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2020-10-24 06:24:36, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_002661               4289 bp    mRNA    linear   PRI 16-JUN-2013
DEFINITION  Homo sapiens phospholipase C, gamma 2
            (phosphatidylinositol-specific) (PLCG2), mRNA.
ACCESSION   NM_002661
VERSION     NM_002661.3  GI:345525418
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4289)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet. 9 (1), E1003225 (2013)
   PUBMED   23382691
REFERENCE   2  (bases 1 to 4289)
  AUTHORS   Zhou,Q., Lee,G.S., Brady,J., Datta,S., Katan,M., Sheikh,A.,
            Martins,M.S., Bunney,T.D., Santich,B.H., Moir,S., Kuhns,D.B., Long
            Priel,D.A., Ombrello,A., Stone,D., Ombrello,M.J., Khan,J.,
            Milner,J.D., Kastner,D.L. and Aksentijevich,I.
  TITLE     A hypermorphic missense mutation in PLCG2, encoding phospholipase
            Cgamma2, causes a dominantly inherited autoinflammatory disease
            with immunodeficiency
  JOURNAL   Am. J. Hum. Genet. 91 (4), 713-720 (2012)
   PUBMED   23000145
  REMARK    GeneRIF: Overexpression of the altered p.Ser707Tyr protein and ex
            vivo experiments using affected individuals' leukocytes showed
            clearly enhanced PLCgamma2 activity.
REFERENCE   3  (bases 1 to 4289)
  AUTHORS   Fu,G., Chen,Y., Schuman,J., Wang,D. and Wen,R.
  TITLE     Phospholipase Cgamma2 plays a role in TCR signal transduction and T
            cell selection
  JOURNAL   J. Immunol. 189 (5), 2326-2332 (2012)
   PUBMED   22837484
  REMARK    GeneRIF: PLCgamma2 participates in T cell receptor (TCR) signal
            transduction and plays a role in T cell selection in a transgenic
            mouse model.
REFERENCE   4  (bases 1 to 4289)
  AUTHORS   Ombrello,M.J., Remmers,E.F., Sun,G., Freeman,A.F., Datta,S.,
            Torabi-Parizi,P., Subramanian,N., Bunney,T.D., Baxendale,R.W.,
            Martins,M.S., Romberg,N., Komarow,H., Aksentijevich,I., Kim,H.S.,
            Ho,J., Cruse,G., Jung,M.Y., Gilfillan,A.M., Metcalfe,D.D.,
            Nelson,C., O'Brien,M., Wisch,L., Stone,K., Douek,D.C., Gandhi,C.,
            Wanderer,A.A., Lee,H., Nelson,S.F., Shianna,K.V., Cirulli,E.T.,
            Goldstein,D.B., Long,E.O., Moir,S., Meffre,E., Holland,S.M.,
            Kastner,D.L., Katan,M., Hoffman,H.M. and Milner,J.D.
  TITLE     Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2
            deletions
  JOURNAL   N. Engl. J. Med. 366 (4), 330-338 (2012)
   PUBMED   22236196
  REMARK    GeneRIF: Genomic deletions in PLCG2 cause gain of PLCgamma(2)
            function, leading to signaling abnormalities in multiple leukocyte
            subsets and a phenotype encompassing both excessive and deficient
            immune function.
REFERENCE   5  (bases 1 to 4289)
  AUTHORS   Leon,C.M., Barbosa,C.M., Justo,G.Z., Borelli,P., Resende,J.D. Jr.,
            de Oliveira,J.S., Ferreira,A.T. and Paredes-Gamero,E.J.
  TITLE     Requirement for PLCgamma2 in IL-3 and GM-CSF-stimulated MEK/ERK
            phosphorylation in murine and human hematopoietic stem/progenitor
            cells
  JOURNAL   J. Cell. Physiol. 226 (7), 1780-1792 (2011)
   PUBMED   21506110
  REMARK    GeneRIF: Data indicate a role for PLCgamma2 and Ca(2+) signaling
            through the modulation of MEK/ERK in IL3/GM-csf stimulated human
            hematopoietic stem/progenitor cells.
