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2024-03-29 07:36:25, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_002792               1050 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens proteasome (prosome, macropain) subunit, alpha type, 7
            (PSMA7), mRNA.
ACCESSION   NM_002792
VERSION     NM_002792.3  GI:395132499
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1050)
  AUTHORS   Tan,J.Y., Huang,X. and Luo,Y.L.
  TITLE     PSMA7 inhibits the tumorigenicity of A549 human lung adenocarcinoma
            cells
  JOURNAL   Mol. Cell. Biochem. 366 (1-2), 131-137 (2012)
   PUBMED   22584585
  REMARK    GeneRIF: PSMA7 inhibits the proliferation, tumorigenicity and
            invasion of A549 cells in vitro
REFERENCE   2  (bases 1 to 1050)
  AUTHORS   Li,N., Zhang,Z., Zhang,W. and Wei,Q.
  TITLE     Calcineurin B subunit interacts with proteasome subunit alpha type
            7 and represses hypoxia-inducible factor-1alpha activity via the
            proteasome pathway
  JOURNAL   Biochem. Biophys. Res. Commun. 405 (3), 468-472 (2011)
   PUBMED   21256111
  REMARK    GeneRIF: CNB binds to proteasome subunit alpha type 7 (PSMA7) and
            inhibits the transactivation activity of hypoxia-inducible
            factor-1alpha (HIF-1alpha) via the proteasome pathway.
REFERENCE   3  (bases 1 to 1050)
  AUTHORS   Tandle,A.T., Calvani,M., Uranchimeg,B., Zahavi,D., Melillo,G. and
            Libutti,S.K.
  TITLE     Endothelial monocyte activating polypeptide-II modulates
            endothelial cell responses by degrading hypoxia-inducible
            factor-1alpha through interaction with PSMA7, a component of the
            proteasome
  JOURNAL   Exp. Cell Res. 315 (11), 1850-1859 (2009)
   PUBMED   19362550
  REMARK    GeneRIF: cell surface binding of EMAP-II results in its
            internalization into the cytoplasmic compartment where it interacts
            with PSMA7, a component of the proteasome degradation pathway. This
            interaction increases HIF-1alpha degradation under hypoxic
            conditions.
REFERENCE   4  (bases 1 to 1050)
  AUTHORS   Du,H., Huang,X., Wang,S., Wu,Y., Xu,W. and Li,M.
  TITLE     PSMA7, a potential biomarker of diseases
  JOURNAL   Protein Pept. Lett. 16 (5), 486-489 (2009)
   PUBMED   19442227
  REMARK    Review article
REFERENCE   5  (bases 1 to 1050)
  AUTHORS   Hu,X.T., Chen,W., Wang,D., Shi,Q.L., Zhang,F.B., Liao,Y.Q., Jin,M.
            and He,C.
  TITLE     [High expression of proteasome subunit PSMA7 in colorectal cancer
            is significantly correlated with liver metastasis]
  JOURNAL   Zhonghua Zhong Liu Za Zhi 30 (7), 515-518 (2008)
   PUBMED   19062718
  REMARK    GeneRIF: High expression of PSMA7 was significantly correlated with
            liver metastasis.
REFERENCE   6  (bases 1 to 1050)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J. Biol. Chem. 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   7  (bases 1 to 1050)
  AUTHORS   Huang,J., Kwong,J., Sun,E.C. and Liang,T.J.
  TITLE     Proteasome complex as a potential cellular target of hepatitis B
            virus X protein
  JOURNAL   J. Virol. 70 (8), 5582-5591 (1996)
   PUBMED   8764072
REFERENCE   8  (bases 1 to 1050)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu. Rev. Biochem. 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
REFERENCE   9  (bases 1 to 1050)
  AUTHORS   Akioka,H., Forsberg,N.E., Ishida,N., Okumura,K., Nogami,M.,
            Taguchi,H., Noda,C. and Tanaka,K.
