LOCUS       NM_002763               8178 bp    mRNA    linear   PRI 08-JUL-2013
DEFINITION  Homo sapiens prospero homeobox 1 (PROX1), transcript variant 2,
            mRNA.
ACCESSION   NM_002763
VERSION     NM_002763.4  GI:397174759
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8178)
  AUTHORS   Lecompte,S., Pasquetti,G., Hermant,X., Grenier-Boley,B.,
            Gonzalez-Gross,M., De Henauw,S., Molnar,D., Stehle,P., Beghin,L.,
            Moreno,L.A., Amouyel,P., Dallongeville,J. and Meirhaeghe,A.
  TITLE     Genetic and molecular insights into the role of PROX1 in glucose
            metabolism
  JOURNAL   Diabetes 62 (5), 1738-1745 (2013)
   PUBMED   23274905
  REMARK    GeneRIF: genetic association studies in adolescent populations in
            Europe: Data suggest that 3 SNPs in PROX1 (rs340838; rs340837;
            rs340836) are associated with fasting plasma insulin levels and may
            play a role in regulation of insulin secretion.
REFERENCE   2  (bases 1 to 8178)
  AUTHORS   Zhou,B., Si,W., Su,Z., Deng,W., Tu,X. and Wang,Q.
  TITLE     Transcriptional activation of the Prox1 gene by HIF-1alpha and
            HIF-2alpha in response to hypoxia
  JOURNAL   FEBS Lett. 587 (6), 724-731 (2013)
   PUBMED   23395615
  REMARK    GeneRIF: Prox1 gene transcription is regulated by HIF-1alpha and
            HIF-2alpha in hypoxia.
REFERENCE   3  (bases 1 to 8178)
  AUTHORS   Lu,M.H., Huang,C.C., Pan,M.R., Chen,H.H. and Hung,W.C.
  TITLE     Prospero homeobox 1 promotes epithelial-mesenchymal transition in
            colon cancer cells by inhibiting E-cadherin via miR-9
  JOURNAL   Clin. Cancer Res. 18 (23), 6416-6425 (2012)
   PUBMED   23045246
  REMARK    GeneRIF: PROX1 promotes epithelial-mesenchymal transition and colon
            cancer progression.
REFERENCE   4  (bases 1 to 8178)
  AUTHORS   Cimpean,A.M., Mazuru,V., Saptefrati,L., Ceausu,R. and Raica,M.
  TITLE     Prox 1, VEGF-C and VEGFR3 expression during cervical neoplasia
            progression as evidence of an early lymphangiogenic switch
  JOURNAL   Histol. Histopathol. 27 (12), 1543-1550 (2012)
   PUBMED   23059885
  REMARK    GeneRIF: The presence of Prox1 nuclear expression was detected
            starting from CIN2 and CIN3 lesions to microinvasive carcinoma, in
            the nuclei of lymphatic and venous endothelial cells and scattered
            stromal cells.
REFERENCE   5  (bases 1 to 8178)
  AUTHORS   Elsir,T., Smits,A., Lindstrom,M.S. and Nister,M.
  TITLE     Transcription factor PROX1: its role in development and cancer
  JOURNAL   Cancer Metastasis Rev. 31 (3-4), 793-805 (2012)
   PUBMED   22733308
  REMARK    Review article
REFERENCE   6  (bases 1 to 8178)
  AUTHORS   Wilting,J., Papoutsi,M., Christ,B., Nicolaides,K.H., von
            Kaisenberg,C.S., Borges,J., Stark,G.B., Alitalo,K., Tomarev,S.I.,
            Niemeyer,C. and Rossler,J.
  TITLE     The transcription factor Prox1 is a marker for lymphatic
            endothelial cells in normal and diseased human tissues
  JOURNAL   FASEB J. 16 (10), 1271-1273 (2002)
   PUBMED   12060670
REFERENCE   7  (bases 1 to 8178)
  AUTHORS   Chen,Q., Dowhan,D.H., Liang,D., Moore,D.D. and Overbeek,P.A.
  TITLE     CREB-binding protein/p300 co-activation of crystallin gene
            expression
  JOURNAL   J. Biol. Chem. 277 (27), 24081-24089 (2002)
   PUBMED   11943779
REFERENCE   8  (bases 1 to 8178)
  AUTHORS   Duncan,M.K., Cui,W., Oh,D.J. and Tomarev,S.I.
