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2024-03-29 03:00:28, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_002758               1879 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens mitogen-activated protein kinase kinase 6 (MAP2K6),
            mRNA.
ACCESSION   NM_002758
VERSION     NM_002758.3  GI:90577186
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1879)
  AUTHORS   Krintel,S.B., Palermo,G., Johansen,J.S., Germer,S., Essioux,L.,
            Benayed,R., Badi,L., Ostergaard,M. and Hetland,M.L.
  TITLE     Investigation of single nucleotide polymorphisms and biological
            pathways associated with response to TNFalpha inhibitors in
            patients with rheumatoid arthritis
  JOURNAL   Pharmacogenet. Genomics 22 (8), 577-589 (2012)
   PUBMED   22569225
REFERENCE   2  (bases 1 to 1879)
  AUTHORS   Otto,K.B., Acharya,S.S. and Robinson,V.L.
  TITLE     Stress-activated kinase pathway alteration is a frequent event in
            bladder cancer
  JOURNAL   Urol. Oncol. 30 (4), 415-420 (2012)
   PUBMED   22154358
  REMARK    GeneRIF: Data suggest aberrant MAP2K protein (MKK3, MKK4, MKK6, and
            MKK7) expression indicates that altered cellular signal
            transduction mediated via JNK and p38 may be common in bladder
            cancer.
REFERENCE   3  (bases 1 to 1879)
  AUTHORS   Matsumoto,T., Kinoshita,T., Matsuzaka,H., Nakai,R., Kirii,Y.,
            Yokota,K. and Tada,T.
  TITLE     Crystal structure of non-phosphorylated MAP2K6 in a putative
            auto-inhibition state
  JOURNAL   J. Biochem. 151 (5), 541-549 (2012)
   PUBMED   22383536
  REMARK    GeneRIF: crystal structure of human non-phosphorylated MAP2K6
            (npMAP2K6) complexed with an ATP analogue was determined at 2.6 A
            resolution and represents an auto-inhibition state of MAP2K6
REFERENCE   4  (bases 1 to 1879)
  AUTHORS   Ding,N., Wang,F., Han,Y., Xiao,H., Xu,L. and She,S.
  TITLE     Mitogen-activated protein kinase kinase 6 mediates mechanical
            stretch-induced high-mobility group box 1 protein expression in
            pulmonary alveolar epithelial cells
  JOURNAL   J Trauma Acute Care Surg 72 (1), 162-168 (2012)
   PUBMED   21926646
  REMARK    GeneRIF: activation by mechanical stretch induces HMGB1 and
            cytokine expression in A549 cells
REFERENCE   5  (bases 1 to 1879)
  AUTHORS   Galan-Moya,E.M., de la Cruz-Morcillo,M.A., Llanos Valero,M.,
            Callejas-Valera,J.L., Melgar-Rojas,P., Hernadez Losa,J.,
            Salcedo,M., Fernandez-Aramburo,A., Ramon y Cajal,S. and
            Sanchez-Prieto,R.
  TITLE     Balance between MKK6 and MKK3 mediates p38 MAPK associated
            resistance to cisplatin in NSCLC
  JOURNAL   PLoS ONE 6 (12), E28406 (2011)
   PUBMED   22164285
  REMARK    GeneRIF: the balance between MKK6 and MKK3 mediates p38 MAPK
            associated resistance to cisplatin in NSCLC
REFERENCE   6  (bases 1 to 1879)
  AUTHORS   Moriguchi,T., Kuroyanagi,N., Yamaguchi,K., Gotoh,Y., Irie,K.,
            Kano,T., Shirakabe,K., Muro,Y., Shibuya,H., Matsumoto,K.,
            Nishida,E. and Hagiwara,M.
  TITLE     A novel kinase cascade mediated by mitogen-activated protein kinase
            kinase 6 and MKK3
  JOURNAL   J. Biol. Chem. 271 (23), 13675-13679 (1996)
   PUBMED   8663074
REFERENCE   7  (bases 1 to 1879)
  AUTHORS   Stein,B., Brady,H., Yang,M.X., Young,D.B. and Barbosa,M.S.
  TITLE     Cloning and characterization of MEK6, a novel member of the
            mitogen-activated protein kinase kinase cascade
  JOURNAL   J. Biol. Chem. 271 (19), 11427-11433 (1996)
   PUBMED   8626699
REFERENCE   8  (bases 1 to 1879)
  AUTHORS   Raingeaud,J., Whitmarsh,A.J., Barrett,T., Derijard,B. and
            Davis,R.J.
