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2024-04-25 15:42:48, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002813 2368 bp mRNA linear PRI 26-MAY-2013
DEFINITION Homo sapiens proteasome (prosome, macropain) 26S subunit,
non-ATPase, 9 (PSMD9), transcript variant 1, mRNA.
ACCESSION NM_002813
VERSION NM_002813.5 GI:386869372
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2368)
AUTHORS Gragnoli,C.
TITLE Proteasome modulator 9 is linked to microvascular pathology of T2D
JOURNAL J. Cell. Physiol. 227 (8), 3116-3118 (2012)
PUBMED 22015693
REMARK GeneRIF: the PSMD9 IVS3 + nt460, IVS3 + nt437, E197G SNPs are
linked via the recessive model to microvascular pathology of type 2
diabetes (T2D) in Italians
REFERENCE 2 (bases 1 to 2368)
AUTHORS He,S.M., Zhao,Z.W., Wang,Y., Zhao,J.P., Wang,L., Hou,F. and
Gao,G.D.
TITLE Potential role of Jun activation domain-binding protein 1 and
phosphorylated p27 expression in prognosis of glioma
JOURNAL Brain Tumor Pathol 29 (1), 3-9 (2012)
PUBMED 21837501
REMARK GeneRIF: overexpression of Jab1, cytoplasmic p27, and pSer10p27
proteins is correlated with poor outcome in patients with glioma
REFERENCE 3 (bases 1 to 2368)
AUTHORS Gragnoli,C.
TITLE Proteasome modulator 9 and depression in type 2 diabetes
JOURNAL Curr. Med. Chem. 19 (30), 5178-5180 (2012)
PUBMED 22934761
REMARK GeneRIF: PSMD9 IVS3+nt460 A>G and +nt437 C>T and exon 5 E197G A>G
single nucleotide polymorphisms studied and/or any variants in
linkage disequilibrium with them are linked to depression in our
type 2 diabetes Italian families.
REFERENCE 4 (bases 1 to 2368)
AUTHORS Gragnoli,C.
TITLE Proteasome modulator 9 and carpal tunnel syndrome
JOURNAL Diabetes Res. Clin. Pract. 94 (2), E47-E49 (2011)
PUBMED 21862167
REMARK GeneRIF: Brief Report: PSMD9 SNPs show linkage to carpal tunnel
syndrome in Italian type 2 diabetics.
REFERENCE 5 (bases 1 to 2368)
AUTHORS Gragnoli,C.
TITLE Proteasome modulator 9 SNPs are linked to hypertension in type 2
diabetes families
JOURNAL Cardiovasc Diabetol 10, 77 (2011)
PUBMED 21871126
REMARK GeneRIF: PSMD9 gene SNPs are linked to elevated blood
pressure/hypertension in Italian families with type 2 diabetes.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 2368)
AUTHORS Simon,J.H., Gaddis,N.C., Fouchier,R.A. and Malim,M.H.
TITLE Evidence for a newly discovered cellular anti-HIV-1 phenotype
JOURNAL Nat. Med. 4 (12), 1397-1400 (1998)
PUBMED 9846577
REFERENCE 7 (bases 1 to 2368)
AUTHORS Madani,N. and Kabat,D.
TITLE An endogenous inhibitor of human immunodeficiency virus in human
lymphocytes is overcome by the viral Vif protein
JOURNAL J. Virol. 72 (12), 10251-10255 (1998)
PUBMED 9811770
REFERENCE 8 (bases 1 to 2368)
AUTHORS Watanabe,T.K., Saito,A., Suzuki,M., Fujiwara,T., Takahashi,E.,
Slaughter,C.A., DeMartino,G.N., Hendil,K.B., Chung,C.H.,
Tanahashi,N. and Tanaka,K.
TITLE cDNA cloning and characterization of a human proteasomal modulator
subunit, p27 (PSMD9)
JOURNAL Genomics 50 (2), 241-250 (1998)
PUBMED 9653651
REFERENCE 9 (bases 1 to 2368)
AUTHORS Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
TITLE HIV-1 tat inhibits the 20 S proteasome and its 11 S
regulator-mediated activation
JOURNAL J. Biol. Chem. 272 (13), 8145-8148 (1997)
PUBMED 9079628
REFERENCE 10 (bases 1 to 2368)
AUTHORS Coux,O., Tanaka,K. and Goldberg,A.L.
TITLE Structure and functions of the 20S and 26S proteasomes
JOURNAL Annu. Rev. Biochem. 65, 801-847 (1996)
PUBMED 8811196
REMARK Review article
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CN260241.1, BC002383.2,
BU726372.1 and AC069503.25.
