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2024-04-27 09:22:57, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002804 1618 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 3
(PSMC3), mRNA.
ACCESSION NM_002804
VERSION NM_002804.4 GI:133987588
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1618)
AUTHORS Franceschini,N., van Rooij,F.J., Prins,B.P., Feitosa,M.F.,
Karakas,M., Eckfeldt,J.H., Folsom,A.R., Kopp,J., Vaez,A.,
Andrews,J.S., Baumert,J., Boraska,V., Broer,L., Hayward,C.,
Ngwa,J.S., Okada,Y., Polasek,O., Westra,H.J., Wang,Y.A., Del Greco
M,F., Glazer,N.L., Kapur,K., Kema,I.P., Lopez,L.M., Schillert,A.,
Smith,A.V., Winkler,C.A., Zgaga,L., Bandinelli,S., Bergmann,S.,
Boban,M., Bochud,M., Chen,Y.D., Davies,G., Dehghan,A., Ding,J.,
Doering,A., Durda,J.P., Ferrucci,L., Franco,O.H., Franke,L.,
Gunjaca,G., Hofman,A., Hsu,F.C., Kolcic,I., Kraja,A., Kubo,M.,
Lackner,K.J., Launer,L., Loehr,L.R., Li,G., Meisinger,C.,
Nakamura,Y., Schwienbacher,C., Starr,J.M., Takahashi,A., Torlak,V.,
Uitterlinden,A.G., Vitart,V., Waldenberger,M., Wild,P.S., Kirin,M.,
Zeller,T., Zemunik,T., Zhang,Q., Ziegler,A., Blankenberg,S.,
Boerwinkle,E., Borecki,I.B., Campbell,H., Deary,I.J.,
Frayling,T.M., Gieger,C., Harris,T.B., Hicks,A.A., Koenig,W., O'
Donnell,C.J., Fox,C.S., Pramstaller,P.P., Psaty,B.M., Reiner,A.P.,
Rotter,J.I., Rudan,I., Snieder,H., Tanaka,T., van Duijn,C.M.,
Vollenweider,P., Waeber,G., Wilson,J.F., Witteman,J.C.,
Wolffenbuttel,B.H., Wright,A.F., Wu,Q., Liu,Y., Jenny,N.S.,
North,K.E., Felix,J.F., Alizadeh,B.Z., Cupples,L.A., Perry,J.R. and
Morris,A.P.
CONSRTM LifeLines Cohort Study
TITLE Discovery and fine mapping of serum protein loci through
transethnic meta-analysis
JOURNAL Am. J. Hum. Genet. 91 (4), 744-753 (2012)
PUBMED 23022100
REFERENCE 2 (bases 1 to 1618)
AUTHORS Sepe,M., Festa,L., Tolino,F., Bellucci,L., Sisto,L., Alfano,D.,
Ragno,P., Calabro,V., de Franciscis,V., La Mantia,G. and Pollice,A.
TITLE A regulatory mechanism involving TBP-1/Tat-Binding Protein 1 and
Akt/PKB in the control of cell proliferation
JOURNAL PLoS ONE 6 (10), E22800 (2011)
PUBMED 21991300
REMARK GeneRIF: These data suggest the existence of a negative feedback
loop involving Akt/PKB that might act as a sensor to modulate TBP-1
levels in proliferating cells.
REFERENCE 3 (bases 1 to 1618)
AUTHORS Truax,A.D., Koues,O.I., Mentel,M.K. and Greer,S.F.
TITLE The 19S ATPase S6a (S6'/TBP1) regulates the transcription
initiation of class II transactivator
JOURNAL J. Mol. Biol. 395 (2), 254-269 (2010)
PUBMED 19853614
REMARK GeneRIF: 19S ATPase S6b (S6'/TBP1) binds CIITApIV in an
S6a-dependent fashion and has effects similar to S6a on CIITApIV
histone acetylation.
REFERENCE 4 (bases 1 to 1618)
AUTHORS Satoh,T., Ishizuka,T., Tomaru,T., Yoshino,S., Nakajima,Y.,
Hashimoto,K., Shibusawa,N., Monden,T., Yamada,M. and Mori,M.
