2024-04-26 07:08:18, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002702 4715 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens POU class 6 homeobox 1 (POU6F1), transcript variant 1, mRNA. ACCESSION NM_002702 XM_370693 VERSION NM_002702.3 GI:223890224 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4715) AUTHORS Suzuki,N., Yoshioka,N., Uekawa,A., Matsumura,N., Tozawa,A., Koike,J., Konishi,I., Kiguchi,K. and Ishizuka,B. TITLE Transcription factor POU6F1 is important for proliferation of clear cell adenocarcinoma of the ovary and is a potential new molecular target JOURNAL Int. J. Gynecol. Cancer 20 (2), 212-219 (2010) PUBMED 20134265 REMARK GeneRIF: POU6F1 siRNA dose-dependently suppressed the proliferation of clear cell adenocarcinoma cell lines. REFERENCE 2 (bases 1 to 4715) AUTHORS Yoshioka,N., Suzuki,N., Uekawa,A., Kiguchi,K. and Ishizuka,B. TITLE POU6F1 is the transcription factor that might be involved in cell proliferation of clear cell adenocarcinoma of the ovary JOURNAL Hum. Cell 22 (4), 94-100 (2009) PUBMED 19874398 REMARK GeneRIF: is the transcription factor that might be involved in cell proliferation of clear cell adenocarcinoma of the ovary. REFERENCE 3 (bases 1 to 4715) AUTHORS Pereira,J.H. and Kim,S.H. TITLE Structure of human Brn-5 transcription factor in complex with CRH gene promoter JOURNAL J. Struct. Biol. 167 (2), 159-165 (2009) PUBMED 19450691 REMARK GeneRIF: The crystal structure of human Brn-5 transcription factor in complex with corticotropin-releasing hormone gene promoter reveals an unexpected recognition mode of the protein to its cognate DNA REFERENCE 4 (bases 1 to 4715) AUTHORS Pereira,J.H., Ha,S.C. and Kim,S.H. TITLE Crystallization and preliminary X-ray analysis of human Brn-5 transcription factor in complex with DNA JOURNAL Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64 (PT 3), 175-178 (2008) PUBMED 18323601 REMARK GeneRIF: Crystallization and preliminary X-ray analysis REFERENCE 5 (bases 1 to 4715) AUTHORS Abdel-Rahman,B., Fiddler,M., Rappolee,D. and Pergament,E. TITLE Expression of transcription regulating genes in human preimplantation embryos JOURNAL Hum. Reprod. 10 (10), 2787-2792 (1995) PUBMED 8567814 REFERENCE 6 (bases 1 to 4715) AUTHORS Wey,E., Lyons,G.E. and Schafer,B.W. TITLE A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues JOURNAL Eur. J. Biochem. 220 (3), 753-762 (1994) PUBMED 7908264 REFERENCE 7 (bases 1 to 4715) AUTHORS Messier,H., Brickner,H., Gaikwad,J. and Fotedar,A. TITLE A novel POU domain protein which binds to the T-cell receptor beta enhancer JOURNAL Mol. Cell. Biol. 13 (9), 5450-5460 (1993) PUBMED 8102789 REFERENCE 8 (bases 1 to 4715) AUTHORS Takeda,J., Seino,S. and Bell,G.I. TITLE Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues JOURNAL Nucleic Acids Res. 20 (17), 4613-4620 (1992) PUBMED 1408763 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL832881.1, BC051326.1, DA026332.1, DA084199.1, AC139768.14, BM703234.1, CK002954.1 and AW445212.1. On Feb 20, 2009 this sequence version replaced gi:57163992. Transcript Variant: This variant (1) represents the protein-coding transcript. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AL832881.1, BC051326.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025082, ERS025083 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1911 AL832881.1 1-1911 1912-2474 BC051326.1 1715-2277 2475-2764 DA026332.1 279-568 2765-3057 DA084199.1 230-522 3058-3651 AC139768.14 57379-57972 3652-4118 BM703234.1 1-467 4119-4360 CK002954.1 249-490 4361-4715 AW445212.1 1-355 c FEATURES Location/Qualifiers source 1..4715 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="12" /map="12q13.13" gene 1..4715 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /note="POU class 6 homeobox 1" /db_xref="GeneID:5463" /db_xref="HGNC:9224" exon 1..398 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /inference="alignment:Splign:1.39.8" misc_feature 114..116 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /note="upstream in-frame stop codon" exon 399..527 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /inference="alignment:Splign:1.39.8" STS 458..1419 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /db_xref="UniSTS:481952" CDS 483..1388 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /note="brn-5; brain-5; mPOU homeobox protein; brain-specific homeobox/POU domain protein 5" /codon_start=1 /product="POU domain, class 6, transcription factor 1" /protein_id="NP_002693.3" /db_xref="GI:223890225" /db_xref="CCDS:CCDS31803.1" /db_xref="GeneID:5463" /db_xref="HGNC:9224" /translation="
