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2024-04-25 10:01:02, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002812 1556 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens proteasome (prosome, macropain) 26S subunit,
non-ATPase, 8 (PSMD8), mRNA.
ACCESSION NM_002812
VERSION NM_002812.4 GI:156631004
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1556)
AUTHORS Baglioni,S., Casamenti,F., Bucciantini,M., Luheshi,L.M., Taddei,N.,
Chiti,F., Dobson,C.M. and Stefani,M.
TITLE Prefibrillar amyloid aggregates could be generic toxins in higher
organisms
JOURNAL J. Neurosci. 26 (31), 8160-8167 (2006)
PUBMED 16885229
REMARK GeneRIF: These findings support the hypothesis that
neurodegenerative disorders result primarily from a generic cell
dysfunction caused by early misfolded species in the aggregation
process.
REFERENCE 2 (bases 1 to 1556)
AUTHORS Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
TITLE Functional proteomics mapping of a human signaling pathway
JOURNAL Genome Res. 14 (7), 1324-1332 (2004)
PUBMED 15231748
REFERENCE 3 (bases 1 to 1556)
AUTHORS Listovsky,T., Oren,Y.S., Yudkovsky,Y., Mahbubani,H.M., Weiss,A.M.,
Lebendiker,M. and Brandeis,M.
TITLE Mammalian Cdh1/Fzr mediates its own degradation
JOURNAL EMBO J. 23 (7), 1619-1626 (2004)
PUBMED 15029244
REFERENCE 4 (bases 1 to 1556)
AUTHORS Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
Myers,R.M., Rubin,E.M. and Lucas,S.M.
TITLE The DNA sequence and biology of human chromosome 19
JOURNAL Nature 428 (6982), 529-535 (2004)
PUBMED 15057824
REFERENCE 5 (bases 1 to 1556)
AUTHORS Conticello,S.G., Harris,R.S. and Neuberger,M.S.
TITLE The Vif protein of HIV triggers degradation of the human
antiretroviral DNA deaminase APOBEC3G
JOURNAL Curr. Biol. 13 (22), 2009-2013 (2003)
PUBMED 14614829
REFERENCE 6 (bases 1 to 1556)
AUTHORS Simon,J.H., Gaddis,N.C., Fouchier,R.A. and Malim,M.H.
TITLE Evidence for a newly discovered cellular anti-HIV-1 phenotype
JOURNAL Nat. Med. 4 (12), 1397-1400 (1998)
PUBMED 9846577
REFERENCE 7 (bases 1 to 1556)
AUTHORS Madani,N. and Kabat,D.
TITLE An endogenous inhibitor of human immunodeficiency virus in human
lymphocytes is overcome by the viral Vif protein
JOURNAL J. Virol. 72 (12), 10251-10255 (1998)
PUBMED 9811770
REFERENCE 8 (bases 1 to 1556)
AUTHORS Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
TITLE HIV-1 tat inhibits the 20 S proteasome and its 11 S
regulator-mediated activation
JOURNAL J. Biol. Chem. 272 (13), 8145-8148 (1997)
PUBMED 9079628
REFERENCE 9 (bases 1 to 1556)
AUTHORS Coux,O., Tanaka,K. and Goldberg,A.L.
TITLE Structure and functions of the 20S and 26S proteasomes
JOURNAL Annu. Rev. Biochem. 65, 801-847 (1996)
PUBMED 8811196
REMARK Review article
REFERENCE 10 (bases 1 to 1556)
AUTHORS Kominami,K., DeMartino,G.N., Moomaw,C.R., Slaughter,C.A.,
Shimbara,N., Fujimuro,M., Yokosawa,H., Hisamatsu,H., Tanahashi,N.,
Shimizu,Y. et al.
TITLE Nin1p, a regulatory subunit of the 26S proteasome, is necessary for
activation of Cdc28p kinase of Saccharomyces cerevisiae
JOURNAL EMBO J. 14 (13), 3105-3115 (1995)
PUBMED 7621825
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BP369299.1 and BC001164.1.
On Aug 31, 2007 this sequence version replaced gi:39812361.