On May 10, 2012 this sequence version replaced gi:34335280.
Summary: The 26S proteasome is a multicatalytic proteinase complex
with a highly ordered structure composed of 2 complexes, a 20S core
and a 19S regulator. The 20S core is composed of 4 rings of 28
non-identical subunits; 2 rings are composed of 7 alpha subunits
and 2 rings are composed of 7 beta subunits. The 19S regulator is
composed of a base, which contains 6 ATPase subunits and 2
non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
subunits. Proteasomes are distributed throughout eukaryotic cells
at a high concentration and cleave peptides in an
ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
essential function of a modified proteasome, the immunoproteasome,
is the processing of class I MHC peptides. This gene encodes a
non-ATPase subunit of the 19S regulator. Three transcript variants
encoding two different isoforms have been found for this gene.
[provided by RefSeq, May 2012].
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longer isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC002383.2, BM552926.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-40 CN260241.1 7-46
41-1954 BC002383.2 1-1914
1955-2296 BU726372.1 73-414 c
2297-2297 AC069503.25 139925-139925 c
2298-2368 BU726372.1 1-71 c
FEATURES Location/Qualifiers
source 1..2368
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q24.31-q24.32"
gene 1..2368
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/note="proteasome (prosome, macropain) 26S subunit,
non-ATPase, 9"
/db_xref="GeneID:5715"
/db_xref="HGNC:9567"
/db_xref="HPRD:04394"
/db_xref="MIM:603146"
exon 1..264
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/inference="alignment:Splign:1.39.8"
variation 9
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:368835435"
variation 11
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="g"
/replace="t"
/db_xref="dbSNP:139013135"
misc_feature 55..57
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/note="upstream in-frame stop codon"
variation 94
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:377666528"
variation 124
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:370876307"
CDS 127..798
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/note="isoform 1 is encoded by transcript variant 1;
proteasome 26S non-ATPase regulatory subunit 9; homolog of
rat Bridge 1; 26S proteasome regulatory subunit p27; 26S
proteasome non-ATPase regulatory subunit 9"
/codon_start=1
/product="26S proteasome non-ATPase regulatory subunit 9
isoform 1"
/protein_id="NP_002804.2"
/db_xref="GI:18543329"
/db_xref="CCDS:CCDS9225.1"
/db_xref="GeneID:5715"
/db_xref="HGNC:9567"
/db_xref="HPRD:04394"
/db_xref="MIM:603146"
/translation="
MSDEEARQSGGSSQAGVVTVSDVQELMRRKEEIEAQIKANYDVLESQKGIGMNEPLVDCEGYPRSDVDLYQVRTARHNIICLQNDHKAVMKQVEEALHQLHARDKEKQARDMAEAHKEAMSRKLGQSESQGPPRAFAKVNSISPGSPASIAGLQVDDEIVEFGSVNTQNFQSLHNIGSVVQHSEGKPLNVTVIRRGEKHQLRLVPTRWAGKGLLGCNIIPLQR
"
misc_feature 511..741
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/note="PDZ domain of bacterial and plant zinc
metalloprotases, presumably membrane-associated or
integral membrane proteases, which may be involved in
signalling and regulatory mechanisms. May be responsible
for substrate recognition and/or binding, as most PDZ...;
Region: PDZ_metalloprotease; cd00989"
/db_xref="CDD:29046"
misc_feature order(514..516,652..657,664..669)
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/note="protein binding site [polypeptide binding]; other
site"
/db_xref="CDD:29046"
variation 144
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="g"
/db_xref="dbSNP:142807207"
variation 157
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:183923514"
variation 169
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:201195366"
variation 176
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:2230681"
variation 197
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:375294307"
exon 265..367
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/inference="alignment:Splign:1.39.8"
variation 272
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:143782226"
variation 275
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:374003798"
variation 276
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="g"
/replace="t"
/db_xref="dbSNP:79203250"
variation 290
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:200752587"
variation 291
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:367872241"
variation 316
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:146859499"
variation 317
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:140713948"
variation 319
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="t"
/db_xref="dbSNP:147461674"
variation 324
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:145848912"
variation 325
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="g"
/db_xref="dbSNP:75048523"
variation 345
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:201710683"
variation 347
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:2291116"
variation 348
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:371346772"
exon 368..579
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/inference="alignment:Splign:1.39.8"
variation 433
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:188268911"
variation 435
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:148814204"
variation 452
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:373590240"
variation 454
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:201206246"