REFERENCE   6  (bases 1 to 4289)
  AUTHORS   Yan,W. and Ratnam,M.
  TITLE     Preferred sites of glycosylphosphatidylinositol modification in
            folate receptors and constraints in the primary structure of the
            hydrophobic portion of the signal
  JOURNAL   Biochemistry 34 (44), 14594-14600 (1995)
   PUBMED   7578066
REFERENCE   7  (bases 1 to 4289)
  AUTHORS   Zauli,G., Previati,M., Caramelli,E., Bassini,A., Falcieri,E.,
            Gibellini,D., Bertolaso,L., Bosco,D., Robuffo,I. and Capitani,S.
  TITLE     Exogenous human immunodeficiency virus type-1 Tat protein
            selectively stimulates a phosphatidylinositol-specific
            phospholipase C nuclear pathway in the Jurkat T cell line
  JOURNAL   Eur. J. Immunol. 25 (9), 2695-2700 (1995)
   PUBMED   7589147
REFERENCE   8  (bases 1 to 4289)
  AUTHORS   Liao,F., Shin,H.S. and Rhee,S.G.
  TITLE     In vitro tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2 by
            src-family protein tyrosine kinases
  JOURNAL   Biochem. Biophys. Res. Commun. 191 (3), 1028-1033 (1993)
   PUBMED   7682059
REFERENCE   9  (bases 1 to 4289)
  AUTHORS   Ohta,S., Matsui,A., Nazawa,Y. and Kagawa,Y.
  TITLE     Complete cDNA encoding a putative phospholipase C from transformed
            human lymphocytes
  JOURNAL   FEBS Lett. 242 (1), 31-35 (1988)
   PUBMED   2849563
REFERENCE   10 (bases 1 to 4289)
  AUTHORS   Banno,Y., Yada,Y. and Nozawa,Y.
  TITLE     Purification and characterization of membrane-bound phospholipase C
            specific for phosphoinositides from human platelets
  JOURNAL   J. Biol. Chem. 263 (23), 11459-11465 (1988)
   PUBMED   2841328
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP351485.1, AB208914.1 and
            BC007565.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Sep 6, 2011 this sequence version replaced gi:117320536.
            
            Summary: The protein encoded by this gene is a transmembrane
            signaling enzyme that catalyzes the conversion of
            1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol
            1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), using calcium
            as a cofactor. IP3 and DAG are second messenger molecules important
            for transmitting signals from growth factor receptors and immune
            system receptors across the cell membrane. [provided by RefSeq, Sep
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007565.1, AB208914.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-529               BP351485.1         1-529
            530-1326            AB208914.1         522-1318
            1327-1365           BC007565.1         1296-1334
            1366-1674           AB208914.1         1358-1666
            1675-2824           BC007565.1         1644-2793
            2825-3834           AB208914.1         2817-3826
            3835-4289           BC007565.1         3804-4258
FEATURES             Location/Qualifiers
     source          1..4289
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.1"
     gene            1..4289
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="phospholipase C, gamma 2
                     (phosphatidylinositol-specific)"
                     /db_xref="GeneID:5336"
                     /db_xref="HGNC:9066"
                     /db_xref="MIM:600220"
     exon            1..131
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     exon            132..371
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    137..139
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="upstream in-frame stop codon"
     variation       138
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141718763"
     variation       145
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375123176"
     variation       171
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150565405"
     variation       174
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138699122"
     CDS             179..3976
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /EC_number="3.1.4.11"
                     /note="PLC-IV; PLC-gamma-2; phospholipase C-IV;
                     phosphoinositide phospholipase C-gamma-2"
                     /codon_start=1
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase gamma-2"
                     /protein_id="NP_002652.2"
                     /db_xref="GI:117320537"
                     /db_xref="CCDS:CCDS42204.1"
                     /db_xref="GeneID:5336"
                     /db_xref="HGNC:9066"
                     /db_xref="MIM:600220"
                     /translation="
MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQIIEDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQLQLYQEKCNKRLREKRVSNSKFYS
"
     misc_feature    227..565
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="Phospholipase C (PLC) pleckstrin homology (PH)
                     domain; Region: PH_PLC; cd01248"
                     /db_xref="CDD:176324"
     misc_feature    order(248..271,293..313,329..349,365..379,392..406,
                     461..481,500..517,530..565)
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="core domain; other site"
                     /db_xref="CDD:176324"
     misc_feature    order(266..268,287..289,299..301,347..349)
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="inositol phosphate binding site [chemical binding];
                     other site"
                     /db_xref="CDD:176324"
     misc_feature    <905..1105
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="Phosphoinositide-specific phospholipase C,
                     efhand-like; Region: efhand_like; pfam09279"
                     /db_xref="CDD:150071"
     misc_feature    1109..>1552
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-gamma; Region:
                     PI-PLCc_gamma; cd08592"
                     /db_xref="CDD:176534"
     misc_feature    order(1157..1162,1247..1249,1253..1255,1292..1294,
                     1394..1396,1538..1540,1544..1546)
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="putative active site [active]"
                     /db_xref="CDD:176534"
     misc_feature    order(1157..1159,1292..1294)
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176534"
     misc_feature    order(1160..1162,1247..1249,1253..1255,1394..1396)
