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2024-04-19 04:14:58, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002745 5916 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens mitogen-activated protein kinase 1 (MAPK1), transcript
variant 1, mRNA.
ACCESSION NM_002745
VERSION NM_002745.4 GI:75709178
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5916)
AUTHORS Piechota-Polanczyk,A., Demyanets,S., Nykonenko,O., Huk,I.,
Mittlboeck,M., Domenig,C.M., Neumayer,C., Wojta,J., Nanobachvili,J.
and Klinger,M.
TITLE Decreased tissue levels of cyclophilin A, a cyclosporine a target
and phospho-ERK1/2 in simvastatin patients with abdominal aortic
aneurysm
JOURNAL Eur J Vasc Endovasc Surg 45 (6), 682-688 (2013)
PUBMED 23558220
REMARK GeneRIF: Simvastatin-treated patients with abdominal aortic
aneurysms exert lower CyPA mRNA/protein levels and a decreased
amount of phospho-ERK1/2.
REFERENCE 2 (bases 1 to 5916)
AUTHORS Suen,K.M., Lin,C.C., George,R., Melo,F.A., Biggs,E.R., Ahmed,Z.,
Drake,M.N., Arur,S., Arold,S.T. and Ladbury,J.E.
TITLE Interaction with Shc prevents aberrant Erk activation in the
absence of extracellular stimuli
JOURNAL Nat. Struct. Mol. Biol. 20 (5), 620-627 (2013)
PUBMED 23584453
REMARK GeneRIF: The Shc-Erk complex restricts Erk nuclear translocation,
restraining Erk-dependent transcription of genes, including those
responsible for oncogenic growth.
REFERENCE 3 (bases 1 to 5916)
AUTHORS Ruppert,C., Deiss,K., Herrmann,S., Vidal,M., Oezkur,M., Gorski,A.,
Weidemann,F., Lohse,M.J. and Lorenz,K.
TITLE Interference with ERK(Thr188) phosphorylation impairs pathological
but not physiological cardiac hypertrophy
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (18), 7440-7445 (2013)
PUBMED 23589880
REMARK GeneRIF: Interference with ERK(Thr188) phosphorylation permits the
impairment of ERK1/2-mediated cardiac hypertrophy without
increasing cardiomyocyte death.
REFERENCE 4 (bases 1 to 5916)
AUTHORS Yu,J.W., Farias,A., Hwang,I., Fernandes-Alnemri,T. and Alnemri,E.S.
TITLE Ribotoxic stress through p38 mitogen-activated protein kinase
activates in vitro the human pyrin inflammasome
JOURNAL J. Biol. Chem. 288 (16), 11378-11383 (2013)
PUBMED 23479736
REMARK GeneRIF: ribotoxic stress activates the human pyrin inflammasome
through a mechanism that requires p38 MAPK signaling and
microtubule stability.
REFERENCE 5 (bases 1 to 5916)
AUTHORS Ratajczak-Wrona,W., Jablonska,E., Garley,M., Jablonski,J. and
Radziwon,P.
TITLE Role of ERK1/2 kinase in the expression of iNOS by NDMA in human
neutrophils
JOURNAL Indian J. Exp. Biol. 51 (1), 73-80 (2013)
PUBMED 23441482
REMARK GeneRIF: in human neutrophils, ERK1/2 kinase is not directly
involved in the regulation of iNOS and NO production induced by
NDMA; however, the kinase participates in superoxide anion
production in these cells
REFERENCE 6 (bases 1 to 5916)
AUTHORS Goedert,M., Cohen,E.S., Jakes,R. and Cohen,P.
TITLE p42 MAP kinase phosphorylation sites in microtubule-associated
protein tau are dephosphorylated by protein phosphatase 2A1.
Implications for Alzheimer's disease [corrected]
JOURNAL FEBS Lett. 312 (1), 95-99 (1992)
PUBMED 1330687
REMARK Erratum:[FEBS Lett 1992 Nov 23;313(2):203]
REFERENCE 7 (bases 1 to 5916)
AUTHORS Rossomando,A.J., Wu,J., Michel,H., Shabanowitz,J., Hunt,D.F.,
Weber,M.J. and Sturgill,T.W.
