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2024-03-30 00:54:17, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_002801               1019 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens proteasome (prosome, macropain) subunit, beta type, 10
            (PSMB10), mRNA.
ACCESSION   NM_002801
VERSION     NM_002801.3  GI:325652084
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1019)
  AUTHORS   Lichter,D.I., Danaee,H., Pickard,M.D., Tayber,O., Sintchak,M.,
            Shi,H., Richardson,P.G., Cavenagh,J., Blade,J., Facon,T.,
            Niesvizky,R., Alsina,M., Dalton,W., Sonneveld,P., Lonial,S., van de
            Velde,H., Ricci,D., Esseltine,D.L., Trepicchio,W.L., Mulligan,G.
            and Anderson,K.C.
  TITLE     Sequence analysis of beta-subunit genes of the 20S proteasome in
            patients with relapsed multiple myeloma treated with bortezomib or
            dexamethasone
  JOURNAL   Blood 120 (23), 4513-4516 (2012)
   PUBMED   23018640
  REMARK    GeneRIF: Data indicate that treatment-emergent resistance to
            single-agent bortezomib was independent of variants in the
            proteasome genes PSMB1, PSMB5, PSMB6, PSMB8, PSMB9, and PSMB10.
REFERENCE   2  (bases 1 to 1019)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet. 8 (3), E1002559 (2012)
   PUBMED   22412388
REFERENCE   3  (bases 1 to 1019)
  AUTHORS   Berhane,S., Areste,C., Ablack,J.N., Ryan,G.B., Blackbourn,D.J.,
            Mymryk,J.S., Turnell,A.S., Steele,J.C. and Grand,R.J.
  TITLE     Adenovirus E1A interacts directly with, and regulates the level of
            expression of, the immunoproteasome component MECL1
  JOURNAL   Virology 421 (2), 149-158 (2011)
   PUBMED   22018786
  REMARK    GeneRIF: Adenovirus E1A causes down-regulation of MECL1 expression
REFERENCE   4  (bases 1 to 1019)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 1019)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am. J. Hum. Genet. 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1019)
  AUTHORS   Foss,G.S., Larsen,F., Solheim,J. and Prydz,H.
  TITLE     Constitutive and interferon-gamma-induced expression of the human
            proteasome subunit multicatalytic endopeptidase complex-like 1
  JOURNAL   Biochim. Biophys. Acta 1402 (1), 17-28 (1998)
   PUBMED   9551082
REFERENCE   7  (bases 1 to 1019)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J. Biol. Chem. 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   8  (bases 1 to 1019)
  AUTHORS   Hisamatsu,H., Shimbara,N., Saito,Y., Kristensen,P., Hendil,K.B.,
            Fujiwara,T., Takahashi,E., Tanahashi,N., Tamura,T., Ichihara,A. and
            Tanaka,K.
  TITLE     Newly identified pair of proteasomal subunits regulated
            reciprocally by interferon gamma
  JOURNAL   J. Exp. Med. 183 (4), 1807-1816 (1996)
   PUBMED   8666937
REFERENCE   9  (bases 1 to 1019)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu. Rev. Biochem. 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
REFERENCE   10 (bases 1 to 1019)
  AUTHORS   Larsen,F., Solheim,J., Kristensen,T., Kolsto,A.B. and Prydz,H.
  TITLE     A tight cluster of five unrelated human genes on chromosome 16q22.1
  JOURNAL   Hum. Mol. Genet. 2 (10), 1589-1595 (1993)
   PUBMED   8268911
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP289065.1 and BM981173.1.
            On Mar 10, 2011 this sequence version replaced gi:23110923.
            
            Summary: The proteasome is a multicatalytic proteinase complex with
            a highly ordered ring-shaped 20S core structure. The core structure
            is composed of 4 rings of 28 non-identical subunits; 2 rings are
            composed of 7 alpha subunits and 2 rings are composed of 7 beta
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes a
            member of the proteasome B-type family, also known as the T1B
            family, that is a 20S core beta subunit. Proteolytic processing is
            required to generate a mature subunit. Expression of this gene is
            induced by gamma interferon, and this gene product replaces
            catalytic subunit 2 (proteasome beta 7 subunit) in the
            immunoproteasome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ066267.1, Y13640.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-582               BP289065.1         1-582
            583-1019            BM981173.1         1-437               c
FEATURES             Location/Qualifiers
     source          1..1019
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1019
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /note="proteasome (prosome, macropain) subunit, beta type,
                     10"
                     /db_xref="GeneID:5699"
                     /db_xref="HGNC:9538"
                     /db_xref="HPRD:01465"
                     /db_xref="MIM:176847"
     exon            1..184
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    33..35
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /note="upstream in-frame stop codon"
     STS             45..188
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /standard_name="RH65000"
                     /db_xref="UniSTS:85016"
     variation       82
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1127725"
     CDS             129..950
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /EC_number="3.4.25.1"
                     /note="proteasome MECl-1; macropain subunit MECl-1;
                     multicatalytic endopeptidase complex subunit MECl-1;
                     proteasome catalytic subunit 2i; proteasome subunit beta
                     7i; proteasome subunit beta type-10; proteasome subunit
                     MECL1; proteasome subunit beta-2i; low molecular mass
                     protein 10"
                     /codon_start=1
                     /product="proteasome subunit beta type-10 precursor"
                     /protein_id="NP_002792.1"
                     /db_xref="GI:4506191"
                     /db_xref="CCDS:CCDS10853.1"
                     /db_xref="GeneID:5699"
                     /db_xref="HGNC:9538"
                     /db_xref="HPRD:01465"
                     /db_xref="MIM:176847"
                     /translation="
MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGRYHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
"
     misc_feature    162..791
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /note="20S proteasome, alpha and beta subunits
                     [Posttranslational modification, protein turnover,
                     chaperones]; Region: PRE1; COG0638"
                     /db_xref="CDD:30983"
     misc_feature    243..248
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="Cleavage, by autocatalysis (By similarity);
                     propagated from UniProtKB/Swiss-Prot (P40306.1); cleavage
                     site"
