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2024-03-28 23:26:26, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_002696                852 bp    mRNA    linear   PRI 21-APR-2013
DEFINITION  Homo sapiens polymerase (RNA) II (DNA directed) polypeptide G
            (POLR2G), mRNA.
ACCESSION   NM_002696
VERSION     NM_002696.2  GI:219879812
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 852)
  AUTHORS   Zhao,Y., Li,K.K., Ng,K.P., Ng,C.H. and Lee,K.A.
  TITLE     The RNA Pol II sub-complex hsRpb4/7 is required for viability of
            multiple human cell lines
  JOURNAL   Protein Cell 3 (11), 846-854 (2012)
   PUBMED   23073835
  REMARK    GeneRIF: The function of Rpb7 interaction with rpb4 in human cells
            indicate that Rpb7 have gene-specific effects but are also more
            generally required for human cell survival.
REFERENCE   2  (bases 1 to 852)
  AUTHORS   Cojocaru,M., Jeronimo,C., Forget,D., Bouchard,A., Bergeron,D.,
            Cote,P., Poirier,G.G., Greenblatt,J. and Coulombe,B.
  TITLE     Genomic location of the human RNA polymerase II general machinery:
            evidence for a role of TFIIF and Rpb7 at both early and late stages
            of transcription
  JOURNAL   Biochem. J. 409 (1), 139-147 (2008)
   PUBMED   17848138
  REMARK    GeneRIF: TFIIF and Rpb7 are involved in both early and late
            transcriptional stages
REFERENCE   3  (bases 1 to 852)
  AUTHORS   Ujvari,A. and Luse,D.S.
  TITLE     RNA emerging from the active site of RNA polymerase II interacts
            with the Rpb7 subunit
  JOURNAL   Nat. Struct. Mol. Biol. 13 (1), 49-54 (2006)
   PUBMED   16327806
  REMARK    GeneRIF: the emerging transcript cross-links to the Rpb7 subunit of
            RNA polymerase II in various complexes containing 26- to 32-nt
            transcripts
REFERENCE   4  (bases 1 to 852)
  AUTHORS   Meka,H., Werner,F., Cordell,S.C., Onesti,S. and Brick,P.
  TITLE     Crystal structure and RNA binding of the Rpb4/Rpb7 subunits of
            human RNA polymerase II
  JOURNAL   Nucleic Acids Res. 33 (19), 6435-6444 (2005)
   PUBMED   16282592
  REMARK    GeneRIF: Identification of the RNA binding region of Rpb7.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 852)
  AUTHORS   Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
            Sanderson,C.M.
  TITLE     Analysis of a high-throughput yeast two-hybrid system and its use
            to predict the function of intracellular proteins encoded within
            the human MHC class III region
  JOURNAL   Genomics 83 (1), 153-167 (2004)
   PUBMED   14667819
REFERENCE   6  (bases 1 to 852)
  AUTHORS   Cramer,P., Bushnell,D.A., Fu,J., Gnatt,A.L., Maier-Davis,B.,
            Thompson,N.E., Burgess,R.R., Edwards,A.M., David,P.R. and
            Kornberg,R.D.
  TITLE     Architecture of RNA polymerase II and implications for the
            transcription mechanism
  JOURNAL   Science 288 (5466), 640-649 (2000)
   PUBMED   10784442
REFERENCE   7  (bases 1 to 852)
  AUTHORS   Schoen,T.J., Chandrasekharappa,S.C., Guru,S.C., Mazuruk,K.,
            Chader,G.J. and Rodriguez,I.R.
  TITLE     Human gene for the RNA polymerase II seventh subunit (hsRPB7):
            structure, expression and chromosomal localization
  JOURNAL   Biochim. Biophys. Acta 1353 (1), 39-49 (1997)
   PUBMED   9256063
REFERENCE   8  (bases 1 to 852)
  AUTHORS   Kato,H., Sumimoto,H., Pognonec,P., Chen,C.H., Rosen,C.A. and
            Roeder,R.G.
  TITLE     HIV-1 Tat acts as a processivity factor in vitro in conjunction
            with cellular elongation factors
  JOURNAL   Genes Dev. 6 (4), 655-666 (1992)
   PUBMED   1559613
REFERENCE   9  (bases 1 to 852)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J. Biol. Chem. 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   10 (bases 1 to 852)
  AUTHORS   Southgate,C., Zapp,M.L. and Green,M.R.