  TITLE     Prox1 is differentially localized during lens development
  JOURNAL   Mech. Dev. 112 (1-2), 195-198 (2002)
   PUBMED   11850194
  REMARK    GeneRIF: Prox1 is differentially localized during lens development
REFERENCE   9  (bases 1 to 8178)
  AUTHORS   Mouta Carreira,C., Nasser,S.M., di Tomaso,E., Padera,T.P.,
            Boucher,Y., Tomarev,S.I. and Jain,R.K.
  TITLE     LYVE-1 is not restricted to the lymph vessels: expression in normal
            liver blood sinusoids and down-regulation in human liver cancer and
            cirrhosis
  JOURNAL   Cancer Res. 61 (22), 8079-8084 (2001)
   PUBMED   11719431
  REMARK    GeneRIF: Prox 1 is expressed in both quiescent and proliferating
            lymphatic endothelial cells in the liver. Unlike the putative
            lymphatic marker LYVE-1, Prox 1 is not expressed in liver
            sinusoidal endothelial cells.
            GeneRIF: Prox 1 is expressed in both quiescent and proliferating
            lymphatic endothelial cells in the adult human and mouse liver.
            Unlike the putative lymphatic marker LYVE-1, Prox 1 is not
            expressed in liver sinusoidal endothelial cells.
REFERENCE   10 (bases 1 to 8178)
  AUTHORS   Zinovieva,R.D., Duncan,M.K., Johnson,T.R., Torres,R.,
            Polymeropoulos,M.H. and Tomarev,S.I.
  TITLE     Structure and chromosomal localization of the human homeobox gene
            Prox 1
  JOURNAL   Genomics 35 (3), 517-522 (1996)
   PUBMED   8812486
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA743374.1, BC024201.2 and
            AL606537.10.
            On Jul 24, 2012 this sequence version replaced gi:34147628.
            
            Summary: The protein encoded by this gene is a member of the
            homeobox transcription factor family. Members of this family
            contain a homeobox domain that consists of a 60-amino acid
            helix-turn-helix structure that binds DNA and RNA. The protein
            encoded by this gene is conserved across vertebrates and may play
            an essential role during development. Altered levels of this
            protein have been reported in cancers of different organs, such as
            colon, brain, blood, breast, pancreas, liver and esophagus.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024201.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025083 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DA743374.1         1-16
            17-3091             BC024201.2         1-3075
            3092-8178           AL606537.10        97690-102776
FEATURES             Location/Qualifiers
     source          1..8178
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..8178
                     /gene="PROX1"
                     /note="prospero homeobox 1"
                     /db_xref="GeneID:5629"
                     /db_xref="HGNC:9459"
                     /db_xref="HPRD:03330"
                     /db_xref="MIM:601546"
     exon            1..221
                     /gene="PROX1"
                     /inference="alignment:Splign:1.39.8"
     variation       27
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372222520"
     variation       156
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76252302"
     variation       184
                     /gene="PROX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:76992635"
     exon            222..2013
                     /gene="PROX1"
                     /inference="alignment:Splign:1.39.8"
     variation       249
                     /gene="PROX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:34584886"
     variation       254
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185136406"
     misc_feature    262..264
                     /gene="PROX1"
                     /note="upstream in-frame stop codon"
     CDS             289..2502
                     /gene="PROX1"
                     /note="prospero-related homeobox 1; homeobox prospero-like
                     protein PROX1"
                     /codon_start=1
                     /product="prospero homeobox protein 1"
                     /protein_id="NP_002754.2"
                     /db_xref="GI:21359846"
                     /db_xref="CCDS:CCDS31021.1"
                     /db_xref="GeneID:5629"
                     /db_xref="HGNC:9459"
                     /db_xref="HPRD:03330"
                     /db_xref="MIM:601546"
                     /translation="

MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSAMNPQGSEQDVEYSVVQHADGEKSNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTGSEVHQEDICSNSSRDSPPECLSPFGRPTMSQFDMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQELNTAMSQVVDTVVKVFSAKPSRQVPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPNPLDTFGNVQMASSTDQTEALPLVVRKNSSDQSASGPAAGGHHQPLHQSPLSATTGFTTSTFRHPFPLPLMAYPFQSPLGAPSGSFSGKDRASPESLDLTRDTTSLRTKMSSHHLSHHPCSPAHPPSTAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQELLHE

"
     misc_feature    289..2493
                     /gene="PROX1"
                     /note="Homeobox prospero-like protein (PROX1); Region:
                     Prox1; pfam05044"
                     /db_xref="CDD:203159"
     misc_feature    2194..2499
                     /gene="PROX1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92786.2);
                     Region: Prospero-like"
     variation       323
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372646482"
     variation       348
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:192143344"
     variation       367
                     /gene="PROX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199560210"
     variation       383
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:189248628"
     variation       387
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144507992"
     variation       396
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:71635949"
     variation       444
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192517068"
     variation       464
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375594682"
     variation       471
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148422967"
     variation       488
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:74404045"
     variation       544
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201731499"
     variation       552
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140658485"
     variation       589
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201187008"
     variation       609
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372904856"
     variation       659
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147839309"
     variation       662..663
                     /gene="PROX1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:34468319"
     variation       699
                     /gene="PROX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373902403"
     variation       711
                     /gene="PROX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:377531255"
     variation       771
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368974011"
     variation       783
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372599303"
