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2024-04-24 20:10:38, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002648 2751 bp mRNA linear PRI 24-JUN-2013
DEFINITION Homo sapiens pim-1 oncogene (PIM1), transcript variant 1, mRNA.
ACCESSION NM_002648
VERSION NM_002648.3 GI:208431772
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2751)
AUTHORS Tahvanainen,J., Kylaniemi,M.K., Kanduri,K., Gupta,B.,
Lahteenmaki,H., Kallonen,T., Rajavuori,A., Rasool,O.,
Koskinen,P.J., Rao,K.V., Lahdesmaki,H. and Lahesmaa,R.
TITLE Proviral integration site for Moloney murine leukemia virus (PIM)
kinases promote human T helper 1 cell differentiation
JOURNAL J. Biol. Chem. 288 (5), 3048-3058 (2013)
PUBMED 23209281
REMARK GeneRIF: PIM kinases promote the production of IFNgamma, the
hallmark cytokine produced by Th1 cells.
REFERENCE 2 (bases 1 to 2751)
AUTHORS Malinen,M., Jaaskelainen,T., Pelkonen,M., Heikkinen,S.,
Vaisanen,S., Kosma,V.M., Nieminen,K., Mannermaa,A. and Palvimo,J.J.
TITLE Proto-oncogene PIM-1 is a novel estrogen receptor target
associating with high grade breast tumors
JOURNAL Mol. Cell. Endocrinol. 365 (2), 270-276 (2013)
PUBMED 23142699
REMARK GeneRIF: PIM-1 is an estrogen receptor alpha target gene adds a
novel potential mechanism by which estrogens can contribute to
breast cancer cell proliferation and carcinogenesis.
REFERENCE 3 (bases 1 to 2751)
AUTHORS Walpen,T., Kalus,I., Schwaller,J., Peier,M.A., Battegay,E.J. and
Humar,R.
TITLE Nuclear PIM1 confers resistance to rapamycin-impaired endothelial
proliferation
JOURNAL Biochem. Biophys. Res. Commun. 429 (1-2), 24-30 (2012)
PUBMED 23131564
REMARK GeneRIF: nuclear localization of PIM1 is important for resistance
of mouse aortic endothelial cells to rapamycin-mediated inhibition
of proliferation.
REFERENCE 4 (bases 1 to 2751)
AUTHORS Walpen,T., Peier,M., Haas,E., Kalus,I., Schwaller,J., Battegay,E.
and Humar,R.
TITLE Loss of pim1 imposes a hyperadhesive phenotype on endothelial cells
JOURNAL Cell. Physiol. Biochem. 30 (4), 1083-1096 (2012)
PUBMED 23202547
REMARK GeneRIF: Reintroduction of human Pim1- cDNA into Pim1-/-mouse
aortic endothelial cell significantly restored wildtype adhesive
characteristics.
REFERENCE 5 (bases 1 to 2751)
AUTHORS Xie,Y., Xu,K., Dai,B., Guo,Z., Jiang,T., Chen,H. and Qiu,Y.
TITLE The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase
Etk/BMX and protects human prostate cancer cells from apoptosis
induced by chemotherapeutic drugs
JOURNAL Oncogene 25 (1), 70-78 (2006)
PUBMED 16186805
REMARK GeneRIF: PIM1 gene encodes two isoforms by alternative translation
initiation at a non-AUG (CUG) and AUG start codons. The two
isoforms differ in preferential cellular localization, and may
regulate distinct substrates.
REFERENCE 6 (bases 1 to 2751)
AUTHORS Ragoussis,J., Senger,G., Mockridge,I., Sanseau,P., Ruddy,S.,
Dudley,K., Sheer,D. and Trowsdale,J.
TITLE A testis-expressed Zn finger gene (ZNF76) in human 6p21.3
centromeric to the MHC is closely linked to the human homolog of
the t-complex gene tcp-11
JOURNAL Genomics 14 (3), 673-679 (1992)
PUBMED 1427894
REFERENCE 7 (bases 1 to 2751)
AUTHORS Saris,C.J., Domen,J. and Berns,A.
TITLE The pim-1 oncogene encodes two related protein-serine/threonine
kinases by alternative initiation at AUG and CUG
JOURNAL EMBO J. 10 (3), 655-664 (1991)
PUBMED 1825810
REFERENCE 8 (bases 1 to 2751)
AUTHORS Reeves,R., Spies,G.A., Kiefer,M., Barr,P.J. and Power,M.
