Home |
Help |
Advanced search
2024-04-24 22:23:48, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002749 2972 bp mRNA linear PRI 16-JUN-2013
DEFINITION Homo sapiens mitogen-activated protein kinase 7 (MAPK7), transcript
variant 3, mRNA.
ACCESSION NM_002749
VERSION NM_002749.3 GI:209529737
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2972)
AUTHORS Erazo,T., Moreno,A., Ruiz-Babot,G., Rodriguez-Asiain,A.,
Morrice,N.A., Espadamala,J., Bayascas,J.R., Gomez,N. and
Lizcano,J.M.
TITLE Canonical and kinase activity-independent mechanisms for
extracellular signal-regulated kinase 5 (ERK5) nuclear
translocation require dissociation of Hsp90 from the ERK5-Cdc37
complex
JOURNAL Mol. Cell. Biol. 33 (8), 1671-1686 (2013)
PUBMED 23428871
REMARK GeneRIF: ERK5 interacts with the Hsp90-Cdc37 chaperone in resting
cells, and inhibition of Hsp90 or Cdc37 results in ERK5
ubiquitylation and proteasomal degradation.
REFERENCE 2 (bases 1 to 2972)
AUTHORS Glatz,G., Gogl,G., Alexa,A. and Remenyi,A.
TITLE Structural mechanism for the specific assembly and activation of
the extracellular signal regulated kinase 5 (ERK5) module
JOURNAL J. Biol. Chem. 288 (12), 8596-8609 (2013)
PUBMED 23382384
REMARK GeneRIF: ERK5 has distinct protein-protein interaction surfaces
compared with ERK2, which is the closest ERK5 paralog.
REFERENCE 3 (bases 1 to 2972)
AUTHORS Ahmad,I., Singh,L.B., Yang,Z.H., Kalna,G., Fleming,J., Fisher,G.,
Cooper,C., Cuzick,J., Berney,D.M., Moller,H., Scardino,P. and
Leung,H.Y.
TITLE Mir143 expression inversely correlates with nuclear ERK5
immunoreactivity in clinical prostate cancer
JOURNAL Br. J. Cancer 108 (1), 149-154 (2013)
PUBMED 23321517
REMARK GeneRIF: we have further validated the potential role of mir143 in
regulating ERK5 levels in the clinical context.
REFERENCE 4 (bases 1 to 2972)
AUTHORS Kim,M., Kim,S., Lim,J.H., Lee,C., Choi,H.C. and Woo,C.H.
TITLE Laminar flow activation of ERK5 protein in vascular endothelium
leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2)
activation
JOURNAL J. Biol. Chem. 287 (48), 40722-40731 (2012)
PUBMED 23043106
REMARK GeneRIF: Laminar flow induces Nrf2 activation dependent on ERK5
activation, leading to up-regulation of Nrf2.
REFERENCE 5 (bases 1 to 2972)
AUTHORS Wilhelmsen,K., Mesa,K.R., Lucero,J., Xu,F. and Hellman,J.
TITLE ERK5 protein promotes, whereas MEK1 protein differentially
regulates, the Toll-like receptor 2 protein-dependent activation of
human endothelial cells and monocytes
JOURNAL J. Biol. Chem. 287 (32), 26478-26494 (2012)
PUBMED 22707717
REMARK GeneRIF: study newly identifies ERK5 as a key regulator of TLR2
signaling in EC and monocytes and indicates that there are
fundamental differences in TLR signaling pathways between EC and
monocytes
REFERENCE 6 (bases 1 to 2972)
AUTHORS Kato,Y., Tapping,R.I., Huang,S., Watson,M.H., Ulevitch,R.J. and
Lee,J.D.
TITLE Bmk1/Erk5 is required for cell proliferation induced by epidermal
growth factor
JOURNAL Nature 395 (6703), 713-716 (1998)
PUBMED 9790194
REFERENCE 7 (bases 1 to 2972)
AUTHORS English,J.M., Pearson,G., Baer,R. and Cobb,M.H.
TITLE Identification of substrates and regulators of the
mitogen-activated protein kinase ERK5 using chimeric protein
kinases
JOURNAL J. Biol. Chem. 273 (7), 3854-3860 (1998)
PUBMED 9461566
REFERENCE 8 (bases 1 to 2972)
AUTHORS Purandare,S.M., Lee,J.D. and Patel,P.I.
TITLE Assignment of big MAP kinase (PRKM7) to human chromosome 17 band
p11.2 with somatic cell hybrids
JOURNAL Cytogenet. Cell Genet. 83 (3-4), 258-259 (1998)
PUBMED 10072598
REFERENCE 9 (bases 1 to 2972)
AUTHORS Lee,J.D., Ulevitch,R.J. and Han,J.