  TITLE     Isolation and characterization of the HC8 subunit gene of the human
            proteasome
  JOURNAL   Biochem. Biophys. Res. Commun. 207 (1), 318-323 (1995)
   PUBMED   7857283
REFERENCE   10 (bases 1 to 1050)
  AUTHORS   Kristensen,P., Johnsen,A.H., Uerkvitz,W., Tanaka,K. and Hendil,K.B.
  TITLE     Human proteasome subunits from 2-dimensional gels identified by
            partial sequencing
  JOURNAL   Biochem. Biophys. Res. Commun. 205 (3), 1785-1789 (1994)
   PUBMED   7811265
  REMARK    Erratum:[Biochem Biophys Res Commun. 1995 Feb 27;207(3):1059. PMID:
            7864893]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY039591.1, BG575009.1,
            AF054185.1, BU632089.1 and BU687782.1.
            On Jul 12, 2012 this sequence version replaced gi:23110945.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. Proteasomes are
            distributed throughout eukaryotic cells at a high concentration and
            cleave peptides in an ATP/ubiquitin-dependent process in a
            non-lysosomal pathway. This gene encodes a member of the peptidase
            T1A family that functions as a 20S core alpha subunit. The encoded
            protein interacts with the hepatitis B virus X protein and plays a
            role in regulating hepatitis C virus internal ribosome entry site
            (IRES) activity, an activity essential for viral replication. The
            encoded protein also plays a role in the cellular stress response
            by regulating hypoxia-inducible factor-1alpha. A pseudogene of this
            gene is located on the long arm of chromosome 9. [provided by
            RefSeq, Jul 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX375857.2, BC004427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                HY039591.1         1-20
            21-95               BG575009.1         8-82
            96-632              AF054185.1         26-562
            633-1030            BU632089.1         19-416              c
            1031-1050           BU687782.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1050
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..1050
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /note="proteasome (prosome, macropain) subunit, alpha
                     type, 7"
                     /db_xref="GeneID:5688"
                     /db_xref="HGNC:9536"
                     /db_xref="HPRD:05967"
                     /db_xref="MIM:606607"
     exon            1..251
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    66..68
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /note="upstream in-frame stop codon"
     CDS             156..902
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /EC_number="3.4.25.1"
                     /note="proteasome subunit alpha 4; proteasome subunit
                     RC6-1; proteasome subunit XAPC7"
                     /codon_start=1
                     /product="proteasome subunit alpha type-7"
                     /protein_id="NP_002783.1"
                     /db_xref="GI:4506189"
                     /db_xref="CCDS:CCDS13489.1"
                     /db_xref="GeneID:5688"
                     /db_xref="HGNC:9536"
                     /db_xref="HPRD:05967"
                     /db_xref="MIM:606607"
                     /translation="
MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVRKICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEENEKKKQKKAS
"
     misc_feature    156..785
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /note="proteasome endopeptidase complex, archaeal, alpha
                     subunit; Region: arc_protsome_A; TIGR03633"
                     /db_xref="CDD:163366"
     misc_feature    162..788
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /note="proteasome_alpha_type_7. The 20S proteasome,
                     multisubunit proteolytic complex, is the central enzyme of
                     nonlysosomal protein degradation in both the cytosol and
                     nucleus. It is composed of 28 subunits arranged as four
                     homoheptameric rings that stack on...; Region:
                     proteasome_alpha_type_7; cd03755"
                     /db_xref="CDD:48453"
     misc_feature    order(168..179,183..188,192..197,207..209,216..218,
                     225..230,237..239,261..263,306..308,312..317,384..392,
                     396..401,492..494,501..503,510..515,522..536,588..590,
                     603..608,612..614,618..623,627..629)
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /note="alpha subunit interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:48453"
     misc_feature    order(243..245,291..293,297..299,336..338,642..644)
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /note="active site"
                     /db_xref="CDD:48453"
     misc_feature    612..614
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by ABL1 and ABL2; propagated from
                     UniProtKB/Swiss-Prot (O14818.1); phosphorylation site"
     misc_feature    834..836
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (O14818.1); acetylation site"
     exon            252..378
