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2024-03-28 23:03:35, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_002689               2514 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens polymerase (DNA directed), alpha 2, accessory subunit
            (POLA2), mRNA.
ACCESSION   NM_002689
VERSION     NM_002689.2  GI:20127447
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2514)
  AUTHORS   Kilkenny,M.L., De Piccoli,G., Perera,R.L., Labib,K. and
            Pellegrini,L.
  TITLE     A conserved motif in the C-terminal tail of DNA polymerase alpha
            tethers primase to the eukaryotic replisome
  JOURNAL   J. Biol. Chem. 287 (28), 23740-23747 (2012)
   PUBMED   22593576
  REMARK    GeneRIF: Findings indicate that tethering of primase to the
            replisome by DNA polymerase alpha (pol alpha) is critical for the
            normal action of DNA replication forks in eukaryotic cells.
REFERENCE   2  (bases 1 to 2514)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat. Res. 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2514)
  AUTHORS   Michiels,S., Laplanche,A., Boulet,T., Dessen,P., Guillonneau,B.,
            Mejean,A., Desgrandchamps,F., Lathrop,M., Sarasin,A. and
            Benhamou,S.
  TITLE     Genetic polymorphisms in 85 DNA repair genes and bladder cancer
            risk
  JOURNAL   Carcinogenesis 30 (5), 763-768 (2009)
   PUBMED   19237606
  REMARK    GeneRIF: Observational study of gene-disease association, gene-gene
            interaction, and gene-environment interaction. (HuGE Navigator)
REFERENCE   4  (bases 1 to 2514)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat. Biotechnol. 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   5  (bases 1 to 2514)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   6  (bases 1 to 2514)
  AUTHORS   Huang,D., Jokela,M., Tuusa,J., Skog,S., Poikonen,K. and
            Syvaoja,J.E.
  TITLE     E2F mediates induction of the Sp1-controlled promoter of the human
            DNA polymerase epsilon B-subunit gene POLE2
  JOURNAL   Nucleic Acids Res. 29 (13), 2810-2821 (2001)
   PUBMED   11433027
REFERENCE   7  (bases 1 to 2514)
  AUTHORS   Podust,V.N., Tiwari,N., Stephan,S. and Fanning,E.
  TITLE     Replication factor C disengages from proliferating cell nuclear
            antigen (PCNA) upon sliding clamp formation, and PCNA itself
            tethers DNA polymerase delta to DNA
  JOURNAL   J. Biol. Chem. 273 (48), 31992-31999 (1998)
   PUBMED   9822671
REFERENCE   8  (bases 1 to 2514)
  AUTHORS   Collins,K.L., Russo,A.A., Tseng,B.Y. and Kelly,T.J.
  TITLE     The role of the 70 kDa subunit of human DNA polymerase alpha in DNA
            replication
  JOURNAL   EMBO J. 12 (12), 4555-4566 (1993)
   PUBMED   8223465
REFERENCE   9  (bases 1 to 2514)
  AUTHORS   Nasheuer,H.P., Moore,A., Wahl,A.F. and Wang,T.S.
  TITLE     Cell cycle-dependent phosphorylation of human DNA polymerase alpha
  JOURNAL   J. Biol. Chem. 266 (12), 7893-7903 (1991)
   PUBMED   1902230
REFERENCE   10 (bases 1 to 2514)
  AUTHORS   Wang,T.S., Hu,S.Z. and Korn,D.
  TITLE     DNA primase from KB cells. Characterization of a primase activity
            tightly associated with immunoaffinity-purified DNA
            polymerase-alpha
  JOURNAL   J. Biol. Chem. 259 (3), 1854-1865 (1984)
   PUBMED   6693436
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC002990.1.