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="putative Ca binding site [ion binding]; other site"
                     /db_xref="CDD:176534"
     misc_feature    1757..2059
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="N-terminal Src homology 2 (N-SH2) domain in
                     Phospholipase C gamma; Region: SH2_N-SH2_PLC_gamma_like;
                     cd10341"
                     /db_xref="CDD:199829"
     misc_feature    order(1796..1798,1868..1870,1874..1876,1898..1900,
                     1931..1933)
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:199829"
     misc_feature    order(1907..1909,1934..1936,1979..1981,2048..2050)
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:199829"
     misc_feature    2099..2410
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="C-terminal Src homology 2 (C-SH2) domain in
                     Phospholipase C gamma; Region: SH2_C-SH2_PLC_gamma_like;
                     cd09932"
                     /db_xref="CDD:198186"
     misc_feature    order(2135..2137,2192..2194,2252..2254,2258..2260)
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198186"
     misc_feature    order(2255..2257,2336..2338)
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198186"
     misc_feature    2375..2377
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    2435..2437
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by BTK; propagated from
                     UniProtKB/Swiss-Prot (P16885.4); phosphorylation site"
     misc_feature    2435..2437
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[8]
                     /db_xref="HPRD:01301"
     misc_feature    2435..2437
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[8]
                     /db_xref="HPRD:00655"
     misc_feature    2435..2437
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[8]
                     /db_xref="HPRD:00796"
     misc_feature    2435..2437
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[8]
                     /db_xref="HPRD:01080"
     misc_feature    2453..2455
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by BTK; propagated from
                     UniProtKB/Swiss-Prot (P16885.4); phosphorylation site"
     misc_feature    2453..2455
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[8]
                     /db_xref="HPRD:01301"
     misc_feature    2453..2455
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[8]
                     /db_xref="HPRD:00655"
     misc_feature    2453..2455
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[8]
                     /db_xref="HPRD:00796"
     misc_feature    2453..2455
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[8]
                     /db_xref="HPRD:01080"
     misc_feature    2453..2455
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02248"
     misc_feature    2495..2659
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="Src homology 3 domain of Phospholipase C (PLC)
                     gamma 2; Region: SH3_PLCgamma2; cd11969"
                     /db_xref="CDD:212902"
     misc_feature    order(2510..2512,2528..2530,2534..2539,2594..2596,
                     2630..2632,2642..2647)
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212902"
     misc_feature    <2954..3271
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="Catalytic domain of phosphoinositide-specific
                     phospholipase C-like phosphodiesterases superfamily;
                     Region: PI-PLCc_GDPD_SF; cl14615"
                     /db_xref="CDD:213131"
     misc_feature    3359..3739
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); Region: C2_PLC_like; cd00275"
                     /db_xref="CDD:175974"
     misc_feature    order(3422..3424,3494..3496,3590..3592,3596..3598,
                     3614..3616,3620..3622)
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /note="Ca2+ binding pocket [ion binding]; other site"
                     /db_xref="CDD:175974"
     misc_feature    3767..3769
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02248"
     misc_feature    3827..3829
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P16885.4); phosphorylation site"
     misc_feature    3827..3829
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02248"
     misc_feature    3911..3913
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P16885.4); phosphorylation site"
     variation       189
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199972098"
     variation       190
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376949064"
     variation       195
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202002041"
     variation       200
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:9936371"
     variation       235
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369542354"
     variation       241
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374235189"
     variation       255
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189301790"
     STS             256..673
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /standard_name="GDB:386186"
                     /db_xref="UniSTS:157145"
     variation       260
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:61749044"
     variation       266
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372502550"
     variation       288
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:147349332"
     variation       305
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370352962"
     variation       311
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368137889"
     variation       327
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370242901"
     variation       328
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370683432"
     variation       349
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374354863"
     variation       352
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1143685"
     exon            372..515
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       380
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:184409507"
     variation       443
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199638859"
     variation       475
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1143686"
     variation       497