  TITLE     MKK3- and MKK6-regulated gene expression is mediated by the p38
            mitogen-activated protein kinase signal transduction pathway
  JOURNAL   Mol. Cell. Biol. 16 (3), 1247-1255 (1996)
   PUBMED   8622669
REFERENCE   9  (bases 1 to 1879)
  AUTHORS   Han,J., Lee,J.D., Jiang,Y., Li,Z., Feng,L. and Ulevitch,R.J.
  TITLE     Characterization of the structure and function of a novel MAP
            kinase kinase (MKK6)
  JOURNAL   J. Biol. Chem. 271 (6), 2886-2891 (1996)
   PUBMED   8621675
REFERENCE   10 (bases 1 to 1879)
  AUTHORS   Doza,Y.N., Cuenda,A., Thomas,G.M., Cohen,P. and Nebreda,A.R.
  TITLE     Activation of the MAP kinase homologue RK requires the
            phosphorylation of Thr-180 and Tyr-182 and both residues are
            phosphorylated in chemically stressed KB cells
  JOURNAL   FEBS Lett. 364 (2), 223-228 (1995)
   PUBMED   7750576
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB111443.1, BC012009.1 and
            AA932919.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Mar 27, 2006 this sequence version replaced gi:14589899.
            
            Summary: This gene encodes a member of the dual specificity protein
            kinase family, which functions as a mitogen-activated protein (MAP)
            kinase kinase. MAP kinases, also known as extracellular
            signal-regulated kinases (ERKs), act as an integration point for
            multiple biochemical signals. This protein phosphorylates and
            activates p38 MAP kinase in response to inflammatory cytokines or
            environmental stress. As an essential component of p38 MAP kinase
            mediated signal transduction pathway, this gene is involved in many
            cellular processes such as stress induced cell cycle arrest,
            transcription activation and apoptosis. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U39657.1, U39656.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025087 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                DB111443.1         1-90
            91-1553             BC012009.1         1-1463
            1554-1879           AA932919.1         1-326               c
FEATURES             Location/Qualifiers
     source          1..1879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q24.3"
     gene            1..1879
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /note="mitogen-activated protein kinase kinase 6"
                     /db_xref="GeneID:5608"
                     /db_xref="HGNC:6846"
                     /db_xref="HPRD:03155"
                     /db_xref="MIM:601254"
     exon            1..304
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    223..225
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /note="upstream in-frame stop codon"
     variation       238
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371950957"
     variation       240
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376268427"
     variation       283
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201001185"
     variation       285
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369288867"
     CDS             289..1293
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /EC_number="2.7.12.2"
                     /note="protein kinase, mitogen-activated, kinase 6 (MAP
                     kinase kinase 6); MEK 6; MAPKK 6; MAPK/ERK kinase 6; SAPK
                     kinase 3; stress-activated protein kinase kinase 3"
                     /codon_start=1
                     /product="dual specificity mitogen-activated protein
                     kinase kinase 6"
                     /protein_id="NP_002749.2"
                     /db_xref="GI:14589900"
                     /db_xref="CCDS:CCDS11686.1"
                     /db_xref="GeneID:5608"
                     /db_xref="HGNC:6846"
                     /db_xref="HPRD:03155"
                     /db_xref="MIM:601254"
                     /translation="
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
"
     misc_feature    298..345
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P52564.1);
                     Region: D domain (By similarity)"
     misc_feature    328..333
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Cleavage, by anthrax lethal factor; propagated from
                     UniProtKB/Swiss-Prot (P52564.1); cleavage site"
     misc_feature    391..393
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    439..1287
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /note="Catalytic domain of the dual-specificity Protein
                     Kinases, MAP kinase kinases 3 and 6; Region: PKc_MKK3_6;
                     cd06617"
                     /db_xref="CDD:173729"
     misc_feature    448..1230
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    order(451..453,457..459,463..486,490..492,496..498,
                     532..537,541..549,643..645,649..654,658..660,664..666,
                     679..693,712..714,835..840,844..846,874..876,889..891,
                     898..909,1282..1287)
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:173729"
     misc_feature    order(463..477,481..483,487..489,526..528,532..534,
                     625..627,673..684,688..693,697..702,823..825,829..840,
                     844..846,877..879,886..888,925..936,940..942,1033..1035,
                     1060..1062)
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /note="active site"
                     /db_xref="CDD:173729"
     misc_feature    order(463..477,481..483,487..489,526..528,532..534,
                     625..627,673..684,688..693,697..702,829..831,835..840,
                     844..846,877..879)
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173729"
     misc_feature    order(472..477,823..825,829..837,886..888,925..936,
                     940..942,1033..1035,1060..1062)
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173729"
     misc_feature    order(874..921,925..942)
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173729"
