2024-03-28 23:26:26, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002696 852 bp mRNA linear PRI 21-APR-2013 DEFINITION Homo sapiens polymerase (RNA) II (DNA directed) polypeptide G (POLR2G), mRNA. ACCESSION NM_002696 VERSION NM_002696.2 GI:219879812 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 852) AUTHORS Zhao,Y., Li,K.K., Ng,K.P., Ng,C.H. and Lee,K.A. TITLE The RNA Pol II sub-complex hsRpb4/7 is required for viability of multiple human cell lines JOURNAL Protein Cell 3 (11), 846-854 (2012) PUBMED 23073835 REMARK GeneRIF: The function of Rpb7 interaction with rpb4 in human cells indicate that Rpb7 have gene-specific effects but are also more generally required for human cell survival. REFERENCE 2 (bases 1 to 852) AUTHORS Cojocaru,M., Jeronimo,C., Forget,D., Bouchard,A., Bergeron,D., Cote,P., Poirier,G.G., Greenblatt,J. and Coulombe,B. TITLE Genomic location of the human RNA polymerase II general machinery: evidence for a role of TFIIF and Rpb7 at both early and late stages of transcription JOURNAL Biochem. J. 409 (1), 139-147 (2008) PUBMED 17848138 REMARK GeneRIF: TFIIF and Rpb7 are involved in both early and late transcriptional stages REFERENCE 3 (bases 1 to 852) AUTHORS Ujvari,A. and Luse,D.S. TITLE RNA emerging from the active site of RNA polymerase II interacts with the Rpb7 subunit JOURNAL Nat. Struct. Mol. Biol. 13 (1), 49-54 (2006) PUBMED 16327806 REMARK GeneRIF: the emerging transcript cross-links to the Rpb7 subunit of RNA polymerase II in various complexes containing 26- to 32-nt transcripts REFERENCE 4 (bases 1 to 852) AUTHORS Meka,H., Werner,F., Cordell,S.C., Onesti,S. and Brick,P. TITLE Crystal structure and RNA binding of the Rpb4/Rpb7 subunits of human RNA polymerase II JOURNAL Nucleic Acids Res. 33 (19), 6435-6444 (2005) PUBMED 16282592 REMARK GeneRIF: Identification of the RNA binding region of Rpb7. Publication Status: Online-Only REFERENCE 5 (bases 1 to 852) AUTHORS Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and Sanderson,C.M. TITLE Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region JOURNAL Genomics 83 (1), 153-167 (2004) PUBMED 14667819 REFERENCE 6 (bases 1 to 852) AUTHORS Cramer,P., Bushnell,D.A., Fu,J., Gnatt,A.L., Maier-Davis,B., Thompson,N.E., Burgess,R.R., Edwards,A.M., David,P.R. and Kornberg,R.D. TITLE Architecture of RNA polymerase II and implications for the transcription mechanism JOURNAL Science 288 (5466), 640-649 (2000) PUBMED 10784442 REFERENCE 7 (bases 1 to 852) AUTHORS Schoen,T.J., Chandrasekharappa,S.C., Guru,S.C., Mazuruk,K., Chader,G.J. and Rodriguez,I.R. TITLE Human gene for the RNA polymerase II seventh subunit (hsRPB7): structure, expression and chromosomal localization JOURNAL Biochim. Biophys. Acta 1353 (1), 39-49 (1997) PUBMED 9256063 REFERENCE 8 (bases 1 to 852) AUTHORS Kato,H., Sumimoto,H., Pognonec,P., Chen,C.H., Rosen,C.A. and Roeder,R.G. TITLE HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors JOURNAL Genes Dev. 6 (4), 655-666 (1992) PUBMED 1559613 REFERENCE 9 (bases 1 to 852) AUTHORS Jacob,G.A., Luse,S.W. and Luse,D.S. TITLE Abortive initiation is increased only for the weakest members of a set of down mutants of the adenovirus 2 major late promoter JOURNAL J. Biol. Chem. 266 (33), 22537-22544 (1991) PUBMED 1939271 REFERENCE 10 (bases 1 to 852) AUTHORS Southgate,C., Zapp,M.L. and Green,M.R. TITLE Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein JOURNAL Nature 345 (6276), 640-642 (1990) PUBMED 2190099 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG530809.1, BC112162.1 and AW016747.1. On Jan 9, 2009 this sequence version replaced gi:4505946. Summary: This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize transcribing polyermase molecules during elongation. [provided by RefSeq, Jan 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI598179.1, BG616101.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-61 BG530809.1 19-79 62-651 BC112162.1 1-590 652-852 AW016747.1 1-201 c FEATURES Location/Qualifiers source 1..852 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="11" /map="11q13.1" gene 1..852 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /note="polymerase (RNA) II (DNA directed) polypeptide G" /db_xref="GeneID:5436" /db_xref="HGNC:9194" /db_xref="HPRD:15995" /db_xref="MIM:602013" exon 1..122 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /inference="alignment:Splign:1.39.8" variation 40 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="c" /replace="g" /db_xref="dbSNP:371168027" variation 52 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="a" /replace="g" /db_xref="dbSNP:375547350" STS 62..651 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /db_xref="UniSTS:486234" variation 72 