LOCUS       NM_002585               6918 bp    mRNA    linear   PRI 16-JUN-2013
DEFINITION  Homo sapiens pre-B-cell leukemia homeobox 1 (PBX1), transcript
            variant 1, mRNA.
ACCESSION   NM_002585
VERSION     NM_002585.3  GI:326320046
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6918)
  AUTHORS   Martinez-Mancilla,M., Rodriguez-Aguirre,I., Tejocote-Romero,I.,
            Medina-Sanson,A., Ocadiz-Delgado,R. and Gariglio,P.
  TITLE     Clinical relevance of the fusion transcripts distribution pattern
            in mexican children with acute lymphoblastic leukemia
  JOURNAL   J. Pediatr. Hematol. Oncol. 35 (3), 170-173 (2013)
   PUBMED   23511488
  REMARK    GeneRIF: E2a-pbx1-positive patients are associated with more
            aggressive acute lymphoblastic leukemia.
REFERENCE   2  (bases 1 to 6918)
  AUTHORS   Rafiq,S., Tapper,W., Collins,A., Khan,S., Politopoulos,I.,
            Gerty,S., Blomqvist,C., Couch,F.J., Nevanlinna,H., Liu,J. and
            Eccles,D.
  TITLE     Identification of inherited genetic variations influencing
            prognosis in early-onset breast cancer
  JOURNAL   Cancer Res. 73 (6), 1883-1891 (2013)
   PUBMED   23319801
REFERENCE   3  (bases 1 to 6918)
  AUTHORS   Cuda,C.M., Li,S., Liang,S., Yin,Y., Potula,H.H., Xu,Z.,
            Sengupta,M., Chen,Y., Butfiloski,E., Baker,H., Chang,L.J.,
            Dozmorov,I., Sobel,E.S. and Morel,L.
  TITLE     Pre-B cell leukemia homeobox 1 is associated with lupus
            susceptibility in mice and humans
  JOURNAL   J. Immunol. 188 (2), 604-614 (2012)
   PUBMED   22180614
  REMARK    GeneRIF: Splice isoform PBX1-d is expressed more frequently in CD4+
            T cells from lupus patients than from healthy controls. Its
            presence correlates with an increased central memory T cell
            population.
REFERENCE   4  (bases 1 to 6918)
  AUTHORS   Thiaville,M.M., Stoeck,A., Chen,L., Wu,R.C., Magnani,L.,
            Oidtman,J., Shih,Ie.M., Lupien,M. and Wang,T.L.
  TITLE     Identification of PBX1 target genes in cancer cells by global
            mapping of PBX1 binding sites
  JOURNAL   PLoS ONE 7 (5), E36054 (2012)
   PUBMED   22567123
  REMARK    GeneRIF: The results demonstrate that MEOX1 is a critical target
            gene and cofactor of PBX1 in ovarian cancers.
REFERENCE   5  (bases 1 to 6918)
  AUTHORS   Magnani,L., Ballantyne,E.B., Zhang,X. and Lupien,M.
  TITLE     PBX1 genomic pioneer function drives ERalpha signaling underlying
            progression in breast cancer
  JOURNAL   PLoS Genet. 7 (11), E1002368 (2011)
   PUBMED   22125492
  REMARK    GeneRIF: PBX1 is a novel pioneer factor defining aggressive
            ERalpha-positive breast tumors, as it guides ERalpha genomic
            activity to unique genomic regions promoting a transcriptional
            program favorable to breast cancer progression.
REFERENCE   6  (bases 1 to 6918)
  AUTHORS   Lu,Q., Wright,D.D. and Kamps,M.P.
  TITLE     Fusion with E2A converts the Pbx1 homeodomain protein into a
            constitutive transcriptional activator in human leukemias carrying
            the t(1;19) translocation
  JOURNAL   Mol. Cell. Biol. 14 (6), 3938-3948 (1994)
   PUBMED   7910944
REFERENCE   7  (bases 1 to 6918)
  AUTHORS   Monica,K., Galili,N., Nourse,J., Saltman,D. and Cleary,M.L.
