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2024-04-25 14:21:26, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002603 6490 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens phosphodiesterase 7A (PDE7A), transcript variant 1,
mRNA.
ACCESSION NM_002603
VERSION NM_002603.3 GI:341823662
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6490)
AUTHORS Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
CONSRTM DREAM investigators
TITLE Variation at the NFATC2 locus increases the risk of
thiazolidinedione-induced edema in the Diabetes REduction
Assessment with ramipril and rosiglitazone Medication (DREAM) study
JOURNAL Diabetes Care 33 (10), 2250-2253 (2010)
PUBMED 20628086
REMARK GeneRIF: Observational study of gene-disease association,
gene-environment interaction, and pharmacogenomic / toxicogenomic.
(HuGE Navigator)
REFERENCE 2 (bases 1 to 6490)
AUTHORS Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
CONSRTM ASCOT investigators; NORDIL investigators; BRIGHT Consortium
TITLE Gene-centric association signals for lipids and apolipoproteins
identified via the HumanCVD BeadChip
JOURNAL Am. J. Hum. Genet. 85 (5), 628-642 (2009)
PUBMED 19913121
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (bases 1 to 6490)
AUTHORS Pekkinen,M., Ahlstrom,M.E., Riehle,U., Huttunen,M.M. and
Lamberg-Allardt,C.J.
TITLE Effects of phosphodiesterase 7 inhibition by RNA interference on
the gene expression and differentiation of human mesenchymal stem
cell-derived osteoblasts
JOURNAL Bone 43 (1), 84-91 (2008)
PUBMED 18420479
REMARK GeneRIF: results show that specific gene silencing with the RNAi
method is a useful tool for inhibiting the gene expression of
specific PDEs and that PDE7 silencing upregulates several
osteogenic genes and increases mineralization
REFERENCE 4 (bases 1 to 6490)
AUTHORS Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
Kim,N.S.
TITLE Transcriptome analysis of human gastric cancer
JOURNAL Mamm. Genome 16 (12), 942-954 (2005)
PUBMED 16341674
REFERENCE 5 (bases 1 to 6490)
AUTHORS Wang,H., Liu,Y., Chen,Y., Robinson,H. and Ke,H.
TITLE Multiple elements jointly determine inhibitor selectivity of cyclic
nucleotide phosphodiesterases 4 and 7
JOURNAL J. Biol. Chem. 280 (35), 30949-30955 (2005)
PUBMED 15994308
REMARK GeneRIF: crystal structure of PDE7A1 catalytic domain complexed
with the inhibitor 3-isobutyl-1-methylxanthine & kinetic analysis
on mutant PDE7A1 and PDE4D2; results show several residues must
work together to switch inhibitor selectivity between PDE4 & PDE7
REFERENCE 6 (bases 1 to 6490)
AUTHORS Han,P., Fletcher,C.F., Copeland,N.G., Jenkins,N.A., Yaremko,L.M.
and Michaeli,T.
TITLE Assignment of the mouse Pde7A gene to the proximal region of
chromosome 3 and of the human PDE7A gene to chromosome 8q13
JOURNAL Genomics 48 (2), 275-276 (1998)
PUBMED 9521885
REFERENCE 7 (bases 1 to 6490)
AUTHORS Han,P., Zhu,X. and Michaeli,T.
TITLE Alternative splicing of the high affinity cAMP-specific
phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart
JOURNAL J. Biol. Chem. 272 (26), 16152-16157 (1997)
PUBMED 9195912
REFERENCE 8 (bases 1 to 6490)
AUTHORS Bloom,T.J. and Beavo,J.A.
TITLE Identification and tissue-specific expression of PDE7
phosphodiesterase splice variants
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (24), 14188-14192 (1996)
PUBMED 8943082
REFERENCE 9 (bases 1 to 6490)
AUTHORS Milatovich,A., Bolger,G., Michaeli,T. and Francke,U.
TITLE Chromosome localizations of genes for five cAMP-specific
phosphodiesterases in man and mouse
JOURNAL Somat. Cell Mol. Genet. 20 (2), 75-86 (1994)
PUBMED 8009369
REFERENCE 10 (bases 1 to 6490)
AUTHORS Michaeli,T., Bloom,T.J., Martins,T., Loughney,K., Ferguson,K.,
Riggs,M., Rodgers,L., Beavo,J.A. and Wigler,M.
TITLE Isolation and characterization of a previously undetected human
cAMP phosphodiesterase by complementation of cAMP
phosphodiesterase-deficient Saccharomyces cerevisiae
JOURNAL J. Biol. Chem. 268 (17), 12925-12932 (1993)
PUBMED 8389765
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from U67932.1, AK057586.1,
AW387924.1, AC055822.10, CN414361.1, N49050.1 and BM818331.1.
On Jul 27, 2011 this sequence version replaced gi:208610004.
Summary: The protein encoded by this gene belongs to the cyclic
nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This
PDE hydrolyzes the second messenger, cAMP, which is a regulator and
mediator of a number of cellular responses to extracellular
signals. Thus, by regulating the cellular concentration of cAMP,
this protein plays a key role in many important physiological
processes. Alternatively spliced transcript variants encoding
different isoforms have been described for this gene. [provided by
RefSeq, Jul 2011].
Transcript Variant: This variant (1, also called PDE7A2) differs in
the 5' UTR and coding sequence compared to variant 3. The resulting
isoform (a) has a distinct N-terminus compared to isoform c.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no single transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK290801.1, U67932.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1736 U67932.1 4-1739
1737-3128 AK057586.1 1390-2781
3129-3257 AW387924.1 357-485 c
3258-3396 AC055822.10 84859-84997
3397-3904 CN414361.1 1-508
3905-4209 N49050.1 1-305 c
4210-6428 AC055822.10 85811-88029
6429-6490 BM818331.1 225-286
FEATURES Location/Qualifiers
source 1..6490
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q13"
gene 1..6490
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/note="phosphodiesterase 7A"
/db_xref="GeneID:5150"
/db_xref="HGNC:8791"
/db_xref="HPRD:01386"
/db_xref="MIM:171885"
exon 1..213
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
STS 9..1645
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/db_xref="UniSTS:491157"
misc_feature 25..27
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/note="upstream in-frame stop codon"
CDS 154..1524
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/EC_number="3.1.4.17"
/note="isoform a precursor is encoded by transcript
variant 1; high affinity cAMP-specific 3',5'-cyclic
phosphodiesterase 7A; phosphodiesterase isozyme 7; TM22"
/codon_start=1
/product="high affinity cAMP-specific 3',5'-cyclic
phosphodiesterase 7A isoform a precursor"
/protein_id="NP_002594.1"
/db_xref="GI:24429566"
/db_xref="CCDS:CCDS34901.1"
/db_xref="GeneID:5150"
/db_xref="HGNC:8791"
/db_xref="HPRD:01386"
/db_xref="MIM:171885"
/translation="
MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
"
sig_peptide 154..210
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
misc_feature 325..327
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[7]
misc_feature 706..1230
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/note="Metal dependent phosphohydrolases with conserved
'HD' motif; Region: HDc; cd00077"
/db_xref="CDD:28958"
misc_feature order(721..723,829..834,1159..1161)
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/note="Zn2+ binding site [ion binding]; other site"
/db_xref="CDD:28958"
misc_feature 832..834
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/note="Mg2+ binding site [ion binding]; other site"
/db_xref="CDD:28958"
exon 214..274
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 275..358
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
variation 302
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/replace="a"
/replace="g"
/db_xref="dbSNP:11557049"
exon 359..510
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 511..574
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 575..670
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 671..771
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 772..903
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 904..995
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 996..1140
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 1141..1237
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 1238..1318
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 1319..6480
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
variation 1425
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/replace="c"
/replace="t"
/db_xref="dbSNP:5002418"
STS 1536..1785
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/standard_name="RH75847"
