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2020-10-26 18:46:32, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_002639               2633 bp    mRNA    linear   PRI 12-MAY-2013
DEFINITION  Homo sapiens serpin peptidase inhibitor, clade B (ovalbumin),
            member 5 (SERPINB5), mRNA.
ACCESSION   NM_002639
VERSION     NM_002639.4  GI:167860125
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2633)
  AUTHORS   Shi,J., Liu,H., Wang,H.L., Prichard,J.W. and Lin,F.
  TITLE     Diagnostic utility of von Hippel-Lindau gene product, maspin, IMP3,
            and S100P in adenocarcinoma of the gallbladder
  JOURNAL   Hum. Pathol. 44 (4), 503-511 (2013)
   PUBMED   23079206
  REMARK    GeneRIF: This study demonstrates that the immunostaining profile of
            pVHL-/IMP3+/maspin+/S100P+ is useful in the distinction of
            adenocarcinoma of the gallbladder from normal/reactive conditions.
REFERENCE   2  (bases 1 to 2633)
  AUTHORS   Kim,M., Ju,H., Lim,B. and Kang,C.
  TITLE     Maspin genetically and functionally associates with gastric cancer
            by regulating cell cycle progression
  JOURNAL   Carcinogenesis 33 (12), 2344-2350 (2012)
   PUBMED   22962304
  REMARK    GeneRIF: Maspin genetically and functionally associates with
            gastric cancer by regulating cell cycle progression.
REFERENCE   3  (bases 1 to 2633)
  AUTHORS   Acikalin,D., Oner,U., Can,C., Acikalin,M.F. and Colak,E.
  TITLE     Predictive value of maspin and Ki-67 expression in transurethral
            resection specimens in patients with T1 bladder cancer
  JOURNAL   Tumori 98 (3), 344-350 (2012)
   PUBMED   22825520
  REMARK    GeneRIF: Findings suggested that the evaluation of maspin
            expression in stage T1 bladder tumors is a useful prognostic marker
            for predicting the tumor behavior.
REFERENCE   4  (bases 1 to 2633)
  AUTHORS   Ma,L., Shen,Y.Y., Zhou,P., Zhou,J. and Guo,F.
  TITLE     [NF-kappaB subunits regulate maspin expression in prostate cancer
            cells in vitro]
  JOURNAL   Zhonghua Zhong Liu Za Zhi 34 (3), 165-168 (2012)
   PUBMED   22780967
  REMARK    GeneRIF: The expression of RelB negatively regulates the endogenous
            expression of maspin in prostate cancer cells in vitro.
REFERENCE   5  (bases 1 to 2633)
  AUTHORS   Neal,C.L., Henderson,V., Smith,B.N., McKeithen,D., Graham,T.,
            Vo,B.T. and Odero-Marah,V.A.
  TITLE     Snail transcription factor negatively regulates maspin tumor
            suppressor in human prostate cancer cells
  JOURNAL   BMC Cancer 12, 336 (2012)
   PUBMED   22857708
  REMARK    GeneRIF: This study is the first report showing that Snail can
            negatively regulate maspin expression by directly repressing maspin
            promoter activity, leading to increased cell migration and
            invasion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2633)
  AUTHORS   Pemberton,P.A., Tipton,A.R., Pavloff,N., Smith,J., Erickson,J.R.,
            Mouchabeck,Z.M. and Kiefer,M.C.
  TITLE     Maspin is an intracellular serpin that partitions into secretory
            vesicles and is present at the cell surface
  JOURNAL   J. Histochem. Cytochem. 45 (12), 1697-1706 (1997)
   PUBMED   9389773
REFERENCE   7  (bases 1 to 2633)
  AUTHORS   Sager,R., Sheng,S., Pemberton,P. and Hendrix,M.J.
  TITLE     Maspin. A tumor suppressing serpin
  JOURNAL   Adv. Exp. Med. Biol. 425, 77-88 (1997)
   PUBMED   9433491
  REMARK    Review article
REFERENCE   8  (bases 1 to 2633)
  AUTHORS   Pemberton,P.A., Wong,D.T., Gibson,H.L., Kiefer,M.C.,
            Fitzpatrick,P.A., Sager,R. and Barr,P.J.
  TITLE     The tumor suppressor maspin does not undergo the stressed to
            relaxed transition or inhibit trypsin-like serine proteases.
            Evidence that maspin is not a protease inhibitory serpin
  JOURNAL   J. Biol. Chem. 270 (26), 15832-15837 (1995)
   PUBMED   7797587
REFERENCE   9  (bases 1 to 2633)
  AUTHORS   Schneider,S.S., Schick,C., Fish,K.E., Miller,E., Pena,J.C.,
            Treter,S.D., Hui,S.M. and Silverman,G.A.
  TITLE     A serine proteinase inhibitor locus at 18q21.3 contains a tandem
            duplication of the human squamous cell carcinoma antigen gene
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (8), 3147-3151 (1995)
   PUBMED   7724531
REFERENCE   10 (bases 1 to 2633)
  AUTHORS   Zou,Z., Anisowicz,A., Hendrix,M.J., Thor,A., Neveu,M., Sheng,S.,
            Rafidi,K., Seftor,E. and Sager,R.
  TITLE     Maspin, a serpin with tumor-suppressing activity in human mammary
            epithelial cells
  JOURNAL   Science 263 (5146), 526-529 (1994)
   PUBMED   8290962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL602439.1, CV575332.1, BM955647.1 and AC036176.8.
            On Feb 15, 2008 this sequence version replaced gi:142377273.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U04313.1, AK312765.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025084, ERS025085 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-648               AL602439.1         4-651
            649-1118            CV575332.1         136-605
            1119-1396           BM955647.1         347-624
            1397-2633           AC036176.8         23638-24874         c
FEATURES             Location/Qualifiers
     source          1..2633
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.33"
     gene            1..2633
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /note="serpin peptidase inhibitor, clade B (ovalbumin),
                     member 5"
                     /db_xref="GeneID:5268"
                     /db_xref="HGNC:8949"
                     /db_xref="MIM:154790"
     exon            1..135
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    26..28
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /note="upstream in-frame stop codon"
     variation       87
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:75113857"
     exon            136..310
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /inference="alignment:Splign:1.39.8"
     variation       140
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:77710366"
     CDS             143..1270
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /note="protease inhibitor 5 (maspin); serine (or cysteine)
                     proteinase inhibitor, clade B (ovalbumin), member 5; PI-5;
                     peptidase inhibitor 5"
                     /codon_start=1
                     /product="serpin B5"
                     /protein_id="NP_002630.2"
                     /db_xref="GI:167860126"
                     /db_xref="CCDS:CCDS32839.1"
                     /db_xref="GeneID:5268"
                     /db_xref="HGNC:8949"
                     /db_xref="MIM:154790"
                     /translation="
MDALQLANSAFAVDLFKQLCEKEPLGNVLFSPICLSTSLSLAQVGAKGDTANEIGQVLHFENVKDVPFGFQTVTSDVNKLSSFYSLKLIKRLYVDKSLNLSTEFISSTKRPYAKELETVDFKDKLEETKGQINNSIKDLTDGHFENILADNSVNDQTKILVVNAAYFVGKWMKKFSESETKECPFRVNKTDTKPVQMMNMEATFCMGNIDSINCKIIELPFQNKHLSMFILLPKDVEDESTGLEKIEKQLNSESLSQWTNPSTMANAKVKLSIPKFKVEKMIDPKACLENLGLKHIFSEDTSDFSGMSETKGVALSNVIHKVCLEITEDGGDSIEVPGARILQHKDELNADHPFIYIIRHNKTRNIIFFGKFCSP
"
     misc_feature    152..1267
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /note="Maspin (mammary serine proteinase inhibitor), a
                     member of the serpin superfamily, with a multitude of
                     effects on cells and tissues at an assortment of
                     developmental stages. Maspin has tumor suppressing
                     activity against breast and prostate cancer. In...;
                     Region: maspin_like; cd02057"
                     /db_xref="CDD:29132"
     misc_feature    221..1267
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /note="serpin-like protein; Provisional; Region: PHA02660"
                     /db_xref="CDD:165039"
     misc_feature    order(629..652,1100..1123)
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /note="shutter residues; other site"
                     /db_xref="CDD:29132"
     misc_feature    order(662..706,719..745)
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /note="gate residues; other site"
                     /db_xref="CDD:29132"
     misc_feature    1127..1132
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /note="hinge residues; other site"
                     /db_xref="CDD:29132"
     misc_feature    order(1130..1141,1184..1201)
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /note="reactive center loop; other site"
                     /db_xref="CDD:29132"
     misc_feature    1160..1165
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="Reactive bond homolog (By similarity); propagated
                     from UniProtKB/Swiss-Prot (P36952.2); other site"
     variation       153
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371513895"
     STS             163..297
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /standard_name="GDB:435245"
                     /db_xref="UniSTS:157216"
     variation       168
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374163653"
     variation       169
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145802990"
     variation       175
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148566348"
     variation       177
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:142546858"
     variation       178
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2292294"
     variation       184
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141915869"
     variation       185
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:145765491"
     variation       186
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147782595"
     variation       229
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377003982"
     variation       261
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201251421"
     variation       262
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113058642"
     variation       267
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:180726460"
     variation       273
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:140384163"
     variation       284
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150383460"
     exon            311..448
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /inference="alignment:Splign:1.39.8"
     variation       312
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:138019543"
     variation       319
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371063228"
     variation       335
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149514262"
     variation       338
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61735448"
     variation       342
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375704233"
     variation       348
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138319338"
     variation       373
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200213704"
     variation       409
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:34866511"
     variation       413
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:372076697"
     variation       414
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146056603"
     variation       422
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377697959"
     variation       439
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371320466"
     exon            449..566
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /inference="alignment:Splign:1.39.8"
     variation       456
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61761883"
     variation       466
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141561710"
     variation       467
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150909720"
     variation       475
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:12454742"
     variation       523
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200364734"
     variation       525
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:145559318"
     variation       530
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374983437"
     exon            567..709
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /inference="alignment:Splign:1.39.8"
     variation       592
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200888395"
     variation       615
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373734502"
     variation       652
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2289518"
     variation       668
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2289519"
     variation       689
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140393612"
     variation       701
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2289520"
     exon            710..877
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /inference="alignment:Splign:1.39.8"
     variation       713
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145448576"
     variation       733
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148829613"
     variation       858
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:367852622"
     variation       862
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371720610"
     variation       864
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373752630"
     exon            878..2633
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /inference="alignment:Splign:1.39.8"
     variation       894
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201024367"
     variation       957
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142654718"
     variation       965
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201595465"
     variation       971
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374389438"
     variation       972
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151011754"
     variation       993
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:140803243"
     variation       998
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144771613"
     variation       1009
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200796901"
     variation       1018
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:138711296"
     variation       1036
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1455556"
     variation       1048
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200606458"
     variation       1097
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1455555"
     variation       1099
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:181635681"
     variation       1105
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138689781"
     variation       1106
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376750114"
     variation       1133
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185364126"
     variation       1136
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:149353823"
     variation       1147
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372972017"
     variation       1165
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370247320"
     variation       1177
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373768833"
     variation       1232
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144814891"
     variation       1240
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8093128"
     STS             1274..1432
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /standard_name="GDB:435240"
                     /db_xref="UniSTS:157215"
     variation       1393
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190132510"
     variation       1431..1433
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35377797"
     variation       1433
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112777966"
     variation       1513
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182350521"
     variation       1557
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:186059840"
     variation       1592
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148559989"
     variation       1636
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12150761"
     STS             1664..1996
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /standard_name="SHGC-12569"
                     /db_xref="UniSTS:11720"
     variation       1674
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73468519"
     variation       1744
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:77230459"
     variation       1879
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115195446"
     variation       1900
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:73964614"
     variation       1905
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1004"
     variation       1912
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:894"
     variation       1991
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:112795011"
     variation       1994
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:56132922"
     variation       2039
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376940464"
     STS             2177..2362
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /standard_name="RH17976"
                     /db_xref="UniSTS:58530"
     variation       2177
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:73468520"
     variation       2218
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:17071220"
     variation       2241
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142907436"
     variation       2244
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:80107199"
     variation       2332
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183993214"
     variation       2435
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150696400"
     variation       2460
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11664401"
     variation       2467
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:73964616"
     variation       2479..2480
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace=""
                     /replace="tac"
                     /db_xref="dbSNP:370788886"
     variation       2499
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112120554"
     variation       2507..2508
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:35023912"
     variation       2513
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:79329017"
     variation       2548
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11152386"
     variation       2563
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:15964"
     variation       2596
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11542560"
ORIGIN      
agtgggcgtggcggtgctgcccaggtgagccaccgctgcttctgcccagacacggtcgcctccacatccaggtctttgtgctcctcgcttgcctgttccttttccacgcattttccaggataactgtgactccaggcccgcaatggatgccctgcaactagcaaattcggcttttgccgttgatctgttcaaacaactatgtgaaaaggagccactgggcaatgtcctcttctctccaatctgtctctccacctctctgtcacttgctcaagtgggtgctaaaggtgacactgcaaatgaaattggacaggttcttcattttgaaaatgtcaaagatgtaccctttggatttcaaacagtaacatcggatgtaaacaaacttagttccttttactcactgaaactaatcaagcggctctacgtagacaaatctctgaatctttctacagagttcatcagctctacgaagagaccgtatgcaaaggaattggaaactgttgacttcaaagataaattggaagaaacgaaaggtcagatcaacaactcaattaaggatctcacagatggccactttgagaacattttagctgacaacagtgtgaacgaccagaccaaaatccttgtggttaatgctgcctactttgttggcaagtggatgaagaaattttctgaatcagaaacaaaagaatgtcctttcagagtcaacaagacagacaccaaaccagtgcagatgatgaacatggaggccacgttctgtatgggaaacattgacagtatcaattgtaagatcatagagcttccttttcaaaataagcatctcagcatgttcatcctactacccaaggatgtggaggatgagtccacaggcttggagaagattgaaaaacaactcaactcagagtcactgtcacagtggactaatcccagcaccatggccaatgccaaggtcaaactctccattccaaaatttaaggtggaaaagatgattgatcccaaggcttgtctggaaaatctagggctgaaacatatcttcagtgaagacacatctgatttctctggaatgtcagagaccaagggagtggccctatcaaatgttatccacaaagtgtgcttagaaataactgaagatggtggggattccatagaggtgccaggagcacggatcctgcagcacaaggatgaattgaatgctgaccatccctttatttacatcatcaggcacaacaaaactcgaaacatcattttctttggcaaattctgttctccttaagtggcatagcccatgttaagtcctccctgacttttctgtggatgccgatttctgtaaactctgcatccagagattcattttctagatacaataaattgctaatgttgctggatcaggaagccgccagtacttgtcatatgtagccttcacacagatagaccttttttttttttccaattctatcttttgtttccttttttcccataagacaatgacatacgcttttaatgaaaaggaatcacgttagaggaaaaatatttattcattatttgtcaaattgtccggggtagttggcagaaatacagtcttccacaaagaaaattcctataaggaagatttggaagctcttcttcccagcactatgctttccttctttgggatagagaatgttccagacattctcgcttccctgaaagactgaagaaagtgtagtgcatgggacccacgaaactgccctggctccagtgaaacttgggcacatgctcaggctactataggtccagaagtccttatgttaagccctggcaggcaggtgtttattaaaattctgaattttggggattttcaaaagataatattttacatacactgtatgttatagaacttcatggatcagatctggggcagcaccctataaatcaacaccttaatatgctgcaacaaaatgtagaatattcagacaaaatggatacataaagactaagtagcccataaggggtcaaaatttgctgccaaatgcgtatgccaccaacttacaaaaacacttcgttcgcagagcttttcagattgtggaatgttggataaggaattatagacctctagtagctgaaatgcaagaccccaagaggaagttcagatcttaatataaattcactttcatttttgatagctgtcccatctggtcatttggttggcactagactggtggcaggggcttctagctgacttgcacagggattctcacaatagccgatatcagaatttgtgttgaaggaacttgtctcttcatctaatatgatagcgggaaaaggagaggaaactactgcctttagaaaatataagtaaagtgattaaagtgctcacgttaccttgacacatagtttttcagtctatgggtttagttactttagatggcaagcatgtaacttatattaatagtaatttgtaaagttggttggataagctatccgtgttgcaggttcatggattacttctctataaaaaatatgtatttaccaaaaattttgtgacattccttctcccatctcttccttgacctgcattgtaaataggttcttcttgttctgagattcaatattgaatttttcctatgctattgacaataaaatattattgaactaca
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5268 -> Molecular function: GO:0004867 [serine-type endopeptidase inhibitor activity] evidence: IBA
            GeneID:5268 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5268 -> Biological process: GO:0002009 [morphogenesis of an epithelium] evidence: IEA
            GeneID:5268 -> Biological process: GO:0006928 [cellular component movement] evidence: TAS
            GeneID:5268 -> Biological process: GO:0010951 [negative regulation of endopeptidase activity] evidence: IBA
            GeneID:5268 -> Biological process: GO:0030162 [regulation of proteolysis] evidence: IBA
            GeneID:5268 -> Biological process: GO:0030198 [extracellular matrix organization] evidence: IEA
            GeneID:5268 -> Biological process: GO:0050678 [regulation of epithelial cell proliferation] evidence: IEA
            GeneID:5268 -> Biological process: GO:0060512 [prostate gland morphogenesis] evidence: IEA
            GeneID:5268 -> Cellular component: GO:0005615 [extracellular space] evidence: IEA
            GeneID:5268 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA

by @meso_cacase at DBCLS
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