     mat_peptide     246..947
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /product="Proteasome subunit beta type-10"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P40306.1)"
     misc_feature    246..809
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /note="proteasome beta type-7 subunit. The 20S proteasome,
                     multisubunit proteolytic complex, is the central enzyme of
                     nonlysosomal protein degradation in both the cytosol and
                     nucleus. It is composed of 28 subunits arranged as four
                     homoheptameric rings that...; Region:
                     proteasome_beta_type_7; cd03763"
                     /db_xref="CDD:48461"
     misc_feature    order(246..248,294..296,300..302,342..344,630..632,
                     741..743,750..755)
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /note="active site"
                     /db_xref="CDD:48461"
     misc_feature    order(300..302,309..311,315..332,390..392,396..398,
                     441..443,477..479,486..491,495..500,507..509,516..518,
                     585..587,591..593,597..608,615..617,639..644,648..653,
                     660..668,714..716,735..746,753..758)
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /note="beta subunit interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:48461"
     misc_feature    819..935
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /note="Proteasome beta subunits C terminal; Region:
                     Pr_beta_C; pfam12465"
                     /db_xref="CDD:204931"
     exon            185..272
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /inference="alignment:Splign:1.39.8"
     exon            273..370
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /inference="alignment:Splign:1.39.8"
     STS             365..604
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /standard_name="MARC_6927-6928:992007571:1"
                     /db_xref="UniSTS:231288"
     exon            371..511
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /inference="alignment:Splign:1.39.8"
     variation       447
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:20549"
     exon            512..627
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /inference="alignment:Splign:1.39.8"
     variation       581
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:14178"
     exon            628..686
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /inference="alignment:Splign:1.39.8"
     STS             658..952
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /standard_name="RH79694"
                     /db_xref="UniSTS:89233"
     exon            687..838
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /inference="alignment:Splign:1.39.8"
     STS             759..994
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /standard_name="WI-20243"
                     /db_xref="UniSTS:83031"
     exon            839..1006
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
                     /inference="alignment:Splign:1.39.8"
     polyA_signal    980..985
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
     polyA_site      1006
                     /gene="PSMB10"
                     /gene_synonym="beta2i; LMP10; MECL1"
ORIGIN      
aaaggcgaaagcgaaagcaggaagtacagacgtgaagcctagcagaggactttttagctgctcactggccccgcttgtctggccgactcatccgcccgcgacccctaatcccctctgcctgccccaagatgctgaagccagccctggagccccgagggggcttctccttcgagaactgccaaagaaatgcatcattggaacgcgtcctcccggggctcaaggtccctcacgcacgcaagaccgggaccaccatcgcgggcctggtgttccaagacggggtcattctgggcgccgatacgcgagccactaacgattcggtcgtggcggacaagagctgcgagaagatccacttcatcgcccccaaaatctactgctgtggggctggagtagccgcggacgccgagatgaccacacggatggtggcgtccaagatggagctacacgcgttatctacgggccgcgagccccgcgtggccacggtcactcgcatcctgcgccagacgctcttcaggtaccagggccacgtgggtgcatcgctgatcgtgggcggcgtagacctgactggaccgcagctctacggtgtgcatccccatggctcctacagccgtctgcccttcacagccctgggctctggtcaggacgcggccctggcggtgctagaagaccggttccagccgaacatgacgctggaggctgctcaggggctgctggtggaagccgtcaccgccgggatcttgggtgacctgggctccgggggcaatgtggacgcatgtgtgatcacaaagactggcgccaagctgctgcggacactgagctcacccacagagcccgtgaagaggtctggccgctaccactttgtgcctggaaccacagctgtcctgacccagacagtgaagccactaaccctggagctagtggaggaaactgtgcaggctatggaggtggagtaagctgaggcttagagcttggaacaagggggaataaacccagaaaatacagttaaacaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5699 -> Molecular function: GO:0004298 [threonine-type endopeptidase activity] evidence: IEA
            GeneID:5699 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
            GeneID:5699 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
            GeneID:5699 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
            GeneID:5699 -> Biological process: GO:0000902 [cell morphogenesis] evidence: IEA
            GeneID:5699 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
            GeneID:5699 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
            GeneID:5699 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
            GeneID:5699 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:5699 -> Biological process: GO:0006959 [humoral immune response] evidence: TAS
            GeneID:5699 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
            GeneID:5699 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:5699 -> Biological process: GO:0016032 [viral process] evidence: TAS
            GeneID:5699 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
            GeneID:5699 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
            GeneID:5699 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
            GeneID:5699 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
            GeneID:5699 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
            GeneID:5699 -> Biological process: GO:0042098 [T cell proliferation] evidence: IEA
            GeneID:5699 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
            GeneID:5699 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
            GeneID:5699 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
            GeneID:5699 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:5699 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5699 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5699 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5699 -> Cellular component: GO:0000502 [proteasome complex] evidence: TAS
            GeneID:5699 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:5699 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:5699 -> Cellular component: GO:0005839 [proteasome core complex] evidence: ISS
            GeneID:5699 -> Cellular component: GO:1990111 [spermatoproteasome complex] evidence: ISS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_002792 -> EC 3.4.25.1

by @meso_cacase at DBCLS
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