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377058251"
     variation       502
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:189282309"
     exon            516..609
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       517
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374930194"
     variation       576
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61755444"
     variation       584
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367885048"
     variation       593
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372085742"
     exon            610..657
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     exon            658..742
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       663
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142022471"
     variation       665
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375598204"
     variation       683
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200464512"
     variation       711
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200981336"
     variation       718
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150276286"
     exon            743..826
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       752
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367898185"
     variation       757
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201080992"
     variation       759
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:372054297"
     variation       760
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:375368103"
     variation       772
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368738612"
     variation       778
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142140333"
     variation       805
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374983573"
     variation       807
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201487295"
     variation       825
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201294738"
     exon            827..870
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       833
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376192123"
     variation       856
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111553163"
     variation       866
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373962897"
     exon            871..943
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       885
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199760975"
     variation       892
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138981519"
     variation       909
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11548656"
     variation       920
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:373142398"
     variation       929
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190840748"
     exon            944..1045
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       948
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:45443101"
     variation       949
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369555285"
     variation       962
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372563994"
     variation       980
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1143687"
     variation       998
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370148064"
     variation       1007
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372494175"
     variation       1030
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190687540"
     variation       1035
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142098187"
     exon            1046..1164
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       1054
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:375222873"
     variation       1057
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368107827"
     variation       1058
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:112648604"
     variation       1067
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370697615"
     variation       1101
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199636472"
     variation       1111
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368534849"
     variation       1123
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372795428"
     exon            1165..1250
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       1165
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200506549"
     variation       1192
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200149635"
     variation       1227
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200824224"
     variation       1228
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:185739725"
     variation       1250
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377757324"
     exon            1251..1371
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       1264
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375876385"
     variation       1270
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369150321"
     variation       1285
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201652976"
     variation       1294
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369732261"
     variation       1303
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374233612"
     variation       1318
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:112374290"
     variation       1324
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138637229"
     variation       1327
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1143688"
     variation       1330
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13333713"
     variation       1338
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201654184"
     variation       1366
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:13333716"
     exon            1372..1540
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       1414
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372240617"
     variation       1436
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201490178"
     variation       1456
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199514190"
     variation       1470
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:367678289"