     variation       798
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140311564"
     variation       844
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149162531"
     variation       873
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372925105"
     variation       889
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200548077"
     variation       962
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146788962"
     variation       966
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376859063"
     variation       986
                     /gene="PROX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371118740"
     variation       988
                     /gene="PROX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199834333"
     variation       1062
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:184188363"
     variation       1101
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140471005"
     variation       1127
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:112763420"
     variation       1189
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200543978"
     variation       1190
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141960216"
     variation       1200
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:188226653"
     variation       1230
                     /gene="PROX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:117278964"
     variation       1247
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200966732"
     variation       1295
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144228107"
     variation       1296
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199970427"
     variation       1325
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376783773"
     variation       1334
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370674000"
     variation       1370
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374118696"
     variation       1384
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370676590"
     variation       1386
                     /gene="PROX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201837366"
     variation       1417
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368029419"
     variation       1505
                     /gene="PROX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201339853"
     variation       1530
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370313551"
     variation       1569
                     /gene="PROX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373721879"
     variation       1595
                     /gene="PROX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200387223"
     variation       1626
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369633751"
     variation       1636
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201989339"
     variation       1704
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367596069"
     variation       1724
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78142452"
     variation       1836
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200358560"
     variation       1840
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376676769"
     variation       1877
                     /gene="PROX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148478012"
     variation       1896
                     /gene="PROX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369562605"
     variation       1919
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201873517"
     variation       1922
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201147907"
     variation       1938
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35176368"
     variation       1941
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115772074"
     variation       1994
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138867261"
     exon            2014..2121
                     /gene="PROX1"
                     /inference="alignment:Splign:1.39.8"
     variation       2039
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12121210"
     variation       2041
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:181080355"
     variation       2112
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369204553"
     exon            2122..2316
                     /gene="PROX1"
                     /inference="alignment:Splign:1.39.8"
     variation       2190
                     /gene="PROX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150983193"
     variation       2202
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369040874"
     variation       2220
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373493766"
     exon            2317..8178
                     /gene="PROX1"
                     /inference="alignment:Splign:1.39.8"
     variation       2442
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369927365"
     variation       2448
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201543962"
     variation       2450..2451
                     /gene="PROX1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:5780753"
     variation       2499
                     /gene="PROX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370883938"
     variation       2506
                     /gene="PROX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:149049354"
     variation       2538
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368745894"
     variation       2551
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199685959"
     variation       2627
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111991025"
     STS             2650..3253
                     /gene="PROX1"
                     /standard_name="PROX1_8568"
                     /db_xref="UniSTS:467846"
     STS             2766..2896
                     /gene="PROX1"
                     /standard_name="RH78799"
                     /db_xref="UniSTS:80708"
     variation       2767
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13375798"
     variation       2785
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145877478"
     variation       2786
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188707422"
     variation       2856
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:180781567"
     variation       2863..2864
                     /gene="PROX1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:150012554"
     STS             2925..3074
                     /gene="PROX1"
                     /standard_name="SHGC-31006"
                     /db_xref="UniSTS:19930"
     variation       2925
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116007960"
     variation       2940
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:115808633"
     variation       3056
                     /gene="PROX1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:201452230"
     polyA_signal    3083..3088
                     /gene="PROX1"
     polyA_site      3091
                     /gene="PROX1"
                     /note="The 3' most polyA site has not been determined.
