed of 2 complexes, a 20S core
and a 19S regulator. The 20S core is composed of 4 rings of 28
non-identical subunits; 2 rings are composed of 7 alpha subunits
and 2 rings are composed of 7 beta subunits. The 19S regulator is
composed of a base, which contains 6 ATPase subunits and 2
non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
subunits. Proteasomes are distributed throughout eukaryotic cells
at a high concentration and cleave peptides in an
ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
essential function of a modified proteasome, the immunoproteasome,
is the processing of class I MHC peptides. This gene encodes a
non-ATPase subunit of the 19S regulator. A pseudogene has been
identified on chromosome 3. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) encodes the longer isoform
(1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC019062.2, AK307821.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-194 AK091198.1 1-194
195-1814 BC019062.2 148-1767
FEATURES Location/Qualifiers
source 1..1814
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q24.2"
gene 1..1814
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/note="proteasome (prosome, macropain) 26S subunit,
non-ATPase, 12"
/db_xref="GeneID:5718"
/db_xref="HGNC:9557"
/db_xref="HPRD:05120"
/db_xref="MIM:604450"
exon 1..194
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/inference="alignment:Splign:1.39.8"
CDS 87..1457
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/note="isoform 1 is encoded by transcript variant 1; 26S
proteasome regulatory subunit p55; 26S proteasome
regulatory subunit RPN5"
/codon_start=1
/product="26S proteasome non-ATPase regulatory subunit 12
isoform 1"
/protein_id="NP_002807.1"
/db_xref="GI:4506221"
/db_xref="CCDS:CCDS11669.1"
/db_xref="GeneID:5718"
/db_xref="HGNC:9557"
/db_xref="HPRD:05120"
/db_xref="MIM:604450"
/translation="
MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ
"
misc_feature 90..92
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylalanine; propagated from
UniProtKB/Swiss-Prot (O00232.3); acetylation site"
misc_feature 126..1454
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/note="26S proteasome regulatory complex component
[Posttranslational modification, protein turnover,
chaperones]; Region: RPN5; COG5071"
/db_xref="CDD:34675"
misc_feature 747..749
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (O00232.3); acetylation site"
misc_feature 990..1331
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/note="PCI domain; Region: PCI; pfam01399"
/db_xref="CDD:201772"
misc_feature 1188..1190
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (O00232.3); acetylation site"
variation 170
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/replace="a"
/replace="t"
/db_xref="dbSNP:11079691"
exon 195..254
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/inference="alignment:Splign:1.39.8"
exon 255..383
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/inference="alignment:Splign:1.39.8"
exon 384..491
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/inference="alignment:Splign:1.39.8"
exon 492..596
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/inference="alignment:Splign:1.39.8"
exon 597..746
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/inference="alignment:Splign:1.39.8"
exon 747..881
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/inference="alignment:Splign:1.39.8"
exon 882..994
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/inference="alignment:Splign:1.39.8"
exon 995..1169
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/inference="alignment:Splign:1.39.8"
variation 1159
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/replace="c"
/replace="t"
/db_xref="dbSNP:2230680"
exon 1170..1247
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/inference="alignment:Splign:1.39.8"
exon 1248..1797
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/inference="alignment:Splign:1.39.8"
variation 1421
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/replace="c"
/replace="t"
/db_xref="dbSNP:1803017"
STS 1516..1611
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
/standard_name="SHGC-56750"
/db_xref="UniSTS:53622"
polyA_signal 1777..1782
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
polyA_site 1797
/gene="PSMD12"
/gene_synonym="p55; Rpn5"
ORIGIN
ctgagcgggtgcgcgggcaacttccggtgtgggtgacgagtggtggccgaagcagggggacagcaagggacgctcaggcggggaccatggcggacggcggctcggagcgggctgacgggcgcatcgtcaagatggaggtggactacagcgccacggtggatcagcgcctacccgagtgtgcgaagctagccaaggaaggaagacttcaagaagtcattgaaacccttctctctctggaaaagcagactcgtactgcttccgatatggtatcgacatcccgtatcttagttgcagtagtgaagatgtgctatgaggctaaagaatgggatttacttaatgaaaatattatgcttttgtccaaaaggcggagtcagttaaaacaagctgttgccaaaatggttcaacagtgctgtacttatgttgaggaaatcacagaccttcctatcaaacttcgattaattgatactctacgaatggttaccgaaggcaagatttatgttgaaattgagcgtgcgcgactgactaaaacattagcaactataaaagaacaaaatggtgatgtgaaagaggcagcctccattttacaggagttacaggtggaaacctacgggtcaatggaaaagaaagagcgagtggaatttattttggagcaaatgaggctctgcctagctgtgaaggattacattcgaacacaaatcatcagcaagaaaattaacaccaaatttttccaggaagaaaatacagagaaattaaagttgaagtactataatttaatgattcagctggatcaacatgagggatcctatttgtctatttgtaagcactacagagcaatatatgatactccctgtatacaggcagaaagtgaaaaatggcagcaggctctgaagagtgttgtactctatgttatcctggctccttttgacaatgaacagtcagatttggttcaccgaataagtggtgacaagaagttagaagaaattcccaaatacaaggatcttttaaagctttttaccacaatggagttgatgcgttggtccacacttgttgaggactatggaatggaattaagaaaaggttcccttgagagtcctgcaacggatgtttttggttctacagaggaaggtgaaaaaaggtggaaagacttgaagaacagagttgttgaacataatattagaataatggccaagtattatactcggataacaatgaaaaggatggcacagcttctggatctatctgttgatgagtccgaagcctttctctcaaatctagtagttaacaagaccatctttgctaaagtagacagattagcaggaattatcaacttccagagacccaaggatccaaataatttattaaatgactggtctcagaaactgaactcattaatgtctctggttaacaaaactacgcatctcatagccaaagaggagatgatacataatctacaataagggtcttagtgctttagaaaaaagttaaaattggaagtcattaaaaaaagactgttataatggtgtatatgttggggttttttttctaagcttctttgtcttaaattttaaaatagtgaatatgtttgagactccctttgacctttcagttccccaagttcattgttaactttgcatttgcaattggtgcaaaaatacagatttctgtcgtctgaatacacaaaaagttgtgtcataacttacccagatatgtttttctatcatttgaaacctttttagctactgtttgttttcattcaactaacaaacatattccaataataaaagcagtatatacataaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5718 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
GeneID:5718 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
GeneID:5718 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:5718 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
GeneID:5718 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
GeneID:5718 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
GeneID:5718 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:5718 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
GeneID:5718 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:5718 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:5718 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:5718 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:5718 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
GeneID:5718 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
GeneID:5718 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
GeneID:5718 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:5718 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:5718 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:5718 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5718 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5718 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5718 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:5718 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5718 -> Cellular component: GO:0005838 [proteasome regulatory particle] evidence: TAS
GeneID:5718 -> Cellular component: GO:0022624 [proteasome accessory complex] evidence: ISS
by
@meso_cacase at
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