TITLE Identification of Tyr-185 as the site of tyrosine
autophosphorylation of recombinant mitogen-activated protein kinase
p42mapk
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (13), 5779-5783 (1992)
PUBMED 1378617
REFERENCE 8 (bases 1 to 5916)
AUTHORS Gonzalez,F.A., Raden,D.L., Rigby,M.R. and Davis,R.J.
TITLE Heterogeneous expression of four MAP kinase isoforms in human
tissues
JOURNAL FEBS Lett. 304 (2-3), 170-178 (1992)
PUBMED 1319925
REFERENCE 9 (bases 1 to 5916)
AUTHORS Owaki,H., Makar,R., Boulton,T.G., Cobb,M.H. and Geppert,T.D.
TITLE Extracellular signal-regulated kinases in T cells: characterization
of human ERK1 and ERK2 cDNAs
JOURNAL Biochem. Biophys. Res. Commun. 182 (3), 1416-1422 (1992)
PUBMED 1540184
REFERENCE 10 (bases 1 to 5916)
AUTHORS Chan,J. and Watt,V.M.
TITLE eek and erk, new members of the eph subclass of receptor
protein-tyrosine kinases
JOURNAL Oncogene 6 (6), 1057-1061 (1991)
PUBMED 1648701
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC017832.1, BC099905.1,
AP000555.1, AP000554.1 and AP000553.1.
This sequence is a reference standard in the RefSeqGene project.
On Sep 15, 2005 this sequence version replaced gi:66932915.
Summary: The protein encoded by this gene is a member of the MAP
kinase family. MAP kinases, also known as extracellular
signal-regulated kinases (ERKs), act as an integration point for
multiple biochemical signals, and are involved in a wide variety of
cellular processes such as proliferation, differentiation,
transcription regulation and development. The activation of this
kinase requires its phosphorylation by upstream kinases. Upon
activation, this kinase translocates to the nucleus of the
stimulated cells, where it phosphorylates nuclear targets. Two
alternatively spliced transcript variants encoding the same
protein, but differing in the UTRs, have been reported for this
gene. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) represents the longer
transcript. Both variants 1 and 2 encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC099905.1, Z11694.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1332 BC017832.1 1-1332
1333-3285 BC099905.1 1298-3250
3286-3428 AP000555.1 587-729 c
3429-4827 AP000554.1 358-1756 c
4828-5916 AP000553.1 163858-164946 c
FEATURES Location/Qualifiers
source 1..5916
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="22"
/map="22q11.21"
gene 1..5916
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/note="mitogen-activated protein kinase 1"
/db_xref="GeneID:5594"
/db_xref="HGNC:6871"
/db_xref="HPRD:01496"
/db_xref="MIM:176948"
exon 1..359
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/inference="alignment:Splign:1.39.8"
variation 112
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="a"
/replace="c"
/db_xref="dbSNP:61762565"
variation 114
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="g"
/replace="t"
/db_xref="dbSNP:61762566"
misc_feature 178..180
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/note="upstream in-frame stop codon"
CDS 241..1323
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/EC_number="2.7.11.24"
/note="protein tyrosine kinase ERK2; extracellular
signal-regulated kinase 2; mitogen-activated protein
kinase 2; ERK-2; MAPK 2; p42-MAPK; MAP kinase 1; MAP
kinase 2; MAP kinase isoform p42"
/codon_start=1
/product="mitogen-activated protein kinase 1"
/protein_id="NP_002736.3"
/db_xref="GI:66932916"
/db_xref="CCDS:CCDS13795.1"
/db_xref="GeneID:5594"
/db_xref="HGNC:6871"
/db_xref="HPRD:01496"
/db_xref="MIM:176948"
/translation="
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
"
misc_feature 244..246
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylalanine; propagated from
UniProtKB/Swiss-Prot (P28482.3); acetylation site"
misc_feature 295..1233
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/note="Catalytic domain of Extracellular signal-Regulated
Kinase 1 and 2-like Serine/Threonine Kinases; Region:
STKc_ERK1_2_like; cd07849"
/db_xref="CDD:143354"
misc_feature 313..1179
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:214567"
misc_feature 325..327
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by SGK1; propagated from
UniProtKB/Swiss-Prot (P28482.3); phosphorylation site"
misc_feature 325..327