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="c" /replace="g" /db_xref="dbSNP:377749685" variation 102 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="c" /replace="t" /db_xref="dbSNP:200126354" CDS 111..629 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /EC_number="2.7.7.6" /note="DNA directed RNA polymerase II 19 kda polypeptide; RNA polymerase II seventh subunit; RNA polymerase II subunit B7; DNA-directed RNA polymerase II subunit G; DNA-directed RNA polymerase II 19 kDa polypeptide; RNA polymerase II 19 kDa subunit" /codon_start=1 /product="DNA-directed RNA polymerase II subunit RPB7" /protein_id="NP_002687.1" /db_xref="GI:4505947" /db_xref="CCDS:CCDS31585.1" /db_xref="GeneID:5436" /db_xref="HGNC:9194" /db_xref="HPRD:15995" /db_xref="MIM:602013" /translation="
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQPGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFDPNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS
" misc_feature 111..617 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /note="DNA-directed RNA polymerase II subunit 7; Provisional; Region: PTZ00162" /db_xref="CDD:240298" misc_feature 114..353 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /note="RNAP_II_Rpb7_N: Rpb7, N-terminal ribonucleoprotein (RNP) domain. Rpb7 is a subunit of eukaryotic RNA polymerase (RNAP) II that is homologous to Rpc25 of RNAP III, RpoE of archaeal RNAP, and Rpa43 of eukaryotic RNAP I. Rpb7 heterodimerizes with Rpb4 and...; Region: RNAP_II_Rpb7_N; cd04329" /db_xref="CDD:239821" misc_feature order(114..119,123..125,132..134,213..218,234..236, 246..248,252..254,321..323,327..329,333..335,342..344, 348..353) /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /note="Rpb4 interaction site [polypeptide binding]; other site" /db_xref="CDD:239821" misc_feature order(156..158,162..164,276..278,297..302) /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /note="Rpb6 interaction site [polypeptide binding]; other site" /db_xref="CDD:239821" misc_feature order(162..170,174..179,279..287,306..308) /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /note="Rpb1 interaction site [polypeptide binding]; other site" /db_xref="CDD:239821" misc_feature 351..617 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /note="S1_RNAPII_Rpb7: Eukaryotic RNA polymerase II (RNAPII) Rpb7 subunit C-terminal S1 domain. RNAPII is composed of 12 subunits (Rpb1-12). Rpb4 and Rpb7 form a heterodimer that associate with the RNAPII core. Rpb7 is a homolog of the Rpc25 of RNA polymerase...; Region: S1_RNAPII_Rpb7; cd04462" /db_xref="CDD:239909" misc_feature order(351..353,360..362,366..368,372..374,408..410, 417..419,528..530,534..536,540..542,609..611) /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /note="RPB7- RPB4 dimer interface [polypeptide binding]; other site" /db_xref="CDD:239909" misc_feature order(378..380,387..392,402..404,429..431,435..437, 441..443,561..563,567..569,582..584) /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /note="RNA binding site [nucleotide binding]; other site" /db_xref="CDD:239909" variation 116 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="a" /replace="c" /db_xref="dbSNP:111270567" exon 123..232 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /inference="alignment:Splign:1.39.8" variation 156 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="c" /replace="g" /db_xref="dbSNP:201119366" variation 209 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="" /replace="g" /db_xref="dbSNP:34019469" exon 233..392 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /inference="alignment:Splign:1.39.8" variation 268 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="a" /replace="g" /db_xref="dbSNP:374123310" variation 296 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="c" /replace="t" /db_xref="dbSNP:141251020" variation 298 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="a" /replace="g" /db_xref="dbSNP:367662130" variation 326 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="c" /replace="g" /db_xref="dbSNP:146948963" variation 375 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="c" /replace="g" /db_xref="dbSNP:147933527" exon 393..443 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /inference="alignment:Splign:1.39.8" variation 404 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="a" /replace="c" /db_xref="dbSNP:11548440" variation 418 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="c" /replace="g" /db_xref="dbSNP:11548441" exon 444..509 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /inference="alignment:Splign:1.39.8" variation 444 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="c" /replace="t" /db_xref="dbSNP:370924341" variation 453 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="g" /replace="t" /db_xref="dbSNP:147126857" variation 