TITLE Primary structure of the putative human oncogene, pim-1
JOURNAL Gene 90 (2), 303-307 (1990)
PUBMED 2205533
REFERENCE 9 (bases 1 to 2751)
AUTHORS Amson,R., Sigaux,F., Przedborski,S., Flandrin,G., Givol,D. and
Telerman,A.
TITLE The human protooncogene product p33pim is expressed during fetal
hematopoiesis and in diverse leukemias
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86 (22), 8857-8861 (1989)
PUBMED 2682662
REFERENCE 10 (bases 1 to 2751)
AUTHORS Telerman,A., Amson,R., Zakut-Houri,R. and Givol,D.
TITLE Identification of the human pim-1 gene product as a 33-kilodalton
cytoplasmic protein with tyrosine kinase activity
JOURNAL Mol. Cell. Biol. 8 (4), 1498-1503 (1988)
PUBMED 2837645
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA434260.1, DA481890.1,
BC020224.1 and AL353579.17.
This sequence is a reference standard in the RefSeqGene project.
On Oct 3, 2008 this sequence version replaced gi:31543400.
Summary: The protein encoded by this gene belongs to the Ser/Thr
protein kinase family, and PIM subfamily. This gene is expressed
primarily in B-lymphoid and myeloid cell lines, and is
overexpressed in hematopoietic malignancies and in prostate cancer.
It plays a role in signal transduction in blood cells, contributing
to both cell proliferation and survival, and thus provides a
selective advantage in tumorigenesis. Both the human and
orthologous mouse genes have been reported to encode two isoforms
(with preferential cellular localization) resulting from the use of
alternative in-frame translation initiation codons, the upstream
non-AUG (CUG) and downstream AUG codons (PMIDs:16186805,
1825810).[provided by RefSeq, Aug 2011].
Transcript Variant: This variant (1) encodes two isoforms resulting
from the use of alternate in-frame, translation initiation codons.
This RefSeq represents the shorter isoform (2, also known as
Pim-1S) derived from the use of a downstream AUG (at nt 431-433).
Pim-1S has been shown to localize predominantly in the nucleus
(PMID:16186805).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: DQ022562.1, M54915.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-129 DA434260.1 1-129
130-132 DA481890.1 23-25
133-1696 BC020224.1 66-1629
1697-2671 AL353579.17 30893-31867
2672-2751 BC020224.1 2605-2684
FEATURES Location/Qualifiers
source 1..2751
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6p21.2"
gene 1..2751
/gene="PIM1"
/gene_synonym="PIM"
/note="pim-1 oncogene"
/db_xref="GeneID:5292"
/db_xref="HGNC:8986"
/db_xref="HPRD:01292"
/db_xref="MIM:164960"
exon 1..512
/gene="PIM1"
/gene_synonym="PIM"
/inference="alignment:Splign:1.39.8"
variation 11
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:149579998"
variation 103..105
/gene="PIM1"
/gene_synonym="PIM"
/replace=""
/replace="gca"
/db_xref="dbSNP:59116171"
variation 111..113
/gene="PIM1"
/gene_synonym="PIM"
/replace=""
/replace="agc"
/db_xref="dbSNP:71686021"
variation 113..115
/gene="PIM1"
/gene_synonym="PIM"
/replace=""
/replace="cag"
/db_xref="dbSNP:71777419"
variation 155
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:113378883"
variation 157
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:11550058"
variation 158
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:192449585"
variation 205
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:112638151"
variation 230
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:370105824"
variation 299
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="g"
/db_xref="dbSNP:262936"
variation 319..324
/gene="PIM1"
/gene_synonym="PIM"
/replace=""
/replace="cagcca"
/db_xref="dbSNP:146002992"
variation 384
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:262937"
variation 390
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:372193637"
variation 425
/gene="PIM1"
/gene_synonym="PIM"
/replace="g"
/replace="t"
/db_xref="dbSNP:377302167"
CDS 431..1372
/gene="PIM1"
/gene_synonym="PIM"
/EC_number="2.7.11.1"
/note="isoform 2 is encoded by transcript variant 1;
Oncogene PIM1; proto-oncogene serine/threonine-protein
kinase pim-1; pim-1 kinase 44 kDa isoform; pim-1 oncogene
(proviral integration site 1)"
/codon_start=1
/product="serine/threonine-protein kinase pim-1 isoform 2"
/protein_id="NP_002639.1"
/db_xref="GI:4505811"
/db_xref="CCDS:CCDS4830.1"
/db_xref="GeneID:5292"
/db_xref="HGNC:8986"
/db_xref="HPRD:01292"
/db_xref="MIM:164960"
/translation="
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
"
misc_feature 542..1300
/gene="PIM1"
/gene_synonym="PIM"
/note="Protein kinase domain; Region: Pkinase; pfam00069"
/db_xref="CDD:200973"
misc_feature 560..1294
/gene="PIM1"
/gene_synonym="PIM"
/note="Catalytic domain of Protein Kinases; Region: PKc;
cd00180"
/db_xref="CDD:173623"
misc_feature order(560..574,584..586,623..625,629..631,740..742,
788..799,812..814,818..820,929..931,935..937,941..946,
950..952,986..988,995..997,1037..1048)
/gene="PIM1"
/gene_synonym="PIM"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(560..574,584..586,623..625,629..631,740..742,
788..799,812..814,929..931,935..937,941..946,950..952,
986..988)
/gene="PIM1"
/gene_synonym="PIM"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature order(572..574,812..814,818..820,929..931,935..937,
941..943,995..997,1037..1048)
/gene="PIM1"
/gene_synonym="PIM"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature order(983..1003,1037..1048)
/gene="PIM1"
/gene_synonym="PIM"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
exon 513..619
/gene="PIM1"
/gene_synonym="PIM"
/inference="alignment:Splign:1.39.8"
variation 513
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:377274719"
variation 527
/gene="PIM1"
/gene_synonym="PIM"
/replace=""
/replace="c"
/db_xref="dbSNP:34095970"
variation 531
/gene="PIM1"
/gene_synonym="PIM"
/replace=""
/replace="t"
/db_xref="dbSNP:66515835"
variation 592
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:201760858"
variation 601
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:368447748"
exon 620..670
/gene="PIM1"
/gene_synonym="PIM"
/inference="alignment:Splign:1.39.8"
STS 629..1021
/gene="PIM1"
/gene_synonym="PIM"
/standard_name="Pim1"
/db_xref="UniSTS:463218"
variation 645
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="t"
/db_xref="dbSNP:373869744"
variation 668
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:376834220"
exon 671..1037
/gene="PIM1"
/gene_synonym="PIM"
/inference="alignment:Splign:1.39.8"
variation 674
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:149210226"
variation 675
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:367638496"
variation 679
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:55846955"
variation 704
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:375506869"
variation 736
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="c"
/db_xref="dbSNP:142449825"
variation 748
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:151311277"
variation 784
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:368369675"
variation 800
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="g"
/db_xref="dbSNP:35760989"
variation 833
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:200523275"
variation 850
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:370931326"
variation 856
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="g"
/db_xref="dbSNP:33989191"
variation 865
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:138700543"
variation 899
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:141143854"
variation 900
/gene="PIM1"
/gene_synonym="PIM"
/replace="g"
/replace="t"
/db_xref="dbSNP:200536541"
variation 922
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="c"
/db_xref="dbSNP:1050852"
variation 949
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:150289969"
variation 980
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="g"
/db_xref="dbSNP:200495767"
STS 1004..1069
/gene="PIM1"
/gene_synonym="PIM"
/standard_name="PIM1"
/db_xref="UniSTS:278910"
variation 1019
/gene="PIM1"
/gene_synonym="PIM"
/replace="g"
/replace="t"
/db_xref="dbSNP:137884665"
exon 1038..1214
/gene="PIM1"
/gene_synonym="PIM"
/inference="alignment:Splign:1.39.8"
variation 1047
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="t"
/db_xref="dbSNP:199791472"
variation 1048
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:367939225"
variation 1051
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:55982566"
variation 1093
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:56008255"
variation 1123
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="g"
/db_xref="dbSNP:201682912"
variation 1161
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:371562493"
variation 1165
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:56213408"
exon 1215..2709
/gene="PIM1"
/gene_synonym="PIM"
/inference="alignment:Splign:1.39.8"
variation 1270