                     This is an internal site."
     variation       3143
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138598878"
     variation       3215
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369285090"
     variation       3229
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185181391"
     variation       3309
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142722706"
     variation       3339
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:192168652"
     variation       3374
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182175922"
     variation       3409..3410
                     /gene="PROX1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:369511554"
     variation       3556..3557
                     /gene="PROX1"
                     /replace=""
                     /replace="at"
                     /db_xref="dbSNP:138905375"
     variation       3678
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113692924"
     variation       3761
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377064485"
     variation       3814
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116305529"
     variation       3907
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76793602"
     variation       3962
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148386217"
     variation       4005
                     /gene="PROX1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:376394115"
     variation       4144
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11810156"
     variation       4213
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41277174"
     variation       4242
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116790107"
     variation       4324
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186795261"
     variation       4328
                     /gene="PROX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:75626032"
     variation       4342
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41277176"
     variation       4412
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373216743"
     variation       4438..4439
                     /gene="PROX1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:148112013"
     variation       4568
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376529172"
     variation       4802
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77615530"
     variation       4810
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191582069"
     variation       4860..4861
                     /gene="PROX1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:11392258"
     variation       4872
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183187936"
     variation       4948
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150871232"
     STS             5015..5162
                     /gene="PROX1"
                     /standard_name="D1S3515"
                     /db_xref="UniSTS:33852"
     variation       5061
                     /gene="PROX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:78844498"
     variation       5189
                     /gene="PROX1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:376893125"
     variation       5198
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77393206"
     variation       5199
                     /gene="PROX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:76087254"
     variation       5211
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2241674"
     variation       5502
                     /gene="PROX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:79969811"
     variation       5534
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139366939"
     variation       5574
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3170994"
     variation       5720
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:115083933"
     variation       5776..5777
                     /gene="PROX1"
                     /replace=""
                     /replace="at"
                     /db_xref="dbSNP:142188045"
     variation       5832
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:185654155"
     variation       5852
                     /gene="PROX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:190365755"
     variation       5915
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149999134"
     variation       5956
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371386813"
     variation       5990
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113250721"
     variation       6028
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182171369"
     variation       6125..6126
                     /gene="PROX1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:71712287"
