2024-03-29 07:36:25, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002792 1050 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens proteasome (prosome, macropain) subunit, alpha type, 7 (PSMA7), mRNA. ACCESSION NM_002792 VERSION NM_002792.3 GI:395132499 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1050) AUTHORS Tan,J.Y., Huang,X. and Luo,Y.L. TITLE PSMA7 inhibits the tumorigenicity of A549 human lung adenocarcinoma cells JOURNAL Mol. Cell. Biochem. 366 (1-2), 131-137 (2012) PUBMED 22584585 REMARK GeneRIF: PSMA7 inhibits the proliferation, tumorigenicity and invasion of A549 cells in vitro REFERENCE 2 (bases 1 to 1050) AUTHORS Li,N., Zhang,Z., Zhang,W. and Wei,Q. TITLE Calcineurin B subunit interacts with proteasome subunit alpha type 7 and represses hypoxia-inducible factor-1alpha activity via the proteasome pathway JOURNAL Biochem. Biophys. Res. Commun. 405 (3), 468-472 (2011) PUBMED 21256111 REMARK GeneRIF: CNB binds to proteasome subunit alpha type 7 (PSMA7) and inhibits the transactivation activity of hypoxia-inducible factor-1alpha (HIF-1alpha) via the proteasome pathway. REFERENCE 3 (bases 1 to 1050) AUTHORS Tandle,A.T., Calvani,M., Uranchimeg,B., Zahavi,D., Melillo,G. and Libutti,S.K. TITLE Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome JOURNAL Exp. Cell Res. 315 (11), 1850-1859 (2009) PUBMED 19362550 REMARK GeneRIF: cell surface binding of EMAP-II results in its internalization into the cytoplasmic compartment where it interacts with PSMA7, a component of the proteasome degradation pathway. This interaction increases HIF-1alpha degradation under hypoxic conditions. REFERENCE 4 (bases 1 to 1050) AUTHORS Du,H., Huang,X., Wang,S., Wu,Y., Xu,W. and Li,M. TITLE PSMA7, a potential biomarker of diseases JOURNAL Protein Pept. Lett. 16 (5), 486-489 (2009) PUBMED 19442227 REMARK Review article REFERENCE 5 (bases 1 to 1050) AUTHORS Hu,X.T., Chen,W., Wang,D., Shi,Q.L., Zhang,F.B., Liao,Y.Q., Jin,M. and He,C. TITLE [High expression of proteasome subunit PSMA7 in colorectal cancer is significantly correlated with liver metastasis] JOURNAL Zhonghua Zhong Liu Za Zhi 30 (7), 515-518 (2008) PUBMED 19062718 REMARK GeneRIF: High expression of PSMA7 was significantly correlated with liver metastasis. REFERENCE 6 (bases 1 to 1050) AUTHORS Seeger,M., Ferrell,K., Frank,R. and Dubiel,W. TITLE HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation JOURNAL J. Biol. Chem. 272 (13), 8145-8148 (1997) PUBMED 9079628 REFERENCE 7 (bases 1 to 1050) AUTHORS Huang,J., Kwong,J., Sun,E.C. and Liang,T.J. TITLE Proteasome complex as a potential cellular target of hepatitis B virus X protein JOURNAL J. Virol. 70 (8), 5582-5591 (1996) PUBMED 8764072 REFERENCE 8 (bases 1 to 1050) AUTHORS Coux,O., Tanaka,K. and Goldberg,A.L. TITLE Structure and functions of the 20S and 26S proteasomes JOURNAL Annu. Rev. Biochem. 65, 801-847 (1996) PUBMED 8811196 REMARK Review article REFERENCE 9 (bases 1 to 1050) AUTHORS Akioka,H., Forsberg,N.E., Ishida,N., Okumura,K., Nogami,M., Taguchi,H., Noda,C. and Tanaka,K. TITLE Isolation and characterization of the HC8 subunit gene of the human proteasome JOURNAL Biochem. Biophys. Res. Commun. 207 (1), 318-323 (1995) PUBMED 7857283 REFERENCE 10 (bases 1 to 1050) AUTHORS Kristensen,P., Johnsen,A.H., Uerkvitz,W., Tanaka,K. and Hendil,K.B. TITLE Human proteasome subunits from 2-dimensional gels identified by partial sequencing JOURNAL Biochem. Biophys. Res. Commun. 205 (3), 1785-1789 (1994) PUBMED 7811265 REMARK Erratum:[Biochem Biophys Res Commun. 1995 Feb 27;207(3):1059. PMID: 7864893] COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY039591.1, BG575009.1, AF054185.1, BU632089.1 and BU687782.1. On Jul 12, 2012 this sequence version replaced gi:23110945. Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX375857.2, BC004427.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-20 HY039591.1 1-20 21-95 BG575009.1 8-82 96-632 AF054185.1 26-562 633-1030 BU632089.1 19-416 c 1031-1050 BU687782.1 1-20 c FEATURES Location/Qualifiers source 1..1050 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="20" /map="20q13.33" gene 1..1050 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /note="proteasome (prosome, macropain) subunit, alpha type, 7" /db_xref="GeneID:5688" /db_xref="HGNC:9536" /db_xref="HPRD:05967" /db_xref="MIM:606607" exon 1..251 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /inference="alignment:Splign:1.39.8" misc_feature 66..68 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /note="upstream in-frame stop codon" CDS 156..902 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /EC_number="3.4.25.1" /note="proteasome subunit alpha 4; proteasome subunit RC6-1; proteasome subunit XAPC7" /codon_start=1 /product="proteasome subunit alpha type-7" /protein_id="NP_002783.1" /db_xref="GI:4506189" /db_xref="CCDS:CCDS13489.1" /db_xref="GeneID:5688" /db_xref="HGNC:9536" /db_xref="HPRD:05967" /db_xref="MIM:606607" /translation="
MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVRKICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEENEKKKQKKAS
" misc_feature 156..785 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /note="proteasome endopeptidase complex, archaeal, alpha subunit; Region: arc_protsome_A; TIGR03633" /db_xref="CDD:163366" misc_feature 162..788 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /note="proteasome_alpha_type_7. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on...; Region: proteasome_alpha_type_7; cd03755" /db_xref="CDD:48453" misc_feature order(168..179,183..188,192..197,207..209,216..218, 225..230,237..239,261..263,306..308,312..317,384..392, 396..401,492..494,501..503,510..515,522..536,588..590, 603..608,612..614,618..623,627..629) /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /note="alpha subunit interaction site [polypeptide binding]; other site" /db_xref="CDD:48453" misc_feature order(243..245,291..293,297..299,336..338,642..644) /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /note="active site" /db_xref="CDD:48453" misc_feature 612..614 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /experiment="experimental evidence, no additional details recorded" /note="Phosphotyrosine, by ABL1 and ABL2; propagated from UniProtKB/Swiss-Prot (O14818.1); phosphorylation site" misc_feature 834..836 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (O14818.1); acetylation site" exon 252..378 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /inference="alignment:Splign:1.39.8" variation 270 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /replace="a" /replace="g" /db_xref="dbSNP:11552072" variation 375 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /replace="g" /replace="t" /db_xref="dbSNP:11552074" exon 379..503 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /inference="alignment:Splign:1.39.8" exon 504..626 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /inference="alignment:Splign:1.39.8" exon 627..746 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /inference="alignment:Splign:1.39.8" variation 633 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /replace="g" /replace="t" /db_xref="dbSNP:1135965" variation 641 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /replace="c" /replace="t" /db_xref="dbSNP:1135961" variation 662 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /replace="c" /replace="t" /db_xref="dbSNP:7076" variation 690 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /replace="a" /replace="g" /db_xref="dbSNP:12041" variation 704 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /replace="a" /replace="g" /db_xref="dbSNP:11552076" variation 742 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /replace="a" /replace="t" /db_xref="dbSNP:11552075" exon 747..809 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /inference="alignment:Splign:1.39.8" exon 810..1032 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" /inference="alignment:Splign:1.39.8" polyA_signal 1006..1011 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" polyA_site 1026 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" polyA_site 1032 /gene="PSMA7" /gene_synonym="C6; HSPC; RC6-1; XAPC7" ORIGIN
gtcgccgcctgacgccgcccgtcgccggcagcgcaggacacggcgccgagggtggggcgcgggcgtagtggcgccgggagtcgcgggtgcgcgcgggccgtgagtgtgcgcttttgagagtcgcggcggaaggagcccggccgccgcccgccggcatgagctacgaccgcgccatcaccgtcttctcgcccgacggccacctcttccaagtggagtacgcgcaggaggccgtcaagaagggctcgaccgcggttggtgttcgaggaagagacattgttgttcttggtgtggagaagaagtcagtggccaaactgcaggatgaaagaacagtgcggaagatctgtgctttggatgacaacgtctgcatggcctttgcaggcctcaccgccgatgcaaggatagtcatcaacagggcccgggtggagtgccagagccaccggctgactgtggaggacccggtcactgtggagtacatcacccgctacatcgccagtctgaagcagcgttatacgcagagcaatgggcgcaggccgtttggcatctctgccctcatcgtgggtttcgactttgatggcactcctaggctctatcagactgacccctcgggcacataccatgcctggaaggccaatgccataggtcggggtgccaagtcagtgcgcgagttcctggagaagaactatactgacgaagccattgaaacagatgatctgaccattaagctggtgatcaaggcactcctggaagtggttcagtcaggtggcaaaaacattgaacttgctgtcatgaggcgagatcaatccctcaagattttaaatcctgaagaaattgagaagtatgttgctgaaattgaaaaagaaaaagaagaaaacgaaaagaagaaacaaaagaaagcatcatgatgaataaaatgtctttgcttgtaatttttaaattcatatcaatcatggatgagtctcgatgtgtaggcctttccattccatttattcacactgagtgtcctacaataaacttccgtatttttaacctgttaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:5688 -> Molecular function: GO:0004298 [threonine-type endopeptidase activity] evidence: IEA GeneID:5688 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:5688 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI GeneID:5688 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS GeneID:5688 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS GeneID:5688 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS GeneID:5688 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS GeneID:5688 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS GeneID:5688 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS GeneID:5688 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:5688 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS GeneID:5688 -> Biological process: GO:0010467 [gene expression] evidence: TAS GeneID:5688 -> Biological process: GO:0016032 [viral process] evidence: TAS GeneID:5688 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS GeneID:5688 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS GeneID:5688 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA GeneID:5688 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS GeneID:5688 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS GeneID:5688 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS GeneID:5688 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS GeneID:5688 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS GeneID:5688 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS GeneID:5688 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS GeneID:5688 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS GeneID:5688 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS GeneID:5688 -> Cellular component: GO:0000502 [proteasome complex] evidence: TAS GeneID:5688 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS GeneID:5688 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:5688 -> Cellular component: GO:0005839 [proteasome core complex] evidence: ISS GeneID:5688 -> Cellular component: GO:0019773 [proteasome core complex, alpha-subunit complex] evidence: IEA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_002783 -> EC 3.4.25.1
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