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2024-04-19 17:19:23, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002814 1585 bp mRNA linear PRI 19-MAY-2013
DEFINITION Homo sapiens proteasome (prosome, macropain) 26S subunit,
non-ATPase, 10 (PSMD10), transcript variant 1, mRNA.
ACCESSION NM_002814
VERSION NM_002814.3 GI:325652103
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1585)
AUTHORS Kim,Y.H., Kim,J.H., Choi,Y.W., Lim,S.K., Yim,H., Kang,S.Y.,
Chung,Y.S., Lee,G.Y. and Park,T.J.
TITLE Gankyrin is frequently overexpressed in breast cancer and is
associated with ErbB2 expression
JOURNAL Exp. Mol. Pathol. 94 (2), 360-365 (2013)
PUBMED 23276718
REMARK GeneRIF: gankyrin was identified in normal breasts and
overexpressed in invasive breast cancers. The overexpression of
gankyrin was associated with extensive intraductal carcinoma and
ErbB2 expression in breast cancer.
REFERENCE 2 (bases 1 to 1585)
AUTHORS Kuo,T.C., Chang,P.Y., Huang,S.F., Chou,C.K. and Chao,C.C.
TITLE Knockdown of HURP inhibits the proliferation of hepacellular
carcinoma cells via downregulation of gankyrin and accumulation of
p53
JOURNAL Biochem. Pharmacol. 83 (6), 758-768 (2012)
PUBMED 22230478
REMARK GeneRIF: Knockdown of HURP inhibits the proliferation of
hepacellular carcinoma cells via downregulation of gankyrin and
accumulation of p53.
REFERENCE 3 (bases 1 to 1585)
AUTHORS Yang,Y., Zhang,C., Li,L., Gao,Y., Luo,X., Zhang,Y., Liu,W. and
Fei,Z.
TITLE Up-regulated oncoprotein P28GANK correlates with proliferation and
poor prognosis of human glioma
JOURNAL World J Surg Oncol 10, 169 (2012)
PUBMED 22913315
REMARK GeneRIF: Increased expression of p28GANK is correlated with glioma.
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 1585)
AUTHORS Luo,X., Chen,L., Dai,J., Gao,Y., Wang,H., Wang,N., Zhao,Y., Liu,F.,
Sang,Z., Wang,J., Li,W., He,K., Jin,B., Man,J., Zhang,W. and Xia,Q.
TITLE Gankyrin gene deletion followed by proteomic analysis: insight into
the roles of Gankyrin in tumorigenesis and metastasis
JOURNAL BMC Med Genomics 5, 36 (2012)
PUBMED 22913272
REMARK GeneRIF: the roles and underlying mechanisms by which gankyrin is
involved in tumorigenesis and cancer metastasis
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 1585)
AUTHORS Krzywda,S., Brzozowski,A.M., Higashitsuji,H., Fujita,J.,
Welchman,R., Dawson,S., Mayer,R.J. and Wilkinson,A.J.
TITLE The crystal structure of gankyrin, an oncoprotein found in
complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase
regulator, and the tumor suppressors Rb and p53
JOURNAL J. Biol. Chem. 279 (2), 1541-1545 (2004)
PUBMED 14573599
REMARK GeneRIF: gankyrin interactions with partner proteins are mediated
by residues situated on its concave surface
REFERENCE 6 (bases 1 to 1585)
AUTHORS Madani,N. and Kabat,D.
TITLE An endogenous inhibitor of human immunodeficiency virus in human
lymphocytes is overcome by the viral Vif protein
JOURNAL J. Virol. 72 (12), 10251-10255 (1998)
PUBMED 9811770
REFERENCE 7 (bases 1 to 1585)
AUTHORS Hori,T., Kato,S., Saeki,M., DeMartino,G.N., Slaughter,C.A.,
Takeuchi,J., Toh-e,A. and Tanaka,K.
TITLE cDNA cloning and functional analysis of p28 (Nas6p) and p40.5
(Nas7p), two novel regulatory subunits of the 26S proteasome
JOURNAL Gene 216 (1), 113-122 (1998)
PUBMED 9714768
REFERENCE 8 (bases 1 to 1585)
AUTHORS Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
TITLE HIV-1 tat inhibits the 20 S proteasome and its 11 S
regulator-mediated activation
JOURNAL J. Biol. Chem. 272 (13), 8145-8148 (1997)
PUBMED 9079628
REFERENCE 9 (bases 1 to 1585)
AUTHORS Sastry,L., Cao,T. and King,C.R.
TITLE Multiple Grb2-protein complexes in human cancer cells
JOURNAL Int. J. Cancer 70 (2), 208-213 (1997)
PUBMED 9009162
REFERENCE 10 (bases 1 to 1585)
AUTHORS Coux,O., Tanaka,K. and Goldberg,A.L.