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /inference="alignment:Splign:1.39.8"
     variation       270
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11552072"
     variation       375
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11552074"
     exon            379..503
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /inference="alignment:Splign:1.39.8"
     exon            504..626
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /inference="alignment:Splign:1.39.8"
     exon            627..746
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /inference="alignment:Splign:1.39.8"
     variation       633
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1135965"
     variation       641
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1135961"
     variation       662
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:7076"
     variation       690
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12041"
     variation       704
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11552076"
     variation       742
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:11552075"
     exon            747..809
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /inference="alignment:Splign:1.39.8"
     exon            810..1032
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
                     /inference="alignment:Splign:1.39.8"
     polyA_signal    1006..1011
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
     polyA_site      1026
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
     polyA_site      1032
                     /gene="PSMA7"
                     /gene_synonym="C6; HSPC; RC6-1; XAPC7"
ORIGIN      
gtcgccgcctgacgccgcccgtcgccggcagcgcaggacacggcgccgagggtggggcgcgggcgtagtggcgccgggagtcgcgggtgcgcgcgggccgtgagtgtgcgcttttgagagtcgcggcggaaggagcccggccgccgcccgccggcatgagctacgaccgcgccatcaccgtcttctcgcccgacggccacctcttccaagtggagtacgcgcaggaggccgtcaagaagggctcgaccgcggttggtgttcgaggaagagacattgttgttcttggtgtggagaagaagtcagtggccaaactgcaggatgaaagaacagtgcggaagatctgtgctttggatgacaacgtctgcatggcctttgcaggcctcaccgccgatgcaaggatagtcatcaacagggcccgggtggagtgccagagccaccggctgactgtggaggacccggtcactgtggagtacatcacccgctacatcgccagtctgaagcagcgttatacgcagagcaatgggcgcaggccgtttggcatctctgccctcatcgtgggtttcgactttgatggcactcctaggctctatcagactgacccctcgggcacataccatgcctggaaggccaatgccataggtcggggtgccaagtcagtgcgcgagttcctggagaagaactatactgacgaagccattgaaacagatgatctgaccattaagctggtgatcaaggcactcctggaagtggttcagtcaggtggcaaaaacattgaacttgctgtcatgaggcgagatcaatccctcaagattttaaatcctgaagaaattgagaagtatgttgctgaaattgaaaaagaaaaagaagaaaacgaaaagaagaaacaaaagaaagcatcatgatgaataaaatgtctttgcttgtaatttttaaattcatatcaatcatggatgagtctcgatgtgtaggcctttccattccatttattcacactgagtgtcctacaataaacttccgtatttttaacctgttaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5688 -> Molecular function: GO:0004298 [threonine-type endopeptidase activity] evidence: IEA
            GeneID:5688 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5688 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
            GeneID:5688 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
            GeneID:5688 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
            GeneID:5688 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
            GeneID:5688 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
            GeneID:5688 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
            GeneID:5688 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
            GeneID:5688 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:5688 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
            GeneID:5688 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:5688 -> Biological process: GO:0016032 [viral process] evidence: TAS
            GeneID:5688 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
            GeneID:5688 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
            GeneID:5688 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
            GeneID:5688 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
            GeneID:5688 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
            GeneID:5688 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
            GeneID:5688 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
            GeneID:5688 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
            GeneID:5688 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:5688 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5688 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5688 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5688 -> Cellular component: GO:0000502 [proteasome complex] evidence: TAS
            GeneID:5688 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:5688 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:5688 -> Cellular component: GO:0005839 [proteasome core complex] evidence: ISS
            GeneID:5688 -> Cellular component: GO:0019773 [proteasome core complex, alpha-subunit complex] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_002783 -> EC 3.4.25.1

by @meso_cacase at DBCLS
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