TITLE Primary structure of BMK1: a new mammalian map kinase
JOURNAL Biochem. Biophys. Res. Commun. 213 (2), 715-724 (1995)
PUBMED 7646528
REFERENCE 10 (bases 1 to 2972)
AUTHORS Zhou,G., Bao,Z.Q. and Dixon,J.E.
TITLE Components of a new human protein kinase signal transduction
pathway
JOURNAL J. Biol. Chem. 270 (21), 12665-12669 (1995)
PUBMED 7759517
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA452383.1, BC009963.2 and
BC030134.1.
On Oct 16, 2008 this sequence version replaced gi:20986496.
Summary: The protein encoded by this gene is a member of the MAP
kinase family. MAP kinases act as an integration point for multiple
biochemical signals, and are involved in a wide variety of cellular
processes such as proliferation, differentiation, transcription
regulation and development. This kinase is specifically activated
by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is
involved in the downstream signaling processes of various receptor
molecules including receptor type kinases, and G protein-coupled
receptors. In response to extracelluar signals, this kinase
translocates to cell nucleus, where it regulates gene expression by
phosphorylating, and activating different transcription factors.
Four alternatively spliced transcript variants of this gene
encoding two distinct isoforms have been reported. [provided by
RefSeq, Jul 2008].
Transcript Variant: This variant (3) is also known as BMK1 gamma.
It differs in the 5' UTR, as compared to variant 1. Variants 1, 3
and 4 encode the same isoform.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC009963.2, U25278.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025083 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-68 DA452383.1 1-68
69-2934 BC009963.2 1-2866
2935-2972 BC030134.1 2782-2819
FEATURES Location/Qualifiers
source 1..2972
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17p11.2"
gene 1..2972
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/note="mitogen-activated protein kinase 7"
/db_xref="GeneID:5598"
/db_xref="HGNC:6880"
/db_xref="HPRD:03952"
/db_xref="MIM:602521"
exon 1..170
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/inference="alignment:Splign:1.39.8"
exon 171..407
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/inference="alignment:Splign:1.39.8"
CDS 176..2626
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/EC_number="2.7.11.24"
/note="isoform 1 is encoded by transcript variant 3;
extracellular-signal-regulated kinase 5; BMK1 kinase; big
MAP kinase 1; BMK-1; ERK-5; MAPK 7; MAP kinase 7;
extracellular signal-regulated kinase 5"
/codon_start=1
/product="mitogen-activated protein kinase 7 isoform 1"
/protein_id="NP_002740.2"
/db_xref="GI:20986497"
/db_xref="CCDS:CCDS11206.1"
/db_xref="GeneID:5598"
/db_xref="HGNC:6880"
/db_xref="HPRD:03952"
/db_xref="MIM:602521"
/translation="
MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIATSTSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP
"
misc_feature 179..406
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q13164.2);
Region: Required for cytoplasmic targeting (By
similarity)"
misc_feature 179..181
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylalanine; propagated from
UniProtKB/Swiss-Prot (Q13164.2); acetylation site"
misc_feature 320..1327
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/note="Catalytic domain of the Serine/Threonine Kinase,
Extracellular signal-Regulated Kinase 5; Region:
STKc_ERK5; cd07855"
/db_xref="CDD:173749"
misc_feature 338..1216
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature order(356..367,371..376,380..382,419..421,425..427,
476..478,518..520,584..595,602..604,608..613,719..721,
725..727,731..736,740..742,770..775,782..784,830..832,
836..847,851..853,965..967)
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/note="active site"
/db_xref="CDD:173749"
misc_feature order(356..367,371..376,380..382,419..421,425..427,
518..520,584..595,602..604,611..613,725..727,731..736,
740..742,770..775)
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173749"
misc_feature 407..592
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q13164.2);
Region: Required for binding to MAP2K5 (By similarity)"
misc_feature order(476..478,608..610,719..721,725..727,782..784,
830..832,836..847,851..853,965..967)
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173749"
misc_feature order(509..511,596..601,614..616,647..649,656..658,
677..679,743..757,1223..1225,1229..1231,1238..1240)
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/note="KIM docking site [polypeptide binding]; other site"
/db_xref="CDD:173749"
misc_feature 593..1393
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q13164.2);
