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2024-03-29 06:26:57, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_002583               1967 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens PRKC, apoptosis, WT1, regulator (PAWR), mRNA.
ACCESSION   NM_002583
VERSION     NM_002583.2  GI:55769532
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1967)
  AUTHORS   Burikhanov,R., Shrestha-Bhattarai,T., Qiu,S., Shukla,N., Hebbar,N.,
            Lele,S.M., Horbinski,C. and Rangnekar,V.M.
  TITLE     Novel mechanism of apoptosis resistance in cancer mediated by
            extracellular PAR-4
  JOURNAL   Cancer Res. 73 (2), 1011-1019 (2013)
   PUBMED   23204231
  REMARK    GeneRIF: our results identify a novel intracellular pathway of
            apoptosis mediated by NF-kappaB through UACA elevation, which by
            attenuating endoplasmic reticulum stress and GRP78 translocation to
            the cell surface can blunt the sensitivity of cancer cells to
            apoptosis.
REFERENCE   2  (bases 1 to 1967)
  AUTHORS   Wang,G., Dinkins,M., He,Q., Zhu,G., Poirier,C., Campbell,A.,
            Mayer-Proschel,M. and Bieberich,E.
  TITLE     Astrocytes secrete exosomes enriched with proapoptotic ceramide and
            prostate apoptosis response 4 (PAR-4): potential mechanism of
            apoptosis induction in Alzheimer disease (AD)
  JOURNAL   J. Biol. Chem. 287 (25), 21384-21395 (2012)
   PUBMED   22532571
  REMARK    GeneRIF: a novel mechanism of apoptosis induction by
            PAR-4/ceramide-enriched exosomes, which may critically contribute
            to Alzheimer disease.
REFERENCE   3  (bases 1 to 1967)
  AUTHORS   Wang,Y., Moreland,M., Wagner,J.G., Ames,B.N., Illek,B., Peden,D.B.
            and Jiang,Q.
  TITLE     Vitamin E forms inhibit IL-13/STAT6-induced eotaxin-3 secretion by
            up-regulation of PAR4, an endogenous inhibitor of atypical PKC in
            human lung epithelial cells
  JOURNAL   J. Nutr. Biochem. 23 (6), 602-608 (2012)
   PUBMED   21764283
  REMARK    GeneRIF: Gamma-tocotrienol inhibited IL-13/STAT6-activated eotaxin
            secretion via up-regulation of PAR4 expression and enhancement of
            aPKC-PAR4 complex formation.
REFERENCE   4  (bases 1 to 1967)
  AUTHORS   Chaudhry,P., Singh,M., Parent,S. and Asselin,E.
  TITLE     Prostate apoptosis response 4 (Par-4), a novel substrate of
            caspase-3 during apoptosis activation
  JOURNAL   Mol. Cell. Biol. 32 (4), 826-839 (2012)
   PUBMED   22184067
  REMARK    GeneRIF: identified a novel specific caspase-3 cleavage site in
            Par-4, and the cleaved fragment of Par-4 retains proapoptotic
            activity
REFERENCE   5  (bases 1 to 1967)
  AUTHORS   Casolari,D.A., Pereira,M.C., de Bessa Garcia,S.A. and Nagai,M.A.
  TITLE     Insulin-like growth factor-1 and 17beta-estradiol down-regulate
            prostate apoptosis response-4 expression in MCF-7 breast cancer
            cells
  JOURNAL   Int. J. Mol. Med. 28 (3), 337-342 (2011)
   PUBMED   21567071
  REMARK    GeneRIF: 17beta-estradiol and Insulin-like growth factor-1 inhibit
            PAR-4 gene expression in MCF-7 cells.
REFERENCE   6  (bases 1 to 1967)
  AUTHORS   Guo,Q., Xie,J., Chang,X. and Du,H.
  TITLE     Prostate apoptosis response-4 enhances secretion of amyloid beta
            peptide 1-42 in human neuroblastoma IMR-32 cells by a
            caspase-dependent pathway
  JOURNAL   J. Biol. Chem. 276 (19), 16040-16044 (2001)
   PUBMED   11278808
  REMARK    GeneRIF: Par-4 increases secretion of amyloid beta peptide 1-42,
            which contributes to the pathogenesis of Alzheimer's disease.
REFERENCE   7  (bases 1 to 1967)
  AUTHORS   Kruman,I.I., Nath,A., Maragos,W.F., Chan,S.L., Jones,M.,
            Rangnekar,V.M., Jakel,R.J. and Mattson,M.P.
  TITLE     Evidence that Par-4 participates in the pathogenesis of HIV
            encephalitis
  JOURNAL   Am. J. Pathol. 155 (1), 39-46 (1999)
   PUBMED   10393834
REFERENCE   8  (bases 1 to 1967)
  AUTHORS   Johnstone,R.W., Tommerup,N., Hansen,C., Vissing,H. and Shi,Y.
  TITLE     Mapping of the human PAWR (par-4) gene to chromosome 12q21
  JOURNAL   Genomics 53 (2), 241-243 (1998)
   PUBMED   9790775
REFERENCE   9  (bases 1 to 1967)
  AUTHORS   Guo,Q., Fu,W., Xie,J., Luo,H., Sells,S.F., Geddes,J.W., Bondada,V.,
            Rangnekar,V.M. and Mattson,M.P.
  TITLE     Par-4 is a mediator of neuronal degeneration associated with the
            pathogenesis of Alzheimer disease
  JOURNAL   Nat. Med. 4 (8), 957-962 (1998)
   PUBMED   9701251
  REMARK    GeneRIF: Par-4 expression is increased in vulnerable neurons in
            Alzheimer's disease, and contributes to apoptotic neuronal cell
            death in the disease.
REFERENCE   10 (bases 1 to 1967)
  AUTHORS   Johnstone,R.W., See,R.H., Sells,S.F., Wang,J., Muthukkumar,S.,
            Englert,C., Haber,D.A., Licht,J.D., Sugrue,S.P., Roberts,T.,
            Rangnekar,V.M. and Shi,Y.
  TITLE     A novel repressor, par-4, modulates transcription and growth
            suppression functions of the Wilms' tumor suppressor WT1
  JOURNAL   Mol. Cell. Biol. 16 (12), 6945-6956 (1996)
   PUBMED   8943350
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN280333.1, BC007018.1,
            U63809.1 and CA313080.1.
            On Nov 15, 2004 this sequence version replaced gi:4505612.
            
            Summary: The tumor suppressor WT1 represses and activates
            transcription. The protein encoded by this gene is a
            WT1-interacting protein that itself functions as a transcriptional
            repressor. It contains a putative leucine zipper domain which
            interacts with the zinc finger DNA binding domain of WT1. This
            protein is specifically upregulated during apoptosis of prostate
            cells. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U63809.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-421               CN280333.1         4-424
            422-882             BC007018.1         268-728
            883-1127            U63809.1           841-1085
            1128-1662           BC007018.1         974-1508
            1663-1672           U63809.1           1621-1630
            1673-1950           BC007018.1         1520-1797
            1951-1967           CA313080.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1967
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21"
     gene            1..1967
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /note="PRKC, apoptosis, WT1, regulator"
                     /db_xref="GeneID:5074"
                     /db_xref="HGNC:8614"
                     /db_xref="MIM:601936"
     exon            1..139
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:1.39.8"
     exon            140..802
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    254..256
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /note="upstream in-frame stop codon"
     CDS             287..1309
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /note="transcriptional repressor PAR4; WT1-interacting
                     protein; prostate apoptosis response protein 4; prostate
                     apoptosis response protein PAR-4; prostate apoptosis
                     response 4 protein; prostate apoptosis response-4"
                     /codon_start=1
                     /product="PRKC apoptosis WT1 regulator protein"
                     /protein_id="NP_002574.2"
                     /db_xref="GI:55769533"
                     /db_xref="CCDS:CCDS31863.1"
                     /db_xref="GeneID:5074"
                     /db_xref="HGNC:8614"
                     /db_xref="MIM:601936"
                     /translation="
MATGGYRTSSGLGGSTTDFLEEWKAKREKMRAKQNPPGPAPPGGGSSDAAGKPPAGALGTPAAAAANELNNNLPGGAPAAPAVPGPGGVNCAVGSAMLTRAAPGPRRSEDEPPAASASAAPPPQRDEEEPDGVPEKGKSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAVNLLDPGSSYLLQEPPRTVSGRYKSTTSVSEEDVSSRYSRTDRSGFPRYNRDANVSGTLVSSSTLEKKIEDLEKEVVRERQENLRLVRLMQDKEEMIGKLKEEIDLLNRDLDDIEDENEQLKQENKTLLKVVGQLTR
"
     misc_feature    719..895
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96IZ0.1);
                     Region: Selective for apoptosis induction in cancer cells
                     (SAC)"
     misc_feature    719..769
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96IZ0.1);
                     Region: Nuclear localization signal (By similarity)"
     misc_feature    1088..>1279
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /note="Plant protein of unknown function (DUF869); Region:
                     DUF869; pfam05911"
                     /db_xref="CDD:203347"
     misc_feature    1184..1306
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96IZ0.1);
                     Region: Leucine-zipper"
     variation       411
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8176804"
     variation       519
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:8176805"
     variation       696
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:8176806"
     exon            803..934
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:1.39.8"
     variation       883
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2307223"
     variation       891
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:8176870"
     exon            935..969
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:1.39.8"
     exon            970..1117
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:1.39.8"
     exon            1118..1222
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:1.39.8"
     exon            1223..1951
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:1.39.8"
     variation       1291
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:8176908"
     variation       1547
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:8176909"
     variation       1822
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2307220"
     polyA_signal    1924..1929
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
     polyA_site      1951
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
ORIGIN      
ctgtcctgggattgcctggagctccgcaccgcgagtttgccgcggcactttccgcgcggcggaagagcgcgcgccagcttcggcacacctgggagccggatcccagccctacgcctcgtcccctacaagctcctccaagccccgccggctgctgtgggagcggcggccgtccctctcctggaggtcgtctcctggcatcctcggggccgcaggaaggaagaggaggcagcggccggagccctggtgggcggcctgaggtgagagcccgaccggcccctttgggaatatggcgaccggtggctaccggaccagcagcggcctcggcggcagcaccacagacttcctggaggagtggaaggcgaaacgcgagaagatgcgcgccaagcagaaccccccgggcccggcccccccgggagggggcagcagcgacgccgctgggaagccccccgcgggggctctgggcaccccggcggccgccgctgccaacgagctcaacaacaacctcccgggcggcgcgccggccgcacctgccgtccccggtcccgggggcgtgaactgcgcggtcggctccgccatgctgacgcgggcggcccccggcccgcggcggtcggaggacgagcccccagccgcctctgcctcggctgcaccgccgccccagcgtgacgaggaggagccggacggcgtcccagagaagggcaagagctcgggccccagtgccaggaaaggcaaggggcagatcgagaagaggaagctgcgggagaagcggcgctccaccggcgtggtcaacatccctgccgcagagtgcttagatgagtacgaagatgatgaagcagggcagaaagagcggaaacgagaagatgcaattacacaacagaacactattcagaatgaagctgtaaacttactagatccaggcagttcctatctgctacaggagccacctagaacagtttcaggcagatataaaagcacaaccagtgtctctgaagaagatgtctcaagtagatattctcgaacagatagaagtgggttccctagatataacagggatgcaaatgtttcaggtactctggtttcaagtagcacactggaaaagaaaattgaagatcttgaaaaggaagtagtaagagaaagacaagaaaacctaagacttgtgagactgatgcaagataaagaggaaatgattggaaaactcaaagaagaaattgatttattaaatagagacctagatgacatagaagatgaaaatgaacagctaaagcaggaaaataaaactcttttgaaagttgtgggtcagctgaccaggtagaggattcaagactcaatgtggaaaaaatattttaaactactgattgaatgttaatggtcaatgctagcacaatattcctatgctgcaatacattaaaataactaagcaagtatatttatttctagcaaacagatgtttgttttcaaaatacttctttttcattattggttttaaaaaagcattatccttttatctcacaaataagtaatatctttcagttattaaatgatagataatgcctttttggttttgtgtggtattcaactaatacatggtttaaagtcacagccgtttgaatatattttatcttggtagtacattttctcccttaggaatatacatagtctttgtttacatgagttcaaatacttttgggatgttaccttcacatgtcctattactgatgtgtgcaaccttttatgtgttgatgactcactcataaaggtttttgtctactgtcatttgttctttccacttattctaagcatttagagtaatagagtcatacttttttataacagcaaccttttaaaaggaaagctcttataaagtcactgtcatgttttagttgactaaatataaatttaagagaatacttgaattgtgctatagtaaataaaaatttactattttgtgtttgaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5074 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: TAS
            GeneID:5074 -> Molecular function: GO:0003779 [actin binding] evidence: ISS
            GeneID:5074 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5074 -> Molecular function: GO:0019899 [enzyme binding] evidence: IDA
            GeneID:5074 -> Molecular function: GO:0043522 [leucine zipper domain binding] evidence: IPI
            GeneID:5074 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: TAS
            GeneID:5074 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:5074 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:5074 -> Biological process: GO:0006917 [induction of apoptosis] evidence: ISS
            GeneID:5074 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: TAS
            GeneID:5074 -> Biological process: GO:0030889 [negative regulation of B cell proliferation] evidence: IEA
            GeneID:5074 -> Biological process: GO:0042094 [interleukin-2 biosynthetic process] evidence: IEA
            GeneID:5074 -> Biological process: GO:0042130 [negative regulation of T cell proliferation] evidence: IEA
            GeneID:5074 -> Biological process: GO:0042986 [positive regulation of amyloid precursor protein biosynthetic process] evidence: IEA
            GeneID:5074 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: NAS
            GeneID:5074 -> Biological process: GO:0050860 [negative regulation of T cell receptor signaling pathway] evidence: IEA
            GeneID:5074 -> Biological process: GO:0051017 [actin filament bundle assembly] evidence: ISS
            GeneID:5074 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:5074 -> Cellular component: GO:0005634 [nucleus] evidence: NAS
            GeneID:5074 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:5074 -> Cellular component: GO:0005737 [cytoplasm] evidence: NAS
            GeneID:5074 -> Cellular component: GO:0005884 [actin filament] evidence: ISS
            GeneID:5074 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA

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