/db_xref="UniSTS:85511"
polyA_signal 2419..2424
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
polyA_site 2450
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
STS 2790..2945
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/standard_name="RH91483"
/db_xref="UniSTS:83716"
STS 2916..3056
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/standard_name="D8S2079"
/db_xref="UniSTS:76580"
polyA_signal 3110..3115
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
polyA_site 3144
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
STS 5158..5539
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/standard_name="GDB:631802"
/db_xref="UniSTS:158429"
variation 6428
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/replace="c"
/replace="g"
/db_xref="dbSNP:2048648"
polyA_signal 6456..6461
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
variation 6463
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/replace="a"
/replace="g"
/db_xref="dbSNP:4366113"
polyA_site 6480
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
ORIGIN
gatcactgttggaaggcagctgcttgaggtccaaggcagtcagtgtcccctctcttttgcctcgggacagctggtatttatcagactcctaagaagttttccttgctccctagtagaagagagagattatgcagcgggcttttgattgatccaatgggaattacattgatctggtgtctggccttggttcttatcaagtggatcacctctaagaggcgtggagctatttcctatgacagttctgatcagactgcattatacattcgtatgctaggagatgtacgtgtaaggagccgagcaggatttgaatcagaaagaagaggttctcacccatatattgattttcgtattttccactctcaatctgaaattgaagtgtctgtctctgcaaggaatatcagaaggctactaagtttccagcgatatcttagatcttcacgcttttttcgtggtactgcggtttcaaattccctaaacattttagatgatgattataatggacaagccaagtgtatgctggaaaaagttggaaattggaattttgatatctttctatttgatagactaacaaatggaaatagtctagtaagcttaacctttcatttatttagtcttcatggattaattgagtacttccatttagatatgatgaaacttcgtagatttttagttatgattcaagaagattaccacagtcaaaatccttaccataacgcagtccacgctgcggatgttactcaggccatgcactgttacttaaaggaacctaagcttgccaattctgtaactccttgggatatcttgctgagcttaattgcagctgccactcatgatctggatcatccaggtgttaatcaacctttccttattaaaactaaccattacttggcaactttatacaagaatacctcagtactggaaaatcaccactggagatctgcagtgggcttattgagagaatcaggcttattctcacatctgccattagaaagcaggcaacaaatggagacacagataggtgctctgatactagccacagacatcagtcgccagaatgagtatctgtctttgtttaggtcccatttggatagaggtgatttatgcctagaagacaccagacacagacatttggttttacagatggctttgaaatgtgctgatatttgtaacccatgtcggacgtgggaattaagcaagcagtggagtgaaaaagtaacggaggaattcttccatcaaggagatatagaaaaaaaatatcatttgggtgtgagtccactttgcgatcgtcacactgaatctattgccaacatccagattggttttatgacttacctagtggagcctttatttacagaatgggccaggttttccaatacaaggctatcccagacaatgcttggacacgtggggctgaataaagccagctggaagggactgcagagagaacagtcgagcagtgaggacactgatgctgcatttgagttgaactcacagttattacctcaggaaaatcggttatcataacccccagaaccagtgggacaaactgcctcctggaggtttttagaaatgtgaaatggggtcttgaggtgagagaacttaactcttgactgccaaggtttccaagtgagtgatgccagccagcattatttatttccaagatttcctctgttggatcatttgaacccacttgttaattgcaagacccgaacatacagcaatatgaatttggctttcatgtgaaaccttgaatatgcaaagcccagcaggagagaatccgaaaggagtaacaaaggaagttttgatatgtgccacgactttttcaaagcatctaatcttcaaaacgtgaaacttgaattgttcagcaacaatctcttggaatttaaccagtctgatgcaacaatgtgtatcttgtaccttccactaagttctctctgagaaaatggaaatgtgaagtgcccagcctctgctgcctctggcaagacaatgtttacaaatcaactctgaaaatattggttctaaattgccttggagcatgattgtgaaggaaccactcaaacaaatttaaagatcaaactttagactgcagctctttccccctggtttgcctttttcttctttggatgccaccaaagcctcccatttgctatagttttatttcatgcactggaaactgagcatttatcgtagagtaccgccaagctttcactccagtgccgtttggcaatgcaattttttttagcaattagtttttaatttggggtgggaggggaagaacaccaatgtcctagctgtattatgattctgcagtgaagacattgcatgttgttttcactactgtacacttgacctgcacatgcgagaaaaaggtggaatgtttaaaacaccataatcagctcagggtatttgccaatctgaaataaaagtgggatgggagagtgtgtccttcagatcaagggtactaaagtccctttcgctgcagtgagtgagaggtatgttgtgtgtgaatgtacggatgtgtgtttgcgtgcatgtttgtgcatgtgtgactgtgcatgttatgtttctccatgtgggcaaagatttgaaatgtaagcttttatttattattttagaatgtgacataatgagcagccacactcgggggaggggaaggttggtaggtaagctgtaacagattgctccagttgccttaaactatgcacatagctaagtgaccaaacttcttgttttgatttgaaaaaagtgcattgttttcttgtccctccctttgatgaaacgttaccctttgacgggccttttgatgtgaacagatgttttctaggacaaactataaggactaattttaaacttcaaacattccacttttgtaatttgttttaaattgttttatgtatagtaagcacaactgtaatctagttttaagagaaaccggtgctttcttttagttcatttgtatttcccttgttactgtaaaagactgtttattaattgtttacagtttgttgcaacagccattttcttgggagaaagcttgagtgtaaagccatttgtaaaaggctttgccatactcattttaatatgtgcctgttgctgttaacttttgatgaataaaaacctatcttttcatatttttatctttgacatttaccttataactcaatcttttggaaaacacaatgctaaattacaaggaaatcaaagttagcttcttggctcttgtaattcatccctcagatgtttactcagtccgagcttatctactaatgactcaccttgcaagtgagtaagcagaagcccagttagggctgttggagtcctgactaacacaggggagaggtcagctttgagccaggccttttgttcctacagtggtgaactgcataagacatcagcaagtcttgcaagtactaaaatactagttgtatttatttctatcaatcattggcctttttaaagtgataagaaaaggccactccactctacttgattgatatcagttgtaaacaaggtaccactgtgccattccctatatcttcccaggtccaactcattagaagggatatggtgcaaacttctaaatcaaacacattaacatattatttgtacagaagagtgttgatgtccaatagaaacagaatccaagccacataattttcggttttctagtagccacatttagaaaacatggaattaattttagtaacatctattccaatacgtccaaaatattgtatcactttaaaatgtcaatataaaaacaattagatgtttttacattcttttggggggtactaagtctttgaaatccagtgtatattgtgtacttacagcacatctcaatttggactagtcatatctcaggcacccaatatccacatgtggctagtggctaccatattggacagtgtgggtatagaggtctgagggtagtagaggaatatggtcagctggtcactctcgtgagatggccataccttggcctatatttaatgtgtacagaaagtctgataactcagatccttaaaaattcaggcccactgtttcagtacatagagagtggaactatcatggcaaacccacattaaccaagctcacagtaactatttttttaaaacactatcaatattttaatttacagtgagaaatgtaactatcaattattctctccctttaggcaaatcttcctgggaagccaaattatgagcagctggtgagcatggattctgagcaagggaagcaagttgcctcgtgcacccatgtccctttgggtgcacagaagacccatgtcttctgtgatattcatgtttgtggaccagggtaccctcttcccctggaaggtgctagagattctctgccagtagttgcttctctacatcagcttctgattggcacatgcattaaataacgtcattacctcaagccttgtttcagttgagcttacctgggctccattctgcctgtatacatgattgcttctgctctgatccattgtttctcttatagtttgaaactgaaaagatcatcctatttccacattctcaggggaactgtgggtgtggctcccatttcctgcctacacatataataaacccattgaaaagttgttttattatgtatatgtgggaatcaccttctatagcccttttgtttttttttttttttgagacagggtctcgctgctaactaggctggagtgcagtggcatgatcactgcagcctccacctcctaggctcaagcaatcctcccacctcagcctcctgagtgccaccacaccacccagctaatttttttttttttttttttttttttttttgagacagagccttgctctgtcgcccaggctggagtgcagtgccgcgatattggctcactgcaagttccgcctcccgggttcacgccattctcctcattctcctgcctcagtctcccaggtcgctgggactacaggcgcccgccaccaggccctgctaatttttttgtactttattagtagagttagggtttcaccatgttagccaggatggtctcaatctcctgacctcgtgatccgcccgcctcggcctcccatagtgctgggattacaggcgtgagccaccgtgcccggccagctaattttttaagaacatttttgtggccgggcatggtggctcacacctgtaatcccagcactttgggaggctgaggtgggtggatcacctgaggtcgggagttcgagaccagtctggccaacatggtgaaaccccatctctactaaaaatgcaaaaattagctgggcgtggtggcgcattcctgtaatcccagctactcgggaggctgaggcggaagaattgcttgaacccaggtggcggaggttgcaaggagcagagattgtgctactgcactccagcctaggtgacagagcaagactctgtctcaaaaaaaaaaaaaaaacttttttatagagacagggtctctctttgttggcttggctggtcttgaactcttgggctcaagcagtcctgccaccgtggcctctcaaagtgctgggattacaggtgtgagacactgcatcaggcctatagctccacttaaatacgacctatattactggaatatttttttctaaaaaattttaggaaacagttaaatatttaaaagattacttttttaaaaagcaagtaaatattacagaacagaatgcaaaatttattttacatgggagactaaaaattttcacacacatggccaccctttgggcctcttggctcaacatttcaggggctgagggagtctctgctctaggagtaaaaggtccttggagagaaaattttgacaagtcctaactttaaaaaagaaaaattggttcctggtcaatatttgtactcactgtaaatgtgatggttggtaatgatactctgtataaaagtaaaaatcatattttatgtcctttgcaaacaaatatatttgtacctgaggtacagattagaggtgctagtaattccttgaagattctgaaaatgatctttttttccaaaatgctttcttggtttttattaaactttctattttcttaaaactctcacatcaggtatttccagtgttttcaagcatgtataaatattttaatgtataaatgttgtttaaaatcccctcaatcggtatctcctgattgagaaaatacacagtgaccaatagctaataggaattcagtattgctttcaaagaaatgtgcatattaatcactgtagcatctgcatacatttgaaacacggagtaatacaggtctgtgcaagaattagcagcttgttccttgctaataatgacttgtgtcatctggaaggcccccaagagcccatggtctacaggtggaatgaccaccacttgggagtgagctgatggagagcacccagcaggtctcctccatcttcctggttcctgtgctcaccatagggctggtgtacattgggccattaataaacgtttgttgaacaaattaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5150 -> Molecular function: GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] evidence: IDA
GeneID:5150 -> Molecular function: GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] evidence: TAS
GeneID:5150 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:5150 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IEA
GeneID:5150 -> Biological process: GO:0007165 [signal transduction] evidence: NAS
GeneID:5150 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_002594 -> EC 3.1.4.17
by
@meso_cacase at
DBCLS
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