  TITLE     PBX2 and PBX3, new homeobox genes with extensive homology to the
            human proto-oncogene PBX1
  JOURNAL   Mol. Cell. Biol. 11 (12), 6149-6157 (1991)
   PUBMED   1682799
REFERENCE   8  (bases 1 to 6918)
  AUTHORS   Hunger,S.P., Galili,N., Carroll,A.J., Crist,W.M., Link,M.P. and
            Cleary,M.L.
  TITLE     The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1
            coding sequences in acute lymphoblastic leukemias
  JOURNAL   Blood 77 (4), 687-693 (1991)
   PUBMED   1671560
REFERENCE   9  (bases 1 to 6918)
  AUTHORS   Kamps,M.P., Murre,C., Sun,X.H. and Baltimore,D.
  TITLE     A new homeobox gene contributes the DNA binding domain of the
            t(1;19) translocation protein in pre-B ALL
  JOURNAL   Cell 60 (4), 547-555 (1990)
   PUBMED   1967983
REFERENCE   10 (bases 1 to 6918)
  AUTHORS   Nourse,J., Mellentin,J.D., Galili,N., Wilkinson,J., Stanbridge,E.,
            Smith,S.D. and Cleary,M.L.
  TITLE     Chromosomal translocation t(1;19) results in synthesis of a
            homeobox fusion mRNA that codes for a potential chimeric
            transcription factor
  JOURNAL   Cell 60 (4), 535-545 (1990)
   PUBMED   1967982
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB270853.1, AL359255.12,
            DA760179.1, BC101578.1, AK291415.1, BX647313.1, DA483403.1,
            AK022962.1, AL390119.25 and AL049381.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Mar 16, 2011 this sequence version replaced gi:198041745.
            
            Summary: This gene encodes a nuclear protein that belongs to the
            PBX homeobox family of transcriptional factors. Studies in mice
            suggest that this gene may be involved in the regulation of
            osteogenesis, and required for skeletal patterning and programming.
            A chromosomal translocation, t(1;19) involving this gene and
            TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic
            leukemia. The resulting fusion protein, in which the DNA binding
            domain of E2A is replaced by the DNA binding domain of this
            protein, transforms cells by constitutively activating
            transcription of genes regulated by the PBX protein family.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Mar
            2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes the longest isoform (1, also known as
            isoform PBX1a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M86546.1, AK291415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               DB270853.1         2-274
            274-274             AL359255.12        7609-7609
            275-591             DA760179.1         235-551
            592-1786            BC101578.1         181-1375
            1787-2073           AK291415.1         1469-1755
            2074-2568           BX647313.1         2670-3164
            2569-2878           DA483403.1         338-647
            2879-3323           BX647313.1         3475-3919
            3324-3415           AK022962.1         506-597
            3416-4749           BX647313.1         4012-5345
            4750-6865           AL390119.25        14712-16827
            6866-6918           AL049381.1         2226-2278
FEATURES             Location/Qualifiers
     source          1..6918
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23"
     gene            1..6918
                     /gene="PBX1"
                     /note="pre-B-cell leukemia homeobox 1"
                     /db_xref="GeneID:5087"
                     /db_xref="HGNC:8632"
                     /db_xref="HPRD:08889"
                     /db_xref="MIM:176310"
     exon            1..654
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       274
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12033962"
     variation       293
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:377078800"
     STS             412..1799
                     /gene="PBX1"
                     /db_xref="UniSTS:484332"
     misc_feature    452..454
                     /gene="PBX1"
                     /note="upstream in-frame stop codon"
     variation       455
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:187406949"
     CDS             464..1756
                     /gene="PBX1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pre-B-cell leukemia transcription factor 1; homeobox
                     protein PRL; homeobox protein PBX1"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 1
                     isoform 1"
                     /protein_id="NP_002576.1"
                     /db_xref="GI:4505623"
                     /db_xref="CCDS:CCDS1246.1"
                     /db_xref="GeneID:5087"
                     /db_xref="HGNC:8632"
                     /db_xref="HPRD:08889"
                     /db_xref="MIM:176310"
                     /translation="

MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEGPGSVHSDTSN

"