variation 463
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:372224851"
variation 470
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="g"
/db_xref="dbSNP:200003030"
variation 473
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:143458397"
variation 487
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="t"
/db_xref="dbSNP:143562133"
variation 491
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:145938110"
variation 516
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:75670767"
variation 519
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:377693170"
variation 526
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:1177573"
variation 527
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:142807741"
variation 535
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:376571677"
variation 546
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="g"
/db_xref="dbSNP:145963867"
variation 559
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:150787302"
variation 577
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:139208583"
exon 580..681
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/inference="alignment:Splign:1.39.8"
variation 614
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="g"
/replace="t"
/db_xref="dbSNP:1803018"
variation 623
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:149556654"
variation 645
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="g"
/replace="t"
/db_xref="dbSNP:368280242"
exon 682..770
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/inference="alignment:Splign:1.39.8"
variation 711
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:118111382"
variation 716
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:14259"
variation 745
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:376869654"
variation 746
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="g"
/replace="t"
/db_xref="dbSNP:376166363"
variation 755
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="g"
/db_xref="dbSNP:369086059"
variation 761
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="g"
/replace="t"
/db_xref="dbSNP:201207198"
exon 771..2352
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/inference="alignment:Splign:1.39.8"
variation 786
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:373134121"
STS 804..1068
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/standard_name="WI-19611"
/db_xref="UniSTS:42480"
variation 804
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:200207711"
variation 812
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:201745629"
variation 834
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:370191768"
variation 840
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:373402172"
variation 841
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="g"
/db_xref="dbSNP:142086448"
STS 936..1078
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/standard_name="RH64869"
/db_xref="UniSTS:56287"
variation 985
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:2272134"
variation 1016
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="c"
/db_xref="dbSNP:3182919"
variation 1017
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:138686848"
variation 1058
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:117351080"
polyA_signal 1104..1109
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
polyA_site 1132
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
variation 1150
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="g"
/replace="t"
/db_xref="dbSNP:149241828"
variation 1286
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="g"
/db_xref="dbSNP:1154517"
variation 1294
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="g"
/db_xref="dbSNP:115859371"
variation 1352
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="g"
/db_xref="dbSNP:192528695"
variation 1429
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:876934"
variation 1497
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:12229068"
variation 1592
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:137953667"
variation 1598
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:58642707"
variation 1604
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="t"
/db_xref="dbSNP:144414624"
variation 1622
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:59695002"
variation 1728
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace=""
/replace="c"
/db_xref="dbSNP:36114040"
variation 1733..1734
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace=""
/replace="a"
/db_xref="dbSNP:11448317"
variation 1734..1735
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace=""
/replace="a"
/db_xref="dbSNP:11385149"
variation 1753
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="t"
/db_xref="dbSNP:185103785"
variation 1766
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:79531339"
variation 1822
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="g"
/replace="t"
/db_xref="dbSNP:368607295"
variation 1923
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace=""
/replace="t"
/db_xref="dbSNP:35204822"
variation 1936
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="t"
/db_xref="dbSNP:186767023"
variation 2101
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="g"
/db_xref="dbSNP:114459208"
variation 2141..2142
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace=""
/replace="g"
/db_xref="dbSNP:63631363"
variation 2186
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="c"
/replace="g"