TITLE Tat-binding protein-1 (TBP-1), an ATPase of 19S regulatory
particles of the 26S proteasome, enhances androgen receptor
function in cooperation with TBP-1-interacting protein/Hop2
JOURNAL Endocrinology 150 (7), 3283-3290 (2009)
PUBMED 19325002
REMARK GeneRIF: findings suggest that a component of 19S regulatory
particles directly binds AR and might participate in AR-mediated
transcriptional activation in cooperation with TBPIP.
REFERENCE 5 (bases 1 to 1618)
AUTHORS Kaneko,T., Hamazaki,J., Iemura,S., Sasaki,K., Furuyama,K.,
Natsume,T., Tanaka,K. and Murata,S.
TITLE Assembly pathway of the Mammalian proteasome base subcomplex is
mediated by multiple specific chaperones
JOURNAL Cell 137 (5), 914-925 (2009)
PUBMED 19490896
REFERENCE 6 (bases 1 to 1618)
AUTHORS Shaw,D.R. and Ennis,H.L.
TITLE Molecular cloning and developmental regulation of Dictyostelium
discoideum homologues of the human and yeast HIV1 Tat-binding
protein
JOURNAL Biochem. Biophys. Res. Commun. 193 (3), 1291-1296 (1993)
PUBMED 8323548
REFERENCE 7 (bases 1 to 1618)
AUTHORS Dubiel,W., Ferrell,K. and Rechsteiner,M.
TITLE Peptide sequencing identifies MSS1, a modulator of HIV Tat-mediated
transactivation, as subunit 7 of the 26 S protease
JOURNAL FEBS Lett. 323 (3), 276-278 (1993)
PUBMED 8500623
REFERENCE 8 (bases 1 to 1618)
AUTHORS Ohana,B., Moore,P.A., Ruben,S.M., Southgate,C.D., Green,M.R. and
Rosen,C.A.
TITLE The type 1 human immunodeficiency virus Tat binding protein is a
transcriptional activator belonging to an additional family of
evolutionarily conserved genes
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (1), 138-142 (1993)
PUBMED 8419915
REFERENCE 9 (bases 1 to 1618)
AUTHORS Dubiel,W., Ferrell,K., Pratt,G. and Rechsteiner,M.
TITLE Subunit 4 of the 26 S protease is a member of a novel eukaryotic
ATPase family
JOURNAL J. Biol. Chem. 267 (32), 22699-22702 (1992)
PUBMED 1429620
REFERENCE 10 (bases 1 to 1618)
AUTHORS Nelbock,P., Dillon,P.J., Perkins,A. and Rosen,C.A.
TITLE A cDNA for a protein that interacts with the human immunodeficiency
virus Tat transactivator
JOURNAL Science 248 (4963), 1650-1653 (1990)
PUBMED 2194290
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BP284685.1 and BC008713.2.
On Mar 22, 2007 this sequence version replaced gi:24430153.
Summary: The 26S proteasome is a multicatalytic proteinase complex
with a highly ordered structure composed of 2 complexes, a 20S core
and a 19S regulator. The 20S core is composed of 4 rings of 28
non-identical subunits; 2 rings are composed of 7 alpha subunits
and 2 rings are composed of 7 beta subunits. The 19S regulator is
composed of a base, which contains 6 ATPase subunits and 2
non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
subunits. Proteasomes are distributed throughout eukaryotic cells
at a high concentration and cleave peptides in an
ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
essential function of a modified proteasome, the immunoproteasome,
is the processing of class I MHC peptides. This gene encodes one of
the ATPase subunits, a member of the triple-A family of ATPases
that have chaperone-like activity. This subunit may compete with
PSMC2 for binding to the HIV tat protein to regulate the
interaction between the viral protein and the transcription
complex. A pseudogene has been identified on chromosome 9.
[provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC008713.2, BC107804.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-70 BP284685.1 3-72
71-1618 BC008713.2 35-1582
FEATURES Location/Qualifiers
source 1..1618
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11p11.2"
gene 1..1618
/gene="PSMC3"
/gene_synonym="TBP1"
/note="proteasome (prosome, macropain) 26S subunit,
ATPase, 3"
/db_xref="GeneID:5702"
/db_xref="HGNC:9549"
/db_xref="HPRD:01733"
/db_xref="MIM:186852"
exon 1..269
/gene="PSMC3"
/gene_synonym="TBP1"
/inference="alignment:Splign:1.39.8"
STS 109..1567
/gene="PSMC3"
/gene_synonym="TBP1"
/db_xref="UniSTS:489731"
CDS 195..1514
/gene="PSMC3"
/gene_synonym="TBP1"
/note="Tat-binding protein 1; proteasome subunit P50;
human immunodeficiency virus tat transactivator binding
protein-1; TBP-1; proteasome 26S subunit ATPase 3; 26S
proteasome AAA-ATPase subunit RPT5"
/codon_start=1
/product="26S protease regulatory subunit 6A"
/protein_id="NP_002795.2"
/db_xref="GI:21361144"
/db_xref="CCDS:CCDS7935.1"
/db_xref="GeneID:5702"
/db_xref="HGNC:9549"
/db_xref="HPRD:01733"
/db_xref="MIM:186852"
/translation="
MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA
"
misc_feature 195..197
/gene="PSMC3"
/gene_synonym="TBP1"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylmethionine; propagated from
UniProtKB/Swiss-Prot (P17980.3); acetylation site"
misc_feature 219..221
/gene="PSMC3"
/gene_synonym="TBP1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P17980.3); phosphorylation site"
misc_feature 258..1490
/gene="PSMC3"
/gene_synonym="TBP1"
/note="ATP-dependent 26S proteasome regulatory subunit
[Posttranslational modification, protein turnover,
chaperones]; Region: RPT1; COG1222"
/db_xref="CDD:31415"
misc_feature 759..1259
/gene="PSMC3"
/gene_synonym="TBP1"
/note="The AAA+ (ATPases Associated with a wide variety of
cellular Activities) superfamily represents an ancient
group of ATPases belonging to the ASCE (for additional
strand, catalytic E) division of the P-loop NTPase fold.
The ASCE division also includes ABC; Region: AAA; cd00009"
/db_xref="CDD:99707"
misc_feature 873..896
/gene="PSMC3"
/gene_synonym="TBP1"
/note="Walker A motif; other site"
/db_xref="CDD:99707"
misc_feature order(876..899,1050..1052,1191..1193)
/gene="PSMC3"
/gene_synonym="TBP1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:99707"
misc_feature 1038..1055
/gene="PSMC3"
/gene_synonym="TBP1"
/note="Walker B motif; other site"
/db_xref="CDD:99707"
misc_feature 1233..1235
/gene="PSMC3"
/gene_synonym="TBP1"
/note="arginine finger; other site"
/db_xref="CDD:99707"
exon 270..353
/gene="PSMC3"
/gene_synonym="TBP1"
/inference="alignment:Splign:1.39.8"
STS 309..453
/gene="PSMC3"
/gene_synonym="TBP1"
/standard_name="MARC_26198-26199:1039556289:1"
/db_xref="UniSTS:268982"
exon 354..479
/gene="PSMC3"
/gene_synonym="TBP1"
/inference="alignment:Splign:1.39.8"
variation 473
/gene="PSMC3"
/gene_synonym="TBP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11548874"
exon 480..584
/gene="PSMC3"
/gene_synonym="TBP1"
/inference="alignment:Splign:1.39.8"
exon 585..647
/gene="PSMC3"
/gene_synonym="TBP1"
/inference="alignment:Splign:1.39.8"
exon 648..785
/gene="PSMC3"
/gene_synonym="TBP1"
/inference="alignment:Splign:1.39.8"
exon 786..929
/gene="PSMC3"
/gene_synonym="TBP1"
/inference="alignment:Splign:1.39.8"
variation 848
/gene="PSMC3"
/gene_synonym="TBP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:34037785"
variation 919
/gene="PSMC3"
/gene_synonym="TBP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11548873"
exon 930..1078
/gene="PSMC3"
/gene_synonym="TBP1"
/inference="alignment:Splign:1.39.8"
exon 1079..1175
/gene="PSMC3"
/gene_synonym="TBP1"
/inference="alignment:Splign:1.39.8"
exon 1176..1321
/gene="PSMC3"
/gene_synonym="TBP1"
/inference="alignment:Splign:1.39.8"
variation 1277
/gene="PSMC3"
/gene_synonym="TBP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35569079"
exon 1322..1403
/gene="PSMC3"
/gene_synonym="TBP1"
/inference="alignment:Splign:1.39.8"
STS 1323..1468
/gene="PSMC3"
/gene_synonym="TBP1"
/standard_name="RH91482"
/db_xref="UniSTS:85283"
STS 1329..1571
/gene="PSMC3"
/gene_synonym="TBP1"
/standard_name="RH98825"
/db_xref="UniSTS:90020"
exon 1404..1580
/gene="PSMC3"
/gene_synonym="TBP1"
/inference="alignment:Splign:1.39.8"
STS 1459..1546
/gene="PSMC3"
/gene_synonym="TBP1"