  TITLE     Activation of transcription by HIV-1 Tat protein tethered to
            nascent RNA through another protein
  JOURNAL   Nature 345 (6276), 640-642 (1990)
   PUBMED   2190099
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG530809.1, BC112162.1 and
            AW016747.1.
            On Jan 9, 2009 this sequence version replaced gi:4505946.
            
            Summary: This gene encodes the seventh largest subunit of RNA
            polymerase II, the polymerase responsible for synthesizing
            messenger RNA in eukaryotes. The protein functions in transcription
            initiation, and is also thought to help stabilize transcribing
            polyermase molecules during elongation. [provided by RefSeq, Jan
            2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI598179.1, BG616101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                BG530809.1         19-79
            62-651              BC112162.1         1-590
            652-852             AW016747.1         1-201               c
FEATURES             Location/Qualifiers
     source          1..852
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..852
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /note="polymerase (RNA) II (DNA directed) polypeptide G"
                     /db_xref="GeneID:5436"
                     /db_xref="HGNC:9194"
                     /db_xref="HPRD:15995"
                     /db_xref="MIM:602013"
     exon            1..122
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /inference="alignment:Splign:1.39.8"
     variation       40
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371168027"
     variation       52
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375547350"
     STS             62..651
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /db_xref="UniSTS:486234"
     variation       72
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377749685"
     variation       102
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200126354"
     CDS             111..629
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /EC_number="2.7.7.6"
                     /note="DNA directed RNA polymerase II 19 kda polypeptide;
                     RNA polymerase II seventh subunit; RNA polymerase II
                     subunit B7; DNA-directed RNA polymerase II subunit G;
                     DNA-directed RNA polymerase II 19 kDa polypeptide; RNA
                     polymerase II 19 kDa subunit"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase II subunit RPB7"
                     /protein_id="NP_002687.1"
                     /db_xref="GI:4505947"
                     /db_xref="CCDS:CCDS31585.1"
                     /db_xref="GeneID:5436"
                     /db_xref="HGNC:9194"
                     /db_xref="HPRD:15995"
                     /db_xref="MIM:602013"
                     /translation="
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQPGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFDPNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS
"
     misc_feature    111..617
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /note="DNA-directed RNA polymerase II subunit 7;
                     Provisional; Region: PTZ00162"
                     /db_xref="CDD:240298"
     misc_feature    114..353
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /note="RNAP_II_Rpb7_N: Rpb7, N-terminal ribonucleoprotein
                     (RNP) domain. Rpb7 is a subunit of eukaryotic RNA
                     polymerase (RNAP) II that is homologous to Rpc25 of RNAP
                     III, RpoE of archaeal RNAP, and Rpa43 of eukaryotic RNAP
                     I. Rpb7 heterodimerizes with Rpb4 and...; Region:
                     RNAP_II_Rpb7_N; cd04329"
                     /db_xref="CDD:239821"
     misc_feature    order(114..119,123..125,132..134,213..218,234..236,
                     246..248,252..254,321..323,327..329,333..335,342..344,
                     348..353)
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /note="Rpb4 interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:239821"
     misc_feature    order(156..158,162..164,276..278,297..302)
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /note="Rpb6 interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:239821"
     misc_feature    order(162..170,174..179,279..287,306..308)
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /note="Rpb1 interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:239821"
     misc_feature    351..617
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /note="S1_RNAPII_Rpb7: Eukaryotic RNA polymerase II
                     (RNAPII) Rpb7 subunit C-terminal S1 domain. RNAPII is
                     composed of 12 subunits (Rpb1-12). Rpb4 and Rpb7 form a
                     heterodimer that associate with the RNAPII core. Rpb7 is a
                     homolog of the Rpc25 of RNA polymerase...; Region:
                     S1_RNAPII_Rpb7; cd04462"
                     /db_xref="CDD:239909"
     misc_feature    order(351..353,360..362,366..368,372..374,408..410,
                     417..419,528..530,534..536,540..542,609..611)
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /note="RPB7- RPB4 dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239909"
     misc_feature    order(378..380,387..392,402..404,429..431,435..437,
                     441..443,561..563,567..569,582..584)
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:239909"
     variation       116
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:111270567"
     exon            123..232
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /inference="alignment:Splign:1.39.8"
     variation       156
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201119366"
     variation       209
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:34019469"
     exon            233..392
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /inference="alignment:Splign:1.39.8"
     variation       268
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374123310"
     variation       296
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141251020"
     variation       298
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367662130"
     variation       326
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146948963"
     variation       375
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:147933527"
     exon            393..443
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /inference="alignment:Splign:1.39.8"
     variation       404
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11548440"
     variation       418
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11548441"
     exon            444..509
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /inference="alignment:Splign:1.39.8"
     variation       444
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370924341"
     variation       453
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147126857"
     variation       488
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201684523"
     exon            510..581
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /inference="alignment:Splign:1.39.8"
     variation       513
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151250126"
     variation       522
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148163879"
     exon            582..615
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /inference="alignment:Splign:1.39.8"
     variation       612
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150186672"
     exon            616..837
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /inference="alignment:Splign:1.39.8"
     STS             629..803
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /standard_name="SGC31630"
                     /db_xref="UniSTS:13507"
     variation       635
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113852446"
     variation       648
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1802756"
     STS             653..802
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /standard_name="SHGC-30229"
                     /db_xref="UniSTS:8220"
     STS             655..827
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /standard_name="A004H14"
                     /db_xref="UniSTS:8663"
     variation       697
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1045097"
     variation       734
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375845393"
     variation       754
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:3795"
     variation       755
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1045122"
     variation       764
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1045125"
     variation       806
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1045183"
     polyA_site      837
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
ORIGIN      
ctcctagtcgcagcaagcgcggaactggggttgcggcgtctaagtgtttccggtggattcccagggactgtcggaggtgtggactctgcctgcctacctggtctgggaagatgttctaccatatctccctagagcacgaaatcctgctgcacccgcgctacttcggccccaacttgctcaacacggtgaagcagaagctcttcaccgaggtggaggggacctgcacagggaagtatggctttgtaattgctgtcaccaccattgacaatattggtgctggtgtgatccagccaggccgaggctttgtcctttatccagttaagtacaaggccattgttttccggccatttaaaggggaggtcgtggatgctgttgtcactcaggtcaacaaggttggactcttcacagaaattgggcccatgtcttgcttcatctctcgacattccatcccttcagagatggagtttgatcctaactccaacccaccatgttacaagacaatggatgaggatattgtgattcagcaggacgatgagatccgcttaaagattgtggggacccgtgtggacaagaatgacatttttgctattggctccctgatggacgattacttggggcttgtaagctgagcctggtggcctcctacccttggtcctactctaggaagtgtgattgtcacacttatcatgttgtccagaggtccagtctggctgctgttgtggaggcaaggaaggcaactcatcccagaaggcatctggtgcttcttgtagcttaactactgcctcctcatttttcagtatgtgttctaagtataaaaagtccttggttctcatggaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5436 -> Molecular function: GO:0003723 [RNA binding] evidence: IEA
            GeneID:5436 -> Molecular function: GO:0003899 [DNA-directed RNA polymerase activity] evidence: IEA
            GeneID:5436 -> Biological process: GO:0000398 [mRNA splicing, via spliceosome] evidence: TAS
            GeneID:5436 -> Biological process: GO:0006281 [DNA repair] evidence: TAS
            GeneID:5436 -> Biological process: GO:0006283 [transcription-coupled nucleotide-excision repair] evidence: TAS
            GeneID:5436 -> Biological process: GO:0006289 [nucleotide-excision repair] evidence: TAS
            GeneID:5436 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:5436 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: TAS
            GeneID:5436 -> Biological process: GO:0006367 [transcription initiation from RNA polymerase II promoter] evidence: TAS
            GeneID:5436 -> Biological process: GO:0006368 [transcription elongation from RNA polymerase II promoter] evidence: TAS
            GeneID:5436 -> Biological process: GO:0006370 [7-methylguanosine mRNA capping] evidence: TAS
            GeneID:5436 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:5436 -> Biological process: GO:0008380 [RNA splicing] evidence: TAS
            GeneID:5436 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:5436 -> Biological process: GO:0016032 [viral process] evidence: TAS
            GeneID:5436 -> Biological process: GO:0050434 [positive regulation of viral transcription] evidence: TAS
            GeneID:5436 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:5436 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:5436 -> Cellular component: GO:0005665 [DNA-directed RNA polymerase II, core complex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_002687 -> EC 2.7.7.6

by @meso_cacase at DBCLS
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