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2024-04-25 18:02:04, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002809 2187 bp mRNA linear PRI 14-MAY-2013
DEFINITION Homo sapiens proteasome (prosome, macropain) 26S subunit,
non-ATPase, 3 (PSMD3), mRNA.
ACCESSION NM_002809
VERSION NM_002809.3 GI:394953896
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2187)
AUTHORS Zheng,J.S., Arnett,D.K., Parnell,L.D., Lee,Y.C., Ma,Y., Smith,C.E.,
Richardson,K., Li,D., Borecki,I.B., Ordovas,J.M., Tucker,K.L. and
Lai,C.Q.
TITLE Genetic variants at PSMD3 interact with dietary fat and
carbohydrate to modulate insulin resistance
JOURNAL J. Nutr. 143 (3), 354-361 (2013)
PUBMED 23303871
REMARK GeneRIF: Our study suggests that PSMD3 variants are associated with
insulin resistance in populations of different ancestries and that
these relationships may also be modified by dietary factors.
REFERENCE 2 (bases 1 to 2187)
AUTHORS Crosslin,D.R., McDavid,A., Weston,N., Nelson,S.C., Zheng,X.,
Hart,E., de Andrade,M., Kullo,I.J., McCarty,C.A., Doheny,K.F.,
Pugh,E., Kho,A., Hayes,M.G., Pretel,S., Saip,A., Ritchie,M.D.,
Crawford,D.C., Crane,P.K., Newton,K., Li,R., Mirel,D.B.,
Crenshaw,A., Larson,E.B., Carlson,C.S. and Jarvik,G.P.
CONSRTM Electronic Medical Records and Genomics (eMERGE) Network
TITLE Genetic variants associated with the white blood cell count in
13,923 subjects in the eMERGE Network
JOURNAL Hum. Genet. 131 (4), 639-652 (2012)
PUBMED 22037903
REMARK GeneRIF: Study identified significantly white blood cell count
(WBC) level associated SNPs of three separate genes GSDMA, MED24,
and PSMD3 in European continent (EA) subjects.
REFERENCE 3 (bases 1 to 2187)
AUTHORS Okada,Y., Hirota,T., Kamatani,Y., Takahashi,A., Ohmiya,H.,
Kumasaka,N., Higasa,K., Yamaguchi-Kabata,Y., Hosono,N., Nalls,M.A.,
Chen,M.H., van Rooij,F.J., Smith,A.V., Tanaka,T., Couper,D.J.,
Zakai,N.A., Ferrucci,L., Longo,D.L., Hernandez,D.G., Witteman,J.C.,
Harris,T.B., O'Donnell,C.J., Ganesh,S.K., Matsuda,K., Tsunoda,T.,
Tanaka,T., Kubo,M., Nakamura,Y., Tamari,M., Yamamoto,K. and
Kamatani,N.
TITLE Identification of nine novel loci associated with white blood cell
subtypes in a Japanese population
JOURNAL PLoS Genet. 7 (6), E1002067 (2011)
PUBMED 21738478
REFERENCE 4 (bases 1 to 2187)
AUTHORS Okada,Y., Kamatani,Y., Takahashi,A., Matsuda,K., Hosono,N.,
Ohmiya,H., Daigo,Y., Yamamoto,K., Kubo,M., Nakamura,Y. and
Kamatani,N.
TITLE Common variations in PSMD3-CSF3 and PLCB4 are associated with
neutrophil count
JOURNAL Hum. Mol. Genet. 19 (10), 2079-2085 (2010)
PUBMED 20172861
REMARK GeneRIF: The significant contribution of PSMD3-CSF3 and PLCB4 loci
to the regulation of neutrophil count, is demonstrated.
GeneRIF: Observational study and genome-wide association study of
gene-disease association. (HuGE Navigator)
REFERENCE 5 (bases 1 to 2187)
AUTHORS Listovsky,T., Oren,Y.S., Yudkovsky,Y., Mahbubani,H.M., Weiss,A.M.,
Lebendiker,M. and Brandeis,M.
TITLE Mammalian Cdh1/Fzr mediates its own degradation
JOURNAL EMBO J. 23 (7), 1619-1626 (2004)
PUBMED 15029244
REFERENCE 6 (bases 1 to 2187)
AUTHORS Simon,J.H., Gaddis,N.C., Fouchier,R.A. and Malim,M.H.
TITLE Evidence for a newly discovered cellular anti-HIV-1 phenotype
JOURNAL Nat. Med. 4 (12), 1397-1400 (1998)
PUBMED 9846577
REFERENCE 7 (bases 1 to 2187)
AUTHORS Madani,N. and Kabat,D.
TITLE An endogenous inhibitor of human immunodeficiency virus in human
lymphocytes is overcome by the viral Vif protein
JOURNAL J. Virol. 72 (12), 10251-10255 (1998)
PUBMED 9811770
REFERENCE 8 (bases 1 to 2187)
AUTHORS Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
TITLE HIV-1 tat inhibits the 20 S proteasome and its 11 S
regulator-mediated activation
JOURNAL J. Biol. Chem. 272 (13), 8145-8148 (1997)
PUBMED 9079628
REFERENCE 9 (bases 1 to 2187)
AUTHORS Kominami,K., Okura,N., Kawamura,M., DeMartino,G.N., Slaughter,C.A.,
Shimbara,N., Chung,C.H., Fujimuro,M., Yokosawa,H., Shimizu,Y.,
Tanahashi,N., Tanaka,K. and Toh-e,A.
TITLE Yeast counterparts of subunits S5a and p58 (S3) of the human 26S
proteasome are encoded by two multicopy suppressors of nin1-1
JOURNAL Mol. Biol. Cell 8 (1), 171-187 (1997)
PUBMED 9017604
REFERENCE 10 (bases 1 to 2187)
AUTHORS Coux,O., Tanaka,K. and Goldberg,A.L.
TITLE Structure and functions of the 20S and 26S proteasomes
JOURNAL Annu. Rev. Biochem. 65, 801-847 (1996)
PUBMED 8811196
REMARK Review article
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from HY034626.1, D67025.1 and
AA143716.1.
On Jul 11, 2012 this sequence version replaced gi:25777611.
Summary: The 26S proteasome is a multicatalytic proteinase complex
with a highly ordered structure composed of 2 complexes, a 20S core
and a 19S regulator. The 20S core is composed of 4 rings of 28
non-identical subunits; 2 rings are composed of 7 alpha subunits
and 2 rings are composed of 7 beta subunits. The 19S regulator is
composed of a base, which contains 6 ATPase subunits and 2
non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
subunits. Proteasomes are distributed throughout eukaryotic cells
at a high concentration and cleave peptides in an
ATP/ubiquitin-dependent process in a non-lysosomal pathway. This
gene encodes a member of the proteasome subunit S3 family that
functions as one of the non-ATPase subunits of the 19S regulator
lid. Single nucleotide polymorphisms in this gene are associated
with neutrophil count. [provided by RefSeq, Jul 2012].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC012302.1, AK054611.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-382 HY034626.1 2-383
383-2180 D67025.1 337-2134
2181-2187 AA143716.1 4-10 c
FEATURES Location/Qualifiers
source 1..2187
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21.1"
gene 1..2187
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/note="proteasome (prosome, macropain) 26S subunit,
non-ATPase, 3"
/db_xref="GeneID:5709"
/db_xref="HGNC:9560"
/db_xref="HPRD:10170"
exon 1..423
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/inference="alignment:Splign:1.39.8"
variation 13
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:3859189"
variation 24
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:371787215"
STS 63..215
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/standard_name="RH93398"
/db_xref="UniSTS:90256"
misc_feature 183..185
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/note="upstream in-frame stop codon"
variation 193
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:11539652"
CDS 204..1808
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/note="tissue specific transplantation antigen 2; 26S
proteasome regulatory subunit S3; proteasome subunit p58;
26S proteasome regulatory subunit RPN3"
/codon_start=1
/product="26S proteasome non-ATPase regulatory subunit 3"
/protein_id="NP_002800.2"
/db_xref="GI:25777612"
/db_xref="CCDS:CCDS11356.1"
/db_xref="GeneID:5709"
/db_xref="HGNC:9560"
/db_xref="HPRD:10170"
/translation="
MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAAEHSQRELDTVTLEDIKEHVKQLEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAVQGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKRYKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVYEFLDKLDVVRSFLHARLRTATLRHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQANNNEWARYLYYTGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDLESAEERREREQQDLEFAKEMAEDDDDSFP
"
misc_feature 1281..1577
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/note="PCI domain; Region: PCI; pfam01399"
/db_xref="CDD:201772"
misc_feature 1596..1799
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/note="Proteasome regulatory subunit C-terminal; Region:
Rpn3_C; pfam08375"
/db_xref="CDD:149439"
variation 340
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:11539651"
variation 344
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3087852"
variation 368
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376867323"
variation 382
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1044248"
exon 424..614
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/inference="alignment:Splign:1.39.8"
variation 447
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375097534"
variation 455
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:139823763"
variation 482
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="g"
/db_xref="dbSNP:201112076"
variation 523
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143231745"
variation 529
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:373296396"
variation 543
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:78909252"
variation 586
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:142613700"
exon 615..752
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/inference="alignment:Splign:1.39.8"