     misc_feature    907..909
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="O-acetylserine, by Yersinia yopJ, alternate;
                     propagated from UniProtKB/Swiss-Prot (P52564.1);
                     acetylation site"
     misc_feature    907..909
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by MAP3K, alternate; propagated from
                     UniProtKB/Swiss-Prot (P52564.1); phosphorylation site"
     misc_feature    907..909
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[8]
     misc_feature    919..921
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="O-acetylthreonine, by Yersinia yopJ, alternate;
                     propagated from UniProtKB/Swiss-Prot (P52564.1);
                     acetylation site"
     misc_feature    919..921
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by MAP3K, alternate; propagated
                     from UniProtKB/Swiss-Prot (P52564.1); phosphorylation
                     site"
     misc_feature    919..921
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[8]
     misc_feature    1219..1290
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P52564.1);
                     Region: DVD domain"
     exon            305..371
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /inference="alignment:Splign:1.39.8"
     variation       360
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371065687"
     variation       371
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201975195"
     exon            372..420
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /inference="alignment:Splign:1.39.8"
     variation       379
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1133228"
     variation       411..412
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace=""
                     /replace="tt"
                     /db_xref="dbSNP:10701683"
     variation       420
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139570867"
     exon            421..534
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /inference="alignment:Splign:1.39.8"
     variation       454
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200064105"
     variation       477
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149312985"
     variation       483
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368214335"
     variation       504
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200217272"
     variation       513
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192863519"
     variation       514
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371754193"
     exon            535..654
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /inference="alignment:Splign:1.39.8"
     variation       571
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144625593"
     variation       639
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55977235"
     exon            655..771
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /inference="alignment:Splign:1.39.8"
     variation       718
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373776681"
     variation       723
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144096992"
     variation       756
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185986382"
     exon            772..823
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /inference="alignment:Splign:1.39.8"
     exon            824..951
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /inference="alignment:Splign:1.39.8"
     variation       825
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373722395"
     variation       858
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148709755"
     variation       876
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143627401"
     variation       903
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375580762"
     variation       922
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146813017"
     exon            952..1029
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /inference="alignment:Splign:1.39.8"
     variation       960
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139650968"
     variation       977
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201074921"
     variation       987
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144298611"
     exon            1030..1169
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /inference="alignment:Splign:1.39.8"
     variation       1049
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146595343"
     variation       1107
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:74734606"
     variation       1113
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367955676"
     variation       1123
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371824152"
     exon            1170..1215
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /inference="alignment:Splign:1.39.8"
     variation       1200
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141053342"
     exon            1216..1869
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /inference="alignment:Splign:1.39.8"
     variation       1237
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149844958"
     variation       1265
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202101413"
     STS             1282..1503
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /standard_name="A005K40"
                     /db_xref="UniSTS:17319"
     STS             1282..1503
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /standard_name="G20292"
                     /db_xref="UniSTS:17318"
     variation       1301
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372722559"
     variation       1312
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377469891"
     variation       1325
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370917523"
     variation       1342
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201121602"
