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2024-04-26 07:10:39, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002789 1235 bp mRNA linear PRI 08-JUN-2013
DEFINITION Homo sapiens proteasome (prosome, macropain) subunit, alpha type, 4
(PSMA4), transcript variant 1, mRNA.
ACCESSION NM_002789
VERSION NM_002789.4 GI:156713440
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1235)
AUTHORS Wang,J., Bansal,A.T., Martin,M., Germer,S., Benayed,R., Essioux,L.,
Lee,J.S., Begovich,A., Hemmings,A., Kenwright,A., Taylor,K.E.,
Upmanyu,R., Cutler,P., Harari,O., Marchini,J., Criswell,L.A. and
Platt,A.
TITLE Genome-wide association analysis implicates the involvement of
eight loci with response to tocilizumab for the treatment of
rheumatoid arthritis
JOURNAL Pharmacogenomics J. 13 (3), 235-241 (2013)
PUBMED 22491018
REFERENCE 2 (bases 1 to 1235)
AUTHORS Hansen,H.M., Xiao,Y., Rice,T., Bracci,P.M., Wrensch,M.R.,
Sison,J.D., Chang,J.S., Smirnov,I.V., Patoka,J., Seldin,M.F.,
Quesenberry,C.P., Kelsey,K.T. and Wiencke,J.K.
TITLE Fine mapping of chromosome 15q25.1 lung cancer susceptibility in
African-Americans
JOURNAL Hum. Mol. Genet. 19 (18), 3652-3661 (2010)
PUBMED 20587604
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (bases 1 to 1235)
AUTHORS Amos,C.I., Gorlov,I.P., Dong,Q., Wu,X., Zhang,H., Lu,E.Y.,
Scheet,P., Greisinger,A.J., Mills,G.B. and Spitz,M.R.
TITLE Nicotinic acetylcholine receptor region on chromosome 15q25 and
lung cancer risk among African Americans: a case-control study
JOURNAL J. Natl. Cancer Inst. 102 (15), 1199-1205 (2010)
PUBMED 20554942
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 1235)
AUTHORS Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
TITLE Association of genetic variants with hemorrhagic stroke in Japanese
individuals
JOURNAL Int. J. Mol. Med. 25 (4), 649-656 (2010)
PUBMED 20198315
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 1235)
AUTHORS Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
TITLE Assessment of a polymorphism of SDK1 with hypertension in Japanese
Individuals
JOURNAL Am. J. Hypertens. 23 (1), 70-77 (2010)
PUBMED 19851296
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 6 (bases 1 to 1235)
AUTHORS Castano,J.G., Mahillo,E., Arizti,P. and Arribas,J.
TITLE Phosphorylation of C8 and C9 subunits of the multicatalytic
proteinase by casein kinase II and identification of the C8
phosphorylation sites by direct mutagenesis
JOURNAL Biochemistry 35 (12), 3782-3789 (1996)
PUBMED 8619999
REFERENCE 7 (bases 1 to 1235)
AUTHORS Kristensen,P., Johnsen,A.H., Uerkvitz,W., Tanaka,K. and Hendil,K.B.
TITLE Human proteasome subunits from 2-dimensional gels identified by
partial sequencing
JOURNAL Biochem. Biophys. Res. Commun. 205 (3), 1785-1789 (1994)
PUBMED 7811265
REMARK Erratum:[Biochem Biophys Res Commun. 1995 Feb 27;207(3):1059. PMID:
7864893]
REFERENCE 8 (bases 1 to 1235)
AUTHORS Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
Yokoyama-Kobayashi,M. and Aoki,T.
TITLE Construction of a human full-length cDNA bank
JOURNAL Gene 150 (2), 243-250 (1994)
PUBMED 7821789
REFERENCE 9 (bases 1 to 1235)
AUTHORS Arribas,J., Arizti,P. and Castano,J.G.
TITLE Antibodies against the C2 COOH-terminal region discriminate the
active and latent forms of the multicatalytic proteinase complex
JOURNAL J. Biol. Chem. 269 (17), 12858-12864 (1994)
PUBMED 8175701
REFERENCE 10 (bases 1 to 1235)
AUTHORS Tamura,T., Lee,D.H., Osaka,F., Fujiwara,T., Shin,S., Chung,C.H.,
Tanaka,K. and Ichihara,A.
TITLE Molecular cloning and sequence analysis of cDNAs for five major
subunits of human proteasomes (multi-catalytic proteinase
complexes)
JOURNAL Biochim. Biophys. Acta 1089 (1), 95-102 (1991)
PUBMED 2025653
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BG528289.1, BC056249.1, BC030529.1 and CD365826.1.
On Sep 1, 2007 this sequence version replaced gi:23110940.
Summary: The proteasome is a multicatalytic proteinase complex with
a highly ordered ring-shaped 20S core structure. The core structure
is composed of 4 rings of 28 non-identical subunits; 2 rings are
composed of 7 alpha subunits and 2 rings are composed of 7 beta
subunits. Proteasomes are distributed throughout eukaryotic cells
at a high concentration and cleave peptides in an
ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
essential function of a modified proteasome, the immunoproteasome,
is the processing of class I MHC peptides. This gene encodes a
member of the peptidase T1A family, that is a 20S core alpha
subunit. Three alternatively spliced transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq, Jul 2008].
Transcript Variant: This variant (1) represents the longest
transcript. Variants 1 and 2 both encode the same protein (isoform
1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC005361.1, BX386545.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-204 BG528289.1 2-205
205-727 BC056249.1 209-731
728-877 BC030529.1 2105-2254
878-1235 CD365826.1 1-358 c
FEATURES Location/Qualifiers
source 1..1235
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q25.1"
gene 1..1235
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/note="proteasome (prosome, macropain) subunit, alpha
type, 4"
/db_xref="GeneID:5685"
/db_xref="HGNC:9533"
/db_xref="HPRD:10168"
/db_xref="MIM:176846"
exon 1..135
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/inference="alignment:Splign:1.39.8"
variation 3
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:151040409"
variation 9
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="c"
/db_xref="dbSNP:75609110"
variation 46
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="c"
/db_xref="dbSNP:3813571"
variation 55
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:371585497"
variation 73
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="c"
/replace="g"
/db_xref="dbSNP:73463040"
variation 80
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="c"
/replace="g"
/db_xref="dbSNP:374081082"
variation 86
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:3813570"
variation 101..102
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace=""
/replace="gtg"
/db_xref="dbSNP:375962734"
exon 136..161
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/inference="alignment:Splign:1.39.8"
variation 136
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:375114621"
misc_feature 144..146
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/note="upstream in-frame stop codon"
variation 146
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="c"
/db_xref="dbSNP:200532673"
CDS 159..944
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/EC_number="3.4.25.1"
/note="isoform 1 is encoded by transcript variant 1;
proteasome component C9; proteasome subunit HC9;
proteasome subunit L; macropain subunit C9; multicatalytic
endopeptidase complex subunit C9; proteasome subunit alpha
type-4"
/codon_start=1
/product="proteasome subunit alpha type-4 isoform 1"
/protein_id="NP_002780.1"
/db_xref="GI:4506185"
/db_xref="CCDS:CCDS10303.1"
/db_xref="GeneID:5685"
/db_xref="HGNC:9533"
/db_xref="HPRD:10168"
/db_xref="MIM:176846"
/translation="
MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQKEKDK
"
misc_feature 159..869
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/note="proteasome subunit alpha; Provisional; Region:
PTZ00246"
/db_xref="CDD:173491"
misc_feature 165..806
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/note="proteasome_alpha_type_4. The 20S proteasome,
multisubunit proteolytic complex, is the central enzyme of
nonlysosomal protein degradation in both the cytosol and
nucleus. It is composed of 28 subunits arranged as four
homoheptameric rings that stack on...; Region:
proteasome_alpha_type_4; cd03752"
/db_xref="CDD:239721"
misc_feature order(177..188,192..197,201..206,216..218,225..227,
234..239,246..248,270..272,315..317,321..326,396..404,
408..413,504..506,513..515,522..527,534..548,600..602,
615..620,624..626,630..635,639..641)
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/note="alpha subunit interaction site [polypeptide
binding]; other site"
/db_xref="CDD:239721"
misc_feature 195..197
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P25789.1); phosphorylation site"
misc_feature order(252..254,300..302,306..308,348..350,654..656)
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/note="active site"
/db_xref="CDD:239721"
misc_feature 381..383
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P25789.1); phosphorylation site"
misc_feature 537..539
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P25789.1); acetylation site"
misc_feature 684..686
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P25789.1); acetylation site"
exon 162..204
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/inference="alignment:Splign:1.39.8"
variation 164
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="g"
/replace="t"
/db_xref="dbSNP:368498566"
variation 176
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:17588"
variation 181
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:11551783"
variation 186
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:11551787"
exon 205..367
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/inference="alignment:Splign:1.39.8"
variation 251
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="c"
/db_xref="dbSNP:11551784"
variation 273
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="c"
/replace="g"
/db_xref="dbSNP:11551779"
variation 275
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:11551776"
variation 306
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:149336836"
variation 314
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="c"
/db_xref="dbSNP:368528101"
variation 344
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:11551775"
variation 345
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:17352537"
variation 363
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:143441800"
exon 368..445
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/inference="alignment:Splign:1.39.8"
variation 369
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="g"
/replace="t"
/db_xref="dbSNP:75116593"
variation 377
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="g"
/replace="t"
/db_xref="dbSNP:183640841"
variation 391
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:11551781"
variation 398
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:11551786"