     variation       1487
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200137340"
     variation       1507
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369281824"
     variation       1520
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200919414"
     exon            1541..1645
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       1560
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3935625"
     variation       1561
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369098550"
     variation       1597
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372678135"
     variation       1622
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187956469"
     variation       1627
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201746780"
     exon            1646..1735
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       1656
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369542682"
     variation       1675
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1143689"
     variation       1682
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199761977"
     variation       1711
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:151013036"
     exon            1736..1911
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       1737
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201391996"
     variation       1743
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:72824905"
     variation       1747
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199708049"
     variation       1750
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373910195"
     variation       1769
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200736474"
     variation       1773
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370429726"
     variation       1780
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375195776"
     variation       1799
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11548657"
     variation       1807
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374641731"
     variation       1849
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372347274"
     variation       1873
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375590398"
     variation       1876
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11548654"
     variation       1890
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75472618"
     variation       1901
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375546602"
     variation       1909
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:147406608"
     exon            1912..2112
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       1923
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200325678"
     variation       1990
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191668546"
     variation       2026
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200081833"
     variation       2037
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147396004"
     variation       2050
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368337142"
     variation       2086
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374419817"
     variation       2094
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377753289"
     variation       2101
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374927413"
     variation       2102
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367884906"
     exon            2113..2232
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       2137
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:117835631"
     variation       2147..2148
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:67343424"
     variation       2189
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150833842"
     variation       2194
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187116990"
     variation       2203
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373752237"
     variation       2214
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374768937"
     exon            2233..2413
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       2251
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377223625"
     variation       2253
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:370718047"
     variation       2261
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374334218"
     variation       2272
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143195637"
     variation       2293
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372245335"
     variation       2326
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367677388"
     variation       2339
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187454354"
     variation       2344
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375200129"
     variation       2356
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201084625"
     variation       2358
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369516453"
     variation       2359
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:372269946"
     variation       2369
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:377095061"
     variation       2372
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369760877"
     variation       2379
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199516791"
     variation       2380
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200025641"
     variation       2389
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368933697"
     variation       2410
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201591234"
     exon            2414..2485
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       2430
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374154653"
     variation       2434
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376208314"
     variation       2437
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370847174"
     variation       2438
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:190001915"
     variation       2440
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74032923"
     variation       2462
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368910187"
     variation       2479
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374390386"
     exon            2486..2595
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       2490
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201803492"
     variation       2497
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375781279"
     variation       2502
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142825971"
     variation       2507
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:181588253"
     variation       2509
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372491825"
     variation       2533
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185307548"
     variation       2553
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202210217"
     variation       2571
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117077093"
     variation       2575
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376061730"
     exon            2596..2692
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       2605
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200844173"
     variation       2647
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376517417"
     variation       2672
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368530152"
     variation       2681
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:186829827"
     variation       2683
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368887042"
     variation       2692
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:115583707"
     exon            2693..2759
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       2720
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114618894"
     variation       2722
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373866566"
     variation       2749
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377749396"
     variation       2756
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370187601"
     exon            2760..2917
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       2775
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11548655"
     variation       2802
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:375364337"
     variation       2809
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200677528"
     variation       2816
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3189935"
     variation       2825
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:17856213"
     variation       2830
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:371218195"
     variation       2832
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199703276"
     variation       2833
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187441573"
     variation       2838
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369092713"
     variation       2839
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201601618"
     variation       2857
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373344892"
     variation       2884
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375379804"
     variation       2899
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3189936"
     variation       2915
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369704658"
     exon            2918..3020
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       2956
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371069005"
     variation       2959
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374334077"
     variation       2978
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73598710"
     variation       3015
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139462941"
     exon            3021..3230
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       3045
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376030995"
     variation       3052
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369336417"
     variation       3060
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371326699"
     variation       3070
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377084065"
     variation       3076
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61749046"
     variation       3091
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377752384"
     variation       3092
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369090249"
     variation       3094
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1143690"
     variation       3103
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377123977"
     variation       3115
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374150535"
     variation       3118
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376216756"
     variation       3131
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199840870"
     variation       3193
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374501993"
     variation       3229
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:190262183"
     exon            3231..3376
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       3253
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368241065"
     variation       3260
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:71400186"
     variation       3271
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1071644"
     variation       3275
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376667295"
     variation       3287
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373561919"
     variation       3290
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200813182"
     variation       3303
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:114262189"
     variation       3305
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201647862"
     STS             3307..3416
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /standard_name="RH65041"
                     /db_xref="UniSTS:88565"
     variation       3310
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369077109"
     variation       3327
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372812991"
     variation       3328
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376070393"
     variation       3370
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200366770"
     variation       3372..3373
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:34401463"
     exon            3377..3491
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       3380
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375154673"
     variation       3439
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368071289"
     variation       3459
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374901017"
     variation       3462
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1130733"
     variation       3484
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372282607"
     variation       3490
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375577536"
     exon            3492..3659
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       3505
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368897845"
     variation       3514
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:193128632"
     variation       3521
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372606303"
     variation       3552
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374877793"
     variation       3558
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369259797"
     variation       3570
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376734359"
     variation       3574
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201475640"
     variation       3592
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61755443"
     variation       3607
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373377275"
     variation       3636
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146175110"
     exon            3660..3748
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       3670
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187113357"
     variation       3671
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372557475"
     variation       3672
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199571184"
     variation       3674
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374517633"
     variation       3701
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368684142"
     variation       3729
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374746148"
     exon            3749..3933
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     variation       3751
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201682723"
     variation       3795
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373686679"
     variation       3806
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377701753"
     variation       3815
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369966847"
     variation       3828
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373013824"
     variation       3829
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377396134"
     variation       3835
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201318091"
     variation       3848
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199530350"
     variation       3849
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370547009"
     variation       3860
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202108152"
     variation       3871
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:62046284"
     variation       3904
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:76506409"
     variation       3908
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200800716"
     variation       3930
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368482871"
     exon            3934..4272
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /inference="alignment:Splign:1.39.8"
     STS             3939..4271
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /standard_name="SHGC-60970"
                     /db_xref="UniSTS:44012"
     STS             3941..4238
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /standard_name="GDB:633458"
                     /db_xref="UniSTS:158510"
     variation       3964
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374430619"
     variation       4004
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200846103"
     variation       4010
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377755967"
     variation       4011
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:45554137"
     variation       4013
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201801906"
     variation       4034
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:187446555"
     STS             4052..4210
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /standard_name="RH68327"
                     /db_xref="UniSTS:8578"
     variation       4086
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1130756"
     variation       4115
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192708751"
     variation       4161
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:80134881"
     variation       4237
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:8357"
     polyA_signal    4250..4255
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
     polyA_site      4272
                     /gene="PLCG2"
                     /gene_synonym="APLAID; FCAS3"
ORIGIN      
agtagcgagcgccggcggcggagggcgtgagcggcgctgagtgacccgagtcgggacgcgggctgcgcgcgcgggaccccggagcccaaacccggggcaggcgggcagctgtgcccgggcggcacggccagcttcctgatttctcccgattccttccttctccctggagcggccgacaatgtccaccacggtcaatgtagattcccttgcggaatatgagaagagccagatcaagagagccctggagctggggacggtgatgactgtgttcagcttccgcaagtccacccccgagcggagaaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagaccgccgacaagatcgagggcttcttggatatcatggaaataaaagaaatccgcccagggaagaactccaaagatttcgagcgagcaaaagcagttcgccagaaagaagactgctgcttcaccatcctatatggcactcagttcgtcctcagcacgctcagcttggcagctgactctaaagaggatgcagttaactggctctctggcttgaaaatcttacaccaggaagcgatgaatgcgtccacgcccaccattatcgagagttggctgagaaagcagatatattctgtggatcaaaccagaagaaacagcatcagtctccgagagttgaagaccatcttgcccctgatcaactttaaagtgagcagtgccaagttccttaaagataagtttgtggaaataggagcacacaaagatgagctcagctttgaacagttccatctcttctataaaaaacttatgtttgaacagcaaaaatcgattctcgatgaattcaaaaaggattcgtccgtgttcatcctggggaacactgacaggccggatgcctctgctgtttacctgcatgacttccagaggtttctcatacatgaacagcaggagcattgggctcaggatctgaacaaagtccgtgagcggatgacaaagttcattgatgacaccatgcgtgaaactgctgagcctttcttgtttgtggatgagttcctcacgtacctgttttcacgagaaaacagcatctgggatgagaagtatgacgcggtggacatgcaggacatgaacaaccccctgtctcattactggatctcctcgtcacataacacgtaccttacaggtgaccagctgcggagcgagtcgtccccagaagcttacatccgctgcctgcgcatgggctgtcgctgcattgaactggactgctgggacgggcccgatgggaagccggtcatctaccatggctggacgcggactaccaagatcaagtttgacgacgtcgtgcaggccatcaaagaccacgcctttgttacctcgagcttcccagtgatcctgtccatcgaggagcactgcagcgtggagcaacagcgtcacatggccaaggccttcaaggaagtatttggcgacctgctgttgacgaagcccacggaggccagtgctgaccagctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccccgaggcgatgtggatgtcaacatggaggacaagaaggacgaacacaagcaacagggggagctgtacatgtgggattccattgaccagaaatggactcggcactactgcgccattgccgatgccaagctgtccttcagtgatgacattgaacagactatggaggaggaagtgccccaggatataccccctacagaactacattttggggagaaatggttccacaagaaggtggagaagaggacgagtgccgagaagttgctgcaggaatactgcatggagacggggggcaaggatggcaccttcctggttcgggagagcgagaccttccccaatgactacaccctgtccttctggcggtcaggccgggtccagcactgccggatccgctccaccatggagggcgggaccctgaaatactacttgactgacaacctcaccttcagcagcatctatgccctcatccagcactaccgcgagacgcacctgcgctgcgccgagttcgagctgcggctcacggaccctgtgcccaaccccaacccccacgagtccaagccgtggtactatgacagcctgagccgcggagaggcagaggacatgctgatgaggattccccgggacggggccttcctgatccggaagcgagaggggagcgactcctatgccatcaccttcagggctaggggcaaggtaaagcattgtcgcatcaaccgggacggccggcactttgtgctggggacctccgcctattttgagagtctggtggagctcgtcagttactacgagaagcattcactctaccgaaagatgagactgcgctaccccgtgacccccgagctcctggagcgctacaatatggaaagagatataaactccctctacgacgtcagcagaatgtatgtggatcccagtgaaatcaatccgtccatgcctcagagaaccgtgaaagctctgtatgactacaaagccaagcgaagcgatgagctgagcttctgccgtggtgccctcatccacaatgtctccaaggagcccgggggctggtggaaaggagactatggaaccaggatccagcagtacttcccatccaactacgtcgaggacatctcaactgcagacttcgaggagctagaaaagcagattattgaagacaatcccttagggtctctttgcagaggaatattggacctcaatacctataacgtcgtgaaagcccctcagggaaaaaaccagaagtcctttgtcttcatcctggagcccaagcagcagggcgatcctccggtggagtttgccacagacagggtggaggagctctttgagtggtttcagagcatccgagagatcacctggaagattgacaccaaggagaacaacatgaagtactgggagaagaaccagtccatcgccatcgagctctctgacctggttgtctactgcaaaccaaccagcaaaaccaaggacaacttagaaaatcctgacttccgagaaatccgctcctttgtggagacgaaggctgacagcatcatcagacagaagcccgtcgacctcctgaagtacaatcaaaagggcctgacccgcgtctacccaaagggacaaagagttgactcttcaaactacgaccccttccgcctctggctgtgcggttctcagatggtggcactcaatttccagacggcagataagtacatgcagatgaatcacgcattgttttctctcaatgggcgcacgggctacgttctgcagcctgagagcatgaggacagagaaatatgacccgatgccacccgagtcccagaggaagatcctgatgacgctgacagtcaaggttctcggtgctcgccatctccccaaacttggacgaagtattgcctgtccctttgtagaagtggagatctgtggagccgagtatgacaacaacaagttcaagacgacggttgtgaatgataatggcctcagccctatctgggctccaacacaggagaaggtgacatttgaaatttatgacccaaacctggcatttctgcgctttgtggtttatgaagaagatatgttcagcgatcccaactttcttgctcatgccacttaccccattaaagcagtcaaatcaggattcaggtccgttcctctgaagaatgggtacagcgaggacatagagctggcttccctcctggttttctgtgagatgcggccagtcctggagagcgaagaggaactttactcctcctgtcgccagctgaggaggcggcaagaagaactgaacaaccagctctttctgtatgacacacaccagaacttgcgcaatgccaaccgggatgccctggttaaagagttcagtgttaatgagaaccagctccagctgtaccaggagaaatgcaacaagaggttaagagagaagagagtcagcaacagcaagttttactcatagaagctggggtatgtgtgtaagggtattgtgtgtgtgcgcatgtgtgtttgcatgtaggagaacgtgccctattcacactctgggaagacgctaatctgtgacatcttttcttcaagcctgccatcaaggacatttcttaagacccaactggcatgagttggggtaatttcctattattttcatcttggacaactttcttaacttatattctttatagaggattccccaaaatgtgctcctcatttttggcctctcatgttccaaacctcattgaataaaagcaatgaaaaccttgaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5336 -> Molecular function: GO:0004435 [phosphatidylinositol phospholipase C activity] evidence: IDA
            GeneID:5336 -> Molecular function: GO:0004435 [phosphatidylinositol phospholipase C activity] evidence: TAS
            GeneID:5336 -> Molecular function: GO:0004629 [phospholipase C activity] evidence: TAS
            GeneID:5336 -> Molecular function: GO:0004871 [signal transducer activity] evidence: IEA
            GeneID:5336 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5336 -> Molecular function: GO:0005543 [phospholipid binding] evidence: IEA
            GeneID:5336 -> Biological process: GO:0002316 [follicular B cell differentiation] evidence: IEA
            GeneID:5336 -> Biological process: GO:0006661 [phosphatidylinositol biosynthetic process] evidence: IDA
            GeneID:5336 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
            GeneID:5336 -> Biological process: GO:0009395 [phospholipid catabolic process] evidence: IEA
            GeneID:5336 -> Biological process: GO:0010468 [regulation of gene expression] evidence: IEA
            GeneID:5336 -> Biological process: GO:0016055 [Wnt receptor signaling pathway] evidence: TAS
            GeneID:5336 -> Biological process: GO:0019722 [calcium-mediated signaling] evidence: NAS
            GeneID:5336 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
            GeneID:5336 -> Biological process: GO:0030183 [B cell differentiation] evidence: ISS
            GeneID:5336 -> Biological process: GO:0032237 [activation of store-operated calcium channel activity] evidence: IEA
            GeneID:5336 -> Biological process: GO:0032496 [response to lipopolysaccharide] evidence: IEA
            GeneID:5336 -> Biological process: GO:0032959 [inositol trisphosphate biosynthetic process] evidence: IEA
            GeneID:5336 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
            GeneID:5336 -> Biological process: GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] evidence: TAS
            GeneID:5336 -> Biological process: GO:0043069 [negative regulation of programmed cell death] evidence: IEA
            GeneID:5336 -> Biological process: GO:0043647 [inositol phosphate metabolic process] evidence: TAS
            GeneID:5336 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:5336 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:5336 -> Biological process: GO:0050852 [T cell receptor signaling pathway] evidence: ISS
            GeneID:5336 -> Biological process: GO:0050853 [B cell receptor signaling pathway] evidence: ISS
            GeneID:5336 -> Biological process: GO:0051209 [release of sequestered calcium ion into cytosol] evidence: IDA
            GeneID:5336 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:5336 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
            GeneID:5336 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_002652 -> EC 3.1.4.11

by @meso_cacase at DBCLS
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