            On Apr 10, 2002 this sequence version replaced gi:4505928.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001347.2, AK025315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2514
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..2514
                     /gene="POLA2"
                     /note="polymerase (DNA directed), alpha 2, accessory
                     subunit"
                     /db_xref="GeneID:23649"
                     /db_xref="HGNC:30073"
                     /db_xref="HPRD:10160"
     variation       16
                     /gene="POLA2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:12794623"
     variation       20
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114534269"
     variation       47..48
                     /gene="POLA2"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:34893642"
     variation       177
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116555805"
     variation       204
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:78415165"
     misc_feature    244..246
                     /gene="POLA2"
                     /note="upstream in-frame stop codon"
     variation       276
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187080464"
     variation       297
                     /gene="POLA2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374352197"
     variation       325
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367947984"
     variation       329
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371818539"
     CDS             343..2139
                     /gene="POLA2"
                     /note="polymerase (DNA-directed), alpha (70kD); DNA
                     polymerase alpha 70 kDa subunit; polymerase (DNA
                     directed), alpha 2 (70kD subunit)"
                     /codon_start=1
                     /product="DNA polymerase alpha subunit B"
                     /protein_id="NP_002680.2"
                     /db_xref="GI:20127448"
                     /db_xref="CCDS:CCDS8098.1"
                     /db_xref="GeneID:23649"
                     /db_xref="HGNC:30073"
                     /db_xref="HPRD:10160"
                     /translation="
MSASAQQLAEELQIFGLDCEEALIEKLVELCVQYGQNEEGMVGELIAFCTSTHKVGLTSEILNSFEHEFLSKRLSKARHSTCKDSGHAGARDIVSIQELIEVEEEEEILLNSYTTPSKGSQKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNRGEVVTSFGLAQGVSWSGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLAPAQEPVTLLGQIGCDSNGKLNNKSVILEGDREHSSGAQIPVDLSELKEYSLFPGQVVIMEGINTTGRKLVATKLYEGVPLPFYQPTEEDADFEQSMVLVACGPYTTSDSITYDPLLDLIAVINHDRPDVCILFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLIIPSELRYFVKDVLGCVCVNPGRLTKGQVGGTFARLYLRRPAADGAERQSPCIAVQVVRI
"
     misc_feature    385..1086
                     /gene="POLA2"
                     /note="DNA polymerase alpha subunit B N-terminal; Region:
                     Pol_alpha_B_N; pfam08418"
                     /db_xref="CDD:203937"
     misc_feature    718..720
                     /gene="POLA2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q14181.2); phosphorylation site"
     misc_feature    721..723
                     /gene="POLA2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (Q14181.2); phosphorylation site"
     misc_feature    721..723
                     /gene="POLA2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    730..732
                     /gene="POLA2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (Q14181.2); phosphorylation site"
     misc_feature    763..765
                     /gene="POLA2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q14181.2); phosphorylation site"
     misc_feature    763..765
                     /gene="POLA2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    781..783
                     /gene="POLA2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q14181.2); phosphorylation site"
     misc_feature    781..783
                     /gene="POLA2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    796..798
                     /gene="POLA2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q14181.2); phosphorylation site"
     misc_feature    796..798
                     /gene="POLA2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1414..1989
                     /gene="POLA2"
                     /note="DNA polymerase alpha/epsilon subunit B; Region:
                     DNA_pol_E_B; pfam04042"
                     /db_xref="CDD:202861"
     variation       355
                     /gene="POLA2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:151129443"
     variation       356
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141406398"
     variation       409
                     /gene="POLA2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373191135"
     variation       411
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377753893"
     variation       419
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191135388"
     variation       440
                     /gene="POLA2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201563360"
     variation       444
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377277692"
     variation       468
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370524216"
     variation       474
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145143636"
     variation       482
                     /gene="POLA2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200613332"
     variation       509
                     /gene="POLA2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:141442372"
     variation       552
                     /gene="POLA2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373673074"
     variation       553
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140460455"
     variation       573
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150431615"
     variation       643
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376958217"
     variation       655
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138206808"
     variation       710
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370368976"
     variation       713
                     /gene="POLA2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373779147"
     variation       757
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149521848"
     variation       758
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367571868"
     variation       786
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371108659"
     variation       813
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372504014"
     variation       832
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187158521"
     variation       842
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377028201"
     STS             852..1050
                     /gene="POLA2"
                     /standard_name="PMC303366P6"
                     /db_xref="UniSTS:272513"
     variation       865
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199754207"
     variation       880
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371926841"
     variation       939
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142933430"
     variation       1027
                     /gene="POLA2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:181525791"
     variation       1029
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138966982"
     variation       1049
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200106919"
     variation       1065
                     /gene="POLA2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:142911171"
     variation       1101
                     /gene="POLA2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201349244"
     variation       1128
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200645119"
     variation       1159
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147424510"
     variation       1182
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372693281"
     variation       1184
                     /gene="POLA2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376500520"
     variation       1210
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370543097"
     variation       1224
                     /gene="POLA2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373645442"
     variation       1249
                     /gene="POLA2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200740193"
     variation       1280
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:137913617"
     variation       1283
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192640239"
     variation       1299
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141608215"
     variation       1329
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150546843"
     variation       1352
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55765473"
     variation       1362
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377231378"
     variation       1368
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369223766"
     variation       1387
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150043535"
     variation       1444
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112783160"
     variation       1470
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199986792"
     variation       1494
                     /gene="POLA2"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:56163475"
     variation       1507
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140114790"
     variation       1542
                     /gene="POLA2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201117545"
     variation       1562
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143904136"
     variation       1590
                     /gene="POLA2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146866280"
     variation       1630
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148938869"
     variation       1642
                     /gene="POLA2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142790860"
     variation       1647
                     /gene="POLA2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201506909"
     variation       1672
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:191375625"
     variation       1711
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372745086"
     variation       1776
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377398033"
     variation       1788
                     /gene="POLA2"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:151070088"
     variation       1789
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200610658"
     variation       1832
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200848446"
     variation       1834
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368001126"
     variation       1839
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370249013"
     variation       1846
                     /gene="POLA2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:140980676"
     variation       1885
                     /gene="POLA2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376934780"
     variation       1914
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150210701"
     variation       1926
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144846742"
     variation       1942..1943
                     /gene="POLA2"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34968471"
     variation       1983
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34997862"
     variation       1985
                     /gene="POLA2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373361083"
     variation       1998
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370926282"
     variation       2011
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373086775"
     variation       2031
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200403723"
     variation       2055
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201640265"
     variation       2057
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141287498"
     variation       2060
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370367077"
     variation       2064
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185175426"
     variation       2082
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41541217"
     variation       2089
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:487989"
     variation       2105
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:7123885"
     variation       2142
                     /gene="POLA2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199847515"
     variation       2152
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4590878"
     STS             2188..2416
                     /gene="POLA2"
                     /standard_name="D11S4591"
                     /db_xref="UniSTS:48269"
     STS             2230..2384
                     /gene="POLA2"
                     /standard_name="G62107"
                     /db_xref="UniSTS:139143"
     variation       2252
                     /gene="POLA2"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:41561615"
     variation       2294
                     /gene="POLA2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372342062"
     STS             2315..2435
                     /gene="POLA2"
                     /standard_name="RH98539"
                     /db_xref="UniSTS:84889"
     variation       2317
                     /gene="POLA2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:8638"
     STS             2342..2463
                     /gene="POLA2"
                     /standard_name="RH17414"
                     /db_xref="UniSTS:13916"
     STS             2344..2487
                     /gene="POLA2"
                     /standard_name="D11S4653"
                     /db_xref="UniSTS:64414"
     variation       2351
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188243167"
     variation       2356
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192780935"
     variation       2370
                     /gene="POLA2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11546563"
     variation       2414
                     /gene="POLA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189780475"
     variation       2415
                     /gene="POLA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184394146"
ORIGIN      
cctcgtgccgcagttctgccaccgtcactgagaagctcagcggtagcttttgggaagcaggacgttctcaccaggagagcgtcctctcgagatttctgctccctccattcagggcgtttgggagccaccccttcattttttaaaaaaagtatttctctgtgaccgacggccggggccttctgacggtctgaggtcttgcttgggccagtcacctcctgtcacggtccgcggaggggggaaggataagagggcgaggagctcatcgctcgccacccccgtgggcttcttgggcgcaggtcggagctgggtgggccggctccccggcccctggcttgggcgaccatgtccgcatccgcccagcagctggcggaggagctgcagatcttcggcctagactgcgaggaggctctaattgagaaattggtagagctttgtgttcagtatggacagaatgaggagggaatggtaggcgagcttatagccttctgcaccagcacacataaagttggccttacctcagagatcctgaactcttttgagcatgagtttctgagcaaaagattatcgaaagccaggcatagtacctgcaaggacagtggccatgcaggagctagagacattgtttccattcaagagctaattgaagtggaagaagaagaggaaatcctcttgaactcttacaccacaccttcaaagggttctcagaagcgagctatctctaccccagaaacccccctaacaaaaaggagtgtgtcaactcgtagcccccatcagctactctcaccgtcaagtttctctccaagtgctactccctcccagaaatacaactcacgaagtaaccgaggagaagtggttacctccttcggcttagcacagggagtatcttggtctgggagaggaggagctggaaacatcagcctgaaggtcttgggatgtccagaggcactaactgggagctacaaatccatgtttcagaagctcccagacattcgagaagttctgacctgtaagatagaagaacttggcagcgaactcaaggaacattacaagattgaagctttcactcctttgctagccccagcacaggagcctgtcactctgctgggccagattggctgtgatagcaacgggaagctgaacaacaagtcagtgattctcgagggagaccgggaacattcctcgggtgctcaaattccagtggatttatctgagcttaaggaatattctctgtttcctggacaggttgtaattatggaaggaatcaacaccactggtaggaaacttgttgccaccaaactctacgagggtgtgccacttccattttatcagcccactgaagaggatgcagactttgagcaaagcatggtcctggttgcctgtggaccatacaccacatctgacagcatcacgtatgaccccctgcttgacctgattgctgtcatcaaccatgaccggccagatgtctgcatcctgtttggccctttcctggatgctaagcatgaacaggtggagaattgtctactgacaagtccatttgaagacattttcaagcagtgtctacgaacaattattgaaggcacaagaagctccggctcccaccttgtctttgtcccgtcattgagagatgtgcaccatgagcctgtgtacccccagccgcctttcagctactccgatctgtctcgagaggacaaaaagcaagtacagtttgtgtccgagccctgcagcctctccataaacggagtgatcttcggcttgacatccacagatctgcttttccacctgggggccgaggagatcagtagttcttccggaacttcagacagattcagccgaatactcaagcacatcttgacccagaggagctactacccactctacccgccccaagaagacatggccattgactatgagtcgttctatgtttacgcacagctgcctgtcaccccagatgtcctcatcatcccgtcagagctgaggtacttcgtgaaggatgtcctcggctgtgtctgtgtgaaccctgggcgccttaccaaagggcaggtgggaggcaccttcgcccgactctaccttaggaggccggcagcggacggggcagagaggcagagcccatgcattgctgtgcaggtcgtcaggatctgaggcttctgtcctctgctgttctctgctgtgtgggcccttaaagtcttagccaagagccaagacatagccctgtgacaaggtgaacagttgggtgggaaaggagagaggagccagccagggaggggcagctgcagtgaccaggcccagcagggaggacttgtgcagccgggcctgcctctgagtggtgcctctcctggaaggaagctcttgcttctcagtccatgctccgtgtccagaagtaagccagctgtggatcccgcccactcagaaaaggcgagaaggctttgtgattttctacatgaatcaaacacagaaacaacttttggagaaattaaattctgagtgtgaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:23649 -> Molecular function: GO:0003674 [molecular_function] evidence: ND
            GeneID:23649 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
            GeneID:23649 -> Molecular function: GO:0003887 [DNA-directed DNA polymerase activity] evidence: IEA
            GeneID:23649 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA
            GeneID:23649 -> Biological process: GO:0000060 [protein import into nucleus, translocation] evidence: IEA
            GeneID:23649 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
            GeneID:23649 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
            GeneID:23649 -> Biological process: GO:0000722 [telomere maintenance via recombination] evidence: TAS
            GeneID:23649 -> Biological process: GO:0000723 [telomere maintenance] evidence: TAS
            GeneID:23649 -> Biological process: GO:0006260 [DNA replication] evidence: NAS
            GeneID:23649 -> Biological process: GO:0006270 [DNA replication initiation] evidence: TAS
            GeneID:23649 -> Biological process: GO:0006271 [DNA strand elongation involved in DNA replication] evidence: TAS
            GeneID:23649 -> Biological process: GO:0032201 [telomere maintenance via semi-conservative replication] evidence: TAS
            GeneID:23649 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:23649 -> Cellular component: GO:0005634 [nucleus] evidence: NAS
            GeneID:23649 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:23649 -> Cellular component: GO:0005658 [alpha DNA polymerase:primase complex] evidence: IEA
            GeneID:23649 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:23649 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA

by @meso_cacase at DBCLS
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