     variation       6148
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186860877"
     variation       6155
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:193214656"
     STS             6186..6319
                     /gene="PROX1"
                     /standard_name="SHGC-76346"
                     /db_xref="UniSTS:21354"
     variation       6256
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183903818"
     variation       6299
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:79936119"
     variation       6343
                     /gene="PROX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:7529248"
     variation       6441
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:189248252"
     variation       6457
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12091447"
     variation       6465
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192884838"
     variation       6468..6471
                     /gene="PROX1"
                     /replace=""
                     /replace="ac"
                     /db_xref="dbSNP:34477510"
     variation       6469..6470
                     /gene="PROX1"
                     /replace=""
                     /replace="ac"
                     /db_xref="dbSNP:66667661"
     variation       6498..6499
                     /gene="PROX1"
                     /replace=""
                     /replace="ca"
                     /db_xref="dbSNP:57174976"
     variation       6499..6500
                     /gene="PROX1"
                     /replace=""
                     /replace="tg"
                     /db_xref="dbSNP:71165945"
     variation       6500
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:74139094"
     variation       6554
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76316620"
     variation       6734
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184458341"
     variation       6855..6856
                     /gene="PROX1"
                     /replace=""
                     /replace="gt"
                     /db_xref="dbSNP:71677617"
     variation       6956
                     /gene="PROX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:140023441"
     variation       7022
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188458481"
     variation       7054
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201348452"
     variation       7060
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114760027"
     variation       7092..7093
                     /gene="PROX1"
                     /replace=""
                     /replace="gt"
                     /db_xref="dbSNP:141470586"
     variation       7166
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191767387"
     variation       7174
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:74719846"
     variation       7183
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79560889"
     variation       7187
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1053283"
     variation       7286
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143625407"
     variation       7294
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370810692"
     variation       7343
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189203361"
     variation       7350
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182199286"
     variation       7427
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1053284"
     variation       7723
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187163705"
     variation       7956
                     /gene="PROX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:190786076"
     STS             8012..8138
                     /gene="PROX1"
                     /standard_name="SHGC-76335"
                     /db_xref="UniSTS:12571"
     variation       8062
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142704534"
     variation       8170..8172
                     /gene="PROX1"
                     /replace=""
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35052233"
     variation       8171
                     /gene="PROX1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:200801369"
ORIGIN      

cccctcgtgagtccctccccttttccagaatcacttgcactgtcttgttcttgaatgagaaaggaagaaaagagcctcccattactcagacccgtgtaaacattattccccccaggagaaaatggtgttattcaaatgaatcataataaaatagcctctaaacagtttctaagcgggagcctccgtggaactcagcgctccgctcctcccagttcctaagaggtcccgggattcttgagctgtgcccagctgacgagcttttgaagatggcacaataaccgtccagtgatgcctgaccatgacagcacagccctcttaagccggcaaaccaagaggagaagagttgacattggagtgaaaaggacggtagggacagcatctgcattttttgctaaggcaagagcaacgttttttagtgccatgaatccccaaggttctgagcaggatgttgagtattcagtggtgcagcatgcagatggggaaaagtcaaatgtactccgcaagctgctgaagagggcgaactcgtatgaagatgccatgatgccttttccaggagcaaccataatttcccagctgttgaaaaataacatgaacaaaaatggtggcacggagcccagtttccaagccagcggtctctctagtacaggctccgaagtacatcaggaggatatatgcagcaactcttcaagagacagccccccagagtgtctttccccttttggcaggcctactatgagccagtttgatatggatcgcttatgtgatgagcacctgagagcaaagcgcgcccgggttgagaatataattcggggtatgagccattcccccagtgtggcattaaggggcaatgaaaatgaaagagagatggccccgcagtctgtgagtccccgagaaagttacagagaaaacaaacgcaagcaaaagcttccccagcagcagcaacagagtttccagcagctggtttcagcccgaaaagaacagaagcgagaggagcgccgacagctgaaacagcagctggaggacatgcagaaacagctgcgccagctgcaggaaaagttctaccaaatctatgacagcactgattcggaaaatgatgaagatggtaacctgtctgaagacagcatgcgctcggagatcctggatgccagggcccaggactctgtcggaaggtcagataatgagatgtgcgagctagacccaggacagtttattgaccgagctcgagccctgatcagagagcaggaaatggctgaaaacaagccgaagcgagaaggcaacaacaaagaaagagaccatgggccaaactccttacaaccggaaggcaaacatttggctgagaccttgaaacaggaactgaacactgccatgtcgcaagttgtggacactgtggtcaaagtcttttcggccaagccctcccgccaggttcctcaggtcttcccacctctccagatcccccaggccagatttgcagtcaatggggaaaaccacaatttccacaccgccaaccagcgcctgcagtgctttggcgacgtcatcattccgaaccccctggacacctttggcaatgtgcagatggccagttccactgaccagacagaagcactgcccctggttgtccgcaaaaactcctctgaccagtctgcctccggccctgccgctggcggccaccaccagcccctgcaccagtcgcctctctctgccaccacgggcttcaccacgtccaccttccgccaccccttcccccttcccttgatggcctatccatttcagagcccattaggtgctccctccggctccttctctggaaaagacagagcctctcctgaatccttagacttaactagggataccacgagtctgaggaccaagatgtcatctcaccacctgagccaccacccttgttcaccagcacacccgcccagcaccgccgaagggctctccttgtcgctcataaagtccgagtgcggcgatcttcaagatatgtctgaaatatcaccttattcgggaagtgcaatgcaggaaggattgtcacccaatcacttgaaaaaagcaaagctcatgtttttttatacccgttatcccagctccaatatgctgaagacctacttctccgacgtaaagttcaacagatgcattacctctcagctcatcaagtggtttagcaatttccgtgagttttactacattcagatggagaagtacgcacgtcaagccatcaacgatggggtcaccagtactgaagagctgtctataaccagagactgtgagctgtacagggctctgaacatgcactacaataaagcaaatgactttgaggttccagagagattcctggaagttgctcagatcacattacgggagtttttcaatgccattatcgcaggcaaagatgttgatccttcctggaagaaggccatatacaaggtcatctgcaagctggatagtgaagtccctgagattttcaaatccccgaactgcctacaagagctgcttcatgagtagaaatttcaacaactctttttgaatgtatgaagagtagcagtcccctttggatgtccaagttatatgtgtctagattttgatttcatatatatgtgtatgggaggcatggatatgttatgaaatcagctggtaattcctcctcatcacgtttctctcattttcttttgttttccattgcaaggggatggttgttttctttctgcctttagtttgcttttgcccaaggcccttaacatttggacacttaaaatagggttaattttcagggaaaaagaatgttggcgtgtgtaaagtctctattagcaatgaagggaatttgttaacgatgcatccacttgattgatgacttattgcaaatggcggttggctgaggaaaacccatgacacagcacaactctacagacagtgatgtgtctcttgtttctactgctaagaaggtctgaaaatttaatgaaaccacttcatacatttaagtattttgtttggtttgaactcaatcagtagcttttccttacatgtttaaaaataattccaatgacagatgagcagctcacttttccaaagtaccccaaaaggccaaattaaaaaagaaaaataatcactctcaagccttgtctaagaaaagaggcaaactctgaaagtcgtaccagtttcttctggaggcaaagcaattttgcacaaaaccagctctctcaagatgagactagaaattcatacctggtcttgtagccacctctctaaacttgaaaataggttcttcttcataagtgagcttacatcattcttcataaagaaaaatcctataacttgttatcatttttgcttcagatactaaaaggcactaagtttccaatttacgctgctcaactttgtttatatgcttaaaaggattctgtttacttaacaattttttcccctaaaatactattttctgaatacttccttccagtaaggaataaaggaaagcccaacttggccataaaattcttgcctacactagaagtttgttgacagccattagctgacttgatcgtcatctcctaagaggaacacatatattttcacaagcaattccacactatcctgatgggtatgcaaagtggtgacagtctaactcagtgtttcttcattttaggtataacattttaaagcaattgataatgcctcttccaattcagaagctagtattgaccaaaatgtgagaagagtgtatagcataggaaaatttggggttaacccaaaagacacaattccagcacacataagaaagctagctgctattttatgctttcttccatggttctcctcttttttcccttttatttttccctgtttttcaatgatgtacagtgttccctacttgcattgaaaaaactcgtatggcattcacactttttttcttaggtgggtttttgtgtccagatgcagtaagaattcattgttcatcctaaaactgttttccagacccttccttccccttaggtaatttgatatacacctcctaaaatgacacagtaacaaatctggtatttagaacatatagaacataaatgccattttttaattcaactttaataagaattacatttgactttggagaatacaggtcttgacccatgtgactgactagctgacccgatcgctgtaatttaacgtcatttataaattctgctgatggacaggaatgtatgaactcaattattgtcagcacaaagccttaaaacctgctgactttaaattaaatggtgcagtcctatgatgccctgcaccatccaggggactaacagggcctcgcagtgtagacagagggtgcagccacacgggcgggggcaccagccacctcactctgcacccgcggcctcacacatctcccagctcacactctactaatgcacagagtcattagatccaatttgttatttttctcacttgctttaaaaaaaagcagtttggataatcatgacattggaataaagtgggaaggaaaaattccatcagcacaaaatagggaagtaatcccaacttgtagtcacagttttctgactggctttgttttaaaagaggatggcagtccttgttcgtgtcagtgtgccactgggtttttgctgttccgtgtaattcatatcaactttgtgttgccatttgcaaggtaaaaggcaaagctgtagtgtattcacctatgtagacagattgctagatatctttttgatctggggcgagttcaatattgattccagacttatttggatttttttagtattattttcccctccctttctaatttaaatagacaaattaagcaaaagtgtgtgttcacaaccaaatgttgatgcccttatctactgataatatcctctcaatgttcactgaggcatagaaattatttcagagtagaaattgcagcatgaggataaactcacctctttgttctgaaaatagaactttatcactatgctttccggtggttttcccttttacaatcgaaatcttgtgcctcccaagtgcattggaaaatgacaaaagcctgtctctccaaattcctatttaacagtttgattttttttttttaatcaccatctttcaaatcttagctcaactctcaccaagtgaaaattggctacttgggagaaagttaactttctatggtgggatggtgaaggatgagggacagtttacataggaaaagaaaaaaaaaagtctaaagtccatgttgaaaaaccacactaccacttattttctgctaaccctaaattatttttgcgtatacgcttgaggttatagtctgtgcctagacctaaaatgcaccagcgggggggattttaaaaaatccttcaaaataccagttttttcccaacaagtacaattgttcttgtgccttctgtggctttcgatttcatctttttgactttatttccaattactacagctgcaataaacactagattttttttctggctgtttgacataacgttgatagctatgcatattttgtgtctttttaaaacaaagcgggagaatacgtttttgaagaagagaatttttagaacagtttgataccgcaaattattttttcctcaattgtttgagcagcattcgagttttgaaaattcttgtagaagccaattttttgtaactgtggtgcaaatcttgtgttttcttagcctaatgaaaagtagtatagaagcaatatttcataccatgtgctatatatgtgtgcgcagatgtgtgaacataaaatcacatacacacatatacacacatgtaaaaatatacatatatatatatgcgtgtgaagtggaaagcttaccttttcctatctagatttaagaacctattttagacatttgttatgttttgtgaaaagaatgttctatttgcaacaaaacatttaattcttactgtatctctggctgtttaatgaggacgtttcacattaaatggtaaaacacatggaagatgttagaatgtagtaattatttaagtaaacgttcacccacatattcctgaagtttgctttgtgcctccgagtattatttaattaaagaagtgttttatgtttgcagaatctttgtcactgtactagggatgtgggtgaatatcatttaaaaaaatttaaaacaacaaaaaaaaagcaaaacagaaacactaaagcaagaggggaacttttataaagcaatgtaaatatttaacctcatggctgtcattatgtaagacatgagattttaataaataactacattctcacgacatctgttgaatttactaggaacactacagtgactgtatagacagttgaaagcattcttgaaaatcctgctctctccttttaaaagttaacaatctcttttatcagatgtcaagggcaagggtaatgcagtttctgtaaatttatgaaatttctttttctatgtacatgaagacatttagtaagtaacacccccccttcccatgcgcacatgtgcgcatacacacacacacacacacacacacacacacaaacacacacactgtcataaagctaatgatttggggactttaaaaaataggatgtcctccaggaacaatcataaatttatgaaagaaagagtagtttacagactcccctgaaagaagcagtgtatatgtgaagacagtgcaaaaatctctttgccatgtatattatagcgtattcattggtgtgaatagtacaaatgtttccttctggtacaaactctgtgtttgcaaatttacaagaagcattgttttcaaaaagctccccttaaaaaatgtaactggtttatatgagtaagcagttaccgtattgcacttaaatgttatgttgaaggaaatgcagttttgttttctgtagatctgttggttgtaaaccatctataaaactaaagctaaaatgctcatattcagagctgggatcaaaactggtatttaacctttgcatcttcttataattatccttctaagaatataacagaatgtggaagtgtctggactttgagtcttttcaactgagccttctctcaaatctgacaccccctcagaatgcacaaacataagcagaaaaggcaaacaagcttaccttcttttgtgaaaacgtattcattctgtatttttttaaatattcaattcccctaaaaatggggagaaaatattttaaaattgtatattacgacttcaaatttagaactaagaaaaaaatgtatttgggattggtctcagcgctacctagaagaatcaaaggtcatggcttccctcaatattgtcccagccatttctcatatgtatatagtataaaccgtgacaaaacactgcctttatattatttagcaatatgttgtaaatagcattattaagctcttttttgtaataaagaccctttgatttgaatatagtacaataactgaactgataaagtcaatttttgatttttgtttgttttttttagctagaggcaatttcaattgtgaatttttgttgttgtctattgttctgaagactttgcataatttattggtttaatttatcctaatttatttgatgaaggtgtacaattttgtattaccaaggatgtactgtaatattaattgatatgataaacacaatgagactccctgtccatattaaaaagaaaataaaaaggtgcagtagacaattgattttaaaggaaaagttaaaaaaattagtttggcagctactaaattttaaaacaggaaaaaaaaaagttgttgtggggagggtgggaaaggggttttactttgtgtgttttaagcttttgtatactctccaaacttttaccttttgctttgtaccacttaaaggatacagtagtccaattgccttgtgtgccttccatctcctcttaaactgaatgtatgtgcagtatatatgcaagcttgtgcaaaataaaatatacattacaagctcagtgccgtttgattttcttaaagaaagagtgacttttaatttttggacctgtatccaattgtaggacagtaggctagttgtgccagtaatgtcaagtatggagattttctttcactacaattcttcattctgttagcctaacgtgcagctcctagaaacaacctcttttactttagatgcttggaataattgcttggatttctctctctgaaacatctttcaggcttaactttatttagccctgaaacttaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5629 -> Molecular function: GO:0003677 [DNA binding] evidence: IMP
            GeneID:5629 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IC
            GeneID:5629 -> Molecular function: GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] evidence: ISS
            GeneID:5629 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: IDA
            GeneID:5629 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5629 -> Molecular function: GO:0016922 [ligand-dependent nuclear receptor binding] evidence: IPI
            GeneID:5629 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:5629 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: IDA
            GeneID:5629 -> Molecular function: GO:0050692 [DBD domain binding] evidence: IPI
            GeneID:5629 -> Molecular function: GO:0050693 [LBD domain binding] evidence: IPI
            GeneID:5629 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:5629 -> Biological process: GO:0001709 [cell fate determination] evidence: IEA
            GeneID:5629 -> Biological process: GO:0001822 [kidney development] evidence: IEP
            GeneID:5629 -> Biological process: GO:0001889 [liver development] evidence: IEP
            GeneID:5629 -> Biological process: GO:0001938 [positive regulation of endothelial cell proliferation] evidence: IDA
            GeneID:5629 -> Biological process: GO:0001946 [lymphangiogenesis] evidence: IDA
            GeneID:5629 -> Biological process: GO:0002088 [lens development in camera-type eye] evidence: IEP
            GeneID:5629 -> Biological process: GO:0002194 [hepatocyte cell migration] evidence: IEA
            GeneID:5629 -> Biological process: GO:0007420 [brain development] evidence: IEP
            GeneID:5629 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IDA
            GeneID:5629 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IMP