Summary: The 26S proteasome is a multicatalytic proteinase complex
with a highly ordered structure composed of 2 complexes, a 20S core
and a 19S regulator. The 20S core is composed of 4 rings of 28
non-identical subunits; 2 rings are composed of 7 alpha subunits
and 2 rings are composed of 7 beta subunits. The 19S regulator is
composed of a base, which contains 6 ATPase subunits and 2
non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
subunits. Proteasomes are distributed throughout eukaryotic cells
at a high concentration and cleave peptides in an
ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
essential function of a modified proteasome, the immunoproteasome,
is the processing of class I MHC peptides. This gene encodes a
non-ATPase subunit of the 19S regulator. A pseudogene has been
identified on chromosome 1. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC001164.1, AK301771.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-249 BP369299.1 15-263
250-1556 BC001164.1 1-1307
FEATURES Location/Qualifiers
source 1..1556
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.2"
gene 1..1556
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/note="proteasome (prosome, macropain) 26S subunit,
non-ATPase, 8"
/db_xref="GeneID:5714"
/db_xref="HGNC:9566"
exon 1..412
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/inference="alignment:Splign:1.39.8"
variation 20
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:369756672"
variation 26
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="g"
/replace="t"
/db_xref="dbSNP:12973506"
variation 42
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:372594226"
CDS 53..1105
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/note="26S proteasome regulatory subunit p31; 26S
proteasome regulatory subunit S14; 26S proteasome
regulatory subunit RPN12"
/codon_start=1
/product="26S proteasome non-ATPase regulatory subunit 8"
/protein_id="NP_002803.2"
/db_xref="GI:156631005"
/db_xref="CCDS:CCDS12515.2"
/db_xref="GeneID:5714"
/db_xref="HGNC:9566"
/translation="
MFIKGRAPRAPPRERRRATRGGLRQVVAPPRALGSTSRPHFRRASVCRRRCRKSGGLLAASRKMAAAAVNGAAGFSSSGPAATSGAVLQAATGMYEQLKGEWNRKSPNLSKCGEELGRLKLVLLELNFLPTTGTKLTKQQLILARDILEIGAQWSILRKDIPSFERYMAQLKCYYFDYKEQLPESAYMHQLLGLNLLFLLSQNRVAEFHTELERLPAKDIQTNVYIKHPVSLEQYLMEGSYNKVFLAKGNIPAESYTFFIDILLDTIRDEIAGCIEKAYEKILFTEATRILFFNTPKKMTDYAKKRGWVLGPNNYYSFASQQQKPEDTTIPSTELAKQVIEYARQLEMIV
"
misc_feature 653..1030
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/note="COP9 signalosome, subunit CSN8; Region: PCI_Csn8;
pfam10075"
/db_xref="CDD:204392"
variation 54
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="t"
/db_xref="dbSNP:376781876"
variation 99
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:375145305"
variation 191
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="g"
/replace="t"
/db_xref="dbSNP:79875980"
variation 206
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="g"
/db_xref="dbSNP:369326461"
variation 224
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:369447667"
variation 228
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="c"
/db_xref="dbSNP:200109220"
variation 230
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:201665089"
variation 249
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:183916438"
variation 260
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:369208449"
variation 279
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="g"
/db_xref="dbSNP:372489810"
variation 283
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:201001430"
variation 291
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:377507303"
variation 363
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:11541762"
variation 396
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="c"
/db_xref="dbSNP:147693309"
variation 397
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:28384479"
exon 413..485
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/inference="alignment:Splign:1.39.8"
variation 424
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:148287182"
variation 445
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="g"
/db_xref="dbSNP:376132803"
variation 466
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:145865086"
exon 486..588
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/inference="alignment:Splign:1.39.8"
variation 525
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:200403794"
variation 529
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="g"
/db_xref="dbSNP:371805034"
variation 534..535
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace=""
/replace="c"
/db_xref="dbSNP:34950088"
variation 538
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="c"
/db_xref="dbSNP:11541759"
exon 589..754
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/inference="alignment:Splign:1.39.8"
variation 601
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:138441628"
variation 608
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:142934372"
variation 646
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:1804245"
variation 652
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:367962688"
variation 662
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:145982766"
variation 668
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="g"
/replace="t"
/db_xref="dbSNP:138444191"
variation 693
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:201667645"
variation 700
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="g"
/replace="t"
/db_xref="dbSNP:149260015"
variation 712
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:376145824"
variation 721
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:368412719"
STS 729..863
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/standard_name="RH39050"
/db_xref="UniSTS:90683"
variation 736
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:11541757"
exon 755..855
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/inference="alignment:Splign:1.39.8"
variation 781
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:141504927"
variation 804..805
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace=""