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:144132371"
variation 1273
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:148258857"
variation 1275
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="t"
/db_xref="dbSNP:141695323"
variation 1310
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="g"
/db_xref="dbSNP:369630887"
variation 1313
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:373550823"
STS 1318..1802
/gene="PIM1"
/gene_synonym="PIM"
/standard_name="MARC_14741-14742:1010683927:1"
/db_xref="UniSTS:267721"
variation 1329
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:9349029"
variation 1335
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:199624946"
variation 1353
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:377586924"
variation 1354
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:146334836"
variation 1357
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:139582752"
variation 1361
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="c"
/db_xref="dbSNP:36084391"
variation 1386
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="t"
/db_xref="dbSNP:9470511"
variation 1401..1402
/gene="PIM1"
/gene_synonym="PIM"
/replace=""
/replace="tt"
/db_xref="dbSNP:372654908"
variation 1413
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:373689005"
variation 1414
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:367733847"
variation 1418
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:371684650"
variation 1466
/gene="PIM1"
/gene_synonym="PIM"
/replace="g"
/replace="t"
/db_xref="dbSNP:35111462"
variation 1467
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:12197850"
variation 1522
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:34646865"
variation 1539
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="c"
/db_xref="dbSNP:2070892"
variation 1615
/gene="PIM1"
/gene_synonym="PIM"
/replace="g"
/replace="t"
/db_xref="dbSNP:72552389"
STS 1626..1768
/gene="PIM1"
/gene_synonym="PIM"
/standard_name="D6S1832"
/db_xref="UniSTS:28797"
variation 1655
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:367993479"
variation 1658
/gene="PIM1"
/gene_synonym="PIM"
/replace="g"
/replace="t"
/db_xref="dbSNP:375169565"
variation 1661
/gene="PIM1"
/gene_synonym="PIM"
/replace="g"
/replace="t"
/db_xref="dbSNP:13209718"
variation 1662
/gene="PIM1"
/gene_synonym="PIM"
/replace="g"
/replace="t"
/db_xref="dbSNP:12205107"
variation 1678
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:190022740"
variation 1693
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="g"
/db_xref="dbSNP:1050853"
variation 1697
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:34698101"
variation 1724
/gene="PIM1"
/gene_synonym="PIM"
/replace="g"
/replace="t"
/db_xref="dbSNP:371589419"
variation 1802
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:1804168"
variation 1833
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:180819997"
variation 1927
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:10507"
variation 1974
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="t"
/db_xref="dbSNP:1804169"
variation 2027
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:35326854"
variation 2028
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="g"
/db_xref="dbSNP:373475716"
variation 2065
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:375366211"
variation 2170
/gene="PIM1"
/gene_synonym="PIM"
/replace="g"
/replace="t"
/db_xref="dbSNP:369081449"
STS 2238..2406
/gene="PIM1"
/gene_synonym="PIM"
/standard_name="G10642"
/db_xref="UniSTS:3993"
variation 2310
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:144025611"
variation 2361
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:373051321"
STS 2389..2572
/gene="PIM1"
/gene_synonym="PIM"
/standard_name="D6S2043"
/db_xref="UniSTS:38683"
variation 2391
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:111567441"
variation 2424
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:15444"
variation 2454
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:35355876"
STS 2470..2609
/gene="PIM1"
/gene_synonym="PIM"
/standard_name="RH46728"
/db_xref="UniSTS:53204"
variation 2509
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="g"
/db_xref="dbSNP:1804170"
variation 2517
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:15445"
variation 2541
/gene="PIM1"
/gene_synonym="PIM"
/replace="c"
/replace="t"
/db_xref="dbSNP:369454735"
variation 2638
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="g"
/db_xref="dbSNP:35893164"
variation 2672
/gene="PIM1"
/gene_synonym="PIM"
/replace="a"
/replace="t"
/db_xref="dbSNP:1804167"
ORIGIN
ccctttactcctggctgcggggcgagccgggcgtctgctgcagcggccgcggtggctgaggaggcccgagaggagtcggtggcagcggcggcggcgggaccggcagcagcagcagcagcagcagcagcagcaaccactagcctcctgccccgcggcgctgccgcacgagccccacgagccgctcaccccgccgttctcagcgctgcccgaccccgctggcgcgccctcccgccgccagtcccggcagcgccctcagttgtcctccgactcgccctcggccttccgcgccagccgcagccacagccgcaacgccacccgcagccacagccacagccacagccccaggcatagccttcggcacagccccggctccggctcctgcggcagctcctctgggcaccgtccctgcgccgacatcctggaggttgggatgctcttgtccaaaatcaactcgcttgcccacctgcgcgccgcgccctgcaacgacctgcacgccaccaagctggcgcccggcaaggagaaggagcccctggagtcgcagtaccaggtgggcccgctactgggcagcggcggcttcggctcggtctactcaggcatccgcgtctccgacaacttgccggtggccatcaaacacgtggagaaggaccggatttccgactggggagagctgcctaatggcactcgagtgcccatggaagtggtcctgctgaagaaggtgagctcgggtttctccggcgtcattaggctcctggactggttcgagaggcccgacagtttcgtcctgatcctggagaggcccgagccggtgcaagatctcttcgacttcatcacggaaaggggagccctgcaagaggagctggcccgcagcttcttctggcaggtgctggaggccgtgcggcactgccacaactgcggggtgctccaccgcgacatcaaggacgaaaacatccttatcgacctcaatcgcggcgagctcaagctcatcgacttcgggtcgggggcgctgctcaaggacaccgtctacacggacttcgatgggacccgagtgtatagccctccagagtggatccgctaccatcgctaccatggcaggtcggcggcagtctggtccctggggatcctgctgtatgatatggtgtgtggagatattcctttcgagcatgacgaagagatcatcaggggccaggttttcttcaggcagagggtctcttcagaatgtcagcatctcattagatggtgcttggccctgagaccatcagataggccaaccttcgaagaaatccagaaccatccatggatgcaagatgttctcctgccccaggaaactgctgagatccacctccacagcctgtcgccggggcccagcaaatagcagcctttctggcaggtcctcccctctcttgtcagatgcccgagggaggggaagcttctgtctccagcttcccgagtaccagtgacacgtctcgccaagcaggacagtgcttgatacaggaacaacatttacaactcattccagatcccaggcccctggaggctgcctcccaacagtggggaagagtgactctccaggggtcctaggcctcaactcctcccatagatactctcttcttctcataggtgtccagcattgctggactctgaaatatcccgggggtggggggtgggggtgggtcagaaccctgccatggaactgtttccttcatcatgagttctgctgaatgccgcgatgggtcaggtaggggggaaacaggttgggatgggataggactagcaccattttaagtccctgtcacctcttccgactctttctgagtgccttctgtggggactccggctgtgctgggagaaatacttgaacttgcctcttttacctgctgcttctccaaaaatctgcctgggttttgttccctatttttctctcctgtcctccctcaccccctccttcatatgaaaggtgccatggaagaggctacagggccaaacgctgagccacctgcccttttttctgcctcctttagtaaaactccgagtgaactggtcttcctttttggtttttacttaactgtttcaaagccaagacctcacacacacaaaaaatgcacaaacaatgcaatcaacagaaaagctgtaaatgtgtgtacagttggcatggtagtatacaaaaagattgtagtggatctaatttttaagaaattttgcctttaagttattttacctgtttttgtttcttgttttgaaagatgcgcattctaacctggaggtcaatgttatgtatttatttatttatttatttggttcccttcctattccaagcttccatagctgctgccctagttttctttcctcctttcctcctctgacttggggaccttttgggggagggctgcgacgcttgctctgtttgtggggtgacgggactcaggcgggacagtgctgcagctccctggcttctgtggggcccctcacctacttacccaggtgggtcccggctctgtgggtgatggggaggggcattgctgactgtgtatataggataattatgaaaagcagttctggatggtgtgccttccagatcctctctggggctgtgttttgagcagcaggtagcctgctggttttatctgagtgaaatactgtacaggggaataaaagagatcttatttttttttttatacttggcgttttttgaataaaaaccttttgtcttaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5292 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:5292 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5292 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
GeneID:5292 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
GeneID:5292 -> Molecular function: GO:0030145 [manganese ion binding] evidence: IDA
GeneID:5292 -> Molecular function: GO:0043024 [ribosomal small subunit binding] evidence: IPI
GeneID:5292 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:5292 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:5292 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:5292 -> Biological process: GO:0007275 [multicellular organismal development] evidence: TAS
GeneID:5292 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA
GeneID:5292 -> Biological process: GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] evidence: IDA
GeneID:5292 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA
GeneID:5292 -> Biological process: GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] evidence: IDA
GeneID:5292 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
GeneID:5292 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IMP
GeneID:5292 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:5292 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:5292 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_002639 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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