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01265"
misc_feature order(331..342,346..351,355..357,394..396,400..402,
448..450,490..492,553..564,571..573,577..582,685..687,
691..693,697..702,706..708,736..741,748..750,793..795,
799..810,814..816,928..930)
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/note="active site"
/db_xref="CDD:143354"
misc_feature order(331..342,346..351,355..357,394..396,400..402,
490..492,553..564,571..573,580..582,697..702,706..708,
736..741)
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:143354"
misc_feature 361..363
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[7]
/db_xref="HPRD:01496"
misc_feature order(448..450,577..579,685..687,691..693,748..750,
793..795,799..810,814..816,928..930)
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:143354"
misc_feature order(481..483,565..570,580..585,592..597,610..615,
622..624,631..633,643..645,709..726,1186..1188,1192..1194,
1201..1203)
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/note="KIM docking site [polypeptide binding]; other site"
/db_xref="CDD:143354"
misc_feature 553..564
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P28482.3);
Region: Inhibitor-binding"
misc_feature 697..702
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P28482.3);
Region: Inhibitor-binding"
misc_feature 736..816
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/note="activation loop (A-loop); other site"
/db_xref="CDD:143354"
misc_feature 793..801
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P28482.3);
Region: TXY"
misc_feature 793..795
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by MAP2K1 and MAP2K2; propagated
from UniProtKB/Swiss-Prot (P28482.3); phosphorylation
site"
misc_feature 793..795
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[7]
/db_xref="HPRD:01496"
misc_feature 799..801
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:01477"
misc_feature 799..801
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:02956"
misc_feature 799..801
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by MAP2K1 and MAP2K2; propagated
from UniProtKB/Swiss-Prot (P28482.3); phosphorylation
site"
misc_feature 799..801
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[7]
/db_xref="HPRD:01496"
misc_feature 799..801
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01266"
misc_feature 799..801
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01469"
misc_feature 808..810
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (P28482.3); phosphorylation site"
misc_feature 853..855
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 976..978
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P28482.3); phosphorylation site"
misc_feature 982..984
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P28482.3); phosphorylation site"
misc_feature 1090..1092
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P28482.3); phosphorylation site"
misc_feature 1192..1206
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P28482.3);
Region: Cytoplasmic retention motif"
misc_feature 1219..1239
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P28482.3);
Region: Nuclear translocation motif"
exon 360..542
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/inference="alignment:Splign:1.39.8"
variation 369
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3729910"
exon 543..732
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/inference="alignment:Splign:1.39.8"
exon 733..849
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/inference="alignment:Splign:1.39.8"
exon 850..964
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/inference="alignment:Splign:1.39.8"
variation 909
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1048748"
variation 954
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1130164"
exon 965..1096
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/inference="alignment:Splign:1.39.8"
exon 1097..1206
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/inference="alignment:Splign:1.39.8"
STS 1147..1352
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/standard_name="Mapk1"
/db_xref="UniSTS:143825"
variation 1203
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1803545"
exon 1207..1332
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/inference="alignment:Splign:1.39.8"
exon 1333..5916
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/inference="alignment:Splign:1.39.8"
variation 1429
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1048752"
variation 1452
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="g"
/replace="t"
/db_xref="dbSNP:1803546"
variation 1950
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="a"
/replace="g"
/db_xref="dbSNP:61757972"
STS 2355..3214
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/standard_name="MAPK1_V207"
/db_xref="UniSTS:277477"
variation 2360
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="g"
/replace="t"
/db_xref="dbSNP:13058"
polyA_signal 2423..2428
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
polyA_site 2443
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
STS 2743..3024
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/standard_name="SHGC-172572"
/db_xref="UniSTS:183602"
polyA_signal 2960..2965
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
polyA_site 2990
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
STS 3153..3255
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/standard_name="D22S1022E"
/db_xref="UniSTS:150803"
variation 3395
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1063311"
variation 3660
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="c"
/replace="g"
/db_xref="dbSNP:13943"
variation 3667
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="c"
/replace="t"
/db_xref="dbSNP:61757974"
STS 3687..3809
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/standard_name="D22S1011E"
/db_xref="UniSTS:150799"
variation 3872
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="a"
/replace="t"
/db_xref="dbSNP:61757975"
variation 3976
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="a"
/replace="g"
/db_xref="dbSNP:13515"
variation 4077
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="a"
/replace="g"
/db_xref="dbSNP:61757976"
variation 4340
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="c"
/replace="g"
/db_xref="dbSNP:12682"
variation 4509
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="c"
/replace="t"
/db_xref="dbSNP:9340"
variation 4764
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="a"
/replace="g"
/db_xref="dbSNP:61757977"
variation 4804
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="c"
/replace="t"
/db_xref="dbSNP:61757978"
variation 4858
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="c"
/replace="g"
/db_xref="dbSNP:6928"
variation 5042
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="a"
/replace="g"
/db_xref="dbSNP:61757979"
STS 5154..5255
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/standard_name="G30303"
/db_xref="UniSTS:81521"
polyA_signal 5224..5229
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
polyA_site 5257
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/experiment="experimental evidence, no additional details
recorded"
variation 5264
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370201883"
variation 5459
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="c"
/replace="g"
/db_xref="dbSNP:61757980"
variation 5463
/gene="MAPK1"
/gene_synonym="ERK; ERK2; ERT1; MAPK2; p38; p40; p41;
p41mapk; P42MAPK; PRKM1; PRKM2"
/replace="c"
/replace="g"
/db_xref="dbSNP:61757981"
ORIGIN
gcccctccctccgcccgcccgccggcccgcccgtcagtctggcaggcaggcaggcaatcggtccgagtggctgtcggctcttcagctctcccgctcggcgtcttccttcctcctcccggtcagcgtcggcggctgcaccggcggcggcgcagtccctgcgggaggggcgacaagagctgagcggcggccgccgagcgtcgagctcagcgcggcggaggcggcggcggcccggcagccaacatggcggcggcggcggcggcgggcgcgggcccggagatggtccgcgggcaggtgttcgacgtggggccgcgctacaccaacctctcgtacatcggcgagggcgcctacggcatggtgtgctctgcttatgataatgtcaacaaagttcgagtagctatcaagaaaatcagcccctttgagcaccagacctactgccagagaaccctgagggagataaaaatcttactgcgcttcagacatgagaacatcattggaatcaatgacattattcgagcaccaaccatcgagcaaatgaaagatgtatatatagtacaggacctcatggaaacagatctttacaagctcttgaagacacaacacctcagcaatgaccatatctgctattttctctaccagatcctcagagggttaaaatatatccattcagctaacgttctgcaccgtgacctcaagccttccaacctgctgctcaacaccacctgtgatctcaagatctgtgactttggcctggcccgtgttgcagatccagaccatgatcacacagggttcctgacagaatatgtggccacacgttggtacagggctccagaaattatgttgaattccaagggctacaccaagtccattgatatttggtctgtaggctgcattctggcagaaatgctttctaacaggcccatctttccagggaagcattatcttgaccagctgaaccacattttgggtattcttggatccccatcacaagaagacctgaattgtataataaatttaaaagctaggaactatttgctttctcttccacacaaaaataaggtgccatggaacaggctgttcccaaatgctgactccaaagctctggacttattggacaaaatgttgacattcaacccacacaagaggattgaagtagaacaggctctggcccacccatatctggagcagtattacgacccgagtgacgagcccatcgccgaagcaccattcaagttcgacatggaattggatgacttgcctaaggaaaagctcaaagaactaatttttgaagagactgctagattccagccaggatacagatcttaaatttgtcaggacaagggctcagaggactggacgtgctcagacatcggtgttcttcttcccagttcttgacccctggtcctgtctccagcccgtcttggcttatccactttgactcctttgagccgtttggaggggcggtttctggtagttgtggcttttatgctttcaaagaatttcttcagtccagagaattcctcctggcagccctgtgtgtgtcacccattggtgacctgcggcagtatgtacttcagtgcacctactgcttactgttgctttagtcactaattgctttctggtttgaaagatgcagtggttcctccctctcctgaatccttttctacatgatgccctgctgaccatgcagccgcaccagagagagattcttccccaattggctctagtcactggcatctcactttatgatagggaaggctactacctagggcactttaagtcagtgacagccccttatttgcacttcaccttttgaccataactgtttccccagagcaggagcttgtggaaataccttggctgatgttgcagcctgcagcaagtgcttccgtctccggaatccttggggagcacttgtccacgtcttttctcatatcatggtagtcactaacatatataaggtatgtgctattggcccagcttttagaaaatgcagtcatttttctaaataaaaaggaagtactgcacccagcagtgtcactctgtagttactgtggtcacttgtaccatatagaggtgtaacacttgtcaagaagcgttatgtgcagtacttaatgtttgtaagacttacaaaaaaagatttaaagtggcagcttcactcgacatttggtgagagaagtacaaaggttgcagtgctgagctgtgggcggtttctggggatgtcccagggtggaactccacatgctggtgcatatacgcccttgagctacttcaaatgtgggtgtttcagtaaccacgttccatgcctgaggatttagcagagaggaacactgcgtctttaaatgagaaagtatacaattctttttccttctacagcatgtcagcatctcaagttcatttttcaacctacagtataacaatttgtaataaagcctccaggagctcatgacgtgaagcactgttctgtcctcaagtactcaaatatttctgatactgctgagtcagactgtcagaaaaagctagcactaactcgtgtttggagctctatccatattttactgatctctttaagtatttgttcctgccactgtgtactgtggagttgactcggtgttctgtcccagtgcggtgcctcctcttgacttccccactgctctctgtggtgagaaatttgccttgttcaataattactgtaccctcgcatgactgttacagctttctgtgcagagatgactgtccaagtgccacatgcctacgattgaaatgaaaactctattgttacctctgagttgtgttccacggaaaatgctatccagcagatcatttaggaaaaataattctatttttagcttttcatttctcagctgtccttttttcttgtttgatttttgacagcaatggagaatgggttatataaagactgcctgctaatatgaacagaaatgcatttgtaattcatgaaaataaatgtacatcttctatcttcacattcatgttaagattcagtgttgctttcctctggatcagcgtgtctgaatggacagtcaggttcaggttgtgctgaacacagaaatgctcacaggcctcactttgccgcccaggcactggcccagcacttggatttacataagatgagttagaaaggtacttctgtagggtcctttttacctctgctcggcagagaatcgatgctgtcatgttcctttattcacaatcttaggtctcaaatattctgtcaaaccctaacaaagaagccccgacatctcaggttggattccctggttctctctaaagagggcctgcccttgtgccccagaggtgctgctgggcacagccaagagttgggaagggccgccccacagtacgcagtcctcaccacccagcccagggtgctcacgctcaccactcctgtggctgaggaaggatagctggctcatcctcggaaaacagacccacatctctattcttgccctgaaatacgcgcttttcacttgcgtgctcagagctgccgtctgaaggtccacacagcattgacgggacacagaaatgtgactgttaccggataacactgattagtcagttttcatttataaaaaagcattgacagttttattactcttgtttctttttaaatggaaagttactattataaggttaatttggagtcctcttctaaatagaaaaccatatccttggctactaacatctggagactgtgagctccttcccattccccttcctggtactgtggagtcagattggcatgaaaccactaacttcattctagaatcattgtagccataagttgtgtgctttttattaatcatgccaaacataatgtaactgggcagagaatggtcctaaccaaggtacctatgaaaagcgctagctatcatgtgtagtagatgcatcattttggctcttcttacatttgtaaaaatgtacagattaggtcatcttaattcatattagtgacacggaacagcacctccactatttgtatgttcaaataagctttcagactaatagcttttttggtgtctaaaatgtaagcaaaaaattcctgctgaaacattccagtcctttcatttagtataaaagaaatactgaacaagccagtgggatggaattgaaagaactaatcatgaggactctgtcctgacacaggtcctcaaagctagcagagatacgcagacattgtggcatctgggtagaagaatactgtattgtgtgtgcagtgcacagtgtgtggtgtgtgcacactcattccttctgctcttgggcacaggcagtgggtgtagaggtaaccagtagctttgagaagctacatgtagctcaccagtggttttctctaaggaatcacaaaagtaaactacccaaccacatgccacgtaatatttcagccattcagaggaaactgttttctctttatttgcttatatgttaatatggtttttaaattggtaacttttatatagtatggtaacagtatgttaatacacacatacatacgcacacatgctttgggtccttccataatacttttatatttgtaaatcaatgttttggagcaatcccaagtttaagggaaatatttttgtaaatgtaatggttttgaaaatctgagcaatccttttgcttatacatttttaaagcatttgtgctttaaaattgttatgctggtgtttgaaacatgatactcctgtggtgcagatgagaagctataacagtgaatatgtggtttctcttacgtcatccaccttgacatgatgggtcagaaacaaatggaaatccagagcaagtcctccagggttgcaccaggtttacctaaagcttgttgccttttcttgtgctgtttatgcgtgtagagcactcaagaaagttctgaaactgctttgtatctgctttgtactgttggtgccttcttggtattgtaccccaaaattctgcatagattatttagtataatggtaagttaaaaaatgttaaaggaagattttattaagaatctgaatgtttattcattatattgttacaatttaacattaacatttatttgtggtatttgtgatttggttaatctgtataaaaattgtaagtagaaaggtttatatttcatcttaattcttttgatgttgtaaacgtactttttaaaagatggattatttgaatgtttatggcacctgacttgtaaaaaaaaaaaactacaaaaaaatccttagaatcattaaattgtgtccctgtattaccaaaataacacagcaccgtgcatgtatagtttaattgcagtttcatctgtgaaaacgtgaaattgtctagtccttcgttatgttccccagatgtcttccagatttgctctgcatgtggtaacttgtgttagggctgtgagctgttcctcgagttgaatggggatgtcagtgctcctagggttctccaggtggttcttcagaccttcacctgtgggggggggggtaggcggtgcccacgcccatctcctcatcctcctgaacttctgcaaccccactgctgggcagacatcctgggcaaccccttttttcagagcaagaagtcataaagataggatttcttggacatttggttcttatcaatattgggcattatgtaatgacttatttacaaaacaaagatactggaaaatgttttggatgtggtgttatggaaagagcacaggccttggacccatccagctgggttcagaactaccccctgcttataactgcggctggctgtgggccagtcattctgcgtctctgctttcttcctctgcttcagactgtcagctgtaaagtggaagcaatattacttgccttgtatatggtaaagattataaaaatacatttcaactgttcagcatagtacttcaaagcaagtactcagtaaatagcaagtctttttaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5594 -> Molecular function: GO:0001784 [phosphotyrosine binding] evidence: IEA
GeneID:5594 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:5594 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:5594 -> Molecular function: GO:0004707 [MAP kinase activity] evidence: IEA
GeneID:5594 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5594 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:5594 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IEA
GeneID:5594 -> Molecular function: GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity] evidence: ISS
GeneID:5594 -> Molecular function: GO:0019902 [phosphatase binding] evidence: IPI
GeneID:5594 -> Molecular function: GO:0031435 [mitogen-activated protein kinase kinase kinase binding] evidence: IEA
GeneID:5594 -> Biological process: GO:0000165 [MAPK cascade] evidence: TAS
GeneID:5594 -> Biological process: GO:0000186 [activation of MAPKK activity] evidence: TAS
GeneID:5594 -> Biological process: GO:0000187 [activation of MAPK activity] evidence: TAS
GeneID:5594 -> Biological process: GO:0000189 [MAPK import into nucleus] evidence: IEA
GeneID:5594 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
GeneID:5594 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:5594 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
GeneID:5594 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:5594 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:5594 -> Biological process: GO:0006917 [induction of apoptosis] evidence: TAS
GeneID:5594 -> Biological process: GO:0006935 [chemotaxis] evidence: TAS
GeneID:5594 -> Biological process: GO:0006950 [response to stress] evidence: TAS
GeneID:5594 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IEA
GeneID:5594 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:5594 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:5594 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
GeneID:5594 -> Biological process: GO:0007264 [small GTPase mediated signal transduction] evidence: TAS
GeneID:5594 -> Biological process: GO:0007265 [Ras protein signal transduction] evidence: TAS
GeneID:5594 -> Biological process: GO:0007268 [synaptic transmission] evidence: TAS
GeneID:5594 -> Biological process: GO:0007411 [axon guidance] evidence: TAS
GeneID:5594 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:5594 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IEA
GeneID:5594 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: TAS
GeneID:5594 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS
GeneID:5594 -> Biological process: GO:0009636 [response to toxic substance] evidence: IEA
GeneID:5594 -> Biological process: GO:0009887 [organ morphogenesis] evidence: IEA
GeneID:5594 -> Biological process: GO:0010800 [positive regulation of peptidyl-threonine phosphorylation] evidence: IDA
GeneID:5594 -> Biological process: GO:0018105 [peptidyl-serine phosphorylation] evidence: IDA
GeneID:5594 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:5594 -> Biological process: GO:0019233 [sensory perception of pain] evidence: IEA
GeneID:5594 -> Biological process: GO:0019858 [cytosine metabolic process] evidence: IEA
GeneID:5594 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
GeneID:5594 -> Biological process: GO:0030335 [positive regulation of cell migration] evidence: IEA
GeneID:5594 -> Biological process: GO:0031663 [lipopolysaccharide-mediated signaling pathway] evidence: IEA
GeneID:5594 -> Biological process: GO:0032872 [regulation of stress-activated MAPK cascade] evidence: TAS