            GeneID:5629 -> Biological process: GO:0010468 [regulation of gene expression] evidence: IDA
            GeneID:5629 -> Biological process: GO:0010595 [positive regulation of endothelial cell migration] evidence: IDA
            GeneID:5629 -> Biological process: GO:0021516 [dorsal spinal cord development] evidence: ISS
            GeneID:5629 -> Biological process: GO:0021542 [dentate gyrus development] evidence: ISS
            GeneID:5629 -> Biological process: GO:0021707 [cerebellar granule cell differentiation] evidence: ISS
            GeneID:5629 -> Biological process: GO:0021915 [neural tube development] evidence: ISS
            GeneID:5629 -> Biological process: GO:0030240 [skeletal muscle thin filament assembly] evidence: ISS
            GeneID:5629 -> Biological process: GO:0030324 [lung development] evidence: IEP
            GeneID:5629 -> Biological process: GO:0030910 [olfactory placode formation] evidence: ISS
            GeneID:5629 -> Biological process: GO:0031016 [pancreas development] evidence: IEP
            GeneID:5629 -> Biological process: GO:0031667 [response to nutrient levels] evidence: IEA
            GeneID:5629 -> Biological process: GO:0043049 [otic placode formation] evidence: ISS
            GeneID:5629 -> Biological process: GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] evidence: IDA
            GeneID:5629 -> Biological process: GO:0045071 [negative regulation of viral genome replication] evidence: IDA
            GeneID:5629 -> Biological process: GO:0045737 [positive regulation of cyclin-dependent protein kinase activity] evidence: IDA
            GeneID:5629 -> Biological process: GO:0045787 [positive regulation of cell cycle] evidence: ISS
            GeneID:5629 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:5629 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IMP
            GeneID:5629 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IMP
            GeneID:5629 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
            GeneID:5629 -> Biological process: GO:0046619 [optic placode formation involved in camera-type eye formation] evidence: ISS
            GeneID:5629 -> Biological process: GO:0048845 [venous blood vessel morphogenesis] evidence: ISS
            GeneID:5629 -> Biological process: GO:0055005 [ventricular cardiac myofibril assembly] evidence: ISS
            GeneID:5629 -> Biological process: GO:0055009 [atrial cardiac muscle tissue morphogenesis] evidence: ISS
            GeneID:5629 -> Biological process: GO:0055010 [ventricular cardiac muscle tissue morphogenesis] evidence: ISS
            GeneID:5629 -> Biological process: GO:0060042 [retina morphogenesis in camera-type eye] evidence: ISS
            GeneID:5629 -> Biological process: GO:0060059 [embryonic retina morphogenesis in camera-type eye] evidence: IEP
            GeneID:5629 -> Biological process: GO:0060214 [endocardium formation] evidence: ISS
            GeneID:5629 -> Biological process: GO:0060298 [positive regulation of sarcomere organization] evidence: ISS
            GeneID:5629 -> Biological process: GO:0060412 [ventricular septum morphogenesis] evidence: ISS
            GeneID:5629 -> Biological process: GO:0060414 [aorta smooth muscle tissue morphogenesis] evidence: ISS
            GeneID:5629 -> Biological process: GO:0060421 [positive regulation of heart growth] evidence: ISS
            GeneID:5629 -> Biological process: GO:0060836 [lymphatic endothelial cell differentiation] evidence: IDA
            GeneID:5629 -> Biological process: GO:0060849 [regulation of transcription involved in lymphatic endothelial cell fate commitment] evidence: IMP
            GeneID:5629 -> Biological process: GO:0070309 [lens fiber cell morphogenesis] evidence: IEP
            GeneID:5629 -> Biological process: GO:0070365 [hepatocyte differentiation] evidence: IEP
            GeneID:5629 -> Biological process: GO:0070858 [negative regulation of bile acid biosynthetic process] evidence: IMP
            GeneID:5629 -> Biological process: GO:0072574 [hepatocyte proliferation] evidence: IEA
            GeneID:5629 -> Biological process: GO:0097150 [neuronal stem cell maintenance] evidence: ISS
            GeneID:5629 -> Biological process: GO:1901978 [positive regulation of cell cycle checkpoint] evidence: IEA
            GeneID:5629 -> Biological process: GO:2000179 [positive regulation of neural precursor cell proliferation] evidence: ISS
            GeneID:5629 -> Biological process: GO:2000979 [positive regulation of forebrain neuron differentiation] evidence: ISS
            GeneID:5629 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:5629 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA