LOCUS       NM_002729               1772 bp    mRNA    linear   PRI 11-MAY-2013
DEFINITION  Homo sapiens hematopoietically expressed homeobox (HHEX), mRNA.
ACCESSION   NM_002729 NM_001529
VERSION     NM_002729.4  GI:126131100
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1772)
  AUTHORS   Gamboa-Melendez,M.A., Huerta-Chagoya,A., Moreno-Macias,H.,
            Vazquez-Cardenas,P., Ordonez-Sanchez,M.L., Rodriguez-Guillen,R.,
            Riba,L., Rodriguez-Torres,M., Guerra-Garcia,M.T.,
            Guillen-Pineda,L.E., Choudhry,S., Del Bosque-Plata,L.,
            Canizales-Quinteros,S., Perez-Ortiz,G., Escobedo-Aguirre,F.,
            Parra,A., Lerman-Garber,I., Aguilar-Salinas,C.A. and
            Tusie-Luna,M.T.
  TITLE     Contribution of common genetic variation to the risk of type 2
            diabetes in the Mexican Mestizo population
  JOURNAL   Diabetes 61 (12), 3314-3321 (2012)
   PUBMED   22923468
  REMARK    GeneRIF: Association to type 2 diabetes was found for rs13266634
            (SLC30A8), rs7923837 (HHEX), rs10811661 (CDKN2A/2B), rs4402960
            (IGF2BP2), rs12779790 (CDC123/CAMK1D), and rs2237892 (KCNQ1).
REFERENCE   2  (bases 1 to 1772)
  AUTHORS   Noy,P., Gaston,K. and Jayaraman,P.S.
  TITLE     Dasatinib inhibits leukaemic cell survival by decreasing PRH/Hhex
            phosphorylation resulting in increased repression of VEGF
            signalling genes
  JOURNAL   Leuk. Res. 36 (11), 1434-1437 (2012)
   PUBMED   22874537
  REMARK    GeneRIF: re-establishment of gene control by PRH is in part
            responsible for the therapeutic effects of dasatinib.
REFERENCE   3  (bases 1 to 1772)
  AUTHORS   Perry,J.R., Voight,B.F., Yengo,L., Amin,N., Dupuis,J., Ganser,M.,
            Grallert,H., Navarro,P., Li,M., Qi,L., Steinthorsdottir,V.,
            Scott,R.A., Almgren,P., Arking,D.E., Aulchenko,Y., Balkau,B.,
            Benediktsson,R., Bergman,R.N., Boerwinkle,E., Bonnycastle,L.,
            Burtt,N.P., Campbell,H., Charpentier,G., Collins,F.S., Gieger,C.,
            Green,T., Hadjadj,S., Hattersley,A.T., Herder,C., Hofman,A.,
            Johnson,A.D., Kottgen,A., Kraft,P., Labrune,Y., Langenberg,C.,
            Manning,A.K., Mohlke,K.L., Morris,A.P., Oostra,B., Pankow,J.,
            Petersen,A.K., Pramstaller,P.P., Prokopenko,I., Rathmann,W.,
            Rayner,W., Roden,M., Rudan,I., Rybin,D., Scott,L.J., Sigurdsson,G.,
            Sladek,R., Thorleifsson,G., Thorsteinsdottir,U., Tuomilehto,J.,
            Uitterlinden,A.G., Vivequin,S., Weedon,M.N., Wright,A.F., Hu,F.B.,
            Illig,T., Kao,L., Meigs,J.B., Wilson,J.F., Stefansson,K., van
            Duijn,C., Altschuler,D., Morris,A.D., Boehnke,M., McCarthy,M.I.,
            Froguel,P., Palmer,C.N., Wareham,N.J., Groop,L., Frayling,T.M. and
            Cauchi,S.
  CONSRTM   MAGIC; DIAGRAM Consortium; GIANT Consortium
  TITLE     Stratifying type 2 diabetes cases by BMI identifies genetic risk
            variants in LAMA1 and enrichment for risk variants in lean compared
            to obese cases
  JOURNAL   PLoS Genet. 8 (5), E1002741 (2012)
   PUBMED   22693455
REFERENCE   4  (bases 1 to 1772)
  AUTHORS   Li,X., Li,Y., Song,B., Guo,S., Chu,S., Jia,N. and Niu,W.
  TITLE     Hematopoietically-expressed homeobox gene three widely-evaluated
            polymorphisms and risk for diabetes: a meta-analysis
  JOURNAL   PLoS ONE 7 (11), E49917 (2012)
   PUBMED   23166797
  REMARK    GeneRIF: A significant association of rs1111875, rs5015480 and
            rs7923837 in HHEX gene with type 2 diabetes.
REFERENCE   5  (bases 1 to 1772)
  AUTHORS   Shukla,A., Burton,N.M., Jayaraman,P.S. and Gaston,K.
  TITLE     The proline rich homeodomain protein PRH/Hhex forms stable
            oligomers that are highly resistant to denaturation
  JOURNAL   PLoS ONE 7 (4), E35984 (2012)
   PUBMED   22540015
  REMARK    GeneRIF: The proline rich homeodomain protein PRH/Hhex forms
            predominantly octameric and/or hexadecameric species in solution as
            well as larger assemblies.
REFERENCE   6  (bases 1 to 1772)
  AUTHORS   Manfioletti,G., Gattei,V., Buratti,E., Rustighi,A., De Iuliis,A.,
            Aldinucci,D., Goodwin,G.H. and Pinto,A.
  TITLE     Differential expression of a novel proline-rich homeobox gene (Prh)
            in human hematolymphopoietic cells
  JOURNAL   Blood 85 (5), 1237-1245 (1995)
   PUBMED   7858254
REFERENCE   7  (bases 1 to 1772)
  AUTHORS   Neidle,S. and Goodwin,G.H.
  TITLE     A homology-based molecular model of the proline-rich homeodomain
            protein Prh, from haematopoietic cells
  JOURNAL   FEBS Lett. 345 (2-3), 93-98 (1994)
   PUBMED   7911091
  REMARK    Review article
REFERENCE   8  (bases 1 to 1772)
  AUTHORS   Hromas,R., Radich,J. and Collins,S.
  TITLE     PCR cloning of an orphan homeobox gene (PRH) preferentially
            expressed in myeloid and liver cells
  JOURNAL   Biochem. Biophys. Res. Commun. 195 (2), 976-983 (1993)
   PUBMED   8103988
REFERENCE   9  (bases 1 to 1772)
  AUTHORS   Bedford,F.K., Ashworth,A., Enver,T. and Wiedemann,L.M.
  TITLE     HEX: a novel homeobox gene expressed during haematopoiesis and
            conserved between mouse and human
  JOURNAL   Nucleic Acids Res. 21 (5), 1245-1249 (1993)
   PUBMED   8096636
REFERENCE   10 (bases 1 to 1772)
  AUTHORS   Crompton,M.R., Bartlett,T.J., MacGregor,A.D., Manfioletti,G.,
            Buratti,E., Giancotti,V. and Goodwin,G.H.
  TITLE     Identification of a novel vertebrate homeobox gene expressed in
            haematopoietic cells
  JOURNAL   Nucleic Acids Res. 20 (21), 5661-5667 (1992)
   PUBMED   1360645
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB504532.1, BC015110.1 and
            BM543214.1.
            On Feb 23, 2007 this sequence version replaced gi:84043965.
            
            Summary: This gene encodes a member of the homeobox family of
            transcription factors, many of which are involved in developmental
            processes. Expression in specific hematopoietic lineages suggests
            that this protein may play a role in hematopoietic differentiation.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015110.1, X67235.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025083, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DB504532.1         1-31
            32-1754             BC015110.1         5-1727
            1755-1772           BM543214.1         247-264
FEATURES             Location/Qualifiers
     source          1..1772
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     gene            1..1772
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /note="hematopoietically expressed homeobox"
                     /db_xref="GeneID:3087"
                     /db_xref="HGNC:4901"
                     /db_xref="HPRD:06829"
                     /db_xref="MIM:604420"
     exon            1..424
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    10..12
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /note="upstream in-frame stop codon"
     variation       18
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:191640546"
     variation       53
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117639730"
     CDS             64..876
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /note="homeobox, hematopoietically expressed; proline-rich
                     homeodomain-containing transcription factor; homeobox
                     protein HEX; homeobox protein PRH"
                     /codon_start=1
                     /product="hematopoietically-expressed homeobox protein
                     HHEX"
                     /protein_id="NP_002720.1"
                     /db_xref="GI:4506049"
                     /db_xref="CCDS:CCDS7423.1"
                     /db_xref="GeneID:3087"
                     /db_xref="HGNC:4901"
                     /db_xref="HPRD:06829"
                     /db_xref="MIM:604420"
                     /translation="

MQYPHPGPAAGAVGVPLYAPTPLLQPAHPTPFYIEDILGRGPAAPTPAPTLPSPNSSFTSLVSPYRTPVYEPTPIHPAFSHHSAAALAAAYGPGGFGGPLYPFPRTVNDYTHALLRHDPLGKPLLWSPFLQRPLHKRKGGQVRFSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQSNKKEELESLDSSCDQRQDLPSEQNKGASLDSSQCSPSPASQEDLESEISEDSDQEVDIEGDKSYFNAG

"
     misc_feature    490..645
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:200956"
     variation       246
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34266926"
     variation       252
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2229328"
     variation       254
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:142036619"
     variation       267
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377053008"
     variation       332
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1418387"
     variation       336
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199544448"
     variation       359
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370000570"
     variation       381
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113121942"
     STS             389..581
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /standard_name="Hhex"
                     /db_xref="UniSTS:516403"
     STS             389..480
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /standard_name="Hhex"
                     /db_xref="UniSTS:525497"
     exon            425..603
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /inference="alignment:Splign:1.39.8"
     variation       460
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150804177"
     variation       543
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201671743"
     variation       574
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17851141"
     exon            604..654
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /inference="alignment:Splign:1.39.8"
     exon            655..1759
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /inference="alignment:Splign:1.39.8"
     variation       668
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139182180"
     variation       704
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:149951495"
     variation       735
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146499847"
     variation       764
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:184882393"
     variation       774
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188232439"
     variation       776
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201876873"
     variation       810
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200052261"
     variation       853
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374722314"
     variation       858
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368062383"
     variation       918
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375633003"
     variation       1041
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181066526"
     variation       1059
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:143956301"
     variation       1144..1145
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace=""
                     /replace="ca"
                     /db_xref="dbSNP:368078419"
     variation       1164
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192493890"
     variation       1165
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147300243"
     variation       1208
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112686755"
     variation       1227
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186360158"
     STS             1304..1520
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /standard_name="SHGC-35774"
                     /db_xref="UniSTS:44520"
     variation       1470
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186282501"
     STS             1496..1739
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /standard_name="RH17624"
                     /db_xref="UniSTS:33759"
     variation       1543
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191529741"
     variation       1573..1574
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:35423905"
     variation       1622
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:183418738"
     variation       1671..1672
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:368502562"
     variation       1692..1693
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:200582511"
     polyA_signal    1723..1728
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
     polyA_site      1748
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
     polyA_site      1755
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
     polyA_site      1759
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
ORIGIN      

ggataaatgtagcgccgcggcgcgggccagcagctctgcgaggggccggagcgcggcggagccatgcagtacccgcaccccgggccggcggcgggcgccgtgggggtgccgctgtacgcgcccacgccgctgctgcaacccgcacacccgacgcccttttacatcgaggacatcctgggccgcgggcccgccgcgcccacgcccgcccccacgctgccgtcccccaactcctccttcaccagcctcgtgtccccctaccggaccccggtgtacgagcccacgccgatccatccagccttctcgcaccactccgccgccgcgctggccgctgcctacggacccggcggcttcgggggccctctgtaccccttcccgcggacggtgaacgactacacgcacgccctgctccgccacgaccccctgggcaaacctctactctggagccccttcttgcagaggcctctgcataaaaggaaaggcggccaggtgagattctccaacgaccagaccatcgagctggagaagaaattcgagacgcagaaatatctctctccgcccgagaggaagcgtctggccaagatgctgcagctcagcgagagacaggtcaaaacctggtttcagaatcgacgcgctaaatggaggagactaaaacaggagaaccctcaaagcaataaaaaagaagaactggaaagtttggacagttcctgtgatcagaggcaagatttgcccagtgaacagaataaaggtgcttctttggatagctctcaatgttcgccctcccctgcctcccaggaagaccttgaatcagagatttcagaggattctgatcaggaagtggacattgagggcgataaaagctattttaatgctggatgatgaccactggcattggcatgttcagaaaactggatttaggaataatgttttgctacagaaaatcttcatagaagaactggaaggctatataagaaagggaatcaattctctggtattctggaaacctaaaaatatttggtgcactgctcaattaacaaacctacatggagaccttaattttgacttaacaaatagtttatgtactgctcttaggttgttttgataaagtgacattatagtgattaaattcttccccctttaaaaaaacagttagtggttttcactatttataaaaaattaattttgaactttttgttaaatttttaagttatagctttaaaggttttaataggaccttcttgaacgacttttctgtaatctgtttatctcccacttaatggaaaggcaaaggggtaccccaaatccagaggtgcctacatttcaggcagccttggagtattttaaaaggaaaacattctttacttttatatgacattcttatactgctgtctcaaatccaaaaacatttcagagctcttgtctcagagatgtgtgttctttttgtcagagatatggttgatgagaatcttaaatgcttgttttgcactatcacttagtacctgtttgaccaaggtgttaaggggatagtacctcccaattcaagcagagaaactgacctgactaaagttaatcgcagatgaactagaagtcacaggttaattaaatgtaagtagattgtagatactgttttatatcaaacaatgtttataatgtgtatatagaattgttcactgtaaaaaaaatggccaaaatgtgttttttttttaataagtaacttgactataaaataaagccgtccgtgggacgactgacctcgttgcaaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3087 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA
            GeneID:3087 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:3087 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:3087 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
            GeneID:3087 -> Molecular function: GO:0008190 [eukaryotic initiation factor 4E binding] evidence: IDA
            GeneID:3087 -> Molecular function: GO:0008301 [DNA binding, bending] evidence: IDA
            GeneID:3087 -> Molecular function: GO:0017025 [TBP-class protein binding] evidence: TAS
            GeneID:3087 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IPI
            GeneID:3087 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IDA
            GeneID:3087 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: IDA
            GeneID:3087 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: TAS
            GeneID:3087 -> Molecular function: GO:0070491 [repressing transcription factor binding] evidence: IDA
            GeneID:3087 -> Molecular function: GO:0071837 [HMG box domain binding] evidence: IEA
            GeneID:3087 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:3087 -> Biological process: GO:0001570 [vasculogenesis] evidence: IEA
            GeneID:3087 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
            GeneID:3087 -> Biological process: GO:0002573 [myeloid leukocyte differentiation] evidence: IEA
            GeneID:3087 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:3087 -> Biological process: GO:0006406 [mRNA export from nucleus] evidence: IDA
            GeneID:3087 -> Biological process: GO:0007049 [cell cycle] evidence: IDA
            GeneID:3087 -> Biological process: GO:0007492 [endoderm development] evidence: IEA
            GeneID:3087 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA
            GeneID:3087 -> Biological process: GO:0009611 [response to wounding] evidence: IEA
            GeneID:3087 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: ISS
            GeneID:3087 -> Biological process: GO:0010621 [negative regulation of transcription by transcription factor localization] evidence: IC
            GeneID:3087 -> Biological process: GO:0010944 [negative regulation of transcription by competitive promoter binding] evidence: TAS
            GeneID:3087 -> Biological process: GO:0016055 [Wnt receptor signaling pathway] evidence: IEA
            GeneID:3087 -> Biological process: GO:0016525 [negative regulation of angiogenesis] evidence: ISS
            GeneID:3087 -> Biological process: GO:0016973 [poly(A)+ mRNA export from nucleus] evidence: IMP
            GeneID:3087 -> Biological process: GO:0022027 [interkinetic nuclear migration] evidence: IEA
            GeneID:3087 -> Biological process: GO:0030154 [cell differentiation] evidence: IC
            GeneID:3087 -> Biological process: GO:0030177 [positive regulation of Wnt receptor signaling pathway] evidence: ISS
            GeneID:3087 -> Biological process: GO:0030183 [B cell differentiation] evidence: ISS
            GeneID:3087 -> Biological process: GO:0030878 [thyroid gland development] evidence: IEA
            GeneID:3087 -> Biological process: GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway] evidence: ISS
            GeneID:3087 -> Biological process: GO:0031016 [pancreas development] evidence: IEA
            GeneID:3087 -> Biological process: GO:0034504 [protein localization to nucleus] evidence: IDA
            GeneID:3087 -> Biological process: GO:0035050 [embryonic heart tube development] evidence: IEA
            GeneID:3087 -> Biological process: GO:0035264 [multicellular organism growth] evidence: IEA
            GeneID:3087 -> Biological process: GO:0042127 [regulation of cell proliferation] evidence: IEA
            GeneID:3087 -> Biological process: GO:0043434 [response to peptide hormone stimulus] evidence: IEA
            GeneID:3087 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:3087 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:3087 -> Biological process: GO:0048853 [forebrain morphogenesis] evidence: IEA
            GeneID:3087 -> Biological process: GO:0060431 [primary lung bud formation] evidence: IEA
            GeneID:3087 -> Biological process: GO:0061009 [common bile duct development] evidence: IEA
            GeneID:3087 -> Biological process: GO:0061010 [gall bladder development] evidence: IEA
            GeneID:3087 -> Biological process: GO:0061011 [hepatic duct development] evidence: IEA
            GeneID:3087 -> Biological process: GO:0061017 [hepatoblast differentiation] evidence: IEA
            GeneID:3087 -> Biological process: GO:0070365 [hepatocyte differentiation] evidence: IEA
            GeneID:3087 -> Biological process: GO:0071103 [DNA conformation change] evidence: IDA
            GeneID:3087 -> Biological process: GO:0090009 [primitive streak formation] evidence: IEA
            GeneID:3087 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:3087 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:3087 -> Cellular component: GO:0032993 [protein-DNA complex] evidence: IDA