GeneID:5594 -> Biological process: GO:0033598 [mammary gland epithelial cell proliferation] evidence: IEA
GeneID:5594 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS
GeneID:5594 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
GeneID:5594 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
GeneID:5594 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS
GeneID:5594 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS
GeneID:5594 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS
GeneID:5594 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:5594 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
GeneID:5594 -> Biological process: GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] evidence: TAS
GeneID:5594 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS
GeneID:5594 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS
GeneID:5594 -> Biological process: GO:0038127 [ERBB signaling pathway] evidence: IDA
GeneID:5594 -> Biological process: GO:0043330 [response to exogenous dsRNA] evidence: IEA
GeneID:5594 -> Biological process: GO:0043627 [response to estrogen stimulus] evidence: IEA
GeneID:5594 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:5594 -> Biological process: GO:0045596 [negative regulation of cell differentiation] evidence: IEA
GeneID:5594 -> Biological process: GO:0045727 [positive regulation of translation] evidence: IEA
GeneID:5594 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IEA
GeneID:5594 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:5594 -> Biological process: GO:0050852 [T cell receptor signaling pathway] evidence: IEA
GeneID:5594 -> Biological process: GO:0050853 [B cell receptor signaling pathway] evidence: IEA
GeneID:5594 -> Biological process: GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] evidence: TAS
GeneID:5594 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS
GeneID:5594 -> Biological process: GO:0051493 [regulation of cytoskeleton organization] evidence: TAS
GeneID:5594 -> Biological process: GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] evidence: TAS
GeneID:5594 -> Biological process: GO:0060716 [labyrinthine layer blood vessel development] evidence: IEA
GeneID:5594 -> Biological process: GO:0070371 [ERK1 and ERK2 cascade] evidence: IDA
GeneID:5594 -> Biological process: GO:0070371 [ERK1 and ERK2 cascade] evidence: TAS
GeneID:5594 -> Biological process: GO:0070849 [response to epidermal growth factor stimulus] evidence: IDA
GeneID:5594 -> Biological process: GO:0072584 [caveolin-mediated endocytosis] evidence: TAS
GeneID:5594 -> Biological process: GO:0090170 [regulation of Golgi inheritance] evidence: TAS
GeneID:5594 -> Biological process: GO:2000641 [regulation of early endosome to late endosome transport] evidence: TAS
GeneID:5594 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:5594 -> Cellular component: GO:0005634 [nucleus] evidence: TAS
GeneID:5594 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:5594 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:5594 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:5594 -> Cellular component: GO:0005739 [mitochondrion] evidence: TAS
GeneID:5594 -> Cellular component: GO:0005769 [early endosome] evidence: TAS
GeneID:5594 -> Cellular component: GO:0005770 [late endosome] evidence: TAS
GeneID:5594 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: TAS
GeneID:5594 -> Cellular component: GO:0005815 [microtubule organizing center] evidence: IEA
GeneID:5594 -> Cellular component: GO:0005819 [spindle] evidence: IEA
GeneID:5594 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5594 -> Cellular component: GO:0005856 [cytoskeleton] evidence: TAS
GeneID:5594 -> Cellular component: GO:0005901 [caveola] evidence: TAS
GeneID:5594 -> Cellular component: GO:0005925 [focal adhesion] evidence: TAS
GeneID:5594 -> Cellular component: GO:0015630 [microtubule cytoskeleton] evidence: IDA
GeneID:5594 -> Cellular component: GO:0031143 [pseudopodium] evidence: IEA
GeneID:5594 -> Cellular component: GO:0032839 [dendrite cytoplasm] evidence: IEA
GeneID:5594 -> Cellular component: GO:0043204 [perikaryon] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_002736 -> EC 2.7.11.24
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.