/db_xref="dbSNP:191573913"
variation 2189
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="t"
/db_xref="dbSNP:75933880"
variation 2190
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="c"
/db_xref="dbSNP:75412527"
variation 2245
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="g"
/replace="t"
/db_xref="dbSNP:184665547"
variation 2297
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:876935"
polyA_signal 2329..2334
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
variation 2343
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
/replace="a"
/replace="g"
/db_xref="dbSNP:115983947"
polyA_site 2352
/gene="PSMD9"
/gene_synonym="p27; Rpn4"
ORIGIN
gactgttctcgcgttcgcggacggctgtggtgttttggcgcatgggcggagccgtagttacggtcgactggggcgtcgtccctagcccgggagccgggtctctggagtcgcggcccggggttcacgatgtccgacgaggaagcgaggcagagcggaggctcctcgcaggccggcgtcgtgactgtcagcgacgtccaggagctgatgcggcgcaaggaggagatagaagcgcagatcaaggccaactatgacgtgctggaaagccaaaaaggcattgggatgaacgagccgctggtggactgtgagggctacccccggtcagacgtggacctgtaccaagtccgcaccgccaggcacaacatcatatgcctgcagaatgatcacaaggcagtgatgaagcaggtggaggaggccctgcaccagctgcacgctcgcgacaaggagaagcaggcccgggacatggctgaggcccacaaagaggccatgagccgcaaactgggtcagagtgagagccagggccctccacgggccttcgccaaagtgaacagcatcagccccggctccccagccagcatcgcgggtctgcaagtggatgatgagattgtggagttcggctctgtgaacacccagaacttccagtcactgcataacattggcagtgtggtgcagcacagtgaggggaagcccctgaatgtgacagtgatccgcaggggggaaaaacaccagcttagacttgttccaacacgctgggcaggaaaaggactgctgggctgcaacattattcctctgcaaagatgattgtccctggggaacagtaacaggaaagcatcttcccttgccctggacttgggtctagggatttccaacttgtcttctctccctgaagcataaggatctggaagaggcttgtaacctgaacttctgtgtggtggcagtactgtggcccaccagtgtaatctccctggattaaggcattcttaaaaacttaggcttggcctctttcacaaattaggccacggccctaaataggaattccctggattgtgggcaagtgggcggaagttattctggcaggtactggtgtgattattattattatttttaataaagagttttacagtgctgatatgaccctgttgtcaccccagctgaatttcttatgaccctcccaaaccaaagctcagatggggtcagaagagcttcatagaaagttgggcaaaacaggctagcaattgcaaagtcaggctttgaccaacatatttctttgcactgaggccttgctgctgtggatacggaaatggttaagtactgtgcttcctcagcagctgggctgtcagggccatagtagctccctttggagaacagggaaagcctggaggcttcccaggtggcccagcgtggtgtcctgtcagcttcctctttaggaacccaccagagggcagcaagctcctttcacttcgctagtaagaacccctccgtttttgtgtgtttttgtttttgttttctggagacaaggtcttgctttgtcacccaggctggagtgcagtgtcgtgatcaaggttcactgaagccttgacgctgtgggcactgcctcagccgcccaagtatctgggaccacaggcgtgcaccaccatgcatagctaatttattttttgtagagacagggtctccctgtgttgaccaggttggtctcgaactcctgggctcaagcagtcctcctgccttggcctcctaaagtgctgggatcacaggcgtgagccactgcgcccagcccactgctagtttgactttttataattgaacctcctggctatgccctgagatcagcgctattttgtaaaccgctgaggtatggataggaacgagtagatcagacctcttgaaaatgcttattcttcctcccttttattttttgtctcttttaagatggtaaaatggttctcagggattcctgccaatactttgaattattttttcctctccatggtatcagtgttcatttccccagttcttgcacaccgctttctgttttggcagttctgccaggcaagccctgtgttccttgggactggttttgctgtggttggatacagataccagcttgccttgatgggattggtattgctgtgtgcttccagccacaggttctcacactcaattccaaagccttcctattgggcgaattccctcaaactctatttgacctgacagccatacgtattcccctctggtagccacagacatgctgtgtttaccaatgtttgctgtttaaattgcatgttctaattccacgtatcttccagtctcttttataaagtctcagactataataaacacagcttgcccagtttaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5715 -> Molecular function: GO:0003713 [transcription coactivator activity] evidence: ISS
GeneID:5715 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5715 -> Molecular function: GO:0043425 [bHLH transcription factor binding] evidence: ISS
GeneID:5715 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
GeneID:5715 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
GeneID:5715 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:5715 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
GeneID:5715 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
GeneID:5715 -> Biological process: GO:0006511 [ubiquitin-dependent protein catabolic process] evidence: NAS
GeneID:5715 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
GeneID:5715 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:5715 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
GeneID:5715 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:5715 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:5715 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:5715 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:5715 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
GeneID:5715 -> Biological process: GO:0032024 [positive regulation of insulin secretion] evidence: ISS
GeneID:5715 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
GeneID:5715 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
GeneID:5715 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:5715 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:5715 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:5715 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: ISS
GeneID:5715 -> Biological process: GO:0046676 [negative regulation of insulin secretion] evidence: ISS
GeneID:5715 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5715 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5715 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5715 -> Biological process: GO:0070682 [proteasome regulatory particle assembly] evidence: IMP
GeneID:5715 -> Cellular component: GO:0005634 [nucleus] evidence: ISS
GeneID:5715 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:5715 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5715 -> Cellular component: GO:0005838 [proteasome regulatory particle] evidence: NAS
GeneID:5715 -> Cellular component: GO:0008540 [proteasome regulatory particle, base subcomplex] evidence: IDA
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