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2024-04-27 00:17:49, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002538 6451 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens occludin (OCLN), transcript variant 1, mRNA.
ACCESSION NM_002538 XM_003118543 XM_936894
VERSION NM_002538.3 GI:327478412
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6451)
AUTHORS Wu,H.L., Gao,X., Jiang,Z.D., Duan,Z.T., Wang,S.K., He,B.S.,
Zhang,Z.Y. and Xie,H.G.
TITLE Attenuated expression of the tight junction proteins is involved in
clopidogrel-induced gastric injury through p38 MAPK activation
JOURNAL Toxicology 304, 41-48 (2013)
PUBMED 23220562
REMARK GeneRIF: It is concluded that attenuated expression of the TJ
proteins occludin and ZO-1 in human gastric epithelial cells could
be involved in clopidogrel-induced gastric mucosal injury through
activation of the p38 MAPK pathway
REFERENCE 2 (bases 1 to 6451)
AUTHORS Yu,T.X., Rao,J.N., Zou,T., Liu,L., Xiao,L., Ouyang,M., Cao,S.,
Gorospe,M. and Wang,J.Y.
TITLE Competitive binding of CUGBP1 and HuR to occludin mRNA controls its
translation and modulates epithelial barrier function
JOURNAL Mol. Biol. Cell 24 (2), 85-99 (2013)
PUBMED 23155001
REMARK GeneRIF: HuR promotes occludin translation by blocking occludin
mRNA translocation to P-bodies via the displacement of CUGBP1.
REFERENCE 3 (bases 1 to 6451)
AUTHORS Den Beste,K.A., Hoddeson,E.K., Parkos,C.A., Nusrat,A. and Wise,S.K.
TITLE Epithelial permeability alterations in an in vitro air-liquid
interface model of allergic fungal rhinosinusitis
JOURNAL Int Forum Allergy Rhinol 3 (1), 19-25 (2013)
PUBMED 22927233
REMARK GeneRIF: Sinonasal epithelium in allergic fungal rhinosinusitis
displays increased epithelial permeability and an altered
expression of occludin.
REFERENCE 4 (bases 1 to 6451)
AUTHORS O'Driscoll,M.C., Daly,S.B., Urquhart,J.E., Black,G.C., Pilz,D.T.,
Brockmann,K., McEntagart,M., Abdel-Salam,G., Zaki,M., Wolf,N.I.,
Ladda,R.L., Sell,S., D'Arrigo,S., Squier,W., Dobyns,W.B.,
Livingston,J.H. and Crow,Y.J.
TITLE Recessive mutations in the gene encoding the tight junction protein
occludin cause band-like calcification with simplified gyration and
polymicrogyria
JOURNAL Am. J. Hum. Genet. 87 (3), 354-364 (2010)
PUBMED 20727516
REMARK GeneRIF: The tight junction protein occludin (encoded by the OCLN
gene) is involved in the pathogenesis of malformations of cortical
development.
REFERENCE 5 (bases 1 to 6451)
AUTHORS Kohaar,I., Ploss,A., Korol,E., Mu,K., Schoggins,J.W., O'Brien,T.R.,
Rice,C.M. and Prokunina-Olsson,L.
TITLE Splicing diversity of the human OCLN gene and its biological
significance for hepatitis C virus entry
JOURNAL J. Virol. 84 (14), 6987-6994 (2010)
PUBMED 20463075
REMARK GeneRIF: Data suggest that the natural splicing diversity of
occludin might contribute to hepatitis C virus tissue tropism and
possibly modify the outcome of HCV infection in humans.
REFERENCE 6 (bases 1 to 6451)
AUTHORS Mankertz,J., Waller,J.S., Hillenbrand,B., Tavalali,S., Florian,P.,
Schoneberg,T., Fromm,M. and Schulzke,J.D.
TITLE Gene expression of the tight junction protein occludin includes
differential splicing and alternative promoter usage
JOURNAL Biochem. Biophys. Res. Commun. 298 (5), 657-666 (2002)
PUBMED 12419305
REMARK GeneRIF: different occludin variants were identified on the mRNA
level
REFERENCE 7 (bases 1 to 6451)
AUTHORS Kimura,Y., Shiozaki,H., Hirao,M., Maeno,Y., Doki,Y., Inoue,M.,
Monden,T., Ando-Akatsuka,Y., Furuse,M., Tsukita,S. and Monden,M.
TITLE Expression of occludin, tight-junction-associated protein, in human
digestive tract
JOURNAL Am. J. Pathol. 151 (1), 45-54 (1997)
PUBMED 9212730
REFERENCE 8 (bases 1 to 6451)
AUTHORS Van Itallie,C.M. and Anderson,J.M.
TITLE Occludin confers adhesiveness when expressed in fibroblasts
JOURNAL J. Cell. Sci. 110 (PT 9), 1113-1121 (1997)
PUBMED 9175707
REFERENCE 9 (bases 1 to 6451)
AUTHORS Ando-Akatsuka,Y., Saitou,M., Hirase,T., Kishi,M., Sakakibara,A.,
Itoh,M., Yonemura,S., Furuse,M. and Tsukita,S.
TITLE Interspecies diversity of the occludin sequence: cDNA cloning of
human, mouse, dog, and rat-kangaroo homologues
JOURNAL J. Cell Biol. 133 (1), 43-47 (1996)
PUBMED 8601611
REFERENCE 10 (bases 1 to 6451)
AUTHORS Furuse,M., Itoh,M., Hirase,T., Nagafuchi,A., Yonemura,S.,
Tsukita,S. and Tsukita,S.
TITLE Direct association of occludin with ZO-1 and its possible
involvement in the localization of occludin at tight junctions
JOURNAL J. Cell Biol. 127 (6 PT 1), 1617-1626 (1994)
PUBMED 7798316
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from U53823.1, AC145146.2, U49184.1,
AC147575.1 and AI093221.1.
This sequence is a reference standard in the RefSeqGene project.
On or before Apr 5, 2011 this sequence version replaced
gi:310119545, gi:9257230.
Summary: This gene encodes an integral membrane protein that is
required for cytokine-induced regulation of the tight junction
paracellular permeability barrier. Mutations in this gene are
thought to be a cause of band-like calcification with simplified
gyration and polymicrogyria (BLC-PMG), an autosomal recessive
neurologic disorder that is also known as pseudo-TORCH syndrome.
Alternative splicing results in multiple transcript variants. A
related pseudogene is present 1.5 Mb downstream on the q arm of
chromosome 5. [provided by RefSeq, Apr 2011].
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longer isoform (a). Both variants 1 and
2 encode isoform a.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U53823.1, U49184.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-142 U53823.1 1-142
143-143 AC145146.2 13256-13256 c
144-269 U53823.1 144-269
270-2640 U49184.1 1-2371
2641-6398 AC147575.1 3515-7272 c
6399-6451 AI093221.1 1-53 c
FEATURES Location/Qualifiers
source 1..6451
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q13.1"
gene 1..6451
/gene="OCLN"
/gene_synonym="BLCPMG"
/note="occludin"
/db_xref="GeneID:100506658"
/db_xref="HGNC:8104"
/db_xref="HPRD:04191"
/db_xref="MIM:602876"
exon 1..368
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
variation 10
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:185570203"
variation 27
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:188911790"
variation 143
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:3733742"
variation 240
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:374271600"
variation 351
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:115253607"
exon 369..486
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
variation 413
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="g"
/replace="t"
/db_xref="dbSNP:201102823"
misc_feature 425..427
/gene="OCLN"
/gene_synonym="BLCPMG"
/note="upstream in-frame stop codon"
CDS 437..2005
/gene="OCLN"
/gene_synonym="BLCPMG"
/EC_number="2.1.1.67"
/note="isoform a is encoded by transcript variant 1; tight
junction protein occludin"
/codon_start=1
/product="occludin isoform a"
/protein_id="NP_002529.1"
/db_xref="GI:4505487"
/db_xref="CCDS:CCDS4006.1"
/db_xref="GeneID:100506658"
/db_xref="HGNC:8104"
/db_xref="HPRD:04191"
/db_xref="MIM:602876"
/translation="
MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIFACVASTLAWDRGYGTSLLGGSVGYPYGGSGFGSYGSGYGYGYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSVIRSEMSRTRRYYLSVIIVSAILGIMVFIATIVYIMGVNPTAQSSGSLYGSQIYALCNQFYTPAATGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVKNVSAGTQDVPSPPSDYVERVDSPMAYSSNGKVNDKRFYPESSYKSTPVPEVVQELPLTSPVDDFRQPRYSSGGNFETPSKRAPAKGRAGRSKRTEQDHYETDYTTGGESCDELEEDWIREYPPITSDQQRQLYKRNFDTGLQEYKSLQSELDEINKELSRLDKELDDYREESEEYMAAADEYNRLKQVKGSADYKSKKNHCKQLKSKLSHIKKMVGDYDRQKT
"
misc_feature 608..1066
/gene="OCLN"
/gene_synonym="BLCPMG"
/note="Membrane-associating domain; Region: MARVEL;
pfam01284"
/db_xref="CDD:201710"
misc_feature 635..703
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q16625.1);
transmembrane region"
misc_feature 842..916
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q16625.1);
transmembrane region"
misc_feature 947..1021
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q16625.1);
transmembrane region"
misc_feature 1166..1231
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q16625.1);
transmembrane region"
misc_feature 1349..1351
/gene="OCLN"
/gene_synonym="BLCPMG"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1454..1456
/gene="OCLN"
/gene_synonym="BLCPMG"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01498"
misc_feature 1454..1456
/gene="OCLN"
/gene_synonym="BLCPMG"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01499"
misc_feature 1454..1456
/gene="OCLN"
/gene_synonym="BLCPMG"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01502"
misc_feature 1628..1630
/gene="OCLN"
/gene_synonym="BLCPMG"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (Q16625.1); phosphorylation site"
misc_feature 1640..1642
/gene="OCLN"
/gene_synonym="BLCPMG"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (Q16625.1); phosphorylation site"
misc_feature 1643..1645
/gene="OCLN"
/gene_synonym="BLCPMG"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by PKC/PRKCH; propagated from
UniProtKB/Swiss-Prot (Q16625.1); phosphorylation site"
misc_feature 1646..1648
/gene="OCLN"
/gene_synonym="BLCPMG"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by PKC/PRKCH; propagated from
UniProtKB/Swiss-Prot (Q16625.1); phosphorylation site"
misc_feature 1646..1648
/gene="OCLN"
/gene_synonym="BLCPMG"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:00278"
misc_feature 1658..1660
/gene="OCLN"
/gene_synonym="BLCPMG"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:00278"
misc_feature 1694..1993
/gene="OCLN"
/gene_synonym="BLCPMG"
/note="Occludin homology domain; Region: Occludin_ELL;
pfam07303"
/db_xref="CDD:115928"
misc_feature 1904..1906
/gene="OCLN"
/gene_synonym="BLCPMG"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q16625.1); phosphorylation site"
variation 440
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:113706384"
variation 459
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:139272416"
exon 487..1165
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
variation 492
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="c"
/db_xref="dbSNP:368281009"
variation 493
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:370812139"
STS 498..666
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="PMC310929P1"
/db_xref="UniSTS:272816"
variation 506
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:147125035"
variation 542
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:373915080"
variation 548
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:201821077"
variation 553
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:201027704"
variation 565
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:374099764"
variation 615
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:200344104"
variation 633
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="g"
/replace="t"
/db_xref="dbSNP:116363086"
variation 669
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:201378122"
variation 766
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:367815590"
variation 794
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:138515133"
variation 809
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:370941532"
variation 820
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:150730577"
variation 888
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:28562785"
variation 889
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:149492224"
variation 891
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:142569075"
variation 905
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:139928771"
variation 990
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="g"
/replace="t"
/db_xref="dbSNP:372258308"
variation 1002
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:200330025"
variation 1014
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:201347125"
variation 1016
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:143065857"
variation 1039
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:374218912"
variation 1057
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:148225175"
variation 1092
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:267606926"
variation 1100
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="c"
/db_xref="dbSNP:377288243"
variation 1111
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:143335340"
variation 1118
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:369493872"
variation 1121
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:141127898"
variation 1134
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:17852716"
variation 1135
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:35107257"
variation 1143
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:200609277"
variation 1144
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:201492433"
exon 1166..1327
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
variation 1167
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:148494605"
variation 1170
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:371270934"
variation 1173
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:199655841"
variation 1190
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:142683205"
variation 1200
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:28418826"
variation 1209
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:79095497"
variation 1221
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="g"
/replace="t"
/db_xref="dbSNP:151045915"
variation 1296
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:200654651"
variation 1307
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:373344533"
variation 1315
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:140924340"
exon 1328..1473
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
variation 1358
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:369518478"
variation 1439
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:372766137"
variation 1440
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:201673353"
variation 1470
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:377673456"
exon 1474..1689
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
variation 1480..1481
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace=""
/replace="g"
/db_xref="dbSNP:34401791"
variation 1536
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:374647565"
variation 1568
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:377718385"
variation 1629
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:370970569"
variation 1641
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:144743806"
variation 1651
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:2666582"
STS 1679..1870
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="Ocln"
/db_xref="UniSTS:495893"
exon 1690..1861
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
exon 1862..1903
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
exon 1904..6438
/gene="OCLN"
/gene_synonym="BLCPMG"
/inference="alignment:Splign:1.39.8"
variation 1912
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:370469574"
variation 1948
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:2666626"
variation 2009
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:374897366"
variation 2138
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:2576903"
variation 2138
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:76080549"
STS 2300..2461
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="STS-U19251"
/db_xref="UniSTS:77742"
variation 2313
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:201056955"
STS 2424..2570
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="STS-H94471"
/db_xref="UniSTS:52040"
variation 2436
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:371132365"
polyA_signal 2619..2624
/gene="OCLN"
/gene_synonym="BLCPMG"
polyA_site 2640
/gene="OCLN"
/gene_synonym="BLCPMG"
variation 2662
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:79809021"
variation 2705
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:2576904"
variation 2705
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:187688506"
variation 2762
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:2561166"
variation 2915
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:192491213"
variation 2937
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:2576905"
variation 2984
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:75912442"
variation 3075
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:112593689"
variation 3151
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:2666599"
variation 3151
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:71622295"
variation 3187
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:111663327"
variation 3205..3206
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace=""
/replace="t"
/db_xref="dbSNP:71957719"
variation 3290
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="g"
/replace="t"
/db_xref="dbSNP:370879112"
variation 3291
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:374446243"
variation 3292
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:185678833"
variation 3294
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:368766545"
variation 3295..3296
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace=""
/replace="ag"
/db_xref="dbSNP:34202353"
variation 3330
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:2568329"
variation 3330
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:371435086"
STS 3373..3794
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 3373..3461
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 3415
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:2568330"
variation 3429
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:6868400"
variation 3429
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:76123058"
variation 3470
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:146986409"
variation 3473
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="c"
/db_xref="dbSNP:6892155"
variation 3473
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="c"
/db_xref="dbSNP:66660167"
STS 3524..3721
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="GDB:434012"
/db_xref="UniSTS:157204"
variation 3571..3572
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace=""
/replace="gt"
/db_xref="dbSNP:373178468"
variation 3591
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace=""
/replace="gtgt"
/db_xref="dbSNP:55639523"
variation 3593
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:371306264"
variation 3595
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:374793047"
variation 3614..3615
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace=""
/replace="t"
/db_xref="dbSNP:56388078"
STS 3664..3879
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="RH80030"
/db_xref="UniSTS:87680"
STS 3701..3794
/gene="OCLN"
/gene_synonym="BLCPMG"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 3795
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:188890364"
variation 3804
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:2666598"
variation 3804
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:371941973"
variation 3851
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:192095324"
variation 3894
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:2244907"
variation 3894
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:375565190"
variation 3927
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:369899490"
variation 3927
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:2666597"
variation 4048
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:256925"
variation 4048
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:55909787"
variation 4070
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:184412724"
variation 4088
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:111417042"
polyA_signal 4693..4698
/gene="OCLN"
/gene_synonym="BLCPMG"
polyA_site 4714
/gene="OCLN"
/gene_synonym="BLCPMG"
polyA_signal 4974..4979
/gene="OCLN"
/gene_synonym="BLCPMG"
polyA_site 4993
/gene="OCLN"
/gene_synonym="BLCPMG"
variation 5041
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:200157655"
variation 5537
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:699901"
variation 5537
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:374275248"
variation 5556
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:113964466"
variation 5678
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:189167216"
variation 5862
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:112951447"
variation 5965
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="g"
/db_xref="dbSNP:71576927"
variation 5974
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:112695697"
variation 5993
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="g"
/db_xref="dbSNP:77392451"
variation 6179
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="a"
/replace="t"
/db_xref="dbSNP:2244652"
variation 6384
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:200773462"
variation 6414
/gene="OCLN"
/gene_synonym="BLCPMG"
/replace="c"
/replace="t"
/db_xref="dbSNP:2244645"
polyA_site 6438
/gene="OCLN"
/gene_synonym="BLCPMG"
ORIGIN
gcctctctccatcagacaccccaaggttccatccgaagcaggcggagcaccgaacgcaccccggggtggtcagggacccccatccgtgctgccccctaggagcccgcgcctctcctctgcgccccgcctctcgggccgcaacgtcgcgcggttcctttaacagcgcgctggcagggtgtgggaagcaggaccgcgtcctcccgccccctcccatccgagtttcaggtgaattggtcaccgagggaggaggccgacacaccacacctacactcccgcgtccacctctccctccctgcttcctctggcggaggcggcaggaaccgagagccaggtccagagcgccgaggagccggtctaggacgcagcagattggtttatcttggaagctaaagggcattgctcatcctgaagatcagctgaccattgacaatcagccatgtcatccaggcctcttgaaagtccacctccttacaggcctgatgaattcaaaccgaatcattatgcaccaagcaatgacatatatggtggagagatgcatgttcgaccaatgctctctcagccagcctactctttttacccagaagatgaaattcttcacttctacaaatggacctctcctccaggagtgattcggatcctgtctatgctcattattgtgatgtgcattgccatctttgcctgtgtggcctccacgcttgcctgggacagaggctatggaacttcccttttaggaggtagtgtaggctacccttatggaggaagtggctttggtagctacggaagtggctatggctatggctatggttatggctatggctacggaggctatacagacccaagagcagcaaagggcttcatgttggccatggctgccttttgtttcattgccgcgttggtgatctttgttaccagtgttataagatctgaaatgtccagaacaagaagatactacttaagtgtgataatagtgagtgctatcctgggcatcatggtgtttattgccacaattgtctatataatgggagtgaacccaactgctcagtcttctggatctctatatggttcacaaatatatgccctctgcaaccaattttatacacctgcagctactggactctacgtggatcagtatttgtatcactactgtgttgtggatccccaggaggccattgccattgtactggggttcatgattattgtggcttttgctttaataattttctttgctgtgaaaactcgaagaaagatggacaggtatgacaagtccaatattttgtgggacaaggaacacatttatgatgagcagccccccaatgtcgaggagtgggttaaaaatgtgtctgcaggcacacaggacgtgccttcacccccatctgactatgtggaaagagttgacagtcccatggcatactcttccaatggcaaagtgaatgacaagcggttttatccagagtcttcctataaatccacgccggttcctgaagtggttcaggagcttccattaacttcgcctgtggatgacttcaggcagcctcgttacagcagcggtggtaactttgagacaccttcaaaaagagcacctgcaaagggaagagcaggaaggtcaaagagaacagagcaagatcactatgagacagactacacaactggcggcgagtcctgtgatgagctggaggaggactggatcagggaatatccacctatcacttcagatcaacaaagacaactgtacaagaggaattttgacactggcctacaggaatacaagagcttacaatcagaacttgatgagatcaataaagaactctcccgtttggataaagaattggatgactatagagaagaaagtgaagagtacatggctgctgctgatgaatacaatagactgaagcaagtgaagggatctgcagattacaaaagtaagaagaatcattgcaagcagttaaagagcaaattgtcacacatcaagaagatggttggagactatgatagacagaaaacatagaaggctgatgccaagttgtttgagaaattaagtatctgacatctctgcaatcttctcagaaggcaaatgactttggaccataaccccggaagccaaacctctgtgagcatcacaaagttttggttgctttaacatcatcagtattgaagcattttataaatcgcttttgataatcaactgggctgaacactccaattaaggattttatgctttaaacattggttcttgtattaagaatgaaatactgtttgaggtttttaagccttaaaggaaggttctggtgtgaactaaactttcacaccccagacgatgtcttcatacctacatgtatttgtttgcataggtgatctcatttaatcctctcaaccacctttcagataactgttatttataatcacttttttccacataaggaaactgggttcctgcaatgaagtctctgaagtgaaactgcttgtttcctagcacacacttttggttaagtctgttttatgacttcattaataataaattccctggcctttcatattttagctactatatatgtgatgatctaccagcctccctattttttttctgttatataaatggttaaaagaggtttttcttaaataataaagatcatgtaaaagtaacaaatgtgtgaaatttaaagattgtaaatatatatttacttttttaagatcaaagtttaaaccccgtggttagaattttgtgtgtttttaaatactttttatctttttgcatgccttttttaaaaaaccaactagaacttttcattatatcagaatatctgattacatttataattcaattgtgacttgaactgtatcttacaggaatgttcaatttctatacatattttataaggtattaaacctggtgttttctttccataataacctgtttgatgttattagtgctgttaacatacagcaatggaaaaccacactcaggagttgtatctgttgttgtttatactcctttggatgctgtgctggttagtcgtttcccattcctttggctgtaagaatgctgatatgtctgggaatagaatgctataccacgaaataccaaataatttcaaatggtgcccttaaattgtatcacttttttaaaaattcagattcttattagtaaaattagttgatagcactgtgctgaccaagttgattgtgatcatcccagcttagacttttctaaaaacttttttttagaataatctataaactgaactttagtatgcatttcagatatttaggtatataatttttttttttttttgagacagagtctcactctcacccaggctggaatgcagtggtgctatcttggctcactgcaacctccacctcccgggttcaagcaattctcctgcctcagcctctcgagtagttgagactacaggtgcccatcaccatgcgtggctaatttttgtatttttaatagagacggggttttaccatagtggccaggttggtcttgaactcctgaccttgtggtctgcctgcctcggcctcccaaagtgctgggattacaggcgtgagccaccatgcctggcctaagtgtgtgtgtgtgtgtgtgtgtgtatttttttttttttttttttgagatggagttttgctcttgttgaacaggctggagtgcaatgtcgcgatctcagctcaccacaacctccgcctcccaggttcaaacaattctcctgcctcggcctcccgagtagctgggattacaggcatgcgccaccacacctggctaattttttttttgtatttttagtagagatggggtttctccatgttggtcaggctggtctcgaactcctgacctcaggtgatccatccacctcggcctcccaaagtgctgggattagaggcgtgagccactgtgcccggcctataatttttgatagatgattttgaattattttccagagataaaattttaaatgtttccattatatcactgatttatttctgcaaattgaataaattcttaattttctgcatgcacataatacaaaaggtattttcatagttttggatttataccaaatgaaaaggattctcttgatgagcacctttaactgatttttctgttaaagttttaacaatttgttcttggaagtcagttcgtgaaggcaagtttgtcagtattttcacaaaactattcagctgaatccagaaagtgaaacagcaagaatttgcattgtaaaattgtgttataaaattggactttgaaatttcaaaaataagaaaaattttcatgtgtatttatactaaataccgttttaggaaactaggatcagggtgtttctgttggcgttggcattaactagctggatgtaaatttgaaaagccactcaagcagcttcctagtctagaaagtcagaggtttagattagatttccgacatcccttccatttctgacctgtagttcttgtctggaattctgctttgttataaactattgttctaaggagtttgttgtgatagcacatagttcattttgtaaagattccctgcgtataaagtgatgccctacatatgtgattttgtattaaaagtatataggatcattattttattttgaaaaatttaaatacagaaaagtataaaatataagtaccatccgcccagaaataacatgtgttaatgttttgtcatatgtgctttatattttttgaaataaagtgaagtcaactagtatttatagtaaataagttacatacacataagtacatatatgatatttaatcctcacaacgatcttttgacatgtgaccatttcttattcttcttttatagacaaggaactaatgatatgatagattaactggctgttgtcacactagcaagtggcaaaacaagggattaggatcttagtctcttcaactgttagattctatacttccatcctgtgttgactttgttaatggattggataatgtgagatcactctgatgtaaataaagtatcctatattaatttcgagtgcattttaagtacttgtaacataaatgcttcctgtgaaatatctgtaaagacctgaatgggtacatgtgtgtaaagaagaatcagggcagaaaagtgcttttatcatggctccggggaccttagcttcagttggtgttgtgagaattcctcacacaaggacattctccttgcttcagcatcaggatggaagtgtttctcatctggactttttcaaagactcagctggaggaatcagaattcataatttcctggcagctcatgattctgctacactacaccatgccatctcttgtgtgaaaggacagatttgatggaggactatgtcatccctcatgcgtttcttattgtctacatttattctaatgggaagaagtgagcaaaaacacctcaataatttgggtagtttttagaaaaccttgttagtaaattagaatagtgccactttggcattatgagaaagaagcatggatacataactagggttttgtgtatgactacaacgaaatgcagaatggtgtctccaaaaggtttccaattgctgccacaagaactgcttggtattgcctacatgtgttgtcctatttttgctttgcccttctgcagttacttgctgtgggaccttggagaaattaacttagcctctctgtacttcagttttttgtatttgtaaaatatatttgtaataatctcatagttaagaaggtagttaatgtgtgactcagtccttgtctaaaagtaaatatgcctagctacccccatcttccaaagccagaaggtgaaactttaacaagttttctaaaagcaaattgtgttttttaaaagtgcatgtgtcatccaatcccatatgattgatctgtgctgggtgcagccttagaatgtaaattcttttgaattctaggcagagaatgcaggattggcattctaaatatttgtacatgataaacaaatgcttctttaggttagagcaaatagtttacttatcaagatcacaattgttagatactgttgtcaattacagaggttttagatgaggctttctggaatgatttagtttccctgtaagggagcctgtctattggaatagacaggttcacttctcccagtctttcaagttgcatgctttttatatctgattccactggctgagctgattgtgaatgtcctaaccctgttgattgtgtctggccactcatgggcaaagaacagattatccattctttatagttgtcttttagttttacaagttgaaaaaacatctgagtaggttagataatttattctaccactttgtaaatgattagaatatgtcagtcataatcatgccaagagattatggatttatgcatattttgttttgctgtagtaccattcctagttgaatcttaacatccatgtctaaaatctatacagaacaaatattacagttgggaaaactgaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:100506658 -> Molecular function: GO:0005198 [structural molecule activity] evidence: IEA
GeneID:100506658 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:100506658 -> Biological process: GO:0006461 [protein complex assembly] evidence: TAS
GeneID:100506658 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:100506658 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
GeneID:100506658 -> Biological process: GO:0045216 [cell-cell junction organization] evidence: IMP
GeneID:100506658 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:100506658 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:100506658 -> Cellular component: GO:0005911 [cell-cell junction] evidence: IDA
GeneID:100506658 -> Cellular component: GO:0005923 [tight junction] evidence: IDA
GeneID:100506658 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
GeneID:100506658 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IEA
GeneID:100506658 -> Cellular component: GO:0016327 [apicolateral plasma membrane] evidence: IEA
GeneID:100506658 -> Cellular component: GO:0030054 [cell junction] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_002529 -> EC 2.1.1.67
by
@meso_cacase at
DBCLS
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