/standard_name="RH70251"
/db_xref="UniSTS:64996"
polyA_signal 1554..1559
/gene="PSMC3"
/gene_synonym="TBP1"
polyA_site 1574
/gene="PSMC3"
/gene_synonym="TBP1"
polyA_site 1580
/gene="PSMC3"
/gene_synonym="TBP1"
ORIGIN
gtggccaggggttggtctttggaatcggagaggcagattcgctgctccgcagcacggccggagctggtcgggtcaagagtcgggatttgtggggagaggttttccactggtcaagagaaggctttaagaaagacggtattaatctcccgttgcggctcccgcctggtcccatcttctgcccgctcctccaggaaatgaatctgctgccgaatattgagagtccagtgactcggcaggagaagatggcgaccgtgtgggatgaggccgagcaagatggaattggggaggaggtgctcaagatgtccacggaggagatcatccagcgcacacggctgctggacagtgagatcaagatcatgaagagtgaagtgttgagagtcacccatgagctccaagccatgaaggacaagataaaagagaacagtgagaaaatcaaagtgaacaagaccctgccgtaccttgtctccaacgtcatcgagctcctggatgttgatcctaatgaccaagaggaggatggtgccaatattgacctggactcccagaggaagggcaagtgtgctgtgatcaaaacctctacacgacagacgtacttccttcctgtgattgggttggtggatgctgaaaagctaaagccaggagacctggtgggtgtgaacaaagactcctatctgatcctggagacgctgcccacagagtatgactcgcgggtgaaggccatggaggtagacgagaggcccacggagcaatacagtgacattgggggtttggacaagcagatccaggagctggtggaggccattgtcttgccaatgaaccacaaggagaagtttgagaacttggggatccaacctccaaaaggggtgctgatgtatgggcccccagggacggggaagaccctcctggcccgggcctgtgccgcacagactaaggccaccttcctaaagctggctggcccccagctggtgcagatgttcattggagatggtgccaagctagtccgggatgcctttgccctggccaaggagaaagcgccctctatcatcttcattgatgagttggatgccatcggcaccaagcgctttgacagtgagaaggctggggaccgggaggtgcagaggacaatgctggagcttctgaaccagctggatggcttccagcccaacacccaagttaaggtaattgcagccacaaacagggtggacatcctggaccccgccctcctccgctcgggccgccttgaccgcaagatagagttcccgatgcccaatgaggaggcccgggccagaatcatgcagatccactcccgaaagatgaatgtcagtcctgacgtgaactacgaggagctggcccgctgcacagatgacttcaatggggcccagtgcaaggctgtgtgtgtggaggcgggcatgatcgcactgcgcaggggtgccacggagctcacccacgaggactacatggaaggcatcctggaggtgcaggccaagaagaaagccaacctacaatactacgcctagggcacacaggccagccccagtctcacggctgaagtgcgcaataaaagatggtttagggtccctgccaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5702 -> Molecular function: GO:0003713 [transcription coactivator activity] evidence: TAS
GeneID:5702 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: TAS
GeneID:5702 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5702 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:5702 -> Molecular function: GO:0016887 [ATPase activity] evidence: ISS
GeneID:5702 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
GeneID:5702 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
GeneID:5702 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:5702 -> Biological process: GO:0001824 [blastocyst development] evidence: IEA
GeneID:5702 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
GeneID:5702 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
GeneID:5702 -> Biological process: GO:0006200 [ATP catabolic process] evidence: ISS
GeneID:5702 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
GeneID:5702 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:5702 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
GeneID:5702 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:5702 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:5702 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:5702 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:5702 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:5702 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
GeneID:5702 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
GeneID:5702 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
GeneID:5702 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:5702 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:5702 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:5702 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5702 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5702 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5702 -> Cellular component: GO:0000502 [proteasome complex] evidence: TAS
GeneID:5702 -> Cellular component: GO:0000932 [cytoplasmic mRNA processing body] evidence: ISS
GeneID:5702 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:5702 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:5702 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:5702 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5702 -> Cellular component: GO:0022624 [proteasome accessory complex] evidence: ISS
GeneID:5702 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
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