Region: Necessary for oligomerization (By similarity)"
misc_feature 770..853
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173749"
misc_feature 830..838
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q13164.2);
Region: TXY"
misc_feature 830..832
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 836..838
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:04169"
misc_feature 836..838
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1394..2593
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q13164.2);
Region: May not be required for kinase activity, required
to stimulate MEF2C activity (By similarity)"
misc_feature 1688..1792
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q13164.2);
Region: Nuclear localization signal (By similarity)"
misc_feature 2333..2335
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13164.2); phosphorylation site"
misc_feature 2372..2374
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q13164.2); phosphorylation site"
STS 333..457
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/standard_name="Mapk7"
/db_xref="UniSTS:516574"
exon 408..573
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/inference="alignment:Splign:1.39.8"
exon 574..1652
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/inference="alignment:Splign:1.39.8"
STS 1066..1534
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/standard_name="MARC_21800-21801:1025034309:1"
/db_xref="UniSTS:268632"
exon 1653..2338
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/inference="alignment:Splign:1.39.8"
exon 2339..2472
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/inference="alignment:Splign:1.39.8"
exon 2473..2939
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/inference="alignment:Splign:1.39.8"
STS 2509..2758
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/standard_name="STS-U29725"
/db_xref="UniSTS:72402"
STS 2642..2838
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/standard_name="RH79913"
/db_xref="UniSTS:87462"
variation complement(2882)
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
/replace="c"
/replace="t"
/db_xref="dbSNP:12073"
polyA_site 2939
/gene="MAPK7"
/gene_synonym="BMK1; ERK4; ERK5; PRKM7"
ORIGIN
agcgtggccttgggaggcggggcggagggggacggacagggcagctcaagacgctgaggtggtggctgcggcctttgaacaagtaagtgagccaccctcggagacccccgcgctggggacgggaggccggcgagcctcgggacctctgaaagccttgaggaggcgcggggacaccatggccgagcctctgaaggaggaagacggcgaggacggctctgcggagccccccgggcccgtgaaggccgaacccgcccacaccgctgcctctgtagcggccaagaacctggccctgcttaaagcccgctccttcgatgtgacctttgacgtgggcgacgagtacgagatcatcgagaccataggcaacggggcctatggagtggtgtcctccgcccgccgccgcctcaccggccagcaggtggccatcaagaagatccctaatgctttcgatgtggtgaccaatgccaagcggaccctcagggagctgaagatcctcaagcactttaaacacgacaacatcatcgccatcaaggacatcctgaggcccaccgtgccctatggcgaattcaaatctgtctacgtggtcctggacctgatggaaagcgacctgcaccagatcatccactcctcacagcccctcacactggaacacgtgcgctacttcctgtaccaactgctgcggggcctgaagtacatgcactcggctcaggtcatccaccgtgacctgaagccctccaacctattggtgaatgagaactgtgagctcaagattggtgactttggtatggctcgtggcctgtgcacctcgcccgctgaacatcagtacttcatgactgagtatgtggccacgcgctggtaccgtgcgcccgagctcatgctctctttgcatgagtatacacaggctattgacctctggtctgtgggctgcatctttggtgagatgctggcccggcgccagctcttcccaggcaaaaactatgtacaccagctacagctcatcatgatggtgctgggtaccccatcaccagccgtgattcaggctgtgggggctgagagggtgcgggcctatatccagagcttgccaccacgccagcctgtgccctgggagacagtgtacccaggtgccgaccgccaggccctatcactgctgggtcgcatgctgcgttttgagcccagcgctcgcatctcagcagctgctgcccttcgccaccctttcctggccaagtaccatgatcctgatgatgagcctgactgtgccccgccctttgactttgcctttgaccgcgaagccctcactcgggagcgcattaaggaggccattgtggctgaaattgaggacttccatgcaaggcgtgagggcatccgccaacagatccgcttccagccttctctacagcctgtggctagtgagcctggctgtccagatgttgaaatgcccagtccctgggctcccagtggggactgtgccatggagtctccaccaccagccccgccaccatgccccggccctgcacctgacaccattgatctgaccctgcagccacctccaccagtcagtgagcctgccccaccaaagaaagatggtgccatctcagacaatactaaggctgcccttaaagctgccctgctcaagtctttgaggagccggctcagagatggccccagcgcacccctggaggctcctgagcctcggaagccggtgacagcccaggagcgccagcgggagcgggaggagaagcggcggaggcggcaagaacgagccaaggagcgggagaaacggcggcaggagcgggagcgaaaggaacggggggctggggcctctgggggcccctccactgaccccttggctggactagtgctcagtgacaatgacagaagcctgttggaacgctggactcgaatggcccggcccgcagccccagccctcacctctgtgccggcccctgccccagcgccaacgccaaccccaaccccagtccaacctaccagtcctcctcctggccctgtagcccagcccactggcccgcaaccacaatctgcgggctctacctctggccctgtaccccagcctgcctgcccaccccctggccctgcaccccaccccactggccctcctgggcccatccctgtccccgcgccaccccagattgccacctccaccagcctcctggctgcccagtcacttgtgccaccccctgggctgcctggctccagcaccccaggagttttgccttacttcccacctggcctgccgcccccagacgccgggggagcccctcagtcttccatgtcagagtcacctgatgtcaaccttgtgacccagcagctatctaagtcacaggtggaggaccccctgccccctgtgttctcaggcacaccaaagggcagtggggctggctacggtgttggctttgacctggaggaattcttaaaccagtctttcgacatgggcgtggctgatgggccacaggatggccaggcagattcagcctctctctcagcctccctgcttgctgactggctcgaaggccatggcatgaaccctgccgatattgagtccctgcagcgtgagatccagatggactccccaatgctgctggctgacctgcctgacctccaggacccctgaggcccccagcctgtgccttgctgccacagtagacctagttccaggatccatgggagcattctcaaaggctttagccctggacccagcaggtgaggctcggcttggattattctgcaggttcatctcagacccacctttcagccttaagcagccacctgagccaccaccgagccatggcaggatcgggagaccccaactccccctgaacaatccttttcagtattatatttttattattattatgttattattacactgtctttttgccatcaaaatgaggcctgtgaaatacaaggttcccttctgcacctgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5598 -> Molecular function: GO:0004707 [MAP kinase activity] evidence: IEA
GeneID:5598 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5598 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:5598 -> Molecular function: GO:0051019 [mitogen-activated protein kinase binding] evidence: IPI
GeneID:5598 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
GeneID:5598 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:5598 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
GeneID:5598 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:5598 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:5598 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:5598 -> Biological process: GO:0018105 [peptidyl-serine phosphorylation] evidence: IEA
GeneID:5598 -> Biological process: GO:0019933 [cAMP-mediated signaling] evidence: NAS
GeneID:5598 -> Biological process: GO:0030154 [cell differentiation] evidence: IEA
GeneID:5598 -> Biological process: GO:0030821 [negative regulation of cAMP catabolic process] evidence: NAS
GeneID:5598 -> Biological process: GO:0034115 [negative regulation of heterotypic cell-cell adhesion] evidence: IGI
GeneID:5598 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS
GeneID:5598 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
GeneID:5598 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
GeneID:5598 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS
GeneID:5598 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS
GeneID:5598 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS
GeneID:5598 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:5598 -> Biological process: GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] evidence: IMP
GeneID:5598 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS
GeneID:5598 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS
GeneID:5598 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:5598 -> Biological process: GO:0045765 [regulation of angiogenesis] evidence: IEA
GeneID:5598 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IGI
GeneID:5598 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:5598 -> Biological process: GO:0050728 [negative regulation of inflammatory response] evidence: TAS
GeneID:5598 -> Biological process: GO:0051247 [positive regulation of protein metabolic process] evidence: IGI
GeneID:5598 -> Biological process: GO:0051344 [negative regulation of cyclic-nucleotide phosphodiesterase activity] evidence: NAS
GeneID:5598 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS
GeneID:5598 -> Biological process: GO:0051534 [negative regulation of NFAT protein import into nucleus] evidence: IEA
GeneID:5598 -> Biological process: GO:0060761 [negative regulation of response to cytokine stimulus] evidence: IGI
GeneID:5598 -> Biological process: GO:0070301 [cellular response to hydrogen peroxide] evidence: IMP
GeneID:5598 -> Biological process: GO:0071363 [cellular response to growth factor stimulus] evidence: IGI
GeneID:5598 -> Biological process: GO:0071499 [cellular response to laminar fluid shear stress] evidence: IMP
GeneID:5598 -> Biological process: GO:0071499 [cellular response to laminar fluid shear stress] evidence: TAS
GeneID:5598 -> Biological process: GO:0071560 [cellular response to transforming growth factor beta stimulus] evidence: IDA
GeneID:5598 -> Biological process: GO:1902176 [negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress] evidence: IMP
GeneID:5598 -> Biological process: GO:2000352 [negative regulation of endothelial cell apoptotic process] evidence: IMP
GeneID:5598 -> Biological process: GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] evidence: IGI
GeneID:5598 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:5598 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:5598 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:5598 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
GeneID:5598 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5598 -> Cellular component: GO:0016605 [PML body] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_002740 -> EC 2.7.11.24
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.