variation 629
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="g"
/replace="t"
/db_xref="dbSNP:3969147"
variation 651
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:150993491"
variation 656
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:113755444"
variation 670
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201862777"
variation 678
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:377229346"
variation 679
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="g"
/replace="t"
/db_xref="dbSNP:201795543"
variation 686
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:79701893"
variation 707
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370395631"
variation 714
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="g"
/replace="t"
/db_xref="dbSNP:138262103"
variation 741
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:199927905"
variation 742
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:142347522"
variation 745
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199529386"
exon 753..889
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/inference="alignment:Splign:1.39.8"
variation 781
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200089350"
variation 824
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:144522090"
variation 830
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:368061511"
variation 850
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:139137910"
variation 856
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:181805133"
variation 881
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:371546214"
variation 884
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="g"
/db_xref="dbSNP:9913561"
exon 890..1080
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/inference="alignment:Splign:1.39.8"
variation 900
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:144777423"
variation 919
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:148147676"
variation 932
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:199540645"
variation 933
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199919324"
variation 969
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:141986603"
variation 982
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370998801"
variation 1046
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:187473049"
variation 1052
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:9916279"
exon 1081..1184
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/inference="alignment:Splign:1.39.8"
variation 1114
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="t"
/db_xref="dbSNP:17855429"
variation 1116
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="g"
/replace="t"
/db_xref="dbSNP:139790687"
variation 1126
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:143390511"
variation 1127
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143167995"
variation 1162
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="g"
/db_xref="dbSNP:372020193"
variation 1169
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:189549088"
exon 1185..1299
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/inference="alignment:Splign:1.39.8"
variation 1193
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:372154095"
variation 1194
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:146195859"
variation 1202
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:77131023"
variation 1235
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="g"
/db_xref="dbSNP:370358057"
variation 1240..1241
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace=""
/replace="g"
/db_xref="dbSNP:35693528"
variation 1267
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201424671"
exon 1300..1419
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/inference="alignment:Splign:1.39.8"
variation 1330
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:374192363"
variation 1354
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376686096"
variation 1366
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:62621374"
exon 1420..1523
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/inference="alignment:Splign:1.39.8"
variation 1496
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:144987407"
exon 1524..1679
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/inference="alignment:Splign:1.39.8"
variation 1584
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:372409387"
variation 1586
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:149090359"
variation 1594
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:111511592"
variation 1619
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374752965"
variation 1667
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:3815609"
exon 1680..1730
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/inference="alignment:Splign:1.39.8"
variation 1718
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:182201774"
variation 1719
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1139744"
variation 1724
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:147851424"
exon 1731..2187
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/inference="alignment:Splign:1.39.8"
variation 1772
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201868855"
variation 1814
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:186684323"
variation 1825
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201113087"
variation 1849
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="t"
/db_xref="dbSNP:7021"