     misc_feature    578..1159
                     /gene="PBX1"
                     /note="PBC domain; Region: PBC; pfam03792"
                     /db_xref="CDD:217730"
     misc_feature    725..730
                     /gene="PBX1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Breakpoint for translocation to form TCF3-PBX1
                     oncogene; propagated from UniProtKB/Swiss-Prot (P40424.1);
                     other site"
     misc_feature    1163..1345
                     /gene="PBX1"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(1163..1177,1181..1183,1241..1243,1259..1261,
                     1298..1300,1304..1309,1316..1321,1325..1333,1337..1342)
                     /gene="PBX1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(1169..1171,1178..1180,1307..1309,1316..1321,
                     1328..1330)
                     /gene="PBX1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     variation       472
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375925928"
     variation       524
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2275558"
     variation       541
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372558581"
     variation       555
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:192264696"
     variation       576
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370561885"
     variation       589
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144593424"
     variation       615
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111531180"
     variation       650
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148894677"
     exon            655..728
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       655
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148071998"
     variation       666
                     /gene="PBX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200380618"
     variation       687
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369144775"
     variation       719
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138090483"
     exon            729..973
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       744
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35543782"
     variation       811
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200580172"
     variation       826
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147201088"
     variation       865
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199855181"
     variation       878
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201279083"
     variation       967
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143132748"
     exon            974..1164
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       997
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375506788"
     variation       1117
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41266608"
     variation       1139
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376272015"
     exon            1165..1300
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       1195
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190363555"
     variation       1252
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139881410"
     exon            1301..1460
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       1396
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148808502"
     exon            1461..1573
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       1556..1557
                     /gene="PBX1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34778614"
     variation       1561
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186124927"
     variation       1562
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142396283"
     exon            1574..1663
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       1587
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201963901"
     variation       1623
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201029742"
     variation       1624
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188237782"
     variation       1627
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143289090"
     variation       1655
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146653553"
     exon            1664..6910
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       1709..1710
                     /gene="PBX1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34262468"
     variation       1726
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369700366"
     variation       1728
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150307059"
     variation       1748
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112169952"
     variation       1767
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377526450"
     variation       1770
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377334192"
