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2024-03-28 19:16:15, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_002702               4715 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens POU class 6 homeobox 1 (POU6F1), transcript variant 1,
            mRNA.
ACCESSION   NM_002702 XM_370693
VERSION     NM_002702.3  GI:223890224
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4715)
  AUTHORS   Suzuki,N., Yoshioka,N., Uekawa,A., Matsumura,N., Tozawa,A.,
            Koike,J., Konishi,I., Kiguchi,K. and Ishizuka,B.
  TITLE     Transcription factor POU6F1 is important for proliferation of clear
            cell adenocarcinoma of the ovary and is a potential new molecular
            target
  JOURNAL   Int. J. Gynecol. Cancer 20 (2), 212-219 (2010)
   PUBMED   20134265
  REMARK    GeneRIF: POU6F1 siRNA dose-dependently suppressed the proliferation
            of clear cell adenocarcinoma cell lines.
REFERENCE   2  (bases 1 to 4715)
  AUTHORS   Yoshioka,N., Suzuki,N., Uekawa,A., Kiguchi,K. and Ishizuka,B.
  TITLE     POU6F1 is the transcription factor that might be involved in cell
            proliferation of clear cell adenocarcinoma of the ovary
  JOURNAL   Hum. Cell 22 (4), 94-100 (2009)
   PUBMED   19874398
  REMARK    GeneRIF: is the transcription factor that might be involved in cell
            proliferation of clear cell adenocarcinoma of the ovary.
REFERENCE   3  (bases 1 to 4715)
  AUTHORS   Pereira,J.H. and Kim,S.H.
  TITLE     Structure of human Brn-5 transcription factor in complex with CRH
            gene promoter
  JOURNAL   J. Struct. Biol. 167 (2), 159-165 (2009)
   PUBMED   19450691
  REMARK    GeneRIF: The crystal structure of human Brn-5 transcription factor
            in complex with corticotropin-releasing hormone gene promoter
            reveals an unexpected recognition mode of the protein to its
            cognate DNA
REFERENCE   4  (bases 1 to 4715)
  AUTHORS   Pereira,J.H., Ha,S.C. and Kim,S.H.
  TITLE     Crystallization and preliminary X-ray analysis of human Brn-5
            transcription factor in complex with DNA
  JOURNAL   Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64 (PT 3),
            175-178 (2008)
   PUBMED   18323601
  REMARK    GeneRIF: Crystallization and preliminary X-ray analysis
REFERENCE   5  (bases 1 to 4715)
  AUTHORS   Abdel-Rahman,B., Fiddler,M., Rappolee,D. and Pergament,E.
  TITLE     Expression of transcription regulating genes in human
            preimplantation embryos
  JOURNAL   Hum. Reprod. 10 (10), 2787-2792 (1995)
   PUBMED   8567814
REFERENCE   6  (bases 1 to 4715)
  AUTHORS   Wey,E., Lyons,G.E. and Schafer,B.W.
  TITLE     A human POU domain gene, mPOU, is expressed in developing brain and
            specific adult tissues
  JOURNAL   Eur. J. Biochem. 220 (3), 753-762 (1994)
   PUBMED   7908264
REFERENCE   7  (bases 1 to 4715)
  AUTHORS   Messier,H., Brickner,H., Gaikwad,J. and Fotedar,A.
  TITLE     A novel POU domain protein which binds to the T-cell receptor beta
            enhancer
  JOURNAL   Mol. Cell. Biol. 13 (9), 5450-5460 (1993)
   PUBMED   8102789
REFERENCE   8  (bases 1 to 4715)
  AUTHORS   Takeda,J., Seino,S. and Bell,G.I.
  TITLE     Human Oct3 gene family: cDNA sequences, alternative splicing, gene
            organization, chromosomal location, and expression at low levels in
            adult tissues
  JOURNAL   Nucleic Acids Res. 20 (17), 4613-4620 (1992)
   PUBMED   1408763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL832881.1, BC051326.1, DA026332.1, DA084199.1, AC139768.14,
            BM703234.1, CK002954.1 and AW445212.1.