/replace="c"
/db_xref="dbSNP:35335693"
variation 808
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:373583013"
variation 820
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:201768988"
variation 838
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:11541756"
variation 844
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:375464238"
exon 856..967
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/inference="alignment:Splign:1.39.8"
variation 877
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:1131182"
variation 880
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="g"
/replace="t"
/db_xref="dbSNP:199786947"
variation 913
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:141110538"
variation 946
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="g"
/replace="t"
/db_xref="dbSNP:374571539"
exon 968..1539
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/inference="alignment:Splign:1.39.8"
variation 969
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:367675318"
variation 982
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:371885326"
variation 1001
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:147213822"
STS 1041..1189
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/standard_name="SGC30294"
/db_xref="UniSTS:56979"
variation 1048
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:10828"
variation 1056
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:201308499"
variation 1083
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:34847046"
variation 1091
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:144402089"
variation 1100
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:151185277"
variation 1106
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="g"
/db_xref="dbSNP:3180566"
variation 1153
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="t"
/db_xref="dbSNP:377149465"
variation 1185
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="c"
/replace="t"
/db_xref="dbSNP:150328547"
variation 1227
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace="a"
/replace="g"
/db_xref="dbSNP:368351923"
STS 1289..1428
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/standard_name="RH11793"
/db_xref="UniSTS:26303"
STS 1328..1471
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/standard_name="D19S1131"
/db_xref="UniSTS:79288"
variation 1362..1363
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
/replace=""
/replace="gccccagcagcactgtggc"
/db_xref="dbSNP:374846245"
polyA_signal 1519..1524
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
polyA_site 1539
/gene="PSMD8"
/gene_synonym="HIP6; HYPF; Nin1p; p31; Rpn12; S14"
ORIGIN
ccaacttccggtcaccatcttgagtgacgacagaggcggagctccaactgacatgttcattaagggcagggctccgagggcgccacctcgagagcgacggcgggctacccggggcgggctgaggcaggttgtagccccgccccgggccttgggctccacctctcggccccacttccgccgggcaagcgtttgtaggcggcgctgccgtaaatcaggcggtctgcttgccgcatcacgcaagatggcggccgcggcggtgaacggggcggcaggcttctcgagctccgggcccgcggcaacctcgggcgctgttctgcaggccgcgaccggcatgtacgagcaactcaagggcgagtggaaccgtaaaagccccaatcttagcaagtgcggggaagagctgggtcgactcaagctagttcttctggagctcaacttcttgccaaccacagggaccaagctgaccaaacagcagctaattctggcccgtgacatactggagatcggggcccaatggagcatcctacgcaaggacatcccctccttcgagcgctacatggcccagctcaaatgctactactttgattacaaggagcagctccccgagtcagcctatatgcaccagctcttgggcctcaacctcctcttcctgctgtcccagaaccgggtggctgagttccacacggagttggagcggctgcctgccaaggacatacagaccaatgtctacatcaagcacccagtgtccctggagcaatacctgatggagggcagctacaacaaagtgttcctggccaagggtaacatccccgccgagagctacaccttcttcattgacatcctgctcgacactatcagggatgagatcgctgggtgcatcgagaaggcctacgagaaaatccttttcactgaggccacccggatcctcttcttcaacacacccaaaaagatgacagactacgccaagaagcgagggtgggtcctgggccccaacaactactacagttttgccagccagcagcagaagccggaagacaccaccattccctccacagaactggccaaacaggtcatcgagtatgcccggcagctggagatgatcgtctgagccccccgggcactgggtggggcagggcacgagttatttaaaacagttacactgcagggtttcgcccaataaaggtggactgacattccctcttccaggcccttgtctccccagttgggacggcagagagacaagttcttatatctgaagaacttggaggttttggggcattcaggagttggagatagcctccaactgggtcagcctctgtctggtgggcattgctcagggtctcaaacatggacgcccactgtggggccccagcagcactgtggcctgcaggagggcatggccccaggtagggggactgttctagccagctgtggacacataggaatgctggaccagggtaccagattttttcaacaaagggggtgaagtgtcctactaaaaagaataaatgttggcagtgaattaaacaatttttcaaatgaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5714 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
GeneID:5714 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
GeneID:5714 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:5714 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
GeneID:5714 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
GeneID:5714 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
GeneID:5714 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:5714 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
GeneID:5714 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:5714 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:5714 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:5714 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:5714 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
GeneID:5714 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
GeneID:5714 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
GeneID:5714 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:5714 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:5714 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:5714 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5714 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5714 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5714 -> Cellular component: GO:0000502 [proteasome complex] evidence: TAS
GeneID:5714 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:5714 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:5714 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:5714 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:5714 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5714 -> Cellular component: GO:0005838 [proteasome regulatory particle] evidence: IEA
GeneID:5714 -> Cellular component: GO:0022624 [proteasome accessory complex] evidence: ISS
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