TITLE Structure and functions of the 20S and 26S proteasomes
JOURNAL Annu. Rev. Biochem. 65, 801-847 (1996)
PUBMED 8811196
REMARK Review article
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BI114640.1, D83197.1 and
R15438.1.
This sequence is a reference standard in the RefSeqGene project.
On Mar 10, 2011 this sequence version replaced gi:28605122.
Summary: This gene encodes a subunit of the PA700/19S complex,
which is the regulatory component of the 26S proteasome. The 26S
proteosome complex is required for ubiquitin-dependent protein
degradation. This protein is a non-ATPase subunit that may be
involved in protein-protein interactions. Aberrant expression of
this gene may paly a role in tumorigenesis. Two transcripts
encoding different isoforms have been described. Pseudogenes have
been identified on chromosomes 3 and 20.[provided by RefSeq, Mar
2011].
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer isoform.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BI114640.1, D83197.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088, ERS025098 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-26 BI114640.1 2-27
27-1570 D83197.1 1-1544
1571-1585 R15438.1 1-15 c
FEATURES Location/Qualifiers
source 1..1585
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq22.3"
gene 1..1585
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/note="proteasome (prosome, macropain) 26S subunit,
non-ATPase, 10"
/db_xref="GeneID:5716"
/db_xref="HGNC:9555"
/db_xref="HPRD:04594"
/db_xref="MIM:603480"
exon 1..238
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/inference="alignment:Splign:1.39.8"
misc_feature 32..34
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/note="upstream in-frame stop codon"
CDS 125..805
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/note="isoform 1 is encoded by transcript variant 1;
hepatocellular carcinoma-associated protein p28-II;
ankyrin repeat protein; gankyrin; 26S proteasome
non-ATPase regulatory subunit 10; 26S proteasome
regulatory subunit p28"
/codon_start=1
/product="26S proteasome non-ATPase regulatory subunit 10
isoform 1"
/protein_id="NP_002805.1"
/db_xref="GI:4506217"
/db_xref="CCDS:CCDS14536.1"
/db_xref="GeneID:5716"
/db_xref="HGNC:9555"
/db_xref="HPRD:04594"
/db_xref="MIM:603480"
/translation="
MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG
"
misc_feature 125..337
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O75832.1);
Region: Interaction with RB1"
misc_feature 125..235
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O75832.1);
Region: Required for nuclear localization"
misc_feature 161..304
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/note="Ankyrin repeats (many copies); Region: Ank_4;
pfam13637"
/db_xref="CDD:205814"
misc_feature 230..601
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/note="ankyrin repeats; ankyrin repeats mediate
protein-protein interactions in very diverse families of
proteins. The number of ANK repeats in a protein can range
from 2 to over 20 (ankyrins, for example). ANK repeats may
occur in combinations with other...; Region: ANK; cd00204"
/db_xref="CDD:29261"
misc_feature 239..802
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O75832.1);
Region: Interaction with RELA"
misc_feature 254..532
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/note="Ankyrin repeats (3 copies); Region: Ank_2;
pfam12796"
/db_xref="CDD:205076"
misc_feature 452..730
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/note="Ankyrin repeats (3 copies); Region: Ank_2;
pfam12796"
/db_xref="CDD:205076"
misc_feature 635..802
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O75832.1);
Region: Interaction with RB1"
misc_feature 635..733
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/note="Ankyrin repeat; Region: Ank; pfam00023"
/db_xref="CDD:200936"
STS 183..360
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/standard_name="A002Q09"
/db_xref="UniSTS:3932"
exon 239..337
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/inference="alignment:Splign:1.39.8"
variation 315
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/replace="c"
/replace="t"
/db_xref="dbSNP:11541113"
variation 331
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/replace="a"
/replace="g"
/db_xref="dbSNP:11541112"
exon 338..484
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/inference="alignment:Splign:1.39.8"
exon 485..651
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/inference="alignment:Splign:1.39.8"
exon 652..1574
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/inference="alignment:Splign:1.39.8"
STS 1133..1267
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/standard_name="RH44542"
/db_xref="UniSTS:94"
variation 1224
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/replace="g"
/replace="t"
/db_xref="dbSNP:1802529"
variation 1299
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
/replace="a"
/replace="t"
/db_xref="dbSNP:1802528"
polyA_signal 1555..1560
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
polyA_site 1574
/gene="PSMD10"
/gene_synonym="dJ889N15.2; p28; p28(GANK)"
ORIGIN