     variation       1776
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370789005"
     variation       1780
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142359401"
     variation       1787
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1057073"
     variation       1802
                     /gene="PBX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374816345"
     variation       1832
                     /gene="PBX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3205270"
     STS             1836..2074
                     /gene="PBX1"
                     /standard_name="RH75790"
                     /db_xref="UniSTS:90797"
     variation       1911
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:12135379"
     variation       1919
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184165420"
     variation       1947
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:9771"
     variation       1951
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:14832"
     variation       2007
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111327965"
     variation       2010
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188518874"
     variation       2045
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375939144"
     variation       2047
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373586993"
     polyA_signal    2130..2135
                     /gene="PBX1"
     polyA_site      2153
                     /gene="PBX1"
     variation       2258
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41266618"
     variation       2321..2322
                     /gene="PBX1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35445188"
     variation       2415
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3738195"
     variation       2449
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115818637"
     STS             2553..2691
                     /gene="PBX1"
                     /standard_name="RH64526"
                     /db_xref="UniSTS:52782"
     variation       2569
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:6426881"
     variation       2602
                     /gene="PBX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:147638800"
     variation       2627
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142283079"
     variation       2632
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368405625"
     variation       2755
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145716228"
     variation       2783
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184230234"
     variation       2799
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3185695"
     variation       2886
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:147776492"
     variation       2950
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141192050"
     variation       3072
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:6683162"
     variation       3114
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:181970491"
     variation       3132
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:143488511"
     variation       3157
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:79721421"
     variation       3230
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375028098"
     variation       3329
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369440305"
     variation       3355
                     /gene="PBX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1128595"
     variation       3412
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1128596"
     variation       3522
                     /gene="PBX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:41266620"
     polyA_signal    3552..3557
                     /gene="PBX1"
     variation       3579
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148020619"
     polyA_site      3585
                     /gene="PBX1"
     variation       3651
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141517830"
     STS             3736..3815
                     /gene="PBX1"
                     /standard_name="RH26827"
                     /db_xref="UniSTS:13448"
     variation       3839
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150459354"
     variation       3989
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:187013832"
     variation       4164
                     /gene="PBX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:190818629"
     variation       4168
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371564314"
     variation       4214
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138455027"
     variation       4222
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:181559889"
     variation       4230
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185832619"
     variation       4330
                     /gene="PBX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:375873881"
     variation       4337
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111698027"
     variation       4346
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190159894"
     variation       4365
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113819464"
     variation       4393
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368896544"
     variation       4505
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:182360910"
     variation       4582
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143084650"
     variation       4638
                     /gene="PBX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:12137588"
     variation       4640
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116759584"
     variation       4711
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377715625"
     variation       4750
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1213289"
     variation       4776
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185807689"
     variation       4777
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146049929"
     variation       4781
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140017132"
     variation       4789
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41266622"
     variation       4897..4904
                     /gene="PBX1"
                     /replace=""
                     /replace="ttcctgct"
                     /db_xref="dbSNP:200522109"
     STS             4914..5022
                     /gene="PBX1"
                     /standard_name="D13S1219"
                     /db_xref="UniSTS:154178"
     variation       4937
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192322594"
     variation       5091
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:183653789"
     variation       5197
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189051618"
     variation       5240
                     /gene="PBX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:4035254"
     variation       5242
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2347802"
     variation       5265..5266
                     /gene="PBX1"
                     /replace=""
                     /replace="aaca"
                     /db_xref="dbSNP:138419870"
     variation       5269..5270
                     /gene="PBX1"
                     /replace=""
                     /replace="aaca"
                     /db_xref="dbSNP:144153490"
     variation       5273
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4035255"
     variation       5303
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2881731"
     variation       5308
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:15171"
     variation       5427
                     /gene="PBX1"
                     /replace=""
                     /replace="aaaaaa"
                     /db_xref="dbSNP:4035256"
     variation       5464
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12119896"
     variation       5547..5548
                     /gene="PBX1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:58819847"
     variation       5587
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149358308"
     variation       5624
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182844405"
     variation       5757
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114960248"
     variation       5940
                     /gene="PBX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144730408"
     variation       6005
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12723035"
     variation       6010
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:187111912"
     variation       6032
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148544292"
     variation       6033
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376221491"
     variation       6080
                     /gene="PBX1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:372152597"
     variation       6144
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191566129"
     variation       6162
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377612148"
     variation       6168
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184546154"
     variation       6208
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370785680"
     variation       6253
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111404742"
     variation       6313..6314
                     /gene="PBX1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:80017588"
     variation       6361
                     /gene="PBX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373883472"
     STS             6406..6533
                     /gene="PBX1"
                     /standard_name="RH102792"
                     /db_xref="UniSTS:97126"
     variation       6500
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189019083"