     STS             1347..1530
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /standard_name="D17S1471E"
                     /db_xref="UniSTS:151679"
     polyA_signal    1531..1536
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
     variation       1538
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61759602"
     polyA_site      1566
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
     variation       1713
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192617996"
     variation       1739
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:200853345"
     variation       1740
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:58590521"
     variation       1748
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:374066307"
     polyA_site      1869
                     /gene="MAP2K6"
                     /gene_synonym="MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3;
                     SAPKK3"
ORIGIN      
agttccaagtttggagcttttagctgccagccctggcccatcatgtagctgcagcacagccttccctaacgttgcaactgggggaaaaatcactttccagtctgttttgcaaggtgtgcatttccatcttgattccctgaaagtccatctgctgcatcggtcaagagaaactccacttgcatgaagattgcacgcctgcagcttgcatctttgttgcaaaactagctacagaagagaagcaaggcaaagtcttttgtgctcccctcccccatcaaaggaaaggggaaaatgtctcagtcgaaaggcaagaagcgaaaccctggccttaaaattccaaaagaagcatttgaacaacctcagaccagttccacaccacctcgagatttagactccaaggcttgcatttctattggaaatcagaactttgaggtgaaggcagatgacctggagcctataatggaactgggacgaggtgcgtacggggtggtggagaagatgcggcacgtgcccagcgggcagatcatggcagtgaagcggatccgagccacagtaaatagccaggaacagaaacggctactgatggatttggatatttccatgaggacggtggactgtccattcactgtcaccttttatggcgcactgtttcgggagggtgatgtgtggatctgcatggagctcatggatacatcactagataaattctacaaacaagttattgataaaggccagacaattccagaggacatcttagggaaaatagcagtttctattgtaaaagcattagaacatttacatagtaagctgtctgtcattcacagagacgtcaagccttctaatgtactcatcaatgctctcggtcaagtgaagatgtgcgattttggaatcagtggctacttggtggactctgttgctaaaacaattgatgcaggttgcaaaccatacatggcccctgaaagaataaacccagagctcaaccagaagggatacagtgtgaagtctgacatttggagtctgggcatcacgatgattgagttggccatccttcgatttccctatgattcatggggaactccatttcagcagctcaaacaggtggtagaggagccatcgccacaactcccagcagacaagttctctgcagagtttgttgactttacctcacagtgcttaaagaagaattccaaagaacggcctacatacccagagctaatgcaacatccatttttcaccctacatgaatccaaaggaacagatgtggcatcttttgtaaaactgattcttggagactaaaaagcagtggacttaatcggttgaccctactgtggattggtgggtttcggggtgaagcaagttcactacagcatcaatagaaagtcatctttgagataatttaaccctgcctctcagagggttttctctcccaattttctttttactccccctcttaagggggccttggaatctatagtatagaatgaactgtctagatggatgaattatgataaaggcttaggacttcaaaaggtgattaaatatttaatgatgtgtcatatgagtcctcaagcttctcagacttctcttattctttacaaaatgaatgcattggccctgacaaaaaggtgctacggtagtgatgaaattataagtagatttgtagtttgtcccatttattattttaatatttatgtttaagtgcttggttgaaaagattccattttatacaagaagggagattcaaaaaaaaaatataaggttgggttagcaatatttatagggcttttattttttaagttcaattgtgtctgtggtccagaagaaattatttaatatgcatctttgagaatattataaaaatatcaaaaaggaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5608 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA
            GeneID:5608 -> Molecular function: GO:0004708 [MAP kinase kinase activity] evidence: TAS
            GeneID:5608 -> Molecular function: GO:0004713 [protein tyrosine kinase activity] evidence: IEA
            GeneID:5608 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5608 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:5608 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI
            GeneID:5608 -> Biological process: GO:0000187 [activation of MAPK activity] evidence: TAS
            GeneID:5608 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
            GeneID:5608 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS
            GeneID:5608 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
            GeneID:5608 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:5608 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
            GeneID:5608 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:5608 -> Biological process: GO:0006975 [DNA damage induced protein phosphorylation] evidence: TAS
            GeneID:5608 -> Biological process: GO:0007050 [cell cycle arrest] evidence: TAS
            GeneID:5608 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:5608 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS
            GeneID:5608 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
            GeneID:5608 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
            GeneID:5608 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS
            GeneID:5608 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS
            GeneID:5608 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS
            GeneID:5608 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
            GeneID:5608 -> Biological process: GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] evidence: TAS
            GeneID:5608 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS
            GeneID:5608 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS
            GeneID:5608 -> Biological process: GO:0042493 [response to drug] evidence: IEA
            GeneID:5608 -> Biological process: GO:0042692 [muscle cell differentiation] evidence: TAS
            GeneID:5608 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA
            GeneID:5608 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:5608 -> Biological process: GO:0051149 [positive regulation of muscle cell differentiation] evidence: TAS
            GeneID:5608 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS
            GeneID:5608 -> Biological process: GO:0060048 [cardiac muscle contraction] evidence: IEA
            GeneID:5608 -> Biological process: GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] evidence: TAS
            GeneID:5608 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:5608 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:5608 -> Cellular component: GO:0005856 [cytoskeleton] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_002749 -> EC 2.7.12.2

by @meso_cacase at DBCLS
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