MPGISSQILTNAQGQVIGTLPWVVNSASVAAPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPLPPPVAVRKPSTPESPAKSEVQPIQPTPTVPQPAVVIASPAPAAKPSASAPIPITCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLNEAELRNQEGQQNLMEFVGGEPSKKRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKLNVFQIP
" misc_feature 897..1121 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /note="Pou domain - N-terminal to homeobox domain; Region: Pou; cl02582" /db_xref="CDD:198730" misc_feature 1185..1361 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /note="Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; Region: homeodomain; cd00086" /db_xref="CDD:28970" misc_feature order(1185..1199,1203..1205,1254..1256,1272..1274, 1311..1313,1317..1322,1329..1334,1338..1346,1350..1355) /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:28970" misc_feature order(1191..1193,1200..1202,1320..1322,1329..1334, 1341..1343) /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /note="specific DNA base contacts [nucleotide binding]; other site" /db_xref="CDD:28970" exon 528..731 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /inference="alignment:Splign:1.39.8" exon 732..873 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /inference="alignment:Splign:1.39.8" exon 874..1042 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /inference="alignment:Splign:1.39.8" exon 1043..4699 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /inference="alignment:Splign:1.39.8" variation 1271 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /replace="a" /replace="g" /db_xref="dbSNP:2228250" variation 1539 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /replace="c" /replace="t" /db_xref="dbSNP:1126902" STS 1560..1752 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /standard_name="D12S1904" /db_xref="UniSTS:36492" STS 1733..1992 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /standard_name="WI-19201" /db_xref="UniSTS:47552" variation 1912 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /replace="c" /replace="t" /db_xref="dbSNP:3490" variation 1917 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /replace="a" /replace="g" /db_xref="dbSNP:1126904" variation 1977 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /replace="a" /replace="g" /db_xref="dbSNP:1126905" STS 1978..2253 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /standard_name="STS-Z21966" /db_xref="UniSTS:32889" polyA_signal 2389..2394 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" polyA_signal 2434..2439 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" polyA_site 2474 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" STS 3483..3610 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /standard_name="D15S1477" /db_xref="UniSTS:474482" STS 4401..4530 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" /standard_name="RH65190" /db_xref="UniSTS:73617" polyA_signal 4675..4680 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" polyA_site 4699 /gene="POU6F1" /gene_synonym="BRN5; MPOU; TCFB1" ORIGIN
aggatcaagggaatcgtggctgcctgccccactgagcccactgccccaaccccctctccttcttgtgccagatcccttgggattggagccgctgtgagcagtggctaggcatttgagcacctctgtctctgccttgctccatagcagctgctgtgctgaacaccgctcttccggcaccggtacaagctgccgcaccagtacaggcctcctcgacggcccaaccccggccaccagcccagccccagacgctgttccagacccagccgctgctgcagaccacacctgccatcctcccgcagcccactgctgccaccgctgctgcccctacccccaagccagtggacacccccccacagatcaccgtccagcctgcaggcttcgcatttagcccaggaatcatcagtgctgcttccctcgggggacagacccagatcctggggtccctcactacagctccagtcattaccagcgccattcccagcatgccagggatcagcagtcagatcctcaccaatgctcagggacaggttattggaacccttccatgggtagtgaactcagctagtgtggcggccccagcaccagcccaaagcctgcaggtccaggccgtgaccccccagctgttgttgaacgcccagggccaggtgattgcgaccctggctagcagccccctgcctccacctgtggctgtccggaagccaagcacacctgagtcccctgctaagagtgaggtgcagcccatccagcccacaccaaccgtgccccagcctgctgtggtcattgccagcccagctccagccgccaagccatctgcctctgctcctatcccaattacctgctcagagacccccaccgtcagccagttggtgtccaagccacatactccaagtctggatgaggatgggatcaacttagaagagatccgggagtttgccaagaactttaagatccggcggctctcgctgggccttacacagacccaggtgggtcaggctctgactgcaacggaaggtccagcctacagccagtcagccatctgccggttcgagaagctagacatcacacccaagagtgcccagaagctaaagccggtgctggaaaagtggctaaacgaagctgaactgcggaaccaggaaggccagcagaacctgatggagtttgtgggaggcgagccctccaagaaacgcaaacgccgcacctccttcaccccccaggccatagaggctctcaatgcctattttgagaagaacccactgcccacaggccaggagatcactgaaattgctaaggagctcaactacgaccgtgaggtagtgcgggtctggttctgcaatcggcgccagacgctcaagaacaccagcaagctgaacgtctttcagatcccttagggctcagcccctggccctgtgttctagcactttgtccatttcccgtggcatccggctgcagccactgccatgacagcacctgtcattttgccacgtgcagctgtgctcaccccaggtcatcagactccaccgtgtgcatgtgcatcaatgtccctcttttctcccacacatctcacatcatggggaggccagagggggccacacgagagctccaggctctgggctggtcactccgaagaagaggatttgtgacgtcacttagagaagcaccttgctagcatggtttctgaagggtgaattctggtggggaaccagaaactccctgtctttggggcagggctaaagcagctcctaaggaccactggccattagctcttgcttttgatggcattctctttccaccttgtcttctcctttgctcctctgtgttagtgtggcaggtatgacaactcatccagtggaaacacagcctcacactgcccttccgccccccacactttgcctgcaggtgcaccgaaaggacctgggagataaaattcaaaaaagtgtgatgtgctgctcagaaggtcagactccatgtctgccttgacctcaaggtcagaaggttcccaaacccctggggctggaacatgggatctcctcttccacctcttcctggttcctttgcggggaaaattgcactaaaacagaaccttttcttaatccatgttggaaggaagcaacagtgaactctacctgttctggagttctcctgggtctgcagaaggttgggaatttagaaaataaggctgttctttcatattttaatttaatctctgtcaatggccatccctcccacaaaaaaacgtgggttaagagaacttgcagactggatatgcaagcaaacgggcaactctggagaaaaataaggaaaggaatgctgactttctctttctttctcttgtccccacacccattcccaacccaatactggggccttctcaaaaggagcaaattaaacaataaaccagacagcaaggccctgggggaaaggacaacatcctgaaataaatgatggagcccaggaaggtctcttgtggaagttgacttaactctaattttctttgtaactttaagccttggatacgggaggagaaatctcattttgtcgagtctcagaccatgtctgtgtgtaagcaatccccacagtgtcctctgagccaaggacacccccagatcagattgagttttgcttctagacggggtagctatggtaccttgggggttagctctcatccaagctgttaagtgagtttccagcctcactgtggctggaaagcccctaaaattcagtatgtaactccaggaagtcaggagagaactgagatttgcctagatgaccacaggcttgcggtgtagattatccctaaagggccccaagtcacgggggtcaaccacccctgtcttcagtactcttatccttacagaggctggtctctaacagctgcctccagtggacctcccatgatccaccctgagggaaggaccgtcagctggggacacatcaccacctctgtcagtcactggtgcagagccacctcctagcctagcttcctctggtgtcctgtttcctttcccacttactgttggtgcctcccaggccctgcagtgccagcgtggccaccctcttggtagcctggccagtaagaggaggacagttgtgtgctgaattagcacacgcacgtgcagcgcgcacagacgcgcgcacacacacacacatacacgctctgctgcatttggacaaaccatgcctgccagagtgtagcagaggtgaggaagcaggtgggcagcttgcctgacccagcttttcaggagagcgtgtctccaacagagagtctccacactctagttcagggttatcgacctgcctcaatgagatgacagactcatttgggaggggtgttgcaaacaagttttcagtgagaatagttaagttccagagcttgtaaaggattcagtgactgacacttcagtaaattaggccaggcacattggcttatgcctgtaattccaacactttggaaggccgaggtgggcggatcatttgaggtctggagttcgagaccagcctgaccaacatggtgaaaccccgtctctactaaaaatacaaaaattagccaggtgtggtagtgcacatctgtaatcccagctacttgggaggtggaggcaggagaattgcttgaaccctggaggttgcaatgagctgagatcacactacttcactccagcctgggtgacagagcaagactcggtctcaaacaaacaaaaacttatggcgatgcaggttttcatgctcagacgcttgcattcaggtatgctttcttttttgagagagacaaatgggtcacagctggcaccctgggaatagcacataatccagggtgtgtctgtggtggtggacgtgcaggggaacaccatctgtcctgtgtcatgatgggaaaacaatcatgaaccactggtctaaattaggcctggccatgctttctcagcccctccctcatttaaatttgtcttcccaaagctgagctaaaactaaaccatttctcctctgctggaatgatggattggtcattcagaggaacaataccaggggtgggaggtttgcaggctgagttccccaggcatgggggtgcagggtgtccctgaggtttacccaaagcacagctcgctggcctgtgacctctgcccttcctcccacagtgtaagaccccccaggaagcagctggggcctgaacctctcacctaggaggtaggtttattttattttttgttagcatcaggctctgaaggagttggtatacattttgttttgaaaacatcttctggacttacaccagagcttagtgtcgtctttactatggaaagagaggagaatggacagaaatggtttaactgtgtggagttttgtttgttttgttttaaatggaagaaagaccaaaactttcctggtggatcagctagggcctttgaccctgcattaccacggcattttatccaggtgaagtccagggaaagaactcagccaaatggactaaggaacacacgagtttggaatgcgagactctgacatttttgtgttcttggaaatccaattaccttcccatgcccagatttccttcctgcctcttggaccaggctctggcactgaggttctcactgttcccaacacagacaaagcttcctgagggctggaggggcagcaaggggagaggagaatggggaagaagcgcttgatgtagttgtgtggaataaacagtattttttcttttgtaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:5463 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA GeneID:5463 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA GeneID:5463 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA GeneID:5463 -> Biological process: GO:0007420 [brain development] evidence: TAS GeneID:5463 -> Biological process: GO:0007507 [heart development] evidence: TAS GeneID:5463 -> Biological process: GO:0007517 [muscle organ development] evidence: TAS GeneID:5463 -> Cellular component: GO:0031965 [nuclear membrane] evidence: IDA GeneID:5463 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA
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