variation 1850
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:12952353"
variation 1851
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:12943299"
variation 1858
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="g"
/db_xref="dbSNP:368398165"
STS 1894..2130
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/standard_name="D19S1091"
/db_xref="UniSTS:23110"
variation 1910
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:369083188"
variation 1917
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:112922735"
variation 1921
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:113846858"
variation 1940
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1062816"
STS 1989..2089
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/standard_name="WIAF-1618"
/db_xref="UniSTS:54561"
variation 2012
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="g"
/db_xref="dbSNP:116877864"
variation 2057
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:140846638"
variation 2058
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="c"
/replace="g"
/db_xref="dbSNP:2012"
variation 2068
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="g"
/replace="t"
/db_xref="dbSNP:1802479"
variation 2105
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
/replace="g"
/replace="t"
/db_xref="dbSNP:114388231"
polyA_signal 2166..2171
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
polyA_site 2186
/gene="PSMD3"
/gene_synonym="P58; RPN3; S3; TSTA2"
ORIGIN
gttgactcggccatcggcctgccgggcctggcgtttcccagaaggcccagcgccgggaaggggtttgcagctgctccgtcatcgtgcggcccgacgctatctcgcgctcgtgtgcaggcccggctcggctcctggtccccggtgcgagggttaacgcgaggccccggcctcggtccccggactaggccgtgaccccgggtgccatgaagcaggagggctcggcgcggcgccgcggcgcggacaaggcgaaaccgccgcccggcggaggagaacaagaacccccaccgccgccggccccccaggatgtggagatgaaagaggaggcagcgacgggtggcgggtcgacgggggaggcagacggcaagacggcggcggcagcggctgagcactcccagcgagagctggacacagtcaccttggaggacatcaaggagcacgtgaaacagctagagaaagcggtttcaggcaaggagccgagattcgtgctgcgggccctgcggatgctgccttccacatcacgccgcctcaaccactatgttctgtataaggctgtgcagggcttcttcacttcaaataatgccactcgagactttttgctccccttcctggaagagcccatggacacagaggctgatttacagttccgtccccgcacgggaaaagctgcgtcgacacccctcctgcctgaagtggaagcctatctccaactcctcgtggtcatcttcatgatgaacagcaagcgctacaaagaggcacagaagatctctgatgatctgatgcagaagatcagtactcagaaccgccgggccctagaccttgtagccgcaaagtgttactattatcacgcccgggtctatgagttcctggacaagctggatgtggtgcgcagcttcttgcatgctcggctccggacagctacgcttcggcatgacgcagacgggcaggccaccctgttgaacctcctgctgcggaattacctacactacagcttgtacgaccaggctgagaagctggtgtccaagtctgtgttcccagagcaggccaacaacaatgagtgggccaggtacctctactacacagggcgaatcaaagccatccagctggagtactcagaggcccggagaacgatgaccaacgcccttcgcaaggcccctcagcacacagctgtcggcttcaaacagacggtgcacaagcttctcatcgtggtggagctgttgctgggggagatccctgaccggctgcagttccgccagccctccctcaagcgctcactcatgccctatttccttctgactcaagctgtcaggacaggaaacctagccaagttcaaccaggtcctggatcagtttggggagaagtttcaagcagatgggacctacaccctaattatccggctgcggcacaacgtgattaagacaggtgtacgcatgatcagcctctcctattcccgaatctccttggctgacatcgcccagaagctgcagttggatagccccgaagatgcagagttcattgttgccaaggccatccgggatggtgtcattgaggccagcatcaaccacgagaagggctatgtccaatccaaggagatgattgacatctattccacccgagagccccagctagccttccaccagcgcatctccttctgcctagatatccacaacatgtctgtcaaggccatgaggtttcctcccaaatcgtacaacaaggacttggagtctgcagaggaacggcgtgagcgagaacagcaggacttggagtttgccaaggagatggcagaagatgatgatgacagcttcccttgagctggggggctggggaggggtagggggaatggggacaggctctttcccccttgggggtcccctgcccagggcactgtccccattttcccacacacagctcatatgctgcattcgtgcagggggtgggggtgctgggagccagccaccctgacctcccccagggctcctccccagccggtgacttactgtacagcaggcaggagggtgggcaggcaacctccccgggcagggtcctggccagcagtgtgggagcaggaggggaaggatagttctgtgtactcctttagggagtgggggactagaactgggatgtcttggcttgtatgttttttgaagcttcgattatgatttttaaacaataaaaagttctccacagtgc
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5709 -> Molecular function: GO:0030234 [enzyme regulator activity] evidence: IEA
GeneID:5709 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
GeneID:5709 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
GeneID:5709 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:5709 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
GeneID:5709 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
GeneID:5709 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
GeneID:5709 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:5709 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
GeneID:5709 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:5709 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:5709 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:5709 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:5709 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
GeneID:5709 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
GeneID:5709 -> Biological process: GO:0042176 [regulation of protein catabolic process] evidence: IEA
GeneID:5709 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
GeneID:5709 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:5709 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:5709 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:5709 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5709 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5709 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5709 -> Cellular component: GO:0000502 [proteasome complex] evidence: TAS
GeneID:5709 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:5709 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5709 -> Cellular component: GO:0022624 [proteasome accessory complex] evidence: ISS
by
@meso_cacase at
DBCLS
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