488 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="a" /replace="t" /db_xref="dbSNP:201684523" exon 510..581 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /inference="alignment:Splign:1.39.8" variation 513 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="a" /replace="g" /db_xref="dbSNP:151250126" variation 522 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="c" /replace="t" /db_xref="dbSNP:148163879" exon 582..615 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /inference="alignment:Splign:1.39.8" variation 612 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="c" /replace="t" /db_xref="dbSNP:150186672" exon 616..837 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /inference="alignment:Splign:1.39.8" STS 629..803 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /standard_name="SGC31630" /db_xref="UniSTS:13507" variation 635 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="a" /replace="g" /db_xref="dbSNP:113852446" variation 648 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="a" /replace="c" /db_xref="dbSNP:1802756" STS 653..802 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /standard_name="SHGC-30229" /db_xref="UniSTS:8220" STS 655..827 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /standard_name="A004H14" /db_xref="UniSTS:8663" variation 697 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="a" /replace="g" /db_xref="dbSNP:1045097" variation 734 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="a" /replace="g" /db_xref="dbSNP:375845393" variation 754 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="a" /replace="t" /db_xref="dbSNP:3795" variation 755 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="c" /replace="t" /db_xref="dbSNP:1045122" variation 764 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="c" /replace="t" /db_xref="dbSNP:1045125" variation 806 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" /replace="c" /replace="t" /db_xref="dbSNP:1045183" polyA_site 837 /gene="POLR2G" /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7" ORIGIN
ctcctagtcgcagcaagcgcggaactggggttgcggcgtctaagtgtttccggtggattcccagggactgtcggaggtgtggactctgcctgcctacctggtctgggaagatgttctaccatatctccctagagcacgaaatcctgctgcacccgcgctacttcggccccaacttgctcaacacggtgaagcagaagctcttcaccgaggtggaggggacctgcacagggaagtatggctttgtaattgctgtcaccaccattgacaatattggtgctggtgtgatccagccaggccgaggctttgtcctttatccagttaagtacaaggccattgttttccggccatttaaaggggaggtcgtggatgctgttgtcactcaggtcaacaaggttggactcttcacagaaattgggcccatgtcttgcttcatctctcgacattccatcccttcagagatggagtttgatcctaactccaacccaccatgttacaagacaatggatgaggatattgtgattcagcaggacgatgagatccgcttaaagattgtggggacccgtgtggacaagaatgacatttttgctattggctccctgatggacgattacttggggcttgtaagctgagcctggtggcctcctacccttggtcctactctaggaagtgtgattgtcacacttatcatgttgtccagaggtccagtctggctgctgttgtggaggcaaggaaggcaactcatcccagaaggcatctggtgcttcttgtagcttaactactgcctcctcatttttcagtatgtgttctaagtataaaaagtccttggttctcatggaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:5436 -> Molecular function: GO:0003723 [RNA binding] evidence: IEA GeneID:5436 -> Molecular function: GO:0003899 [DNA-directed RNA polymerase activity] evidence: IEA GeneID:5436 -> Biological process: GO:0000398 [mRNA splicing, via spliceosome] evidence: TAS GeneID:5436 -> Biological process: GO:0006281 [DNA repair] evidence: TAS GeneID:5436 -> Biological process: GO:0006283 [transcription-coupled nucleotide-excision repair] evidence: TAS GeneID:5436 -> Biological process: GO:0006289 [nucleotide-excision repair] evidence: TAS GeneID:5436 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: IDA GeneID:5436 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: TAS GeneID:5436 -> Biological process: GO:0006367 [transcription initiation from RNA polymerase II promoter] evidence: TAS GeneID:5436 -> Biological process: GO:0006368 [transcription elongation from RNA polymerase II promoter] evidence: TAS GeneID:5436 -> Biological process: GO:0006370 [7-methylguanosine mRNA capping] evidence: TAS GeneID:5436 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:5436 -> Biological process: GO:0008380 [RNA splicing] evidence: TAS GeneID:5436 -> Biological process: GO:0010467 [gene expression] evidence: TAS GeneID:5436 -> Biological process: GO:0016032 [viral process] evidence: TAS GeneID:5436 -> Biological process: GO:0050434 [positive regulation of viral transcription] evidence: TAS GeneID:5436 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:5436 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS GeneID:5436 -> Cellular component: GO:0005665 [DNA-directed RNA polymerase II, core complex] evidence: IDA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_002687 -> EC 2.7.7.6
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.