            On Feb 20, 2009 this sequence version replaced gi:57163992.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832881.1, BC051326.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025083 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1911              AL832881.1         1-1911
            1912-2474           BC051326.1         1715-2277
            2475-2764           DA026332.1         279-568
            2765-3057           DA084199.1         230-522
            3058-3651           AC139768.14        57379-57972
            3652-4118           BM703234.1         1-467
            4119-4360           CK002954.1         249-490
            4361-4715           AW445212.1         1-355               c
FEATURES             Location/Qualifiers
     source          1..4715
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..4715
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /note="POU class 6 homeobox 1"
                     /db_xref="GeneID:5463"
                     /db_xref="HGNC:9224"
     exon            1..398
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    114..116
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /note="upstream in-frame stop codon"
     exon            399..527
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:1.39.8"
     STS             458..1419
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /db_xref="UniSTS:481952"
     CDS             483..1388
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /note="brn-5; brain-5; mPOU homeobox protein;
                     brain-specific homeobox/POU domain protein 5"
                     /codon_start=1
                     /product="POU domain, class 6, transcription factor 1"
                     /protein_id="NP_002693.3"
                     /db_xref="GI:223890225"
                     /db_xref="CCDS:CCDS31803.1"
                     /db_xref="GeneID:5463"
                     /db_xref="HGNC:9224"
                     /translation="
MPGISSQILTNAQGQVIGTLPWVVNSASVAAPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPLPPPVAVRKPSTPESPAKSEVQPIQPTPTVPQPAVVIASPAPAAKPSASAPIPITCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLNEAELRNQEGQQNLMEFVGGEPSKKRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKLNVFQIP
"
     misc_feature    897..1121
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /note="Pou domain - N-terminal to homeobox domain; Region:
                     Pou; cl02582"
                     /db_xref="CDD:198730"
     misc_feature    1185..1361
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(1185..1199,1203..1205,1254..1256,1272..1274,
                     1311..1313,1317..1322,1329..1334,1338..1346,1350..1355)
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(1191..1193,1200..1202,1320..1322,1329..1334,
                     1341..1343)
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     exon            528..731
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:1.39.8"
     exon            732..873
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:1.39.8"
     exon            874..1042
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:1.39.8"
     exon            1043..4699
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:1.39.8"
     variation       1271
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2228250"
     variation       1539
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1126902"
     STS             1560..1752
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /standard_name="D12S1904"
                     /db_xref="UniSTS:36492"
     STS             1733..1992
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /standard_name="WI-19201"
                     /db_xref="UniSTS:47552"
     variation       1912
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3490"
     variation       1917
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1126904"
     variation       1977
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1126905"
     STS             1978..2253
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /standard_name="STS-Z21966"
                     /db_xref="UniSTS:32889"
     polyA_signal    2389..2394
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
     polyA_signal    2434..2439
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
     polyA_site      2474
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
     STS             3483..3610
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /standard_name="D15S1477"
                     /db_xref="UniSTS:474482"
     STS             4401..4530
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /standard_name="RH65190"
                     /db_xref="UniSTS:73617"
     polyA_signal    4675..4680
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
     polyA_site      4699
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
ORIGIN      
aggatcaagggaatcgtggctgcctgccccactgagcccactgccccaaccccctctccttcttgtgccagatcccttgggattggagccgctgtgagcagtggctaggcatttgagcacctctgtctctgccttgctccatagcagctgctgtgctgaacaccgctcttccggcaccggtacaagctgccgcaccagtacaggcctcctcgacggcccaaccccggccaccagcccagccccagacgctgttccagacccagccgctgctgcagaccacacctgccatcctcccgcagcccactgctgccaccgctgctgcccctacccccaagccagtggacacccccccacagatcaccgtccagcctgcaggcttcgcatttagcccaggaatcatcagtgctgcttccctcgggggacagacccagatcctggggtccctcactacagctccagtcattaccagcgccattcccagcatgccagggatcagcagtcagatcctcaccaatgctcagggacaggttattggaacccttccatgggtagtgaactcagctagtgtggcggccccagcaccagcccaaagcctgcaggtccaggccgtgaccccccagctgttgttgaacgcccagggccaggtgattgcgaccctggctagcagccccctgcctccacctgtggctgtccggaagccaagcacacctgagtcccctgctaagagtgaggtgcagcccatccagcccacaccaaccgtgccccagcctgctgtggtcattgccagcccagctccagccgccaagccatctgcctctgctcctatcccaattacctgctcagagacccccaccgtcagccagttggtgtccaagccacatactccaagtctggatgaggatgggatcaacttagaagagatccgggagtttgccaagaactttaagatccggcggctctcgctgggccttacacagacccaggtgggtcaggctctgactgcaacggaaggtccagcctacagccagtcagccatctgccggttcgagaagctagacatcacacccaagagtgcccagaagctaaagccggtgctggaaaagtggctaaacgaagctgaactgcggaaccaggaaggccagcagaacctgatggagtttgtgggaggcgagccctccaagaaacgcaaacgccgcacctccttcaccccccaggccatagaggctctcaatgcctattttgagaagaacccactgcccacaggccaggagatcactgaaattgctaaggagctcaactacgaccgtgaggtagtgcgggtctggttctgcaatcggcgccagacgctcaagaacaccagcaagctgaacgtctttcagatcccttagggctcagcccctggccctgtgttctagcactttgtccatttcccgtggcatccggctgcagccactgccatgacagcacctgtcattttgccacgtgcagctgtgctcaccccaggtcatcagactccaccgtgtgcatgtgcatcaatgtccctcttttctcccacacatctcacatcatggggaggccagagggggccacacgagagctccaggctctgggctggtcactccgaagaagaggatttgtgacgtcacttagagaagcaccttgctagcatggtttctgaagggtgaattctggtggggaaccagaaactccctgtctttggggcagggctaaagcagctcctaaggaccactggccattagctcttgcttttgatggcattctctttccaccttgtcttctcctttgctcctctgtgttagtgtggcaggtatgacaactcatccagtggaaacacagcctcacactgcccttccgccccccacactttgcctgcaggtgcaccgaaaggacctgggagataaaattcaaaaaagtgtgatgtgctgctcagaaggtcagactccatgtctgccttgacctcaaggtcagaaggttcccaaacccctggggctggaacatgggatctcctcttccacctcttcctggttcctttgcggggaaaattgcactaaaacagaaccttttcttaatccatgttggaaggaagcaacagtgaactctacctgttctggagttctcctgggtctgcagaaggttgggaatttagaaaataaggctgttctttcatattttaatttaatctctgtcaatggccatccctcccacaaaaaaacgtgggttaagagaacttgcagactggatatgcaagcaaacgggcaactctggagaaaaataaggaaaggaatgctgactttctctttctttctcttgtccccacacccattcccaacccaatactggggccttctcaaaaggagcaaattaaacaataaaccagacagcaaggccctgggggaaaggacaacatcctgaaataaatgatggagcccaggaaggtctcttgtggaagttgacttaactctaattttctttgtaactttaagccttggatacgggaggagaaatctcattttgtcgagtctcagaccatgtctgtgtgtaagcaatccccacagtgtcctctgagccaaggacacccccagatcagattgagttttgcttctagacggggtagctatggtaccttgggggttagctctcatccaagctgttaagtgagtttccagcctcactgtggctggaaagcccctaaaattcagtatgtaactccaggaagtcaggagagaactgagatttgcctagatgaccacaggcttgcggtgtagattatccctaaagggccccaagtcacgggggtcaaccacccctgtcttcagtactcttatccttacagaggctggtctctaacagctgcctccagtggacctcccatgatccaccctgagggaaggaccgtcagctggggacacatcaccacctctgtcagtcactggtgcagagccacctcctagcctagcttcctctggtgtcctgtttcctttcccacttactgttggtgcctcccaggccctgcagtgccagcgtggccaccctcttggtagcctggccagtaagaggaggacagttgtgtgctgaattagcacacgcacgtgcagcgcgcacagacgcgcgcacacacacacacatacacgctctgctgcatttggacaaaccatgcctgccagagtgtagcagaggtgaggaagcaggtgggcagcttgcctgacccagcttttcaggagagcgtgtctccaacagagagtctccacactctagttcagggttatcgacctgcctcaatgagatgacagactcatttgggaggggtgttgcaaacaagttttcagtgagaatagttaagttccagagcttgtaaaggattcagtgactgacacttcagtaaattaggccaggcacattggcttatgcctgtaattccaacactttggaaggccgaggtgggcggatcatttgaggtctggagttcgagaccagcctgaccaacatggtgaaaccccgtctctactaaaaatacaaaaattagccaggtgtggtagtgcacatctgtaatcccagctacttgggaggtggaggcaggagaattgcttgaaccctggaggttgcaatgagctgagatcacactacttcactccagcctgggtgacagagcaagactcggtctcaaacaaacaaaaacttatggcgatgcaggttttcatgctcagacgcttgcattcaggtatgctttcttttttgagagagacaaatgggtcacagctggcaccctgggaatagcacataatccagggtgtgtctgtggtggtggacgtgcaggggaacaccatctgtcctgtgtcatgatgggaaaacaatcatgaaccactggtctaaattaggcctggccatgctttctcagcccctccctcatttaaatttgtcttcccaaagctgagctaaaactaaaccatttctcctctgctggaatgatggattggtcattcagaggaacaataccaggggtgggaggtttgcaggctgagttccccaggcatgggggtgcagggtgtccctgaggtttacccaaagcacagctcgctggcctgtgacctctgcccttcctcccacagtgtaagaccccccaggaagcagctggggcctgaacctctcacctaggaggtaggtttattttattttttgttagcatcaggctctgaaggagttggtatacattttgttttgaaaacatcttctggacttacaccagagcttagtgtcgtctttactatggaaagagaggagaatggacagaaatggtttaactgtgtggagttttgtttgttttgttttaaatggaagaaagaccaaaactttcctggtggatcagctagggcctttgaccctgcattaccacggcattttatccaggtgaagtccagggaaagaactcagccaaatggactaaggaacacacgagtttggaatgcgagactctgacatttttgtgttcttggaaatccaattaccttcccatgcccagatttccttcctgcctcttggaccaggctctggcactgaggttctcactgttcccaacacagacaaagcttcctgagggctggaggggcagcaaggggagaggagaatggggaagaagcgcttgatgtagttgtgtggaataaacagtattttttcttttgtaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5463 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:5463 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:5463 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:5463 -> Biological process: GO:0007420 [brain development] evidence: TAS
            GeneID:5463 -> Biological process: GO:0007507 [heart development] evidence: TAS
            GeneID:5463 -> Biological process: GO:0007517 [muscle organ development] evidence: TAS
            GeneID:5463 -> Cellular component: GO:0031965 [nuclear membrane] evidence: IDA
            GeneID:5463 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA

by @meso_cacase at DBCLS
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