     variation       6537..6538
                     /gene="PBX1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:200183940"
     variation       6623
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142594726"
     polyA_signal    6880..6885
                     /gene="PBX1"
     variation       6900
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192705206"
     polyA_site      6910
                     /gene="PBX1"
ORIGIN      

aaagtttgcattgcaatccccctgccttcctctcctttctcccgatcaatgcatatttgcaaaaggattaagccacagatttaagcgccgggagcccatttctgccttgcaaaggagaccggactgaaaaacctaaagccagctctgatttcttttcgccaagtgggaaggtggtttatttttcttgctttttggagtcaacacccttccccaccagcccttatccccaccctcaccccgcaaccccttcacgccccctccccctccccctcctcatcctcccaccatcctctaaagaggcaaagggattttttttttcttttggtcttcttttttcccccttccctgtttatcctgaaaaggatttgaagacaagcttgaaggataaaaagccttggtgcttcccaggagccgagccgaggagcagaagaggaagagccgggggctgccgtagcctttggagatggacgagcagcccaggctgatgcattcccatgctggggtcgggatggccggacaccccggcctgtcccagcacttgcaggatggggccggagggaccgagggggagggcgggaggaagcaggacattggagacattttacagcaaattatgaccatcacagaccagagtttggatgaggcgcaggccagaaaacatgctttaaactgccacagaatgaagcctgccttgtttaatgtgttgtgtgaaatcaaagaaaaaacagttttgagtatccgaggagcccaggaggaggaacccacagacccccagctgatgcggctggacaacatgctgttagcggaaggcgtggcggggcctgagaagggcggagggtcggcggcagcggcggcagcggcggcggcttctggaggggcaggttcagacaactcagtggagcattcagattacagagccaaactctcacagatcagacaaatctaccatacggagctggagaaatacgagcaggcctgcaacgagttcaccacccacgtgatgaatctcctgcgagagcaaagccggaccaggcccatctccccaaaggagattgagcggatggtcagcatcatccaccgcaagttcagctccatccagatgcagctcaagcagagcacgtgcgaggcggtgatgatcctgcgttcccgatttctggatgcgcggcggaagagacggaatttcaacaagcaagcgacagaaatcctgaatgaatatttctattcccatctcagcaacccttaccccagtgaggaagccaaagaggagttagccaagaagtgtggcatcacagtctcccaggtatcaaactggtttggaaataagcgaatccggtacaagaagaacataggtaaatttcaagaggaagccaatatttatgctgccaaaacagctgtcactgctaccaatgtgtcagcccatggaagccaagctaactcgccctcaactcccaactcggctggttcttccagttcttttaacatgtcaaactctggagatttgttcatgagcgtgcagtcactcaatggggattcttaccaaggggcccaggttggagccaacgtgcaatcacaggtggatacccttcgccatgttatcagccagacaggaggatacagtgatggactcgcagccagtcagatgtacagtccgcagggcatcagtgctaatggaggttggcaggatgctactaccccttcatcagtgacctcccctacagaaggccctggcagtgttcactctgatacctccaactgatctcccagcaatcgcatcccggctgaccctgtgccccagttggggcaggggcaggagggagggtttctctcccaacgctgaagcggtcagactggaggtcgaagcaatcagcaaacacaataagagtctccttctcttctcttctttgggatgctatttcagccaatctggacacttctttatactctcttcccttttttttctgggtagaagccacccttccctgcctccagctgtcagcctggttttcgtcatcttccctgcccctgtgcctctgtcctagactcccggggtccccgccctctctcatatcactgaaggatattttcaacaattagaggaatttaaagaggaaaaaaattacaaagaaaataataaaagtgtttgtacgttttcatgctggtggtttgaggagccaaatttacctcactcgaatccctcactccctatgttaacaggcaatccttctctgtttctcttattactctcactacctcttagcaggaatactccacattgccctattcattccaggcctccctgcttcctcttgctcttcctccctggggacagtactgattggaacactttcctcctcttccttcctagccccagctattcactggggactgtcatagctgggattctaaaggtgccacatttttcagtttcatctccactaggttggttcccgggcaggaagtcaggcagcagggaaggacacgggaacagcaggtggagaattcctacagtctttcttaccctgctagcaatagctctcagtttcagaggcacagtctttggagaccattcagcactgagaaagcaatatttagaacctattgcaaaactgggcctgagttaggcatggtgatgaatgcatcagcaaggaatagaaagttcttatcgtgaaacccttcaacctcaactatgccttcatagacacacacgttcatgcacatgtaggcacatgtaccatctcacatcttcactttcccgagatgccatatacaattacctacattaataactgtagcactatgccttttgagcccgagagagggaattagtgactctaagtgaaggtcactgacacagagaagcagtatgtgtctggggcttccaggacctgcaggcccactagcgtgcacttaccagaatggcatacacaggacctgatcatgaggaagaccaggtttccagtgtaaactactcttgttcccaccacctctggagcactcagggagccccatacagtacttacaatgtctttaatggacttgattctgtttaattttttgttttatattaggcacactgtattaattttccaaaatgttataccacactatgttcttggtcctgacctattgctctggaggaaagagttgtataagaacgtggctcatgtgaacttttgctagcttcatttgaggacctgagaatcatggggaaagggaaggtaatgttttcattgaaatcatcacagtgatttttattccctgggaacacagcgtgtactaaaaatacatgagaaaatagcatgtatatgaaagctattctcaaaagtcacctgagctcaccatcttcatagccaaccctaccagttataaagatggcagctctatcacttgattaagtgggaggtggtcaaatattttggtgcctcattttcttcatctgtgagatgggaactgttatgcctggcttactaagagtcttgtgagagactgagaagttgattttgttcatatccaatctgtaaatgcgaagtcaggggaagtaatgtccctgaaataaacgggttcatgccatctagggacaataaatggttttcttgttgtaacttctggttaatatcagtaccttgatgtcatcaccgtgatgacaaagagaagagttattgttgatcttcttggttttggtctgtctcttttcttaggataaagaaaaacttccaaactagaaaaacaggccctggttcccttagtttgcacttgaacccaatatgttgccttgtacatacttggtccctgtcacattgactgcttgggaggcttccagggagaagtatgagaccctgaggggtgagaatgggcagctagcaagaacatggaaattctgcttggcactacagtcataaatagaaaacactgtgtgtgctcaggggagcaggggatgccactgaagaaactcaagggaatgtgtatttgaaggaaatgcaaaaactaagtatttagcaaaatgaaattatgccttgatgactaaaaggcactagaaaggttgtgtctactaacttcagccctaatcagaacagatgcctagaaggagcatttttgtgacaacttcatagtgattagaatcagtggagaactccatcttagtggcaggaatataatgaaactacccacgcaagaacatggttgaatcacatttgcttgacttagggcaaagtacgaaagagagacaaaagggttctcttggaaacaagaagagtgactccagatgtggcctgaataattgccatgttaagttaatgcaaaagatcagaacagggctacatttgcacaggcagtttctctccgggccgtagttttcactgatgatcacctttcacagcattttccccaaccagcatttcacttagtcttctctatacccagcacctcccccggcacccccggcaagcccactatcacttccgacttccaacgtggcatccgtgagatctgtccacattaggcgaagcaggagaacactgagagcagcaggatgggtttggaaagagcatgcctctggaaacacagcttcctgggaattcacatgaggccagtcctacagagagcaagatgcaccccaggatttcttcattttctaatagatgtgggagtgctccattttccccgacagcgaatttcccctgagaaacgatactagaccctgggtttgcccaccttgtaactcttccttatctcctccttttcatccctaatccatcctccctctggcatggaattgacgcccgtgcagtacatttgccaagtggcaccttctttcaatttatgttttattttgctatggtggtgattctttatttgctggttgtcttttctcacacatctttctctctgtctctctctttcctgctctttgtttttctgcccagaaaaacctgacttcgataccaaaaaagatgaaactacagaaactcaaatttaaaaaaaactttaaaagaaacaaaaaaatactcaacgattctttcagctttattaacattttccattgtttcttgcgacttgtgtctcgttctttgtagtattgatgatgaacatttgataatgaatgttcttgtatattcagataaagaaaaaaaaaaccaaaaaagcggtctgaatttaatagtgtttataataaaaattttaaaaatgaccctcatagcacgcaaaacaggatggggaatttcccctcttctttctgtgacaatgcgcatcattcctgcattagtttttaacaccagactacctacattcatcatttccctcatttttcttttattttcttgcatttgtgaattagttcaagaatgctagaaaagtgtcgagttgtgcacatccatttcttgtttcacaatgtttaaaagtgacagtaattcattttgtaaactaaaaaaaaaaaaaaaaaggttggaatagtgagcataataggtacaacctaacacattattatgtttattaactttgagacccagaaataaattcttttcttttcttgattcttgctcttaaaaatacaaaaaaaaaaatgttttgttttgtgttatttttggtttgtttattggggggctttttttaattgtcaggattatgatcttgctgtttttcttcaatatgtatacaaggtgatgtgaaaagatgacttgggcagaggagtaagaacaagtaggcttgttcttctactttgcttcagaattcagttaatgccaaaagcgaagatcaagcccatgttgatgtctcgttgctcacctgcatttccagagagtgtgacactcatgcagtccctgagaaaaataaaatcagggacatacttctccttttagccttttaaaaattcaaaaacgtttagtccaagggaactttttatgctatcaggaaaggtttttgctgtttttgattctgattatcacagccaagtactttgttttatttctccctaattaataactacattccatgaggcctcttccaaccaaagaggccttttcttccaggagagtcccgcaggagatgctggtatgatgggcaccattggttaagtaaactacatgcaggaagaagtccttggggccagtctgccagctgagtcctggttttggatgaagagttaatgagatattgggccaggctcaatgctgtagttttaatgctaagaggttacgtttacttcacagagtacacctcttagtaacctctgacttaggcagctgcttaaagcaaattgcaaaactggcttgatttggaatgtttttattagaggaaaaaagaaagccatattatctggaaaaaaattcattttaaataccatcattcaacaaattatgttcagaaagtggtcagaacttaagcaagaaaagtaaagaaagaatgcagaattgtggagcaatgctttaggaaatatttctacctgaacacttgtactcttgaagtcacaacaaaataatgatgagcttttcacatcacctttatggtttcaatccctagctcaaagcttcctggaatcttttattttttgtaaacttttttttcttttgttaaaataaataaaacattcaatgtttttctccttttctctcttattacttctttcctttggcattttcaatttgaaatgctttcctttggttgttggttttattctccccctacccctccccttttcttattattcagaatataaacctgcaaagctctgctctgttttggttttgaaagtttaagcttttctgcttctgtgagagcacaggcttctgtcccttttgattccaactgaacttttgtgttctctaatgatactaacacggtgtaggttttacagtctcctaatttgtactggtaatgcatattccaaataaatagtttcttttgttgcaaaaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5087 -> Molecular function: GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] evidence: IEA
            GeneID:5087 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA
            GeneID:5087 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: NAS
            GeneID:5087 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5087 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
            GeneID:5087 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:5087 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA
            GeneID:5087 -> Biological process: GO:0001658 [branching involved in ureteric bud morphogenesis] evidence: IEA
            GeneID:5087 -> Biological process: GO:0006694 [steroid biosynthetic process] evidence: IEA
            GeneID:5087 -> Biological process: GO:0007548 [sex differentiation] evidence: IEA
            GeneID:5087 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IEA
            GeneID:5087 -> Biological process: GO:0009887 [organ morphogenesis] evidence: IEA
            GeneID:5087 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: IEA
            GeneID:5087 -> Biological process: GO:0009954 [proximal/distal pattern formation] evidence: IEA
            GeneID:5087 -> Biological process: GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle] evidence: IEA
            GeneID:5087 -> Biological process: GO:0030278 [regulation of ossification] evidence: IEA
            GeneID:5087 -> Biological process: GO:0030325 [adrenal gland development] evidence: IEA
            GeneID:5087 -> Biological process: GO:0030326 [embryonic limb morphogenesis] evidence: IEA
            GeneID:5087 -> Biological process: GO:0035162 [embryonic hemopoiesis] evidence: IEA
            GeneID:5087 -> Biological process: GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] evidence: IDA
            GeneID:5087 -> Biological process: GO:0045665 [negative regulation of neuron differentiation] evidence: IEA
            GeneID:5087 -> Biological process: GO:0048536 [spleen development] evidence: IEA
            GeneID:5087 -> Biological process: GO:0048538 [thymus development] evidence: IEA
            GeneID:5087 -> Biological process: GO:0048706 [embryonic skeletal system development] evidence: IEA
            GeneID:5087 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:5087 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
            GeneID:5087 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:5087 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA