Home |
Help |
Advanced search
2024-04-20 14:18:24, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002577 6139 bp mRNA linear PRI 06-MAY-2013
DEFINITION Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 2 (PAK2),
mRNA.
ACCESSION NM_002577 XM_936511
VERSION NM_002577.4 GI:191250770
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6139)
AUTHORS Yan,X., Zhang,J., Sun,Q., Tuazon,P.T., Wu,X., Traugh,J.A. and
Chen,Y.G.
TITLE p21-Activated kinase 2 (PAK2) inhibits TGF-beta signaling in
Madin-Darby canine kidney (MDCK) epithelial cells by interfering
with the receptor-Smad interaction
JOURNAL J. Biol. Chem. 287 (17), 13705-13712 (2012)
PUBMED 22393057
REMARK GeneRIF: PAK2 negatively modulate TGF-beta signaling by attenuating
the receptor-Smad interaction and thus Smad activation
REFERENCE 2 (bases 1 to 6139)
AUTHORS Carroll,L.S., Williams,H.J., Walters,J., Kirov,G., O'Donovan,M.C.
and Owen,M.J.
TITLE Mutation screening of the 3q29 microdeletion syndrome candidate
genes DLG1 and PAK2 in schizophrenia
JOURNAL Am. J. Med. Genet. B Neuropsychiatr. Genet. 156B (7), 844-849
(2011)
PUBMED 21850710
REMARK GeneRIF: Low-to-moderate penetrance protein coding mutations or
non-coding mutations at DLG1 and/or PAK2, or a nearby gene, may
reproduce the behavioral characteristics of the 3q29 microdeletion.
REFERENCE 3 (bases 1 to 6139)
AUTHORS Li,X., Wen,W., Liu,K., Zhu,F., Malakhova,M., Peng,C., Li,T.,
Kim,H.G., Ma,W., Cho,Y.Y., Bode,A.M., Dong,Z. and Dong,Z.
TITLE Phosphorylation of caspase-7 by p21-activated protein kinase (PAK)
2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer
cell lines
JOURNAL J. Biol. Chem. 286 (25), 22291-22299 (2011)
PUBMED 21555521
REMARK GeneRIF: highly expressed PAK2 mediates chemotherapeutic resistance
in human breast invasive ductal carcinoma by negatively regulating
caspase-7 activity
REFERENCE 4 (bases 1 to 6139)
AUTHORS Li,T., Zhang,J., Zhu,F., Wen,W., Zykova,T., Li,X., Liu,K., Peng,C.,
Ma,W., Shi,G., Dong,Z., Bode,A.M. and Dong,Z.
TITLE P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation
at 5 threonine sites promotes cell transformation
JOURNAL Carcinogenesis 32 (5), 659-666 (2011)
PUBMED 21177766
REMARK GeneRIF: High PAK2 is associated with melanoma.
REFERENCE 5 (bases 1 to 6139)
AUTHORS Olivieri,K.C., Mukerji,J. and Gabuzda,D.
TITLE Nef-mediated enhancement of cellular activation and human
immunodeficiency virus type 1 replication in primary T cells is
dependent on association with p21-activated kinase 2
JOURNAL Retrovirology 8, 64 (2011)
PUBMED 21819585
REMARK GeneRIF: The ability of Nef to associate with PAK2 correlates with
the ability to enhance HIV-1 replication.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 6139)
AUTHORS Benner,G.E., Dennis,P.B. and Masaracchia,R.A.
TITLE Activation of an S6/H4 kinase (PAK 65) from human placenta by
intramolecular and intermolecular autophosphorylation
JOURNAL J. Biol. Chem. 270 (36), 21121-21128 (1995)
PUBMED 7673144
REFERENCE 7 (bases 1 to 6139)
AUTHORS Martin,G.A., Bollag,G., McCormick,F. and Abo,A.
TITLE A novel serine kinase activated by rac1/CDC42Hs-dependent
autophosphorylation is related to PAK65 and STE20
JOURNAL EMBO J. 14 (17), 4385 (1995)
PUBMED 7556080
REMARK Correction to:[EMBO J. 1995 May 1;14(9):1970-8. PMID: 7744004]
REFERENCE 8 (bases 1 to 6139)
AUTHORS Knaus,U.G., Morris,S., Dong,H.J., Chernoff,J. and Bokoch,G.M.
TITLE Regulation of human leukocyte p21-activated kinases through G
protein--coupled receptors
JOURNAL Science 269 (5221), 221-223 (1995)
PUBMED 7618083
REFERENCE 9 (bases 1 to 6139)
AUTHORS Martin,G.A., Bollag,G., McCormick,F. and Abo,A.
TITLE A novel serine kinase activated by rac1/CDC42Hs-dependent
autophosphorylation is related to PAK65 and STE20
JOURNAL EMBO J. 14 (9), 1970-1978 (1995)
PUBMED 7744004
REMARK Erratum:[EMBO J. 1995 Sep 1;14(17):4385. PMID: 7556080]
REFERENCE 10 (bases 1 to 6139)
AUTHORS Brandon,S.D. and Masaracchia,R.A.
TITLE Multisite phosphorylation of a synthetic peptide derived from the
carboxyl terminus of the ribosomal protein S6
JOURNAL J. Biol. Chem. 266 (1), 380-385 (1991)
PUBMED 1985906
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB164364.1, AK291339.1,
BC069613.1 and AC127904.8.
This sequence is a reference standard in the RefSeqGene project.
On Jun 21, 2008 this sequence version replaced gi:45827795.
Summary: The p21 activated kinases (PAK) are critical effectors
that link Rho GTPases to cytoskeleton reorganization and nuclear
signaling. The PAK proteins are a family of serine/threonine
kinases that serve as targets for the small GTP binding proteins,
CDC42 and RAC1, and have been implicated in a wide range of
biological activities. The protein encoded by this gene is
activated by proteolytic cleavage during caspase-mediated
apoptosis, and may play a role in regulating the apoptotic events
in the dying cell. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK291339.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-116 DB164364.1 1-116
117-649 AK291339.1 1-533
650-678 BC069613.1 363-391
679-2102 AK291339.1 563-1986
2103-6139 AC127904.8 28592-32628
FEATURES Location/Qualifiers
source 1..6139
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q29"
gene 1..6139
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/note="p21 protein (Cdc42/Rac)-activated kinase 2"
/db_xref="GeneID:5062"
/db_xref="HGNC:8591"
/db_xref="MIM:605022"
exon 1..301
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/inference="alignment:Splign:1.39.8"
variation 8
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="t"
/db_xref="dbSNP:187831555"
variation 72
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:187239531"
variation 147
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="c"
/db_xref="dbSNP:1718406"
variation 191
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:377602300"
STS 284..1947
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/db_xref="UniSTS:481256"
STS 298..1918
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/db_xref="UniSTS:482146"
exon 302..509
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/inference="alignment:Splign:1.39.8"
variation 304
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:138339398"
misc_feature 317..319
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/note="upstream in-frame stop codon"
CDS 323..1897
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/EC_number="2.7.11.1"
/note="p21 (CDKN1A)-activated kinase 2; S6/H4 kinase; p58;
PAK-2; gamma-PAK; p21-activated kinase 2"
/codon_start=1
/product="serine/threonine-protein kinase PAK 2"
/protein_id="NP_002568.2"
/db_xref="GI:32483399"
/db_xref="CCDS:CCDS3321.1"
/db_xref="GeneID:5062"
/db_xref="HGNC:8591"
/db_xref="MIM:605022"
/translation="
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPALNAKGTEAPAVVTEEEDDDEETAPPVIAPRPDHTKSIYTRSVIDPVPAPVGDSHVDGAAKSLDKQKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLIMAAKEAMKSNR
"
misc_feature 326..328
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylserine; propagated from
UniProtKB/Swiss-Prot (Q13177.3); acetylation site"
misc_feature 326..328
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13177.3); phosphorylation site"
misc_feature 326..328
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 377..379
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05428"
misc_feature 380..382
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05428"
misc_feature 485..487
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05428"
misc_feature 494..496
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13177.3); phosphorylation site"
misc_feature 527..733
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q13177.3);
Region: Autoregulatory region (By similarity)"
misc_feature 527..658
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q13177.3);
Region: GTPase-binding (By similarity)"
misc_feature 536..673
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/note="PAK (p21 activated kinase) Binding Domain (PBD),
binds Cdc42p- and/or Rho-like small GTPases; also known as
the Cdc42/Rac interactive binding (CRIB) motif; has been
shown to inhibit transcriptional activation and cell
transformation mediated by the...; Region: CRIB_PAK_like;
cd01093"
/db_xref="CDD:29038"
misc_feature order(542..544,551..553,560..562,566..568,575..577,
626..628,638..640)
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/note="GTPase interaction site [polypeptide binding];
other site"
/db_xref="CDD:29038"
misc_feature 704..706
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q13177.3); acetylation site"
misc_feature 710..712
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01819"
misc_feature 743..745
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13177.3); phosphorylation site"
misc_feature 743..745
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05428"
misc_feature 743..745
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 749..751
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 827..829
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q13177.3); phosphorylation site"
misc_feature 896..898
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05428"
misc_feature 911..913
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13177.3); phosphorylation site"
misc_feature 911..913
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05428"
misc_feature 956..961
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="Cleavage, by caspase-3 or caspase-3-like proteases;
propagated from UniProtKB/Swiss-Prot (Q13177.3); cleavage
site"
misc_feature 956..958
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02799"
misc_feature 1007..1885
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/note="Catalytic domain of the Protein Serine/Threonine
Kinase, Group I p21-activated kinase; Region: STKc_PAK_I;
cd06647"
/db_xref="CDD:132978"
misc_feature 1055..1075
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q13177.3);
Region: Nuclear localization signal"
misc_feature 1067..1822
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature order(1085..1099,1109..1111,1148..1150,1154..1156,
1241..1243,1289..1303,1307..1312,1319..1321,1424..1426,
1430..1441,1445..1447,1475..1480,1487..1489,1526..1540,
1544..1546,1625..1627,1652..1660)
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/note="active site"
/db_xref="CDD:132978"
misc_feature order(1085..1099,1109..1111,1148..1150,1154..1156,
1241..1243,1289..1303,1307..1312,1319..1321,1436..1441,
1445..1447,1475..1480)
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:132978"
misc_feature order(1094..1099,1424..1426,1430..1438,1487..1489,
1526..1540,1544..1546,1625..1627,1652..1660)
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:132978"
misc_feature order(1100..1102,1202..1204,1409..1411,1415..1426,
1478..1483,1562..1567,1571..1573,1586..1588,1661..1663,
1670..1672,1679..1681)
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/note="autoinhibitory domain (AID) interaction site; other
site"
/db_xref="CDD:132978"
misc_feature 1475..1546
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/note="activation loop (A-loop); other site"
/db_xref="CDD:132978"
misc_feature 1526..1528
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05428"
variation 327
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="g"
/db_xref="dbSNP:67093638"
variation 349
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:79361419"
variation 382
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="g"
/db_xref="dbSNP:76714248"
variation 396
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="c"
/db_xref="dbSNP:148812897"
variation 429
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:199528043"
variation 445
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:7620283"
variation 476
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:189118527"
variation 490
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:140632720"
exon 510..610
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/inference="alignment:Splign:1.39.8"
variation 532
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:369443431"
variation 571
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="g"
/db_xref="dbSNP:145780663"
variation 575..576
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="c"
/db_xref="dbSNP:34174040"
exon 611..758
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/inference="alignment:Splign:1.39.8"
variation 625
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="g"
/db_xref="dbSNP:201465227"
variation 637
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:55926500"
variation 640
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:183020057"
variation 649
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="c"
/db_xref="dbSNP:77470308"
variation 701
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:79726945"
variation 705
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:78043821"
variation 718
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="c"
/db_xref="dbSNP:200828622"
variation 736
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:73205842"
variation 745
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:115224945"
exon 759..790
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/inference="alignment:Splign:1.39.8"
exon 791..898
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/inference="alignment:Splign:1.39.8"
variation 865
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:73891516"
variation 883
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:190858822"
variation 884..885
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="g"
/db_xref="dbSNP:36084236"
variation 892
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:141767764"
exon 899..1031
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/inference="alignment:Splign:1.39.8"
variation 904
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:73074693"
variation 919
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:191988670"
variation 952
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:144954628"
exon 1032..1095
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/inference="alignment:Splign:1.39.8"
variation 1039
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:144419620"
variation 1061
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="a"
/db_xref="dbSNP:143600502"
variation 1074
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="g"
/db_xref="dbSNP:147795175"
exon 1096..1144
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/inference="alignment:Splign:1.39.8"
variation 1097
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="g"
/db_xref="dbSNP:35150956"
variation 1127
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:199761020"
exon 1145..1257
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/inference="alignment:Splign:1.39.8"
variation 1157..1158
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="c"
/db_xref="dbSNP:35630790"
variation 1201
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:372974626"
variation 1208
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:56386946"
variation 1223
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:369343784"
exon 1258..1375
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/inference="alignment:Splign:1.39.8"
variation 1273
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:139118165"
variation 1315
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:189854746"
variation 1363
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:144911835"
exon 1376..1475
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/inference="alignment:Splign:1.39.8"
variation 1396
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:56172538"
exon 1476..1672
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/inference="alignment:Splign:1.39.8"
variation 1504
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:56020042"
variation 1534
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:375799971"
variation 1543
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:370690993"
variation 1562
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="g"
/replace="t"
/db_xref="dbSNP:1046714"
variation 1585
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="c"
/db_xref="dbSNP:3210515"
variation 1594
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:201099222"
variation 1598
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:374071259"
variation 1610
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:199827146"
exon 1673..1810
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/inference="alignment:Splign:1.39.8"
variation 1673
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="g"
/replace="t"
/db_xref="dbSNP:375935414"
variation 1717
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:368539952"
variation 1736
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:145872250"
exon 1811..6139
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/inference="alignment:Splign:1.39.8"
variation 1837
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:376525228"
variation 1839
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:367798998"
variation 1893
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:201021023"
STS 1894..2046
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/standard_name="RH70587"
/db_xref="UniSTS:92150"
STS 1900..2120
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/standard_name="RH121965"
/db_xref="UniSTS:95010"
variation 1901
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="g"
/db_xref="dbSNP:372020069"
variation 1917
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:200028313"
variation 1945
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:369652191"
variation 1964
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="g"
/replace="t"
/db_xref="dbSNP:1046718"
variation 1967
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="g"
/replace="t"
/db_xref="dbSNP:1046719"
variation 1971
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:146000049"
variation 1973
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="g"
/replace="t"
/db_xref="dbSNP:1046720"
variation 2018
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="g"
/db_xref="dbSNP:1046722"
variation 2019
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:6804618"
variation 2043
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="g"
/db_xref="dbSNP:3659"
variation 2056
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="g"
/db_xref="dbSNP:1046725"
variation 2064
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="c"
/db_xref="dbSNP:3662"
variation 2090
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="g"
/replace="t"
/db_xref="dbSNP:1046727"
variation 2103
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:7614370"
variation 2125
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:185080719"
variation 2144
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="g"
/db_xref="dbSNP:1046728"
variation 2188
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:1046735"
variation 2196
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="g"
/db_xref="dbSNP:1046736"
STS 2198..2861
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/standard_name="PAK2_V275"
/db_xref="UniSTS:277550"
variation 2221
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="g"
/replace="t"
/db_xref="dbSNP:1046737"
variation 2320
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:112895397"
variation 2321
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:115360023"
variation 2377
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="g"
/replace="t"
/db_xref="dbSNP:146911796"
variation 2411
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:148346857"
variation 2421
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:190802764"
variation 2579
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:4638940"
variation 2673
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:138220843"
variation 2682
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:116698093"
variation 2713
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:4638939"
variation 2742
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="g"
/db_xref="dbSNP:114305365"
variation 2745
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:114265067"
variation 2762
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:1046745"
variation 2762
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:56466085"
variation 2788
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:3204142"
variation 2879..2880
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="ct"
/db_xref="dbSNP:149774321"
variation 2880..2881
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="tc"
/db_xref="dbSNP:77592848"
variation 2934
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:115183495"
variation 2947
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="t"
/db_xref="dbSNP:78440408"
variation 3002
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:77016548"
variation 3093
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:201071992"
variation 3104
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:9222"
variation 3121
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:368715352"
variation 3143
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:1046766"
variation 3147
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="g"
/replace="t"
/db_xref="dbSNP:1046767"
variation 3157
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:17091614"
variation 3241
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="t"
/db_xref="dbSNP:77971940"
variation 3260
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:1046777"
variation 3271..3272
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="taa"
/db_xref="dbSNP:16658"
variation 3282
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:1046779"
variation 3311
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="g"
/replace="t"
/db_xref="dbSNP:1046781"
variation 3327
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:14784"
variation 3341
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:1046782"
variation 3346
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:369126764"
variation 3352
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="g"
/db_xref="dbSNP:9843578"
variation 3430
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:1129168"
variation 3455
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="t"
/db_xref="dbSNP:369108797"
variation 3464
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:9109"
variation 3539..3540
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="c"
/db_xref="dbSNP:34266682"
variation 3571
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="c"
/db_xref="dbSNP:182166405"
variation 3573..3574
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="a"
/db_xref="dbSNP:143690612"
variation 3603
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:186292121"
variation 3720
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:145178969"
variation 3751
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:75759102"
variation 3895
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:116730258"
variation 3945
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:145877084"
variation 3975..3976
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="ca"
/db_xref="dbSNP:3839084"
variation 3985
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="c"
/db_xref="dbSNP:368788142"
STS 3986..4161
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/standard_name="RH11274"
/db_xref="UniSTS:84185"
variation 4071
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:189937859"
variation 4078
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="t"
/db_xref="dbSNP:372947043"
variation 4081
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="t"
/db_xref="dbSNP:35185640"
variation 4085
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:141297484"
variation 4120
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="g"
/replace="t"
/db_xref="dbSNP:11555145"
variation 4143..4144
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="c"
/db_xref="dbSNP:35556393"
variation 4161..4162
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="ca"
/db_xref="dbSNP:200646253"
variation 4201
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:150153979"
variation 4260
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="c"
/db_xref="dbSNP:180748535"
variation 4294
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="t"
/db_xref="dbSNP:114565695"
variation 4327
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="c"
/db_xref="dbSNP:75602200"
variation 4336
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:147170548"
variation 4388..4389
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="t"
/db_xref="dbSNP:111516701"
STS 4406..4558
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/standard_name="D11S3732"
/db_xref="UniSTS:152962"
STS 4420..4522
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/standard_name="D11S2921"
/db_xref="UniSTS:152074"
variation 4465
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:140268545"
STS 4482..4571
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 4494
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:35457022"
variation 4561
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:373188639"
variation 4678
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="c"
/db_xref="dbSNP:151315802"
variation 4691
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:185840735"
variation 4720
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="t"
/db_xref="dbSNP:34733757"
variation 4766
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:373705411"
variation 4775
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:150074324"
variation 4801
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:2342070"
variation 4873
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:376276643"
variation 4934
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:79962700"
variation 4936
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="g"
/db_xref="dbSNP:2029003"
variation 4949
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:1052100"
variation 4958
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:3192504"
variation 4971
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:183838020"
variation 4987
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:145038146"
variation 4988
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:1052102"
variation 5033..5034
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="a"
/db_xref="dbSNP:36098029"
variation 5061..5062
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="c"
/db_xref="dbSNP:34255271"
STS 5088..5246
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/standard_name="RH102113"
/db_xref="UniSTS:96447"
variation 5109
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:146815533"
variation 5121
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="g"
/db_xref="dbSNP:6802607"
variation 5143..5144
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="at"
/db_xref="dbSNP:200015581"
variation 5168
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="g"
/db_xref="dbSNP:188333623"
variation 5179
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:191655273"
STS 5284..5353
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/standard_name="GDB:595844"
/db_xref="UniSTS:158033"
variation 5439
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="a"
/db_xref="dbSNP:371520480"
variation 5458
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="t"
/db_xref="dbSNP:6769337"
variation 5509
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:148098967"
variation 5544
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:115489804"
variation 5561
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="g"
/db_xref="dbSNP:114996266"
variation 5563
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="c"
/db_xref="dbSNP:1052130"
variation 5569
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:377104878"
variation 5570
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:15614"
variation 5678
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="c"
/db_xref="dbSNP:143651154"
variation 5755
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:114072668"
variation 5786
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:28463065"
variation 5848
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:9837782"
variation 5863
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="t"
/db_xref="dbSNP:11555147"
variation 5880
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:374193465"
polyA_signal 5962..5967
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
variation 5974
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="t"
/db_xref="dbSNP:183877413"
polyA_site 5980
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
polyA_site 5984
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
variation 6050..6051
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace=""
/replace="tt"
/db_xref="dbSNP:149253912"
variation 6060
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:115619392"
polyA_site 6139
/gene="PAK2"
/gene_synonym="PAK65; PAKgamma"
ORIGIN
gtcttcctcccccagggttgtggccacgcgcagcggcggcggttgttccgcttcccctccggcccgggccgtcgccattgccgaaggctccctcccctcccctccctggcgtgcgcaggactccgccgccgctgggcctagcggtagcagcggctgctccagcgcggcgtctcttcccgccccgcttccccttccctcccctcccctccccgcaccgcgcgctagcccggggcggctccgcagcccgccgggagctctgaccgaggcgcctcgctggggcggggaccttgccttgcccggggccatttcataattctgaatcatgtctgataacggagaactggaagataagcctccagcacctcctgtgcgaatgagcagcaccatctttagcactggaggcaaagaccctttgtcagccaatcacagtttgaaacctttgccctctgttccagaagagaaaaagcccaggcataaaatcatctccatattctcaggcacagagaaaggaagtaaaaagaaagaaaaggaacggccagaaatttctcctccatctgattttgagcacaccatccatgttggctttgatgctgttactggagaattcactggcatgccagaacagtgggctcgattactacagacctccaatatcaccaaactagagcaaaagaagaatcctcaggctgtgctggatgtcctaaagttctacgactccaacacagtgaagcagaaatatctgagctttactcctcctgagaaagatggctttccttctggaacaccagcactgaatgccaagggaacagaagcacccgcagtagtgacagaggaggaggatgatgatgaagagactgctcctcccgttattgccccgcgaccggatcatacgaaatcaatttacacacggtctgtaattgaccctgttcctgcaccagttggtgattcacatgttgatggtgctgccaagtctttagacaaacagaaaaagaagactaagatgacagatgaagagattatggagaaattaagaactatcgtgagcataggtgaccctaagaaaaaatatacaagatatgaaaaaattggacaaggggcttctggtacagttttcactgctactgacgttgcactgggacaggaggttgctatcaaacaaattaatttacagaaacagccaaagaaggaactgatcattaacgagattctggtgatgaaagaattgaaaaatcccaacatcgttaactttttggacagttacctggtaggagatgaattgtttgtggtcatggaataccttgctggggggtcactcactgatgtggtaacagaaacgtgcatggatgaagcacagattgctgctgtatgcagagagtgtttacaggcattggagtttttacatgctaatcaagtgatccacagagacatcaaaagtgacaatgtacttttgggaatggaaggatctgttaagctcactgactttggtttctgtgcccagatcacccctgagcagagcaaacgcagtaccatggtcggaacgccatactggatggcaccagaggtggttacacggaaagcttatggccctaaagtcgacatatggtctctgggtatcatggctattgagatggtagaaggagagcctccatacctcaatgaaaatcccttgagggccttgtacctaatagcaactaatggaaccccagaacttcagaatccagagaaactttccccaatatttcgggatttcttaaatcgatgtttggaaatggatgtggaaaaaaggggttcagccaaagaattattacagcatcctttcctgaaactggccaaaccgttatctagcttgacaccactgatcatggcagctaaagaagcaatgaagagtaaccgttaacatcactgctgtggcctcatactcttttttccattttctacaagaagccttttagtatatgaaaattattactctttttggggtttaaagaaatggtctgcataacctgaatgaaagaagcaaatgactattctctgaagacaaccaagagaaaattgcaaaaagacaagtatgacttttatatgaaccccttctttagggtccagaaggaattgtggactgaatcactagccttaggtctttcagcaaacagcctatcagggccatttatcatgtgtgagatttgcattttactttgctgactttgttgtaatagatcccattcattgtcccctttggggtatttccaatacttgaatggcagattggagtttttcagagtatgtgtttcatctgctagtctttctctccttcatagcttttcttttcctggacttgctccttttgagttgcttttgcgtttctcatgcctaggcaagtgtaatagaaattatgtagctccttatgttggcaaaggagctctatatagtttcactttgtataaaagttaggaccagctgttgttacatgtaatattttagttcagaacttgacctgaaggaagggaagaaaagtatgtgatttttaccttttttaacaaatgtgaaaaagtcagttttagaaatttcgtggtagtaagttcggcatttgttacatgtatagagagaagactaataatctctatttataactaaatcattgagatagaaaaagattcccattgactgtagacttcttcccattttgtcttcccttctgcctgtttccccttcaggcttggctctaggaaccaaagtgatttgttgttgttccaacctgggctttgtgactttggttagtgccactaccttcttccctcctttcccccttcaatttggaaataaatttctgtatatgttgcaattttaggtttaggtttgttctttttctttttcattaatcctctctcacctcacagataccccctcccatggcaaataatataataaccagtgaattttcaggaatttaaaaattagcttttttccacttaaaggagaaaaatatttgggactagcagcagaggcagtaagagatgtgaaccttggtgagctctgatacagtgagaagagattatactcatgaaagagaatgttagtgttacagagaagcagccgatagcaaatcgactgtagagacttggcggcggtggcattgccccaggtcgtcagcagtgtggtattatctatgagaacttgagcgacagagtatttcttgatgaatttatagatcatttgagatgttgagttactttagtttagttttgttttgttttttcaaataagtagagactattgtaaaaaacgagaaaggaaaatgaaatgtgcgtgttgatagcaataatttgtttcttttaaagattctaaaaggtctgagacctgtagcattaattatttgagtgccctcccttctcccctcccctcccttttctcttctcttttttcctctcctcttcttctcctttattcattgttttgcttttggagtgggtgttgttcaagtatctgtggtttggttctggcattttgttcccaccatccccttcccccattaacttcccccctgcttgccatcctgcagtagtataaatcatgaataaaaaataattttgctgttgtagtatacattggagaaactggcaggttttatttccattattttatttccactatatctatgataagatgcaattataaggagagaagtgactgttttttattgataaggcaagattttcagaaaaatgagtaaaataattaatgaaacatatttagagcacttaatggtctctgttttcaatataattcttgatttcatttttctctggaatatattggccttctacagctattactgaattatagaaactggtttatttctggcagaaagctgcagtgccacctgagttccaaattttaccattctttgtaaacagttggatggattatgataaagaagatgctaccaatgaaatagaaaaccaacgagatgagaagactgtgatcctcatgtactcagaggcacttccctcctaagtcaaagaccatcctcactgactatgtgccaacgcctcgtttcaggcttgtgactcaacaaagggcttttccattgatagaagcagtttgggatttgtagttgcgacttcttcgatagttacctgcacgtccattgctggcaactgacttgtcattaaaacctggctctttggttaagggagctacgctgtggtttattcttaagttacgtggataaactaacctctaacagaaatatactttggttaattttgaaatgtgtcatttttaaacaatcttaaaagtaatacagaattgtgatttattaattttaaaacattcagaacttgttgaaagaaaaattatatctgaatcaagattcatgttttttatttttattttttttgatacagagtctcactctgtcactcaggctggagtgcagtgacatgatctcagctcactgcaacctccgcttcctgggttcaagcaattctcatgcctcagcctcctgagtagctgagaccacaggcacccgccaccacacccagctatttttttgtatttttagtagagacagagtctcaccacattgcccaggctggtctccaactcctgagctcaggcagtctgcccaccttggcctcccaaagtgctgcagttacaggcgtgagccactgcacctggcctcatgttttttaaataattgccttttatatttaccctttttgtcatcactttagaatgaaaattcccatttaaatctgaaagttaccttaatagtcctcttgtgttattaggacagtattattatagtacttatttattttattttagatttaaagttatcttctctttttcttttttcttctgctgcttttagggacaattaaaactgggaaactatgaaacatggaacattttatcctacctgaaagtaaacgagtaattgtgaagcataagacactgaggctaatacaactctgtcttcatgtgttgactgcctggcacatagtattcattctcttccctttaacatagaagtgtccagctgcgtacagtctagtaaccagcaactgtaaacgaacctgtgcctctaacaagcgattctaaaccacctatgagtatttcttttagggctcacttaaatacatgtttgtatatactgtattctagccagaataattttagatctgatcaggtagtagctaaaattagaaaaaaacaaaatagatgcttaaagaatttgcatccatttttgagtctaaatcttttaaaatatactgagatccacatctagtgaaatgtcagtgtcaaaatattatagattatagctaaaatccagattaatactcatttggggttttttatagtggaacttcatagtaatacaaaaagcagattgtcttcctgtctccgctgctcccacagtaggtattgaaactggtaaaatcagttttttgatagtgtgtgtatataagaaaaaatagatacacacattcttttttctcagtcaacacattgattgaacactctggcaaagatgctgtggtggatgaggttggagttcgaaagaagaagcaagcgctggcctggccttgaaagaaccgaagtctttcccattcacttctctagaaagctgccaagacagaggcagaaagaaatggatgatagttctgtcaagcacacttctgttctcttagaacttagaagtgtttctaagagaacagaagtaataagagaaacagttacgtgtggaattcaacatctttggttggaacgcattggctttttttttcttgttttgatagaaatggaattaagcaaaagtagtttttgtcttttctgttgtcttcaaattttatgccttttatttttaatttaatcccgttcaattatttaattgttatacattgacattaactgctgtattttgactttgttcaataattttgttctttcagggctagaaataaactttttaaaaaaagtgtgcatttttccctttcctaaacttttattctttcttttgatcagcgtaaaagaatattttaatgtcttttgatagcataaaagaatatttaaatgtcttaataggttttcaaagaacatttagtatttttagtgataaatgttttaaaccttttaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5062 -> Molecular function: GO:0004672 [protein kinase activity] evidence: TAS
GeneID:5062 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:5062 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: TAS
GeneID:5062 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5062 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:5062 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI
GeneID:5062 -> Molecular function: GO:0030296 [protein tyrosine kinase activator activity] evidence: IDA
GeneID:5062 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
GeneID:5062 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:5062 -> Biological process: GO:0006469 [negative regulation of protein kinase activity] evidence: TAS
GeneID:5062 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:5062 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
GeneID:5062 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:5062 -> Biological process: GO:0007411 [axon guidance] evidence: TAS
GeneID:5062 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:5062 -> Biological process: GO:0016310 [phosphorylation] evidence: IDA
GeneID:5062 -> Biological process: GO:0018105 [peptidyl-serine phosphorylation] evidence: IDA
GeneID:5062 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:5062 -> Biological process: GO:0031295 [T cell costimulation] evidence: TAS
GeneID:5062 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
GeneID:5062 -> Biological process: GO:0040008 [regulation of growth] evidence: IEA
GeneID:5062 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:5062 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IMP
GeneID:5062 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:5062 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:5062 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
GeneID:5062 -> Biological process: GO:0050690 [regulation of defense response to virus by virus] evidence: TAS
GeneID:5062 -> Biological process: GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] evidence: IDA
GeneID:5062 -> Biological process: GO:0050852 [T cell receptor signaling pathway] evidence: TAS
GeneID:5062 -> Biological process: GO:0061098 [positive regulation of protein tyrosine kinase activity] evidence: IDA
GeneID:5062 -> Biological process: GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] evidence: IMP
GeneID:5062 -> Biological process: GO:2001271 [negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis] evidence: IDA
GeneID:5062 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:5062 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5062 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:5062 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_002568 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.