variation 424
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:11551782"
variation 443
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:200102081"
exon 446..534
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/inference="alignment:Splign:1.39.8"
variation 496
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:147984456"
variation 497
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:11551774"
exon 535..665
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/inference="alignment:Splign:1.39.8"
variation 561
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="c"
/replace="g"
/db_xref="dbSNP:373384097"
variation 626
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:377378619"
variation 662
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:370716397"
variation 663
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:147172987"
exon 666..789
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/inference="alignment:Splign:1.39.8"
variation 668
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:140433184"
exon 790..1220
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/inference="alignment:Splign:1.39.8"
STS 841..978
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/standard_name="G62016"
/db_xref="UniSTS:139094"
variation 865
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="g"
/replace="t"
/db_xref="dbSNP:147521961"
variation 878
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:8053"
variation 907
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:113098925"
variation 915
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:1065640"
variation 927
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:201574707"
variation 969
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="c"
/replace="g"
/db_xref="dbSNP:370714227"
STS 975..1091
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/standard_name="WI-9202"
/db_xref="UniSTS:30996"
variation 977
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:111842716"
STS 997..1155
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/standard_name="D15S636E"
/db_xref="UniSTS:58748"
variation 1005
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:113789828"
variation 1011
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:1052035"
variation 1043
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:111362317"
variation 1046..1047
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace=""
/replace="g"
/db_xref="dbSNP:35919397"
variation 1079
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:369831856"
variation 1125
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="c"
/replace="g"
/db_xref="dbSNP:143345504"
variation 1139
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:1052040"
variation 1145
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:3206623"
variation 1162
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace=""
/replace="t"
/db_xref="dbSNP:113738721"
variation 1213
/gene="PSMA4"
/gene_synonym="HC9; HsT17706; PSC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:371007026"
ORIGIN
cccgccccaacccagcggttctgcgcatgcgcgggggccatattagcagcggttattcggtgagcggtggtggtttattcttccgtggagttaagggctccgtggacatctcaggtcttcagggtcttccatctggaactatataaagttcagaaaacatgtctcgaagatatgactccaggaccactatattttctccagaaggtcgcttataccaagttgaatatgccatggaagctattggacatgcaggcacctgtttgggaattttagcaaatgatggtgttttgcttgcagcagagagacgcaacatccacaagcttcttgatgaagtctttttttctgaaaaaatttataaactcaatgaggacatggcttgcagtgtggcaggcataacttctgatgctaatgttctgactaatgaactaaggctcattgctcaaaggtatttattacagtatcaggagccaataccttgtgagcagttggttacagcgctgtgtgatatcaaacaagcttatacacaatttggaggaaaacgtccctttggtgtttcattgctgtacattggctgggataagcactatggctttcagctctatcagagtgaccctagtggaaattacgggggatggaaggccacatgcattggaaataatagcgctgcagctgtgtcaatgttgaaacaagactataaagaaggagaaatgaccttgaagtcagcacttgctttagctatcaaagtactaaataagaccatggatgttagtaaactctctgctgaaaaagtggaaattgcaacactaacaagagagaatggaaagacagtaatcagagttctcaaacaaaaagaagtggagcagttgatcaaaaaacatgaggaagaagaagccaaagctgagcgtgagaagaaagaaaaagaacagaaagaaaaggataaatagaatcagagattttattactcatttggggcaccatttcagtgtaaaagcagtcctactcttccacactaggaaggctttactttttttaactggtgcagtgggaaaataggacattacatactgaattgggtccttgtcatttctgtccaattgaatactttattgtaacgatgatggttacccttcatggacgtcttaatcttccacacacatcccctttttttggaataaaatttggaaaatggaaatgaaggaataaattctctgtagcagtaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5685 -> Molecular function: GO:0004298 [threonine-type endopeptidase activity] evidence: IEA
GeneID:5685 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5685 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
GeneID:5685 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
GeneID:5685 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:5685 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
GeneID:5685 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
GeneID:5685 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
GeneID:5685 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:5685 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
GeneID:5685 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:5685 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:5685 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:5685 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:5685 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:5685 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
GeneID:5685 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
GeneID:5685 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
GeneID:5685 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:5685 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:5685 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:5685 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5685 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5685 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5685 -> Cellular component: GO:0000502 [proteasome complex] evidence: TAS
GeneID:5685 -> Cellular component: GO:0000932 [cytoplasmic mRNA processing body] evidence: ISS
GeneID:5685 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:5685 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5685 -> Cellular component: GO:0005839 [proteasome core complex] evidence: ISS
GeneID:5685 -> Cellular component: GO:0019773 [proteasome core complex, alpha-subunit complex] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_002780 -> EC 3.4.25.1
by
@meso_cacase at
DBCLS
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