agaaaagggaacgaggaaggccggtgattggtgaagctctaacggctgttttgactggcgtagccggagccggcgacgtgaggcgggcgttgctcgcgcgacaagtagttgctgggacagcgaaatggaggggtgtgtgtctaacctaatggtctgcaacctggcctacagcgggaagctggaagagttgaaggagagtattctggccgataaatccctggctactagaactgaccaggacagcagaactgcattgcactgggcatgctcagctggacatacagaaattgttgaatttttgttgcaacttggagtgccagtgaatgataaagacgatgcaggttggtctcctcttcatattgcggcttctgctggccgggatgagattgtaaaagcccttctgggaaaaggtgctcaagtgaatgctgtcaatcaaaatggctgtactcccttacattatgcagcttcgaaaaacaggcatgagatcgctgtcatgttactggaaggcggggctaatccagatgctaaggaccattatgaggctacagcaatgcaccgggcagcagccaagggtaacttgaagatgattcatatccttctgtactacaaagcatccacaaacatccaagacactgagggtaacactcctctacacttagcctgtgatgaggagagagtggaagaagcaaaactgctggtgtcccaaggagcaagtatttacattgagaataaagaagaaaagacacccctgcaagtggccaaaggtggcctgggtttaatactcaagagaatggtggaaggttaaacagcttggatttattcttactttgtatgttgtgttgttgtccccagtgtcctacaaactaatgtatttgtgcacaagacatcatctatgaatgatgaagttttctcaccttcaaagtcttataaacatgttgactcttgttcctgctgagttacttgttcgaagcttacagcttgttttccaggcatcgaataactgttgagattgttctactgttgtcgtatattcttctatattgaattctggttaatttggagtaactaattctgtggctgttgtgagtcttcagcaccctcccatgtaccttatatccctctctgaaacagaacagctccaatagcaacaagctagttgttctgccagatgtttctatgtggattctgtaatgttcctccatacagttaaaacatcctaacttgtttttcaagctcactcaggcctacgccaaacgtttctgttttttttaaccatgaggtttaatttatttttgtgataggagggatatttacatattttagtggaccacattttaagttggatggtgtgctctaaaatactgaaaaacaatagcccatatacctatgtatttgtttttgatgggttgtttactctgaaataaaatgtatggttttcttaaaaggaagttttaaagtacctattttgtgtcatcctgtattgaaaagaatgtcaagcttgttaaaatgacatgtaacaaaaatgtattttgatttgtatttcagaaactaaaaaataaaatgttgaaagaatcaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5716 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5716 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
GeneID:5716 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
GeneID:5716 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:5716 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
GeneID:5716 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:5716 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
GeneID:5716 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
GeneID:5716 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
GeneID:5716 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:5716 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
GeneID:5716 -> Biological process: GO:0007253 [cytoplasmic sequestering of NF-kappaB] evidence: IDA
GeneID:5716 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:5716 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:5716 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:5716 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:5716 -> Biological process: GO:0030307 [positive regulation of cell growth] evidence: IDA
GeneID:5716 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
GeneID:5716 -> Biological process: GO:0031398 [positive regulation of protein ubiquitination] evidence: IMP
GeneID:5716 -> Biological process: GO:0032088 [negative regulation of NF-kappaB transcription factor activity] evidence: IDA
GeneID:5716 -> Biological process: GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] evidence: IDA
GeneID:5716 -> Biological process: GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
GeneID:5716 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
GeneID:5716 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
GeneID:5716 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:5716 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA
GeneID:5716 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IMP
GeneID:5716 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:5716 -> Biological process: GO:0043409 [negative regulation of MAPK cascade] evidence: IMP
GeneID:5716 -> Biological process: GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] evidence: IDA
GeneID:5716 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:5716 -> Biological process: GO:0045737 [positive regulation of cyclin-dependent protein kinase activity] evidence: IDA
GeneID:5716 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5716 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5716 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5716 -> Biological process: GO:0070682 [proteasome regulatory particle assembly] evidence: IMP
GeneID:5716 -> Biological process: GO:0090201 [negative regulation of release of cytochrome c from mitochondria] evidence: IMP
GeneID:5716 -> Cellular component: GO:0000502 [proteasome complex] evidence: TAS
GeneID:5716 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:5716 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:5716 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:5716 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5716 -> Cellular component: GO:0005838 [proteasome regulatory particle] evidence: TAS
GeneID:5716 -> Cellular component: GO:0008540 [proteasome regulatory particle, base subcomplex] evidence: IDA
GeneID:5716 -> Cellular component: GO:0015629 [actin cytoskeleton] evidence: IDA
GeneID:5716 -> Cellular component: GO:0045111 [intermediate filament cytoskeleton] evidence: IDA
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@meso_cacase at
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